SK287335B6 - Použitie 4-{(4-metylpiperazin-1-ylmetyl)-N-[4-metyl-3-(4-pyrid-3- yl)pyrimidin-2-ylamino]fenyl}-benzamidu na prípravu farmaceutických kompozícií na liečenie gastrointestinálnych strómových tumorov - Google Patents

Použitie 4-{(4-metylpiperazin-1-ylmetyl)-N-[4-metyl-3-(4-pyrid-3- yl)pyrimidin-2-ylamino]fenyl}-benzamidu na prípravu farmaceutických kompozícií na liečenie gastrointestinálnych strómových tumorov Download PDF

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Publication number
SK287335B6
SK287335B6 SK518-2003A SK5182003A SK287335B6 SK 287335 B6 SK287335 B6 SK 287335B6 SK 5182003 A SK5182003 A SK 5182003A SK 287335 B6 SK287335 B6 SK 287335B6
Authority
SK
Slovakia
Prior art keywords
treatment
formula
salt
methyl
pyrimidin
Prior art date
Application number
SK518-2003A
Other languages
English (en)
Slovak (sk)
Other versions
SK5182003A3 (en
Inventor
Elisabeth Buchdunger
Renaud Capdeville
George Daniel Demetri
Sasa Dimitrijevic
Brian J. Druker
Jonathan A. Fletcher
Heikki Joensuu
Sandra Leta Silberman
David Tuveson
Michael C. Heinrich
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22920224&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK287335(B6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SK5182003A3 publication Critical patent/SK5182003A3/sk
Publication of SK287335B6 publication Critical patent/SK287335B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Farming Of Fish And Shellfish (AREA)
SK518-2003A 2000-10-27 2001-10-26 Použitie 4-{(4-metylpiperazin-1-ylmetyl)-N-[4-metyl-3-(4-pyrid-3- yl)pyrimidin-2-ylamino]fenyl}-benzamidu na prípravu farmaceutických kompozícií na liečenie gastrointestinálnych strómových tumorov SK287335B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24381000P 2000-10-27 2000-10-27
PCT/EP2001/012442 WO2002034727A2 (en) 2000-10-27 2001-10-26 Treatment of gastrointestinal stromal tumors

Publications (2)

Publication Number Publication Date
SK5182003A3 SK5182003A3 (en) 2004-02-03
SK287335B6 true SK287335B6 (sk) 2010-07-07

Family

ID=22920224

Family Applications (1)

Application Number Title Priority Date Filing Date
SK518-2003A SK287335B6 (sk) 2000-10-27 2001-10-26 Použitie 4-{(4-metylpiperazin-1-ylmetyl)-N-[4-metyl-3-(4-pyrid-3- yl)pyrimidin-2-ylamino]fenyl}-benzamidu na prípravu farmaceutických kompozícií na liečenie gastrointestinálnych strómových tumorov

Country Status (26)

Country Link
US (1) US6958335B2 (de)
EP (1) EP1332137B1 (de)
JP (1) JP4386635B2 (de)
KR (1) KR100885129B1 (de)
CN (1) CN1276754C (de)
AT (1) ATE321556T1 (de)
AU (2) AU1826202A (de)
BR (1) BRPI0114870B8 (de)
CA (1) CA2424470C (de)
CY (1) CY1105055T1 (de)
CZ (1) CZ303944B6 (de)
DE (1) DE60118430T2 (de)
DK (1) DK1332137T3 (de)
ES (1) ES2260317T3 (de)
HK (1) HK1058193A1 (de)
HU (1) HU229106B1 (de)
IL (2) IL155029A0 (de)
MX (1) MXPA03003703A (de)
NO (1) NO324948B1 (de)
NZ (1) NZ525254A (de)
PL (1) PL209733B1 (de)
PT (1) PT1332137E (de)
RU (1) RU2301066C2 (de)
SK (1) SK287335B6 (de)
WO (1) WO2002034727A2 (de)
ZA (1) ZA200302155B (de)

