IL155029A0 - Treatment of gastrointestinal stromal tumors - Google Patents

Treatment of gastrointestinal stromal tumors

Info

Publication number
IL155029A0
IL155029A0 IL15502901A IL15502901A IL155029A0 IL 155029 A0 IL155029 A0 IL 155029A0 IL 15502901 A IL15502901 A IL 15502901A IL 15502901 A IL15502901 A IL 15502901A IL 155029 A0 IL155029 A0 IL 155029A0
Authority
IL
Israel
Prior art keywords
treatment
gastrointestinal stromal
stromal tumors
methylpiperazin
ylamino
Prior art date
Application number
IL15502901A
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22920224&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL155029(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of IL155029A0 publication Critical patent/IL155029A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Farming Of Fish And Shellfish (AREA)
IL15502901A 2000-10-27 2001-10-26 Treatment of gastrointestinal stromal tumors IL155029A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24381000P 2000-10-27 2000-10-27
PCT/EP2001/012442 WO2002034727A2 (en) 2000-10-27 2001-10-26 Treatment of gastrointestinal stromal tumors

Publications (1)

Publication Number Publication Date
IL155029A0 true IL155029A0 (en) 2003-10-31

Family

ID=22920224

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15502901A IL155029A0 (en) 2000-10-27 2001-10-26 Treatment of gastrointestinal stromal tumors
IL155029A IL155029A (en) 2000-10-27 2003-03-20 Use of 4 - (4 - methylphyprazine - 1 - il - methyl) - N - [4 - methyl - 3 - (4 - pyridine - 3 - il) pyrimidine - 2 - il - amino) phenyl] - benzamide for the preparation of a drug for treatment In cancer of the gastrointestinal tract

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL155029A IL155029A (en) 2000-10-27 2003-03-20 Use of 4 - (4 - methylphyprazine - 1 - il - methyl) - N - [4 - methyl - 3 - (4 - pyridine - 3 - il) pyrimidine - 2 - il - amino) phenyl] - benzamide for the preparation of a drug for treatment In cancer of the gastrointestinal tract

Country Status (26)

