SK287335B6 - Použitie 4-{(4-metylpiperazin-1-ylmetyl)-N-[4-metyl-3-(4-pyrid-3- yl)pyrimidin-2-ylamino]fenyl}-benzamidu na prípravu farmaceutických kompozícií na liečenie gastrointestinálnych strómových tumorov - Google Patents

Použitie 4-{(4-metylpiperazin-1-ylmetyl)-N-[4-metyl-3-(4-pyrid-3- yl)pyrimidin-2-ylamino]fenyl}-benzamidu na prípravu farmaceutických kompozícií na liečenie gastrointestinálnych strómových tumorov Download PDF

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Publication number
SK287335B6
SK287335B6 SK518-2003A SK5182003A SK287335B6 SK 287335 B6 SK287335 B6 SK 287335B6 SK 5182003 A SK5182003 A SK 5182003A SK 287335 B6 SK287335 B6 SK 287335B6
Authority
SK
Slovakia
Prior art keywords
treatment
formula
salt
methyl
pyrimidin
Prior art date
Application number
SK518-2003A
Other languages
English (en)
Slovak (sk)
Other versions
SK5182003A3 (en
Inventor
Elisabeth Buchdunger
Renaud Capdeville
George Daniel Demetri
Sasa Dimitrijevic
Brian J. Druker
Jonathan A. Fletcher
Heikki Joensuu
Sandra Leta Silberman
David Tuveson
Michael C. Heinrich
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22920224&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK287335(B6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SK5182003A3 publication Critical patent/SK5182003A3/sk
Publication of SK287335B6 publication Critical patent/SK287335B6/sk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Farming Of Fish And Shellfish (AREA)
SK518-2003A 2000-10-27 2001-10-26 Použitie 4-{(4-metylpiperazin-1-ylmetyl)-N-[4-metyl-3-(4-pyrid-3- yl)pyrimidin-2-ylamino]fenyl}-benzamidu na prípravu farmaceutických kompozícií na liečenie gastrointestinálnych strómových tumorov SK287335B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24381000P 2000-10-27 2000-10-27
PCT/EP2001/012442 WO2002034727A2 (en) 2000-10-27 2001-10-26 Treatment of gastrointestinal stromal tumors

Publications (2)

Publication Number Publication Date
SK5182003A3 SK5182003A3 (en) 2004-02-03
SK287335B6 true SK287335B6 (sk) 2010-07-07

Family

ID=22920224

Family Applications (1)

Application Number Title Priority Date Filing Date
SK518-2003A SK287335B6 (sk) 2000-10-27 2001-10-26 Použitie 4-{(4-metylpiperazin-1-ylmetyl)-N-[4-metyl-3-(4-pyrid-3- yl)pyrimidin-2-ylamino]fenyl}-benzamidu na prípravu farmaceutických kompozícií na liečenie gastrointestinálnych strómových tumorov

Country Status (26)

Country Link
US (1) US6958335B2 (no)
EP (1) EP1332137B1 (no)
JP (1) JP4386635B2 (no)
KR (1) KR100885129B1 (no)
CN (1) CN1276754C (no)
AT (1) ATE321556T1 (no)
AU (2) AU2002218262B2 (no)
BR (1) BRPI0114870B8 (no)
CA (1) CA2424470C (no)
CY (1) CY1105055T1 (no)
CZ (1) CZ303944B6 (no)
DE (1) DE60118430T2 (no)
DK (1) DK1332137T3 (no)
ES (1) ES2260317T3 (no)
HK (1) HK1058193A1 (no)
HU (1) HU229106B1 (no)
IL (2) IL155029A0 (no)
MX (1) MXPA03003703A (no)
NO (1) NO324948B1 (no)
NZ (1) NZ525254A (no)
PL (1) PL209733B1 (no)
PT (1) PT1332137E (no)
RU (1) RU2301066C2 (no)
SK (1) SK287335B6 (no)
WO (1) WO2002034727A2 (no)
ZA (1) ZA200302155B (no)

