NO20031833L - Behandling av gastrointestinale stromatumorer - Google Patents

Behandling av gastrointestinale stromatumorer

Info

Publication number
NO20031833L
NO20031833L NO20031833A NO20031833A NO20031833L NO 20031833 L NO20031833 L NO 20031833L NO 20031833 A NO20031833 A NO 20031833A NO 20031833 A NO20031833 A NO 20031833A NO 20031833 L NO20031833 L NO 20031833L
Authority
NO
Norway
Prior art keywords
treatment
gastrointestinal stromal
stromal tumors
methylpiperazin
ylamino
Prior art date
Application number
NO20031833A
Other languages
English (en)
Other versions
NO20031833D0 (no
NO324948B1 (no
Inventor
Elisabeth Buchdunger
Renaud Capdeville
George Daniel Demetri
Sasa Dimitrijevic
Brian J Druker
Jonathan A Fletcher
Heikki Joensuu
Sandra L Silberman
David Tuveson
Michael C Heinrich
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22920224&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20031833(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of NO20031833D0 publication Critical patent/NO20031833D0/no
Publication of NO20031833L publication Critical patent/NO20031833L/no
Publication of NO324948B1 publication Critical patent/NO324948B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20031833A 2000-10-27 2003-04-24 Anvendelse av 4-(4-metylpiperazin-1-ylmetyl)-N-[4-metyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)fenyl]benzamid ved behandling av gastrointestinale stromatumorer. NO324948B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24381000P 2000-10-27 2000-10-27
PCT/EP2001/012442 WO2002034727A2 (en) 2000-10-27 2001-10-26 Treatment of gastrointestinal stromal tumors

Publications (3)

Publication Number Publication Date
NO20031833D0 NO20031833D0 (no) 2003-04-24
NO20031833L true NO20031833L (no) 2003-04-24
NO324948B1 NO324948B1 (no) 2008-01-07

Family

ID=22920224

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20031833A NO324948B1 (no) 2000-10-27 2003-04-24 Anvendelse av 4-(4-metylpiperazin-1-ylmetyl)-N-[4-metyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)fenyl]benzamid ved behandling av gastrointestinale stromatumorer.

Country Status (26)

Country Link
US (1) US6958335B2 (no)
EP (1) EP1332137B1 (no)
JP (1) JP4386635B2 (no)
KR (1) KR100885129B1 (no)
CN (1) CN1276754C (no)
AT (1) ATE321556T1 (no)
AU (2) AU2002218262B2 (no)
BR (1) BRPI0114870B8 (no)
CA (1) CA2424470C (no)
CY (1) CY1105055T1 (no)
CZ (1) CZ303944B6 (no)
DE (1) DE60118430T2 (no)
DK (1) DK1332137T3 (no)
ES (1) ES2260317T3 (no)
HK (1) HK1058193A1 (no)
HU (1) HU229106B1 (no)
IL (2) IL155029A0 (no)
MX (1) MXPA03003703A (no)
NO (1) NO324948B1 (no)
NZ (1) NZ525254A (no)
PL (1) PL209733B1 (no)
PT (1) PT1332137E (no)
RU (1) RU2301066C2 (no)
SK (1) SK287335B6 (no)
WO (1) WO2002034727A2 (no)
ZA (1) ZA200302155B (no)

Families Citing this family (35)

