BR9708518A - Moduladores de fator associado a receptor tnf (traf) sua preparação e uso - Google Patents
Moduladores de fator associado a receptor tnf (traf) sua preparação e usoInfo
- Publication number
- BR9708518A BR9708518A BR9708518A BR9708518A BR9708518A BR 9708518 A BR9708518 A BR 9708518A BR 9708518 A BR9708518 A BR 9708518A BR 9708518 A BR9708518 A BR 9708518A BR 9708518 A BR9708518 A BR 9708518A
- Authority
- BR
- Brazil
- Prior art keywords
- traf
- modulators
- preparation
- tnf receptor
- factor associated
- Prior art date
Links
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 title abstract 2
- 102000003298 tumor necrosis factor receptor Human genes 0.000 title abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 4
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 102000014914 Carrier Proteins Human genes 0.000 abstract 1
- 102000001708 Protein Isoforms Human genes 0.000 abstract 1
- 108010029485 Protein Isoforms Proteins 0.000 abstract 1
- 108091008324 binding proteins Proteins 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL11780096A IL117800A0 (en) | 1996-04-02 | 1996-04-02 | Modulators of TNF receptor associated factor (TRAF) their preparation and use |
IL11913396A IL119133A0 (en) | 1996-08-26 | 1996-08-26 | Modulators of TNF receptor associated factor (TRAF) their preparation and use |
PCT/IL1997/000117 WO1997037016A1 (en) | 1996-04-02 | 1997-04-01 | Modulators of tnf receptor associated factor (traf), their preparation and use |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9708518A true BR9708518A (pt) | 1999-08-03 |
Family
ID=26323248
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9708518A BR9708518A (pt) | 1996-04-02 | 1997-04-01 | Moduladores de fator associado a receptor tnf (traf) sua preparação e uso |
Country Status (23)
Country | Link |
---|---|
US (2) | US7485456B1 (pt) |
EP (1) | EP0894130B1 (pt) |
JP (1) | JP4180114B2 (pt) |
CN (1) | CN1197966C (pt) |
AT (1) | ATE380866T1 (pt) |
AU (1) | AU732793B2 (pt) |
BG (1) | BG64755B1 (pt) |
BR (1) | BR9708518A (pt) |
CA (1) | CA2250085C (pt) |
CZ (3) | CZ299682B6 (pt) |
DE (1) | DE69738370T2 (pt) |
DK (1) | DK0894130T3 (pt) |
EA (1) | EA004309B1 (pt) |
EE (1) | EE04783B1 (pt) |
ES (1) | ES2294796T3 (pt) |
HK (1) | HK1018910A1 (pt) |
HU (1) | HU226328B1 (pt) |
NO (1) | NO327054B1 (pt) |
NZ (1) | NZ331902A (pt) |
PT (1) | PT894130E (pt) |
SK (3) | SK287085B6 (pt) |
UA (1) | UA71889C2 (pt) |
WO (1) | WO1997037016A1 (pt) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA71889C2 (uk) * | 1996-04-02 | 2005-01-17 | Йєда Рісерч Енд Дівелопмент Ко. Лтд. | Модулятори зв'язаного з рецептором tnf фактора (traf), їх одержання та застосування |
US5843721A (en) * | 1997-07-03 | 1998-12-01 | Tularik Inc. | Nucleic acids encoding human NIK protein |
WO1999024469A1 (en) * | 1997-11-07 | 1999-05-20 | Genetics Institute, Inc. | Secreted proteins and polynucleotides encoding them |
WO1999043704A1 (en) * | 1998-02-27 | 1999-09-02 | The Regents Of The University Of California | A NOVEL INHIBITOR OF THE INFLAMMATORY RESPONSE INDUCED BY TNFα AND IL-1 |
