SK287889B6 - Isolated polypeptide that binds to TRAF2 and modulates activity of NF-B, DNA sequence encoding its, pharmaceutical composition containing them and their use - Google Patents
Isolated polypeptide that binds to TRAF2 and modulates activity of NF-B, DNA sequence encoding its, pharmaceutical composition containing them and their use Download PDFInfo
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- SK287889B6 SK287889B6 SK50016-2007A SK500162007A SK287889B6 SK 287889 B6 SK287889 B6 SK 287889B6 SK 500162007 A SK500162007 A SK 500162007A SK 287889 B6 SK287889 B6 SK 287889B6
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL11780096A IL117800A0 (en) | 1996-04-02 | 1996-04-02 | Modulators of TNF receptor associated factor (TRAF) their preparation and use |
| IL11913396A IL119133A0 (en) | 1996-08-26 | 1996-08-26 | Modulators of TNF receptor associated factor (TRAF) their preparation and use |
| PCT/IL1997/000117 WO1997037016A1 (fr) | 1996-04-02 | 1997-04-01 | Modulateurs du facteur associe au recepteur de tnf (traf), leur preparation et leur utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK287889B6 true SK287889B6 (sk) | 2012-03-02 |
Family
ID=26323248
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK50016-2007A SK287889B6 (sk) | 1996-04-02 | 1997-04-01 | Isolated polypeptide that binds to TRAF2 and modulates activity of NF-B, DNA sequence encoding its, pharmaceutical composition containing them and their use |
| SK1361-98A SK287085B6 (sk) | 1996-04-02 | 1997-04-01 | Izolovaný polypeptid, ktorý sa viaže na TRAF2 a modeluje aktivitu NF-kB, DNA sekvencia, ktorá ho kóduje, farmaceutický prostriedok s ich obsahom a ich použitie |
| SK50017-2007A SK287890B6 (sk) | 1996-04-02 | 1997-04-01 | Isolated polypeptide that binds to TRAF2 and modulates activity of NF-B, DNA sequence encoding its, pharmaceutical composition containing them and their use |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1361-98A SK287085B6 (sk) | 1996-04-02 | 1997-04-01 | Izolovaný polypeptid, ktorý sa viaže na TRAF2 a modeluje aktivitu NF-kB, DNA sekvencia, ktorá ho kóduje, farmaceutický prostriedok s ich obsahom a ich použitie |
| SK50017-2007A SK287890B6 (sk) | 1996-04-02 | 1997-04-01 | Isolated polypeptide that binds to TRAF2 and modulates activity of NF-B, DNA sequence encoding its, pharmaceutical composition containing them and their use |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US7485456B1 (fr) |
| EP (1) | EP0894130B1 (fr) |
| JP (1) | JP4180114B2 (fr) |
| CN (1) | CN1197966C (fr) |
| AT (1) | ATE380866T1 (fr) |
| AU (1) | AU732793B2 (fr) |
| BG (1) | BG64755B1 (fr) |
| BR (1) | BR9708518A (fr) |
| CA (1) | CA2250085C (fr) |
| CZ (3) | CZ299094B6 (fr) |
| DE (1) | DE69738370T2 (fr) |
| DK (1) | DK0894130T3 (fr) |
| EA (1) | EA004309B1 (fr) |
| EE (1) | EE04783B1 (fr) |
| ES (1) | ES2294796T3 (fr) |
| HK (1) | HK1018910A1 (fr) |
| HU (1) | HU226328B1 (fr) |
| NO (1) | NO327054B1 (fr) |
| NZ (1) | NZ331902A (fr) |
| PT (1) | PT894130E (fr) |
| SK (3) | SK287889B6 (fr) |
| UA (1) | UA71889C2 (fr) |
| WO (1) | WO1997037016A1 (fr) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA71889C2 (uk) * | 1996-04-02 | 2005-01-17 | Йєда Рісерч Енд Дівелопмент Ко. Лтд. | Модулятори зв'язаного з рецептором tnf фактора (traf), їх одержання та застосування |
| US5843721A (en) * | 1997-07-03 | 1998-12-01 | Tularik Inc. | Nucleic acids encoding human NIK protein |
| WO1999024469A1 (fr) * | 1997-11-07 | 1999-05-20 | Genetics Institute, Inc. | Proteines secretees et polynucleotides les codant |
