SK287566B6 - Derivát čiastočne desulfátovaných glykózaminoglykánov, spôsob jeho prípravy a použitie - Google Patents

Derivát čiastočne desulfátovaných glykózaminoglykánov, spôsob jeho prípravy a použitie Download PDF

Info

Publication number
SK287566B6
SK287566B6 SK1067-2002A SK10672002A SK287566B6 SK 287566 B6 SK287566 B6 SK 287566B6 SK 10672002 A SK10672002 A SK 10672002A SK 287566 B6 SK287566 B6 SK 287566B6
Authority
SK
Slovakia
Prior art keywords
heparin
uranium
modified
acids
partially
Prior art date
Application number
SK1067-2002A
Other languages
English (en)
Slovak (sk)
Other versions
SK10672002A3 (sk
Inventor
Benito Casu
Giangiacomo Torri
Anna Maria Naggi
Giuseppe Giannini
Claudio Pisano
Sergio Penco
Original Assignee
Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. filed Critical Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Publication of SK10672002A3 publication Critical patent/SK10672002A3/sk
Publication of SK287566B6 publication Critical patent/SK287566B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Polymers & Plastics (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
SK1067-2002A 2000-01-25 2001-01-24 Derivát čiastočne desulfátovaných glykózaminoglykánov, spôsob jeho prípravy a použitie SK287566B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2000RM000041A IT1316986B1 (it) 2000-01-25 2000-01-25 Derivati glicosamminoglicani parzialmente desolfatati nonanticoagulanti ad attivita' antiangiogenica.
PCT/IT2001/000034 WO2001055221A1 (en) 2000-01-25 2001-01-24 Derivatives of partially desulphated glycosaminoglycans endowed with antiangiogenic activity and devoid of anticoagulating effect

Publications (2)

Publication Number Publication Date
SK10672002A3 SK10672002A3 (sk) 2002-12-03
SK287566B6 true SK287566B6 (sk) 2011-02-04

Family

ID=11454382

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1067-2002A SK287566B6 (sk) 2000-01-25 2001-01-24 Derivát čiastočne desulfátovaných glykózaminoglykánov, spôsob jeho prípravy a použitie

Country Status (22)