DE69928244T2 (de) | 1998-05-06 | 2006-08-10 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. | Inhibitoren der nf-kb aktivierung |
TR200103840T2 (tr) * | 1998-08-18 | 2002-06-21 | Basf Aktiengesellschaft | TPL-2/cot kinaz ve kullanım yöntemleri |
IL131719A0 (en) * | 1999-09-02 | 2001-03-19 | Yeda Res & Dev | Iren protein its preparation and use |
GB9930616D0 (en) * | 1999-12-24 | 2000-02-16 | Mathilda & Terence Kennedy Ins | Activation and inhibition of the immune system |
US20040109854A1 (en) * | 2001-02-21 | 2004-06-10 | Zang-Hee Lee | Novel traf6 inhibiting protein |
CA2447249A1 (en) | 2001-06-22 | 2003-01-03 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Abin-mediated hepatitis protection |
EP1499724B1 (en) * | 2002-04-18 | 2013-05-22 | Yeda Research And Development Co., Ltd. | Derivatives of the il-2 receptor gamma chain, their production and use |
PT1678209E (pt) * | 2003-10-07 | 2011-06-30 | Yeda Res & Dev | Anticorpos para a nik, a sua preparação e a sua utilização |
IL158287A0 (en) * | 2003-10-07 | 2004-05-12 | Yeda Res & Dev | Antibodies to nik, their preparation and use |
ES2469670T3 (es) * | 2003-11-30 | 2014-06-18 | Yeda Research And Development Co., Ltd. | Métodos y agentes para inmunomodulaci�n y métodos para identificar inmunomoduladores |
IL173104A0 (en) * | 2006-01-12 | 2006-06-11 | Yeda Res & Dev | Siva and ubiquintination |
EP3629022A1 (en) | 2008-07-25 | 2020-04-01 | Richard W. Wagner | Protein screening methods |
GB201012420D0 (en) | 2010-07-23 | 2010-09-08 | Univ Erasmus Medical Ct | Foetal heamoglobin inhibitor |
CN103108650A (zh) | 2010-08-25 | 2013-05-15 | Atyr医药公司 | 与酪氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
CN102382850A (zh) * | 2010-09-01 | 2012-03-21 | 山东新时代药业有限公司 | 新型人肿瘤坏死因子受体-Fc融合基因及其产物蛋白 |
BR112013023681A2 (pt) | 2011-03-16 | 2016-12-13 | Hoffmann La Roche | compostos de álcool propargílico 6,5-heterocíclico e uso dos mesmos |
HUE040455T2 (hu) | 2011-06-30 | 2019-03-28 | Genzyme Corp | T-sejt aktiválás inhibitorai |
US9549981B2 (en) | 2011-07-19 | 2017-01-24 | Philogen S.P.A. | Sequential antibody therapy |
UY34317A (es) | 2011-09-12 | 2013-02-28 | Genzyme Corp | Anticuerpo antireceptor de célula T (alfa)/ß |
US10441654B2 (en) | 2014-01-24 | 2019-10-15 | Children's Hospital Of Eastern Ontario Research Institute Inc. | SMC combination therapy for the treatment of cancer |
CN105986001B (zh) * | 2015-02-12 | 2019-12-03 | 上海交通大学 | 一种基于膜结合蛋白和荧光互补的高通量猎物拮抗剂筛选方法 |
CA3135032A1 (en) | 2019-04-03 | 2020-10-08 | Genzyme Corporation | Anti-alpha beta tcr binding polypeptides with reduced fragmentation |
WO2024062074A1 (en) | 2022-09-21 | 2024-03-28 | Sanofi Biotechnology | Humanized anti-il-1r3 antibody and methods of use |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5641876A (en) * | 1990-01-05 | 1997-06-24 | Cornell Research Foundation, Inc. | Rice actin gene and promoter |
AU705777B2 (en) * | 1995-08-02 | 1999-06-03 | Teresa J. Ingram | Composition for administration to patients with chronic fatigue syndrome and acquired immune deficiency syndrome |