| US6265538B1 (en) * | 1998-02-27 | 2001-07-24 | The Regents Of The University Of California | Inhibitor of the inflammatory response induced by the TNFA and IL-1 |
| ES2251831T3 (es) * | 1998-05-06 | 2006-05-01 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. | Inhibidores de la activacion de nf-kb. |
| BR9913070A (pt) * | 1998-08-18 | 2001-05-08 | Basf Ag | Processos para modular a atividade do knfb, para identificar um composto ou compostos capazes de, direta ou indiretamente, modular a atividade do p105, para identificar um composto de referência para um produto farmacêutico utilizável no tratamento de doença que envolva ou use uma resposta inflamatória, composto identificável anticorpo, polipeptìdeo, e, processos para modular a atividade do p105 em uma célula, uso de um composto, para identificar um composto que regule uma resposta infamatória mediada pelo tpl-2, para identificar um composto que regule a transdução de sinal pelo tpl-2, para identificar um composto que module a interação de um polipeptìdeo do tpl-2 com um componente alvo de modulação do tpl-2, para tratar uma condição do sistema imune em um paciente em necessidade deste pela modulação da atividade do tpl-2, para tratar uma condição mediada pelo tpl-2 em um paciente, e para modular a regulagem do nfkb mediada pelo tpl-2 em um paciente em necessidade deste, processo para tratar a artrite reumatóide . |
| IL131719A0 (en) | 1999-09-02 | 2001-03-19 | Yeda Res & Dev | Iren protein its preparation and use |
| GB9930616D0 (en) | 1999-12-24 | 2000-02-16 | Mathilda & Terence Kennedy Ins | Activation and inhibition of the immune system |
| KR20020069140A (ko) * | 2001-02-21 | 2002-08-29 | 주식회사 코메드 | 종양 괴사 인자 수용체 관련 인자 6 억제 단백질 |
| WO2003000280A2 (fr) | 2001-06-22 | 2003-01-03 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Protection contre l'hepatite a mediation abin |
| CA2482387C (fr) * | 2002-04-18 | 2015-03-03 | Yeda Research And Development Co. Ltd | Derives de l'enzyme inductrice du fc-kappab, leur preparation et utilisation |
| DK1678209T3 (da) * | 2003-10-07 | 2011-06-27 | Yeda Res & Dev | Antistoffer mod nik, deres frembringelse samt anvendelse |
| IL158287A0 (en) * | 2003-10-07 | 2004-05-12 | Yeda Res & Dev | Antibodies to nik, their preparation and use |
| CA2547459C (fr) * | 2003-11-30 | 2013-10-08 | Yeda Research And Development Co. Ltd | Procedes et agents pour mettre en oeuvre une modulation immunitaire et procedes d'identification de modulateurs immunitaires |
| IL173104A0 (en) * | 2006-01-12 | 2006-06-11 | Yeda Res & Dev | Siva and ubiquintination |
| CN102177438A (zh) | 2008-07-25 | 2011-09-07 | 理查德·W·瓦格纳 | 蛋白筛选方法 |
| GB201012420D0 (en) | 2010-07-23 | 2010-09-08 | Univ Erasmus Medical Ct | Foetal heamoglobin inhibitor |
| CA2808539C (fr) | 2010-08-25 | 2021-05-25 | Atyr Pharma, Inc. | Decouverte innovante de compositions therapeutiques, diagnostiques et d'anticorps associees a des fragments proteiniques des tyrosyl-arnt synthetases |
| CN102382850A (zh) * | 2010-09-01 | 2012-03-21 | 山东新时代药业有限公司 | 新型人肿瘤坏死因子受体-Fc融合基因及其产物蛋白 |
| BR112013023681A2 (pt) | 2011-03-16 | 2016-12-13 | Hoffmann La Roche | compostos de álcool propargílico 6,5-heterocíclico e uso dos mesmos |
| KR20140058532A (ko) | 2011-06-30 | 2014-05-14 | 겐자임 코포레이션 | Ｔ-세포 활성화 억제제 |
| US9549981B2 (en) | 2011-07-19 | 2017-01-24 | Philogen S.P.A. | Sequential antibody therapy |
| UY34317A (es) | 2011-09-12 | 2013-02-28 | Genzyme Corp | Anticuerpo antireceptor de célula T (alfa)/ß |
| CA2974651A1 (fr) | 2014-01-24 | 2015-07-30 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Polytherapie anticancereuse a base de smc |
