SK287748B6 - Substituované 5-amino-pyrazolo[4,3-e]-1,2,4-triazolo[1,5- c]pyrimidíny, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie - Google Patents

Substituované 5-amino-pyrazolo[4,3-e]-1,2,4-triazolo[1,5- c]pyrimidíny, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie Download PDF

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Publication number
SK287748B6
SK287748B6 SK1671-2002A SK16712002A SK287748B6 SK 287748 B6 SK287748 B6 SK 287748B6 SK 16712002 A SK16712002 A SK 16712002A SK 287748 B6 SK287748 B6 SK 287748B6
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SK
Slovakia
Prior art keywords
alkyl
alkoxy
formula
mmol
amino
Prior art date
Application number
SK1671-2002A
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English (en)
Slovak (sk)
Other versions
SK16712002A3 (sk
Inventor
Bernard R. Neustadt
Neil A. Lindo
William J. Greenlee
Deen Tulshian
Lisa S. Silverman
Yan Xia
Craig D. Boyle
Samuel Chackalamannil
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Schering Corporation
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Application filed by Schering Corporation filed Critical Schering Corporation
Publication of SK16712002A3 publication Critical patent/SK16712002A3/sk
Publication of SK287748B6 publication Critical patent/SK287748B6/sk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SK1671-2002A 2000-05-26 2001-05-24 Substituované 5-amino-pyrazolo[4,3-e]-1,2,4-triazolo[1,5- c]pyrimidíny, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie SK287748B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20714300P 2000-05-26 2000-05-26
PCT/US2001/016954 WO2001092264A1 (en) 2000-05-26 2001-05-24 Adenosine a2a receptor antagonists

Publications (2)

Publication Number Publication Date
SK16712002A3 SK16712002A3 (sk) 2003-08-05
SK287748B6 true SK287748B6 (sk) 2011-08-04

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SK1671-2002A SK287748B6 (sk) 2000-05-26 2001-05-24 Substituované 5-amino-pyrazolo[4,3-e]-1,2,4-triazolo[1,5- c]pyrimidíny, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie

Country Status (31)

Country Link
US (4) US6630475B2 (zh)
EP (1) EP1283839B1 (zh)
JP (3) JP4574112B2 (zh)
KR (1) KR100520907B1 (zh)
CN (2) CN100384847C (zh)
AR (1) AR028621A1 (zh)
AT (1) ATE293627T1 (zh)
AU (2) AU6808901A (zh)
BR (1) BRPI0111015B8 (zh)
CA (1) CA2410237C (zh)
CZ (1) CZ303790B6 (zh)
DE (1) DE60110219T2 (zh)
DK (1) DK1283839T3 (zh)
EC (1) ECSP024364A (zh)
ES (1) ES2237576T3 (zh)
HK (1) HK1049007B (zh)
HU (1) HU230420B1 (zh)
IL (3) IL152726A0 (zh)
MX (1) MXPA02011625A (zh)
MY (1) MY132006A (zh)
NO (1) NO325008B1 (zh)
NZ (1) NZ522326A (zh)
PE (1) PE20020062A1 (zh)
PL (1) PL218764B1 (zh)
PT (1) PT1283839E (zh)
RU (1) RU2315053C2 (zh)
SI (1) SI1283839T1 (zh)
SK (1) SK287748B6 (zh)
TW (1) TWI288137B (zh)
WO (1) WO2001092264A1 (zh)
ZA (1) ZA200208898B (zh)

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EP1934227B1 (en) * 2005-09-19 2011-12-21 Schering Corporation 2-HETEROARYL-PYRAZOLO-[4, 3-e]-1, 2, 4-TRIAZOLO-[1,5-c]-PYRIMIDINE AS ADENOSINE A2a RECEPTOR ANTAGONISTS

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