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PL392652A1 (pl) * 2001-05-16 2010-12-06 Novartis Ag Kombinacja zawierająca N-{5-[4-(4-metylo-piperazyno-metylo)-benzoiloamido]-2-metylofenylo}-4-(3-pirydylo)-2-pirymidyno-aminę oraz środek chemoterapeutyczny, jej zastosowanie, kompozycja farmaceutyczna ją zawierająca oraz zestaw zawierający taką kombinację
ATE343415T1 (de) * 2001-06-29 2006-11-15 Ab Science Die verwendung von c-kit hemmer zur behandlung von entzündlichen darmerkrankungen
EP1401413B1 (de) * 2001-06-29 2006-11-22 AB Science Die verwendung von tyrosinkinasehemmer zur behandlung von allergischen erkrankungen
ATE330608T1 (de) * 2001-06-29 2006-07-15 Ab Science Die verwendung von n-phenyl-2-pyrimidine-amine derivaten zur behandlung von entzündlichen erkrankungen
CA2452368A1 (en) * 2001-06-29 2003-01-09 Ab Science New potent, selective and non toxic c-kit inhibitors
EP1401412A2 (de) * 2001-06-29 2004-03-31 AB Science Verwendung von potenten, selektiven und nontoxischen c-kithemmer zur behandlung von tumorangiogenese
DE60228278D1 (de) * 2001-09-20 2008-09-25 Ab Science Die verwendung von potenten, selektiven und nontoxischen c-kithemmern zur behandlung von interstitieller blasenentzündung
EP1461032B1 (de) * 2001-09-20 2008-07-16 AB Science Die verwendung von c-kithemmern zur förderung des haarwuchses
ATE334693T1 (de) * 2002-02-27 2006-08-15 Ab Science Verwendung von tyrosine-kinase inhibitoren zur behandlung von cns krankheiten
FR2844452A1 (fr) * 2002-09-18 2004-03-19 Inst Gustave Roussy Igr Utilisation d'inhibiteurs specifiques de tyrosine kinases pour l'immunomodulation
US7144911B2 (en) 2002-12-31 2006-12-05 Deciphera Pharmaceuticals Llc Anti-inflammatory medicaments
US7202257B2 (en) 2003-12-24 2007-04-10 Deciphera Pharmaceuticals, Llc Anti-inflammatory medicaments
US7279576B2 (en) 2002-12-31 2007-10-09 Deciphera Pharmaceuticals, Llc Anti-cancer medicaments
CN100467064C (zh) * 2003-09-19 2009-03-11 诺瓦提斯公司 伊马替尼和米哚妥林在制备治疗胃肠道基质肿瘤药物中的应用
US20100210596A1 (en) * 2006-02-01 2010-08-19 Bluestone Jeffrey A Use of aminopyrimidine compounds in the treatment of immune disorders
JP2010502743A (ja) * 2006-09-11 2010-01-28 キュリス，インコーポレイテッド 抗増殖薬剤としての多機能性低分子
AU2007296743B2 (en) * 2006-09-11 2012-02-16 Curis, Inc. Tyrosine kinase inhibitors containing a zinc binding moiety
US8642067B2 (en) 2007-04-02 2014-02-04 Allergen, Inc. Methods and compositions for intraocular administration to treat ocular conditions
US20090082361A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched imatinib
CN101584696A (zh) 2008-05-21 2009-11-25 上海艾力斯医药科技有限公司 包含喹唑啉衍生物的组合物及制备方法、用途
US8530492B2 (en) 2009-04-17 2013-09-10 Nektar Therapeutics Oligomer-protein tyrosine kinase inhibitor conjugates
KR20200003933A (ko) 2011-03-04 2020-01-10 뉴젠 세러퓨틱스 인코포레이티드 알킨 치환된 퀴나졸린 화합물 및 그것의 사용 방법
WO2012155339A1 (zh) 2011-05-17 2012-11-22 江苏康缘药业股份有限公司 4-苯胺-6-丁烯酰胺-7-烷醚喹唑啉衍生物及其制备方法和用途
IN2014DN07898A (de) 2012-02-21 2015-04-24 Ranbaxy Lab Ltd
US8461179B1 (en) 2012-06-07 2013-06-11 Deciphera Pharmaceuticals, Llc Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
AU2013295549B2 (en) 2012-07-27 2018-04-19 Izumi Technology, Llc Efflux inhibitor compositions and methods of treatment using the same
WO2015017728A1 (en) 2013-07-31 2015-02-05 Windward Pharma, Inc. Aerosol tyrosine kinase inhibitor compounds and uses thereof
US11285152B2 (en) 2017-07-20 2022-03-29 Kashiv Biosciences, Llc Stable oral pharmaceutical composition of imatinib
CA3089630A1 (en) 2018-01-31 2019-08-08 Deciphera Pharmaceuticals, Llc Combination therapy for the treatment of mastocytosis
SG11202007198WA (en) 2018-01-31 2020-08-28 Deciphera Pharmaceuticals Llc Combination therapy for the treatment of gastrointestinal stromal tumors
US20220354951A1 (en) 2019-08-02 2022-11-10 Onehealthcompany, Inc. Treatment of Canine Cancers
MX2022001863A (es) 2019-08-12 2022-05-30 Deciphera Pharmaceuticals Llc Metodos para tratar los tumores del estroma gastrointestinal.
TW202122082A (zh) 2019-08-12 2021-06-16 美商迪賽孚爾製藥有限公司 治療胃腸道基質瘤方法
KR20220123058A (ko) 2019-12-30 2022-09-05 데시페라 파마슈티칼스, 엘엘씨. 1-(4-브로모-5-(1-에틸-7-(메틸아미노)-2-옥소-1,2-디히드로-1,6-나프티리딘-3-일)-2-플루오로페닐)-3-페닐우레아의 조성물
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KR102535840B1 (ko) 2020-07-31 2023-05-23 (주)파로스아이바이오 2,3,5-치환된 싸이오펜 화합물의 위장관기질종양 예방, 개선 또는 치료 용도
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TW225528B (de) * 1992-04-03 1994-06-21 Ciba Geigy Ag
CO4940418A1 (es) * 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
EP1117397A1 (de) * 1998-08-31 2001-07-25 Sugen, Inc. Geometrisch verhinderte 2-indolinonderivate als modulatoren der protein kinase aktivität

