NO984551L - Modulatorer av TNF-receptorforbundet faktor (TRAF), deres fremstilling og anvendelse - Google Patents

Modulatorer av TNF-receptorforbundet faktor (TRAF), deres fremstilling og anvendelse

Info

Publication number
NO984551L
NO984551L NO984551A NO984551A NO984551L NO 984551 L NO984551 L NO 984551L NO 984551 A NO984551 A NO 984551A NO 984551 A NO984551 A NO 984551A NO 984551 L NO984551 L NO 984551L
Authority
NO
Norway
Prior art keywords
traf
preparation
modulators
associated factor
tnf receptor
Prior art date
Application number
NO984551A
Other languages
English (en)
Other versions
NO327054B1 (no
NO984551D0 (no
Inventor
David Wallach
Nikolai Malinin
Mark Boldin
Andrei Kovalenko
Igor Mett
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL11780096A external-priority patent/IL117800A0/xx
Priority claimed from IL11913396A external-priority patent/IL119133A0/xx
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Publication of NO984551D0 publication Critical patent/NO984551D0/no
Publication of NO984551L publication Critical patent/NO984551L/no
Publication of NO327054B1 publication Critical patent/NO327054B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Det er beskrevet en DNA-sekvens kodende for et protein som har evne til å bli bundet til en tumornekrosefaktorreseptor-assosiert faktor (TRAF) molekyl, TRAF-bindende proteiner, isoformer, analoger, fragmenter og derivater som blir kodet av DNA-sekvensen, fremgangsmåter for fremstilling av DNA-sekvenser og proteiner og anvendelser for DNA-sekvens og proteiner.
NO19984551A 1996-04-02 1998-09-29 Polypeptid som bindes til TRAF2, samt fremgangsmate for fremstilling og isolering og identifisering derav og DNA-sekvens, vektor, transformerte eukaryote eller prokariote vertsceller, antistoffer, farmasoytisk sammensetning anvendelse derav. NO327054B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL11780096A IL117800A0 (en) 1996-04-02 1996-04-02 Modulators of TNF receptor associated factor (TRAF) their preparation and use
IL11913396A IL119133A0 (en) 1996-08-26 1996-08-26 Modulators of TNF receptor associated factor (TRAF) their preparation and use
PCT/IL1997/000117 WO1997037016A1 (en) 1996-04-02 1997-04-01 Modulators of tnf receptor associated factor (traf), their preparation and use

Publications (3)

Publication Number Publication Date
NO984551D0 NO984551D0 (no) 1998-09-29
NO984551L true NO984551L (no) 1998-11-24
NO327054B1 NO327054B1 (no) 2009-04-14

Family

ID=26323248

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19984551A NO327054B1 (no) 1996-04-02 1998-09-29 Polypeptid som bindes til TRAF2, samt fremgangsmate for fremstilling og isolering og identifisering derav og DNA-sekvens, vektor, transformerte eukaryote eller prokariote vertsceller, antistoffer, farmasoytisk sammensetning anvendelse derav.

Country Status (23)

Country Link
US (2) US7485456B1 (no)
EP (1) EP0894130B1 (no)
JP (1) JP4180114B2 (no)
CN (1) CN1197966C (no)
AT (1) ATE380866T1 (no)
AU (1) AU732793B2 (no)
BG (1) BG64755B1 (no)
BR (1) BR9708518A (no)
CA (1) CA2250085C (no)
CZ (3) CZ299094B6 (no)
DE (1) DE69738370T2 (no)
DK (1) DK0894130T3 (no)
EA (1) EA004309B1 (no)
EE (1) EE04783B1 (no)
ES (1) ES2294796T3 (no)
HK (1) HK1018910A1 (no)
HU (1) HU226328B1 (no)
NO (1) NO327054B1 (no)
NZ (1) NZ331902A (no)
PT (1) PT894130E (no)
SK (3) SK287085B6 (no)
UA (1) UA71889C2 (no)
WO (1) WO1997037016A1 (no)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA71889C2 (uk) * 1996-04-02 2005-01-17 Йєда Рісерч Енд Дівелопмент Ко. Лтд. Модулятори зв'язаного з рецептором tnf фактора (traf), їх одержання та застосування
US5843721A (en) * 1997-07-03 1998-12-01 Tularik Inc. Nucleic acids encoding human NIK protein
JP2003525567A (ja) * 1997-11-07 2003-09-02 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー 分泌蛋白およびそれらをコードするポリヌクレオチド
AU2877899A (en) * 1998-02-27 1999-09-15 Regents Of The University Of California, The A novel inhibitor of the inflammatory response induced by tnfalpha and il-1
EP1075519B1 (en) * 1998-05-06 2005-11-09 Vlaams Interuniversitair Instituut voor Biotechnologie vzw. Inhibitors of nf-kb activation
US20020099169A1 (en) * 1998-08-18 2002-07-25 Basf Aktiengesellchaft Tpl-2/cot kinase and methods of use
IL131719A0 (en) * 1999-09-02 2001-03-19 Yeda Res & Dev Iren protein its preparation and use
GB9930616D0 (en) * 1999-12-24 2000-02-16 Mathilda & Terence Kennedy Ins Activation and inhibition of the immune system
KR20020069140A (ko) * 2001-02-21 2002-08-29 주식회사 코메드 종양 괴사 인자 수용체 관련 인자 6 억제 단백질
WO2003000280A2 (en) 2001-06-22 2003-01-03 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Abin-mediated hepatitis protection
PT1499729E (pt) 2002-04-18 2011-09-06 Yeda Res & Dev Derivados da enzima de indução de nf-kappab, sua preparação e utilização
ATE509034T1 (de) * 2003-10-07 2011-05-15 Yeda Res & Dev Antikörper gegen nik, deren herstellung und verwendung
IL158287A0 (en) 2003-10-07 2004-05-12 Yeda Res & Dev Antibodies to nik, their preparation and use
JP5039383B2 (ja) * 2003-11-30 2012-10-03 イエダ リサーチ アンド ディベロップメント カンパニー リミテッド 免疫モジュレーションのための方法および薬剤ならびに免疫モジュレーターの同定方法
IL173104A0 (en) * 2006-01-12 2006-06-11 Yeda Res & Dev Siva and ubiquintination
EP2316030B1 (en) 2008-07-25 2019-08-21 Wagner, Richard W. Protein screeing methods
GB201012420D0 (en) 2010-07-23 2010-09-08 Univ Erasmus Medical Ct Foetal heamoglobin inhibitor
US9029506B2 (en) 2010-08-25 2015-05-12 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tyrosyl-tRNA synthetases
CN105177032B (zh) * 2010-09-01 2019-05-10 山东新时代药业有限公司 新型人肿瘤坏死因子受体-Fc融合基因及其产物蛋白
AR085908A1 (es) 2011-03-16 2013-11-06 Hoffmann La Roche DERIVADOS DE 3-BUTIN-2-OL Y DE CARBONITRILO CON ACTIVIDAD INHIBIDORA DE LA QUINASA INDUCTORA DE NF-kB (NIK)
PT2726101T (pt) 2011-06-30 2018-11-21 Genzyme Corp Inibidores da ativação de células t
EP2734232B1 (en) 2011-07-19 2017-11-01 Philogen S.p.A. Sequential anti-ctla4 and targeted il-2 therapy
UY34317A (es) 2011-09-12 2013-02-28 Genzyme Corp Anticuerpo antireceptor de célula T (alfa)/ß
US10441654B2 (en) 2014-01-24 2019-10-15 Children's Hospital Of Eastern Ontario Research Institute Inc. SMC combination therapy for the treatment of cancer
CN105986001B (zh) * 2015-02-12 2019-12-03 上海交通大学 一种基于膜结合蛋白和荧光互补的高通量猎物拮抗剂筛选方法
CA3135032A1 (en) 2019-04-03 2020-10-08 Genzyme Corporation Anti-alpha beta tcr binding polypeptides with reduced fragmentation
US12054552B2 (en) 2022-09-21 2024-08-06 Sanofi Biotechnology Humanized anti-IL-1R3 antibody and methods of use