AU6692996A (en) | 1995-08-08 | 1997-03-05 | Tularik Inc. | Inhibitors of apoptosis |
US5804412A (en) * | 1996-04-01 | 1998-09-08 | The Regents Of The University Of California | Nucleic acids encoding sorting nexins and methods of using same |
UA71889C2 (uk) * | 1996-04-02 | 2005-01-17 | Йєда Рісерч Енд Дівелопмент Ко. Лтд. | Модулятори зв'язаного з рецептором tnf фактора (traf), їх одержання та застосування |
JP2000509713A (ja) | 1996-05-08 | 2000-08-02 | ヘンケル コーポレーション | アルキルポリグリコシドエーテルカルボン酸 |
US5843721A (en) * | 1997-07-03 | 1998-12-01 | Tularik Inc. | Nucleic acids encoding human NIK protein |
-
1997
- 1997-01-04 UA UA98105743A patent/UA71889C2/uk unknown
- 1997-04-01 DE DE69738370T patent/DE69738370T2/de not_active Expired - Lifetime
- 1997-04-01 HU HU9902429A patent/HU226328B1/hu unknown
- 1997-04-01 CZ CZ0318398A patent/CZ299682B6/cs not_active IP Right Cessation
- 1997-04-01 EA EA199800885A patent/EA004309B1/ru not_active IP Right Cessation
- 1997-04-01 CZ CZ20060017A patent/CZ298866B6/cs not_active IP Right Cessation
- 1997-04-01 CZ CZ20060018A patent/CZ299094B6/cs not_active IP Right Cessation
- 1997-04-01 SK SK1361-98A patent/SK287085B6/sk not_active IP Right Cessation
- 1997-04-01 ES ES97914534T patent/ES2294796T3/es not_active Expired - Lifetime
- 1997-04-01 EE EE9800322A patent/EE04783B1/xx unknown
- 1997-04-01 AU AU21755/97A patent/AU732793B2/en not_active Expired
- 1997-04-01 WO PCT/IL1997/000117 patent/WO1997037016A1/en active IP Right Grant
- 1997-04-01 JP JP53509997A patent/JP4180114B2/ja not_active Expired - Lifetime
- 1997-04-01 CA CA002250085A patent/CA2250085C/en not_active Expired - Lifetime
- 1997-04-01 US US09/155,676 patent/US7485456B1/en not_active Expired - Fee Related
- 1997-04-01 BR BR9708518A patent/BR9708518A/pt not_active Application Discontinuation
- 1997-04-01 SK SK50017-2007A patent/SK287890B6/sk not_active IP Right Cessation
- 1997-04-01 DK DK97914534T patent/DK0894130T3/da active
- 1997-04-01 CN CNB971951934A patent/CN1197966C/zh not_active Expired - Lifetime
- 1997-04-01 SK SK50016-2007A patent/SK287889B6/sk not_active IP Right Cessation
- 1997-04-01 EP EP97914534A patent/EP0894130B1/en not_active Expired - Lifetime
- 1997-04-01 PT PT97914534T patent/PT894130E/pt unknown
- 1997-04-01 AT AT97914534T patent/ATE380866T1/de active
- 1997-04-01 NZ NZ331902A patent/NZ331902A/en not_active IP Right Cessation
-
1998
- 1998-09-29 NO NO19984551A patent/NO327054B1/no not_active IP Right Cessation
- 1998-10-07 BG BG102817A patent/BG64755B1/bg unknown
-
1999
- 1999-09-15 HK HK99104000A patent/HK1018910A1/xx not_active IP Right Cessation
-
2009
- 2009-02-03 US US12/365,136 patent/US8236507B2/en not_active Expired - Fee Related
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 37, SUGIRO O INDEFERIMENTO DO PRESENTE PEDIDO, TENDO POR BASE OS ARTIGOS 10, 24, 25 DA LEI 9.279 DE 14/05/1996. |
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B12B | Appeal against refusal [chapter 12.2 patent gazette] |