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US20040167134A1 (en) * 2001-05-16 2004-08-26 Christian Bruns Combination comprising n-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2pyrimidine-amine and a chemotherapeutic agent
CA2452368A1 (en) * 2001-06-29 2003-01-09 Ab Science New potent, selective and non toxic c-kit inhibitors
JP2004537542A (ja) * 2001-06-29 2004-12-16 アブ サイエンス 炎症性腸疾患（ｉｂｄ）を治療するための、チロシンキナーゼ阻害剤の使用
WO2003004006A2 (en) * 2001-06-29 2003-01-16 Ab Science Use of potent, selective and non toxic c-kit inhibitors for treating tumor angiogenesis
EP1401415B1 (en) * 2001-06-29 2006-06-21 AB Science Use of n-phenyl-2-pyrimidine-amine derivatives for treating inflammatory diseases
DK1401413T3 (da) * 2001-06-29 2007-03-26 Ab Science Anvendelse af tyrosinkinaseinhibitorer til behandling af allergiske sygdomme
EP1427379B1 (en) * 2001-09-20 2008-08-13 AB Science Use of potent, selective and non toxic c-kit inhibitors for treating interstitial cystitis
CA2461182A1 (en) * 2001-09-20 2003-05-01 Ab Science Use of tyrosine kinase inhibitors for promoting hair growth
PT1478380E (pt) * 2002-02-27 2006-12-29 Ab Science Utilização de inibidores de tirosina-cinases para tratar doenças do snc
FR2844452A1 (fr) * 2002-09-18 2004-03-19 Inst Gustave Roussy Igr Utilisation d'inhibiteurs specifiques de tyrosine kinases pour l'immunomodulation
US7279576B2 (en) 2002-12-31 2007-10-09 Deciphera Pharmaceuticals, Llc Anti-cancer medicaments
US7202257B2 (en) 2003-12-24 2007-04-10 Deciphera Pharmaceuticals, Llc Anti-inflammatory medicaments
US7144911B2 (en) 2002-12-31 2006-12-05 Deciphera Pharmaceuticals Llc Anti-inflammatory medicaments
CN100467064C (zh) * 2003-09-19 2009-03-11 诺瓦提斯公司 伊马替尼和米哚妥林在制备治疗胃肠道基质肿瘤药物中的应用
US20100210596A1 (en) * 2006-02-01 2010-08-19 Bluestone Jeffrey A Use of aminopyrimidine compounds in the treatment of immune disorders
AU2007296744A1 (en) * 2006-09-11 2008-03-20 Curis, Inc. Multi-functional small molecules as anti-proliferative agents
SG174790A1 (en) * 2006-09-11 2011-10-28 Curis Inc Tyrosine kinase inhibitors containing a zinc binding moiety
US8642067B2 (en) 2007-04-02 2014-02-04 Allergen, Inc. Methods and compositions for intraocular administration to treat ocular conditions
US20090082361A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched imatinib
CN101584696A (zh) 2008-05-21 2009-11-25 上海艾力斯医药科技有限公司 包含喹唑啉衍生物的组合物及制备方法、用途
WO2010120386A1 (en) 2009-04-17 2010-10-21 Nektar Therapeutics Oligomer-protein tyrosine kinase inhibitor conjugates
WO2012122058A2 (en) 2011-03-04 2012-09-13 Newgen Therapeutics, Inc. Alkyne substituted quinazoline compound and methods of use
CN102918029B (zh) 2011-05-17 2015-06-17 江苏康缘药业股份有限公司 4-苯胺-6-丁烯酰胺-7-烷醚喹唑啉衍生物及其制备方法和用途
IN2014DN07898A (no) 2012-02-21 2015-04-24 Ranbaxy Lab Ltd
US8461179B1 (en) 2012-06-07 2013-06-11 Deciphera Pharmaceuticals, Llc Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
CA2880236C (en) 2012-07-27 2022-09-13 Antonius Martinus Gustave Bunt Efflux inhibitor compositions and methods of treatment using the same
JP6799201B2 (ja) 2013-07-31 2020-12-16 アヴァリン ファーマ インク． エアロゾルチロシンキナーゼ阻害剤の化合物、及びその使用
WO2019016673A2 (en) 2017-07-20 2019-01-24 Kashiv Pharma Llc STABLE PHARMACEUTICAL COMPOSITION OF ORAL ADMINISTRATION OF IMATINIB
KR20200115607A (ko) 2018-01-31 2020-10-07 데시페라 파마슈티칼스, 엘엘씨. 위장관 기질 종양의 치료를 위한 병용 요법
TW202122082A (zh) 2019-08-12 2021-06-16 美商迪賽孚爾製藥有限公司 治療胃腸道基質瘤方法
AU2020329956B2 (en) 2019-08-12 2023-11-16 Deciphera Pharmaceuticals, Llc. Ripretinib for treating gastrointestinal stromal tumors
CN115135308A (zh) 2019-12-30 2022-09-30 德西费拉制药有限责任公司 非晶型激酶抑制剂制剂及其使用方法
MX2022008097A (es) 2019-12-30 2022-09-19 Deciphera Pharmaceuticals Llc Composiciones de 1-(4-bromo-5-(1-etil-7-(metilamino)-2-oxo-1,2-dih idro-1,6-naftiridin-3-yl)-2-fluorofeil)-3-fenilurea.
KR102535840B1 (ko) 2020-07-31 2023-05-23 (주)파로스아이바이오 2,3,5-치환된 싸이오펜 화합물의 위장관기질종양 예방, 개선 또는 치료 용도
US11779572B1 (en) 2022-09-02 2023-10-10 Deciphera Pharmaceuticals, Llc Methods of treating gastrointestinal stromal tumors