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US5641876A (en) * 1990-01-05 1997-06-24 Cornell Research Foundation, Inc. Rice actin gene and promoter
AU705777B2 (en) * 1995-08-02 1999-06-03 Teresa J. Ingram Composition for administration to patients with chronic fatigue syndrome and acquired immune deficiency syndrome
AU6692996A (en) 1995-08-08 1997-03-05 Tularik Inc. Inhibitors of apoptosis
US5804412A (en) * 1996-04-01 1998-09-08 The Regents Of The University Of California Nucleic acids encoding sorting nexins and methods of using same
UA71889C2 (uk) * 1996-04-02 2005-01-17 Йєда Рісерч Енд Дівелопмент Ко. Лтд. Модулятори зв'язаного з рецептором tnf фактора (traf), їх одержання та застосування
WO1997042299A1 (en) 1996-05-08 1997-11-13 Henkel Corporation Alkyl polyglycoside ether carboxylates
US5843721A (en) * 1997-07-03 1998-12-01 Tularik Inc. Nucleic acids encoding human NIK protein

Also Published As

Publication number Publication date
CN1221449A (zh) 1999-06-30
ES2294796T3 (es) 2008-04-01
WO1997037016A1 (en) 1997-10-09
EP0894130B1 (en) 2007-12-12
EE04783B1 (et) 2007-02-15
CN1197966C (zh) 2005-04-20
AU732793B2 (en) 2001-05-03
US7485456B1 (en) 2009-02-03
PT894130E (pt) 2008-01-14
CA2250085C (en) 2009-10-20
CZ318398A3 (cs) 1999-05-12
HU226328B1 (en) 2008-09-29
DE69738370T2 (de) 2008-12-04
SK287889B6 (sk) 2012-03-02
ATE380866T1 (de) 2007-12-15
EA199800885A1 (ru) 1999-04-29
JP2000507826A (ja) 2000-06-27
NO327054B1 (no) 2009-04-14
HK1018910A1 (en) 2000-01-07
CZ298866B6 (cs) 2008-02-27
DK0894130T3 (da) 2008-01-07
BG64755B1 (bg) 2006-02-28
SK136198A3 (en) 1999-05-07
JP4180114B2 (ja) 2008-11-12
US20090291888A1 (en) 2009-11-26
BR9708518A (pt) 1999-08-03
SK287085B6 (sk) 2009-11-05
CZ299094B6 (cs) 2008-04-23
CA2250085A1 (en) 1997-10-09
HUP9902429A2 (hu) 1999-10-28
CZ299682B6 (cs) 2008-10-15
EP0894130A1 (en) 1999-02-03
HUP9902429A3 (en) 2001-11-28
BG102817A (en) 1999-05-31
EA004309B1 (ru) 2004-02-26
SK287890B6 (sk) 2012-03-02
EE9800322A (et) 1999-04-15
US8236507B2 (en) 2012-08-07
NZ331902A (en) 2000-02-28
DE69738370D1 (de) 2008-01-24
NO984551D0 (no) 1998-09-29
UA71889C2 (uk) 2005-01-17
AU2175597A (en) 1997-10-22

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