Country Link
US (4) US20030013682A1 (ja)
EP (1) EP1268558B1 (ja)
JP (1) JP5371167B2 (ja)
KR (1) KR100812406B1 (ja)
CN (1) CN100540570C (ja)
AT (1) ATE348115T1 (ja)
AU (1) AU782632B2 (ja)
BR (1) BR0107696A (ja)
CA (1) CA2397964C (ja)
CY (1) CY1108001T1 (ja)
CZ (1) CZ303030B6 (ja)
DE (1) DE60125154T2 (ja)
DK (1) DK1268558T3 (ja)
ES (1) ES2277911T3 (ja)
HK (1) HK1051867A1 (ja)
HU (1) HU229509B1 (ja)
IT (1) IT1316986B1 (ja)
MX (1) MXPA02007195A (ja)
PL (1) PL209479B1 (ja)
PT (1) PT1268558E (ja)
SK (1) SK287566B6 (ja)
WO (1) WO2001055221A1 (ja)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7781416B2 (en) 2000-01-25 2010-08-24 Sigma-Tau Research Switzerland S.A. Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
IT1316986B1 (it) 2000-01-25 2003-05-26 Sigma Tau Ind Farmaceuti Derivati glicosamminoglicani parzialmente desolfatati nonanticoagulanti ad attivita' antiangiogenica.
EP1427427B1 (en) * 2001-09-12 2011-06-08 SIGMA-TAU Research Switzerland S.A. Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
AU2008202261B2 (en) * 2001-09-12 2011-07-28 Leadiant Biosciences S.A. Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
US8128966B2 (en) 2004-03-26 2012-03-06 La Jolla Pharmaceutical Company Modified pectins, compositions and methods related thereto
WO2009007224A1 (en) * 2007-07-10 2009-01-15 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Low molecular weight heparin derivatives having neuroprotective activity
US8569262B2 (en) 2007-11-02 2013-10-29 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
JP5572095B2 (ja) * 2007-11-02 2014-08-13 モメンタ ファーマシューティカルズ インコーポレイテッド 非抗凝固性多糖組成物
WO2009059284A2 (en) * 2007-11-02 2009-05-07 Momenta Pharmaceuticals, Inc. Non-anticoagulant polysaccharide compositions
US8592393B2 (en) 2007-11-02 2013-11-26 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
JP5982361B2 (ja) 2010-04-16 2016-08-31 モメンタ ファーマシューティカルズ インコーポレイテッド 組織標的化方法
US8431826B2 (en) 2010-05-14 2013-04-30 James Robert Howard Capacitive power and ground plane structure utilizing fractal elements for the reduction of radiated emissions
WO2011159770A2 (en) 2010-06-17 2011-12-22 Momenta Pharmaceuticals, Inc. Methods and compositions for modulating hair growth
WO2013095215A1 (en) 2011-12-19 2013-06-27 Dilaforette Ab Low anticoagulant heparins
SI2794665T1 (en) 2011-12-19 2018-03-30 Dilafor Ab Non-coagulating glycosaminoglycans containing a recurring disaccharide unit and their medical use
US8871925B2 (en) 2011-12-28 2014-10-28 Galectin Therapeutics Inc. Compositions of novel carbohydrate drug for treatment of human diseases
BR112014030534A2 (pt) 2012-06-06 2017-06-27 Galectin Therapeutics Inc composições de galacto-ramnogalacturonato para o tratamento de doenças associadas com óxido nítrico sintase induzível elevada
US9507912B2 (en) 2012-08-31 2016-11-29 Nuvectra Corporation Method and system of simulating a pulse generator on a clinician programmer
MX2015003416A (es) 2012-09-17 2015-10-29 Galectin Therapeutics Inc Metodo para mejorar las inmunoterapias especificas en el tratamiento contra el cancer.
MX363178B (es) 2012-10-10 2019-03-13 Galectin Therapeutics Inc Compuestos de carbohidratos con funcion de galactosa para el tratamiento de la nefropatia diabetica y de los trastornos asociados.
US9339515B2 (en) 2013-02-20 2016-05-17 Galectin Therapeutics, Inc. Method for treatment of pulmonary fibrosis
JP6132302B2 (ja) * 2013-05-28 2017-05-24 リーディアント・バイオサイエンシーズ・ソシエタ・アノニマＬｅａｄｉａｎｔ Ｂｉｏｓｃｉｅｎｃｅｓ Ｓ．Ａ． 抗血管新生活性を有し、抗凝血効果を有さない、ヘパラナーゼ阻害剤としての部分的に脱硫酸化されたグリコサミノグリカンの誘導体
CA2910837A1 (en) 2013-05-28 2014-12-04 Momenta Pharmaceuticals, Inc. Pharmaceutical compositions
ITLO20130005A1 (it) * 2013-10-31 2015-05-01 He E Biochimiche G Ronzonr S R Derivati di glucosamminoglicani n-desolfatati e loro uso come farmaci
ITLO20130006A1 (it) 2013-11-06 2015-05-07 He E Biochimiche G Ronzoni S R Derivati carbossilati di glucosamminoglicani e loro uso come farmaci
CN103724458B (zh) * 2014-01-17 2016-03-30 福州大学 含n-非取代葡萄糖胺肝素六糖的制备及其纯化
PL3265075T3 (pl) 2015-03-06 2020-10-05 Leadiant Biosciences S.P.A. Terapia skojarzona szpiczaka mnogiego obejmująca roneparstat
JP2016014148A (ja) * 2015-09-10 2016-01-28 シグマ−タウ・リサーチ・スウィッツァーランド・ソシエテ・アノニム 抗血管新生活性を有し、抗凝血効果を有さない、ヘパラナーゼ阻害剤としての部分的に脱硫酸化されたグリコサミノグリカンの誘導体
CN107177015A (zh) * 2016-03-11 2017-09-19 梁颖 一种重乙酰化肝素修饰物及其制备方法和应用
MX2019006863A (es) 2016-12-13 2019-09-13 Beta Therapeutics Pty Ltd Inhibidores de heparanasa y uso de los mismos.
US11787783B2 (en) 2016-12-13 2023-10-17 Beta Therapeutics Pty Ltd Heparanase inhibitors and use thereof
CN108424474B (zh) * 2017-02-15 2023-07-25 清华大学 去抗凝肝素衍生物及其用于炎症性肠病的治疗
CN111670038B (zh) * 2018-02-02 2024-01-26 深圳市海普瑞药业集团股份有限公司 糖胺聚糖衍生物及其制备方法和用途
EP3705126A1 (en) 2019-03-05 2020-09-09 Leadiant Biosciences S.p.A. Roneparstat for the treatment of amyloidosis
WO2021128253A1 (zh) * 2019-12-27 2021-07-01 深圳市海普瑞药业集团股份有限公司 一种糖胺聚糖衍生物及其应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4500519A (en) * 1978-11-06 1985-02-19 Choay S.A. Mucopolysaccharides having biological properties, preparation and method of use
US5262403A (en) 1986-03-10 1993-11-16 Board Of Regents, The University Of Texas System Glycosaminoglycan derivatives and their use as inhibitors of tumor invasiveness of metastatic profusion-II
IL79255A0 (en) 1986-06-26 1986-09-30 Hadassah Med Org Composition for metastasis prevention
AU7852687A (en) * 1986-08-21 1988-03-08 University Of Texas System, The Glycosaminoglycan derivatives and their use as inhibitors of tumor invasiveness or metastatic profusion
FR2614026B1 (fr) * 1987-04-16 1992-04-17 Sanofi Sa Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
US5280016A (en) * 1991-03-29 1994-01-18 Glycomed Incorporated Non-anticoagulant heparin derivatives
JPH05157344A (ja) * 1991-12-09 1993-06-22 Mitsubishi Heavy Ind Ltd 空気調和機の吹出口
JPH0512822A (ja) 1991-12-16 1993-01-22 Seiko Epson Corp カートリツジ
JPH06157344A (ja) * 1992-02-07 1994-06-03 Childrens Medical Center Corp:The 血管新生阻害のための医薬製剤及び血管新生阻害方法
US5668118A (en) * 1992-07-24 1997-09-16 Cavalier Pharmaceuticals Method of synthesis of 2-O-desulfated Heparin and use thereof for inhibition of elastase and Cathepspin G
US5696100A (en) * 1992-12-22 1997-12-09 Glycomed Incorporated Method for controlling O-desulfation of heparin and compositions produced thereby
US5296471A (en) 1992-12-22 1994-03-22 Glycomed Incorporated Method for controlling o-desulfation of heparin and compositions produced thereby
IT1264709B1 (it) 1993-07-12 1996-10-04 Italfarmaco Spa Derivati eparinici ad attivita' antimetastatica
US5583121A (en) * 1994-01-12 1996-12-10 Michigan State University Non-anticoagulant chemically modified heparinoids for treating hypovolemic shock and related shock syndromes
CA2189038A1 (en) * 1994-05-06 1995-11-09 Kevin R. Holme O-desulfated heparin derivatives, methods of making and uses thereof
IL114951A (en) * 1995-08-15 1999-08-17 Hadasit Med Res Service Quinazolinone-containing pharmaceutical compositions for prevention of neovascularization
US5854221A (en) * 1996-12-12 1998-12-29 The Children's Medical Center Corporation Endothelial cell proliferation inhibitor and method of use
NZ326354A (en) * 1996-01-15 1999-05-28 Janssen Pharmaceutica Nv 3-(substituted-1-piperazinyl)-6-(substituted-1,2,4-thiadiazol-5 -yl)-pyridazine derivatives and medicaments
JP4051099B2 (ja) * 1997-01-31 2008-02-20 生化学工業株式会社 低分子化ヘパリン、その製造法及び医薬組成物
IT1296581B1 (it) * 1997-11-28 1999-07-14 Istituto Scient Di Chimica E B Materiali polimerici non trombogenici e ad esaltata compatibilita' con fluidi e tessuti organici
IT1296998B1 (it) * 1997-12-19 1999-08-03 Derivati Organici Lab Composizione costituita da frazioni di eparina avente caratteristiche riproducibili con peso molecolare medio di 5200 d
IT1316986B1 (it) * 2000-01-25 2003-05-26 Sigma Tau Ind Farmaceuti Derivati glicosamminoglicani parzialmente desolfatati nonanticoagulanti ad attivita' antiangiogenica.
US7781416B2 (en) * 2000-01-25 2010-08-24 Sigma-Tau Research Switzerland S.A. Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect