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TW225528B (no) * 1992-04-03 1994-06-21 Ciba Geigy Ag
CO4940418A1 (es) * 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
JP2002523455A (ja) * 1998-08-31 2002-07-30 スージェン・インコーポレーテッド 蛋白質キナーゼ活性の調節剤としての幾何学的に制限された２−インドリノン誘導体

Also Published As

Publication number Publication date
ES2260317T3 (es) 2006-11-01
PL209733B1 (pl) 2011-10-31
ATE321556T1 (de) 2006-04-15
IL155029A (en) 2009-09-22
NO20031833D0 (no) 2003-04-24
WO2002034727A3 (en) 2003-03-27
BR0114870A (pt) 2004-02-17
NO324948B1 (no) 2008-01-07
NO20031833L (no) 2003-04-24
DE60118430T2 (de) 2006-10-26
HUP0301512A2 (hu) 2003-11-28
WO2002034727A2 (en) 2002-05-02
JP2004512328A (ja) 2004-04-22
KR100885129B1 (ko) 2009-02-23
MXPA03003703A (es) 2005-01-25
NZ525254A (en) 2006-02-24
CZ20031152A3 (en) 2004-04-14
KR20030051656A (ko) 2003-06-25
SK5182003A3 (en) 2004-02-03
CN1276754C (zh) 2006-09-27
PT1332137E (pt) 2006-07-31
US6958335B2 (en) 2005-10-25
DK1332137T3 (da) 2006-07-17
EP1332137A2 (en) 2003-08-06
PL362148A1 (en) 2004-10-18
JP4386635B2 (ja) 2009-12-16
EP1332137B1 (en) 2006-03-29
HK1058193A1 (en) 2004-05-07
HU229106B1 (en) 2013-07-29
US20040023976A1 (en) 2004-02-05
CA2424470C (en) 2009-06-09
CA2424470A1 (en) 2002-05-02
BRPI0114870B1 (pt) 2020-06-16
AU2002218262B2 (en) 2005-09-29
AU1826202A (en) 2002-05-06
ZA200302155B (en) 2004-04-22
DE60118430D1 (de) 2006-05-18
IL155029A0 (en) 2003-10-31
CN1622808A (zh) 2005-06-01
CY1105055T1 (el) 2010-03-03
BRPI0114870B8 (pt) 2021-05-25
CZ303944B6 (cs) 2013-07-10
RU2301066C2 (ru) 2007-06-20

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PC4A Assignment and transfer of rights

Owner name: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., BOSTO, US

Free format text: FORMER OWNER: NOVARTIS AG, BASEL, CH

Effective date: 20130917

Owner name: OREGON HEALTH & SCIENCE UNIVERSITY, PORTLAND, , US

Free format text: FORMER OWNER: NOVARTIS AG, BASEL, CH

Effective date: 20130917

Owner name: NOVARTIS AG, BASEL, CH

Free format text: FORMER OWNER: NOVARTIS AG, BASEL, CH

Effective date: 20130917

Owner name: DANA-FARBER CANCER INSTITUTE INC., BOSTON, MA, US

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Effective date: 20130917

QB4A Licence contract registered or granted

Free format text: NON-EXCLUSIVE LICENSE

Name of requester: NOVARTIS SLOVAKIA S.R.O., SK

Effective date: 20131031

MK4A Expiry of patent

Expiry date: 20211026