Country Link
US (1) US6958335B2 (xx)
EP (1) EP1332137B1 (xx)
JP (1) JP4386635B2 (xx)
KR (1) KR100885129B1 (xx)
CN (1) CN1276754C (xx)
AT (1) ATE321556T1 (xx)
AU (2) AU2002218262B2 (xx)
BR (1) BRPI0114870B8 (xx)
CA (1) CA2424470C (xx)
CY (1) CY1105055T1 (xx)
CZ (1) CZ303944B6 (xx)
DE (1) DE60118430T2 (xx)
DK (1) DK1332137T3 (xx)
ES (1) ES2260317T3 (xx)
HK (1) HK1058193A1 (xx)
HU (1) HU229106B1 (xx)
IL (2) IL155029A0 (xx)
MX (1) MXPA03003703A (xx)
NO (1) NO324948B1 (xx)
NZ (1) NZ525254A (xx)
PL (1) PL209733B1 (xx)
PT (1) PT1332137E (xx)
RU (1) RU2301066C2 (xx)
SK (1) SK287335B6 (xx)
WO (1) WO2002034727A2 (xx)
ZA (1) ZA200302155B (xx)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03010401A (es) * 2001-05-16 2004-03-09 Novartis Ag Combinacion que comprende n-[5-[4- (4-metil- piperazino-metil) -benzoilamido] -2-metilfenil] -4-(3-piridil)-2 -pirimidin-amina, y un agente quimioterapeutico.
WO2003002106A2 (en) * 2001-06-29 2003-01-09 Ab Science Use of tyrosine kinase inhibitions for treating allergic diseases
JP2004530730A (ja) * 2001-06-29 2004-10-07 アブ サイエンス 腫瘍の血管新生を治療するための強力で選択的かつ非毒性のｃ−ｋｉｔ阻害剤の使用法
WO2003003006A2 (en) * 2001-06-29 2003-01-09 Ab Science New potent, selective and non toxic c-kit inhibitors
US7741335B2 (en) * 2001-06-29 2010-06-22 Ab Science Use of tyrosine kinase inhibitors for treating inflammatory diseases
US7678805B2 (en) * 2001-06-29 2010-03-16 Ab Science Use of tyrosine kinase inhibitors for treating inflammatory bowel diseases (IBD)
DE60228278D1 (de) * 2001-09-20 2008-09-25 Ab Science Die verwendung von potenten, selektiven und nontoxischen c-kithemmern zur behandlung von interstitieller blasenentzündung
WO2003035050A2 (en) * 2001-09-20 2003-05-01 Ab Science Use of tyrosine kinase inhibitors for promoting hair growth
WO2003072090A2 (en) * 2002-02-27 2003-09-04 Ab Science Use of tyrosine kinase inhibitors for treating cns disorders
FR2844452A1 (fr) * 2002-09-18 2004-03-19 Inst Gustave Roussy Igr Utilisation d'inhibiteurs specifiques de tyrosine kinases pour l'immunomodulation
US7202257B2 (en) 2003-12-24 2007-04-10 Deciphera Pharmaceuticals, Llc Anti-inflammatory medicaments
US7279576B2 (en) 2002-12-31 2007-10-09 Deciphera Pharmaceuticals, Llc Anti-cancer medicaments
US7144911B2 (en) 2002-12-31 2006-12-05 Deciphera Pharmaceuticals Llc Anti-inflammatory medicaments
AU2004273605B2 (en) * 2003-09-19 2008-07-31 Novartis Ag Treatment of gastrointestinal stromal tumors with imatinib and midostaurin
US20100210596A1 (en) * 2006-02-01 2010-08-19 Bluestone Jeffrey A Use of aminopyrimidine compounds in the treatment of immune disorders
AU2007296743B2 (en) * 2006-09-11 2012-02-16 Curis, Inc. Tyrosine kinase inhibitors containing a zinc binding moiety
EP2061772A4 (en) * 2006-09-11 2011-06-29 Curis Inc MULTIFUNCTIONAL SMALL MOLECULES AS PROLIFERATION-ACTIVE ACTIVE SUBSTANCES
US8642067B2 (en) 2007-04-02 2014-02-04 Allergen, Inc. Methods and compositions for intraocular administration to treat ocular conditions
US20090082361A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched imatinib
CN101584696A (zh) 2008-05-21 2009-11-25 上海艾力斯医药科技有限公司 包含喹唑啉衍生物的组合物及制备方法、用途
US8530492B2 (en) 2009-04-17 2013-09-10 Nektar Therapeutics Oligomer-protein tyrosine kinase inhibitor conjugates
SG193291A1 (en) 2011-03-04 2013-10-30 Newgen Therapeutics Inc Alkyne substituted quinazoline compound and methods of use
WO2012155339A1 (zh) 2011-05-17 2012-11-22 江苏康缘药业股份有限公司 4-苯胺-6-丁烯酰胺-7-烷醚喹唑啉衍生物及其制备方法和用途
EP2817030A1 (en) 2012-02-21 2014-12-31 Ranbaxy Laboratories Limited Stable dosage forms of imatinib mesylate
US8461179B1 (en) 2012-06-07 2013-06-11 Deciphera Pharmaceuticals, Llc Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
EP2877159B8 (en) 2012-07-27 2018-02-14 Izumi Technology, LLC. Efflux inhibitor compositions and methods of treatment using the same
WO2015017728A1 (en) 2013-07-31 2015-02-05 Windward Pharma, Inc. Aerosol tyrosine kinase inhibitor compounds and uses thereof
US11285152B2 (en) 2017-07-20 2022-03-29 Kashiv Biosciences, Llc Stable oral pharmaceutical composition of imatinib
AU2019215081A1 (en) 2018-01-31 2020-09-24 Deciphera Pharmaceuticals, Llc Combination therapy for the treatment of gastrointestinal stromal tumors
TW202122082A (zh) 2019-08-12 2021-06-16 美商迪賽孚爾製藥有限公司 治療胃腸道基質瘤方法
CA3150433A1 (en) 2019-08-12 2021-02-18 Deciphera Pharmaceuticals, Llc Ripretinib for treating gastrointestinal stromal tumors
KR20220123058A (ko) 2019-12-30 2022-09-05 데시페라 파마슈티칼스, 엘엘씨. 1-(4-브로모-5-(1-에틸-7-(메틸아미노)-2-옥소-1,2-디히드로-1,6-나프티리딘-3-일)-2-플루오로페닐)-3-페닐우레아의 조성물
MX2022008103A (es) 2019-12-30 2022-09-19 Deciphera Pharmaceuticals Llc Formulaciones de inhibidores de la cinasa amorfa y metodos de estas.
KR102535840B1 (ko) 2020-07-31 2023-05-23 (주)파로스아이바이오 2,3,5-치환된 싸이오펜 화합물의 위장관기질종양 예방, 개선 또는 치료 용도
US11779572B1 (en) 2022-09-02 2023-10-10 Deciphera Pharmaceuticals, Llc Methods of treating gastrointestinal stromal tumors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW225528B (xx) * 1992-04-03 1994-06-21 Ciba Geigy Ag
CO4940418A1 (es) * 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
WO2000012084A1 (en) * 1998-08-31 2000-03-09 Sugen, Inc. Geometrically restricted 2-indolinone derivatives as modulators of protein kinase activity

Also Published As

Publication number Publication date
SK287335B6 (sk) 2010-07-07
HU229106B1 (en) 2013-07-29
IL155029A (en) 2009-09-22
ZA200302155B (en) 2004-04-22
PT1332137E (pt) 2006-07-31
DE60118430T2 (de) 2006-10-26
JP4386635B2 (ja) 2009-12-16
BRPI0114870B8 (pt) 2021-05-25
NO20031833D0 (no) 2003-04-24
WO2002034727A3 (en) 2003-03-27
US20040023976A1 (en) 2004-02-05
RU2301066C2 (ru) 2007-06-20
BRPI0114870B1 (pt) 2020-06-16
SK5182003A3 (en) 2004-02-03
BR0114870A (pt) 2004-02-17
CZ303944B6 (cs) 2013-07-10
EP1332137A2 (en) 2003-08-06
CZ20031152A3 (en) 2004-04-14
PL362148A1 (en) 2004-10-18
CY1105055T1 (el) 2010-03-03
MXPA03003703A (es) 2005-01-25
US6958335B2 (en) 2005-10-25
NO324948B1 (no) 2008-01-07
CA2424470C (en) 2009-06-09
DE60118430D1 (de) 2006-05-18
NZ525254A (en) 2006-02-24
CN1622808A (zh) 2005-06-01
ATE321556T1 (de) 2006-04-15
WO2002034727A2 (en) 2002-05-02
HK1058193A1 (en) 2004-05-07
CA2424470A1 (en) 2002-05-02
AU1826202A (en) 2002-05-06
JP2004512328A (ja) 2004-04-22
ES2260317T3 (es) 2006-11-01
CN1276754C (zh) 2006-09-27
NO20031833L (no) 2003-04-24
KR100885129B1 (ko) 2009-02-23
AU2002218262B2 (en) 2005-09-29
EP1332137B1 (en) 2006-03-29
KR20030051656A (ko) 2003-06-25
PL209733B1 (pl) 2011-10-31
DK1332137T3 (da) 2006-07-17
HUP0301512A2 (hu) 2003-11-28

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