| CN105986001B (zh) * | 2015-02-12 | 2019-12-03 | 上海交通大学 | 一种基于膜结合蛋白和荧光互补的高通量猎物拮抗剂筛选方法 |
| CA3135032A1 (fr) | 2019-04-03 | 2020-10-08 | Genzyme Corporation | Polypeptides de liaison anti-alpha beta tcr a fragmentation reduite |
| WO2024062074A1 (fr) | 2022-09-21 | 2024-03-28 | Sanofi Biotechnology | Anticorps anti-il-1r3 humanisé et procédés d'utilisation |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5641876A (en) * | 1990-01-05 | 1997-06-24 | Cornell Research Foundation, Inc. | Rice actin gene and promoter |
| AU705777B2 (en) * | 1995-08-02 | 1999-06-03 | Teresa J. Ingram | Composition for administration to patients with chronic fatigue syndrome and acquired immune deficiency syndrome |
| AU6692996A (en) | 1995-08-08 | 1997-03-05 | Tularik Inc. | Inhibitors of apoptosis |
| US5804412A (en) * | 1996-04-01 | 1998-09-08 | The Regents Of The University Of California | Nucleic acids encoding sorting nexins and methods of using same |
| UA71889C2 (uk) * | 1996-04-02 | 2005-01-17 | Йєда Рісерч Енд Дівелопмент Ко. Лтд. | Модулятори зв'язаного з рецептором tnf фактора (traf), їх одержання та застосування |
| EP0904346A4 (fr) | 1996-05-08 | 2000-11-29 | Henkel Corp | Carboxylates d'alkyl polyglycoside ether |
| US5843721A (en) * | 1997-07-03 | 1998-12-01 | Tularik Inc. | Nucleic acids encoding human NIK protein |
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1997
- 1997-01-04 UA UA98105743A patent/UA71889C2/uk unknown
- 1997-04-01 EP EP97914534A patent/EP0894130B1/fr not_active Expired - Lifetime
- 1997-04-01 US US09/155,676 patent/US7485456B1/en not_active Expired - Fee Related
- 1997-04-01 CZ CZ20060018A patent/CZ299094B6/cs not_active IP Right Cessation
- 1997-04-01 NZ NZ331902A patent/NZ331902A/en not_active IP Right Cessation
- 1997-04-01 CZ CZ20060017A patent/CZ298866B6/cs not_active IP Right Cessation
- 1997-04-01 JP JP53509997A patent/JP4180114B2/ja not_active Expired - Lifetime
- 1997-04-01 PT PT97914534T patent/PT894130E/pt unknown
- 1997-04-01 SK SK50016-2007A patent/SK287889B6/sk not_active IP Right Cessation
- 1997-04-01 WO PCT/IL1997/000117 patent/WO1997037016A1/fr active IP Right Grant
- 1997-04-01 AU AU21755/97A patent/AU732793B2/en not_active Expired
- 1997-04-01 CZ CZ0318398A patent/CZ299682B6/cs not_active IP Right Cessation
- 1997-04-01 EA EA199800885A patent/EA004309B1/ru not_active IP Right Cessation
- 1997-04-01 HU HU9902429A patent/HU226328B1/hu unknown
- 1997-04-01 EE EE9800322A patent/EE04783B1/xx unknown
- 1997-04-01 BR BR9708518A patent/BR9708518A/pt not_active Application Discontinuation
- 1997-04-01 CA CA002250085A patent/CA2250085C/fr not_active Expired - Lifetime
- 1997-04-01 SK SK1361-98A patent/SK287085B6/sk not_active IP Right Cessation
- 1997-04-01 ES ES97914534T patent/ES2294796T3/es not_active Expired - Lifetime
- 1997-04-01 DK DK97914534T patent/DK0894130T3/da active
- 1997-04-01 CN CNB971951934A patent/CN1197966C/zh not_active Expired - Lifetime
- 1997-04-01 SK SK50017-2007A patent/SK287890B6/sk not_active IP Right Cessation
- 1997-04-01 DE DE69738370T patent/DE69738370T2/de not_active Expired - Lifetime
- 1997-04-01 AT AT97914534T patent/ATE380866T1/de active
-
1998
- 1998-09-29 NO NO19984551A patent/NO327054B1/no not_active IP Right Cessation
- 1998-10-07 BG BG102817A patent/BG64755B1/bg unknown
-
1999
- 1999-09-15 HK HK99104000A patent/HK1018910A1/xx not_active IP Right Cessation
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2009
- 2009-02-03 US US12/365,136 patent/US8236507B2/en not_active Expired - Fee Related
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| MK4A | Patent expired |
Expiry date: 20170401 |