Also Published As

Publication number Publication date
ES2277911T3 (es) 2007-08-01
CY1108001T1 (el) 2013-09-04
US8222231B2 (en) 2012-07-17
CA2397964A1 (en) 2001-08-02
CN100540570C (zh) 2009-09-16
US7790700B2 (en) 2010-09-07
JP5371167B2 (ja) 2013-12-18
CZ303030B6 (cs) 2012-03-07
DE60125154T2 (de) 2007-10-25
US20100298263A1 (en) 2010-11-25
PT1268558E (pt) 2007-02-28
AU782632B2 (en) 2005-08-18
EP1268558A1 (en) 2003-01-02
JP2003523460A (ja) 2003-08-05
CA2397964C (en) 2010-10-12
CN1396930A (zh) 2003-02-12
US20050222084A1 (en) 2005-10-06
PL357209A1 (en) 2004-07-26
EP1268558B1 (en) 2006-12-13
US20050107331A1 (en) 2005-05-19
DE60125154D1 (de) 2007-01-25
DK1268558T3 (da) 2007-04-10
BR0107696A (pt) 2002-10-15
HUP0204196A3 (en) 2003-05-28
MXPA02007195A (es) 2003-01-28
AU3406401A (en) 2001-08-07
HK1051867A1 (en) 2003-08-22
HUP0204196A2 (hu) 2003-03-28
IT1316986B1 (it) 2003-05-26
ITRM20000041A1 (it) 2001-07-25
ITRM20000041A0 (it) 2000-01-25
WO2001055221A1 (en) 2001-08-02
KR100812406B1 (ko) 2008-03-11
SK10672002A3 (sk) 2002-12-03
ATE348115T1 (de) 2007-01-15
CZ20022308A3 (cs) 2003-01-15
PL209479B1 (pl) 2011-09-30
US20030013682A1 (en) 2003-01-16
HU229509B1 (en) 2014-01-28
KR20020080381A (ko) 2002-10-23

Similar Documents

Publication Publication Date Title
SK287566B6 (sk) Derivát čiastočne desulfátovaných glykózaminoglykánov, spôsob jeho prípravy a použitie
US9351992B2 (en) Non-anticoagulant polysaccharide compositions
CA2703848C (en) Non-anticoagulant polysaccharide compositions
US9212233B2 (en) Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
EP2419736B1 (en) Methods of assessing activity of a polysaccharide composition

Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20160124