Also Published As

Publication number Publication date
CZ20031152A3 (en) 2004-04-14
PT1332137E (pt) 2006-07-31
WO2002034727A2 (en) 2002-05-02
NO20031833D0 (no) 2003-04-24
WO2002034727A3 (en) 2003-03-27
CN1276754C (zh) 2006-09-27
US20040023976A1 (en) 2004-02-05
DK1332137T3 (da) 2006-07-17
DE60118430T2 (de) 2006-10-26
MXPA03003703A (es) 2005-01-25
CY1105055T1 (el) 2010-03-03
BRPI0114870B8 (pt) 2021-05-25
BRPI0114870B1 (pt) 2020-06-16
ATE321556T1 (de) 2006-04-15
US6958335B2 (en) 2005-10-25
CN1622808A (zh) 2005-06-01
IL155029A (en) 2009-09-22
KR20030051656A (ko) 2003-06-25
KR100885129B1 (ko) 2009-02-23
ES2260317T3 (es) 2006-11-01
EP1332137B1 (de) 2006-03-29
ZA200302155B (en) 2004-04-22
JP4386635B2 (ja) 2009-12-16
CA2424470C (en) 2009-06-09
NO324948B1 (no) 2008-01-07
IL155029A0 (en) 2003-10-31
EP1332137A2 (de) 2003-08-06
CA2424470A1 (en) 2002-05-02
SK5182003A3 (en) 2004-02-03
HK1058193A1 (en) 2004-05-07
HUP0301512A2 (hu) 2003-11-28
HU229106B1 (en) 2013-07-29
NZ525254A (en) 2006-02-24
NO20031833L (no) 2003-04-24
BR0114870A (pt) 2004-02-17
PL209733B1 (pl) 2011-10-31
AU1826202A (en) 2002-05-06
PL362148A1 (en) 2004-10-18
RU2301066C2 (ru) 2007-06-20
AU2002218262B2 (en) 2005-09-29
CZ303944B6 (cs) 2013-07-10
JP2004512328A (ja) 2004-04-22
DE60118430D1 (de) 2006-05-18

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PC4A Assignment and transfer of rights

Owner name: THE BRIGHAM AND WOMEN'S HOSPITAL, INC., BOSTO, US

Free format text: FORMER OWNER: NOVARTIS AG, BASEL, CH

Effective date: 20130917

Owner name: OREGON HEALTH & SCIENCE UNIVERSITY, PORTLAND, , US

Free format text: FORMER OWNER: NOVARTIS AG, BASEL, CH

Effective date: 20130917

Owner name: NOVARTIS AG, BASEL, CH

Free format text: FORMER OWNER: NOVARTIS AG, BASEL, CH

Effective date: 20130917

Owner name: DANA-FARBER CANCER INSTITUTE INC., BOSTON, MA, US

Free format text: FORMER OWNER: NOVARTIS AG, BASEL, CH

Effective date: 20130917

QB4A Licence contract registered or granted

Free format text: NON-EXCLUSIVE LICENSE

Name of requester: NOVARTIS SLOVAKIA S.R.O., SK

Effective date: 20131031

MK4A Expiry of patent

Expiry date: 20211026