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Publication number Priority date Publication date Assignee Title
BR0209647A (pt) * 2001-05-16 2004-07-27 Novartis Ag Combinação que compreende n-{5-[4-(4-metil-piperazino-metil)-benzoilamido]-2-metil fenil}-4-(3-piridil)-2-pirimidina-amina e um agente quimioterapêutico
DE60223063T2 (de) * 2001-06-29 2008-07-17 Ab Science C-kit inhibitoren
JP2004537536A (ja) * 2001-06-29 2004-12-16 アブ サイエンス アレルギー疾患を治療するためのチロシンキナーゼ阻害剤の使用方法
DK1401415T3 (da) * 2001-06-29 2006-10-16 Ab Science Anvendelse af N-phenyl-2-pyrimidinamin-derivater til behandling af inflammatoriske sygdomme
PT1401416E (pt) * 2001-06-29 2007-02-28 Ab Science Utilização de inibidores de c-kit para tratar doenças inflamatórias intestinais (dii)
US20040266797A1 (en) * 2001-06-29 2004-12-30 Alain Moussy Use of potent,selective and non toxic c-kit inhibitors for treating tumor angiogensis
DE60228278D1 (de) * 2001-09-20 2008-09-25 Ab Science Die verwendung von potenten, selektiven und nontoxischen c-kithemmern zur behandlung von interstitieller blasenentzündung
EP1461032B1 (en) * 2001-09-20 2008-07-16 AB Science Use of c-kit inhibitors for promoting hair growth
JP2005526048A (ja) * 2002-02-27 2005-09-02 アブ サイエンス Ｃｎｓ疾患を治療するためのチロシンキナーゼ阻害剤の使用方法
FR2844452A1 (fr) * 2002-09-18 2004-03-19 Inst Gustave Roussy Igr Utilisation d'inhibiteurs specifiques de tyrosine kinases pour l'immunomodulation
US7202257B2 (en) 2003-12-24 2007-04-10 Deciphera Pharmaceuticals, Llc Anti-inflammatory medicaments
US7144911B2 (en) 2002-12-31 2006-12-05 Deciphera Pharmaceuticals Llc Anti-inflammatory medicaments
US7279576B2 (en) 2002-12-31 2007-10-09 Deciphera Pharmaceuticals, Llc Anti-cancer medicaments
ATE489109T1 (de) * 2003-09-19 2010-12-15 Novartis Pharma Gmbh Behandlung von gastrointestinalen stromatumoren mit imatinib und midostaurin
WO2007089716A2 (en) * 2006-02-01 2007-08-09 The Regents Of The University Of California Use of aminopyrimidine compounds in the treatment of immune disorders
SG174790A1 (en) * 2006-09-11 2011-10-28 Curis Inc Tyrosine kinase inhibitors containing a zinc binding moiety
CA2662937A1 (en) * 2006-09-11 2008-03-20 Curis, Inc. Multi-functional small molecules as anti-proliferative agents
US8642067B2 (en) 2007-04-02 2014-02-04 Allergen, Inc. Methods and compositions for intraocular administration to treat ocular conditions
US20090082361A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched imatinib
CN101584696A (zh) 2008-05-21 2009-11-25 上海艾力斯医药科技有限公司 包含喹唑啉衍生物的组合物及制备方法、用途
US8530492B2 (en) 2009-04-17 2013-09-10 Nektar Therapeutics Oligomer-protein tyrosine kinase inhibitor conjugates
KR20200003933A (ko) 2011-03-04 2020-01-10 뉴젠 세러퓨틱스 인코포레이티드 알킨 치환된 퀴나졸린 화합물 및 그것의 사용 방법
CN102918029B (zh) 2011-05-17 2015-06-17 江苏康缘药业股份有限公司 4-苯胺-6-丁烯酰胺-7-烷醚喹唑啉衍生物及其制备方法和用途
SG11201405099UA (en) 2012-02-21 2014-10-30 Ranbaxy Lab Ltd Stable dosage forms of imatinib mesylate
US8461179B1 (en) 2012-06-07 2013-06-11 Deciphera Pharmaceuticals, Llc Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
BR112015001838B1 (pt) 2012-07-27 2022-10-25 Izumi Technology, Llc Composição de inibidor de efluxo
EP3027026A4 (en) 2013-07-31 2017-05-03 Windward Pharma, Inc. Aerosol tyrosine kinase inhibitor compounds and uses thereof
US11285152B2 (en) 2017-07-20 2022-03-29 Kashiv Biosciences, Llc Stable oral pharmaceutical composition of imatinib
EA202091761A1 (ru) 2018-01-31 2020-12-14 ДЕСИФЕРА ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи Комбинированная терапия для лечения гастроинтестинальных стромальных опухолей
CN114615982A (zh) 2019-08-12 2022-06-10 德西费拉制药有限责任公司 用于治疗胃肠道间质瘤的瑞普替尼
TW202122082A (zh) 2019-08-12 2021-06-16 美商迪賽孚爾製藥有限公司 治療胃腸道基質瘤方法
IL293864A (en) 2019-12-30 2022-08-01 Deciphera Pharmaceuticals Llc Preparations of 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3- phenylurea
CA3163053A1 (en) 2019-12-30 2021-07-08 Michael D. Kaufman Amorphous kinase inhibitor formulations and methods of use thereof
KR102535840B1 (ko) 2020-07-31 2023-05-23 (주)파로스아이바이오 2,3,5-치환된 싸이오펜 화합물의 위장관기질종양 예방, 개선 또는 치료 용도
US11779572B1 (en) 2022-09-02 2023-10-10 Deciphera Pharmaceuticals, Llc Methods of treating gastrointestinal stromal tumors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW225528B (no) * 1992-04-03 1994-06-21 Ciba Geigy Ag
CO4940418A1 (es) * 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
CA2342222A1 (en) * 1998-08-31 2000-03-09 Sugen, Inc. Geometrically restricted 2-indolinone derivatives as modulators of protein kinase activity

Also Published As

Publication number Publication date
SK5182003A3 (en) 2004-02-03
ZA200302155B (en) 2004-04-22
SK287335B6 (sk) 2010-07-07
BR0114870A (pt) 2004-02-17
CZ303944B6 (cs) 2013-07-10
KR100885129B1 (ko) 2009-02-23
CZ20031152A3 (en) 2004-04-14
NO20031833D0 (no) 2003-04-24
EP1332137A2 (en) 2003-08-06
NZ525254A (en) 2006-02-24
HU229106B1 (en) 2013-07-29
BRPI0114870B8 (pt) 2021-05-25
RU2301066C2 (ru) 2007-06-20
CA2424470A1 (en) 2002-05-02
CY1105055T1 (el) 2010-03-03
CN1276754C (zh) 2006-09-27
DE60118430T2 (de) 2006-10-26
ES2260317T3 (es) 2006-11-01
HK1058193A1 (en) 2004-05-07
HUP0301512A2 (hu) 2003-11-28
AU2002218262B2 (en) 2005-09-29
US20040023976A1 (en) 2004-02-05
EP1332137B1 (en) 2006-03-29
IL155029A0 (en) 2003-10-31
NO324948B1 (no) 2008-01-07
PL209733B1 (pl) 2011-10-31
CA2424470C (en) 2009-06-09
JP2004512328A (ja) 2004-04-22
JP4386635B2 (ja) 2009-12-16
WO2002034727A3 (en) 2003-03-27
PT1332137E (pt) 2006-07-31
US6958335B2 (en) 2005-10-25
KR20030051656A (ko) 2003-06-25
DE60118430D1 (de) 2006-05-18
PL362148A1 (en) 2004-10-18
CN1622808A (zh) 2005-06-01
ATE321556T1 (de) 2006-04-15
AU1826202A (en) 2002-05-06
MXPA03003703A (es) 2005-01-25
IL155029A (en) 2009-09-22
WO2002034727A2 (en) 2002-05-02
DK1332137T3 (da) 2006-07-17
BRPI0114870B1 (pt) 2020-06-16

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