SK286992B6 - Pyrolopyridinónový derivát, jeho použitie na výrobu liečiva na liečenie sexuálnej dysfunkcie a farmaceutická kompozícia s jeho obsahom - Google Patents

Pyrolopyridinónový derivát, jeho použitie na výrobu liečiva na liečenie sexuálnej dysfunkcie a farmaceutická kompozícia s jeho obsahom Download PDF

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Publication number
SK286992B6
SK286992B6 SK1713-2002A SK17132002A SK286992B6 SK 286992 B6 SK286992 B6 SK 286992B6 SK 17132002 A SK17132002 A SK 17132002A SK 286992 B6 SK286992 B6 SK 286992B6
Authority
SK
Slovakia
Prior art keywords
group
alkyl
methylenedioxyphenyl
pyridyl
mmol
Prior art date
Application number
SK1713-2002A
Other languages
English (en)
Slovak (sk)
Other versions
SK17132002A3 (sk
Inventor
Zhihua Sui
Mark J. Macielag
Jihua Guan
Weiqin Jiang
James C. Lanter
Original Assignee
Ortho-Mcneil Pharmaceutical, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho-Mcneil Pharmaceutical, Inc. filed Critical Ortho-Mcneil Pharmaceutical, Inc.
Publication of SK17132002A3 publication Critical patent/SK17132002A3/sk
Publication of SK286992B6 publication Critical patent/SK286992B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pulmonology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SK1713-2002A 2000-05-17 2001-05-03 Pyrolopyridinónový derivát, jeho použitie na výrobu liečiva na liečenie sexuálnej dysfunkcie a farmaceutická kompozícia s jeho obsahom SK286992B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20464600P 2000-05-17 2000-05-17
PCT/US2001/014391 WO2001087882A2 (en) 2000-05-17 2001-05-03 Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors

Publications (2)

Publication Number Publication Date
SK17132002A3 SK17132002A3 (sk) 2003-12-02
SK286992B6 true SK286992B6 (sk) 2009-09-07

Family

ID=22758822

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1713-2002A SK286992B6 (sk) 2000-05-17 2001-05-03 Pyrolopyridinónový derivát, jeho použitie na výrobu liečiva na liečenie sexuálnej dysfunkcie a farmaceutická kompozícia s jeho obsahom

Country Status (29)

Country Link
US (3) US6635638B2 (bg)
EP (1) EP1296981B1 (bg)
JP (1) JP5366349B2 (bg)
KR (2) KR20030031483A (bg)
CN (1) CN1280291C (bg)
AR (1) AR028575A1 (bg)
AT (1) ATE278690T1 (bg)
AU (1) AU6117801A (bg)
BG (1) BG65925B1 (bg)
CA (1) CA2409743C (bg)
CZ (1) CZ20023945A3 (bg)
DE (1) DE60106252T2 (bg)
ES (1) ES2230316T3 (bg)
GE (1) GEP20053510B (bg)
HK (1) HK1054034B (bg)
HR (1) HRP20020911B1 (bg)
HU (1) HUP0302226A3 (bg)
IL (2) IL152872A0 (bg)
MX (1) MXPA02011425A (bg)
MY (1) MY126917A (bg)
NO (1) NO324843B1 (bg)
NZ (1) NZ522732A (bg)
PL (1) PL363150A1 (bg)
PT (1) PT1296981E (bg)
RU (1) RU2267490C2 (bg)
SK (1) SK286992B6 (bg)
UA (1) UA72611C2 (bg)
WO (1) WO2001087882A2 (bg)
ZA (1) ZA200210114B (bg)

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AU2002246728A1 (en) * 2001-02-12 2002-08-28 Lilly Icos Llc Carboline derivatives
AU2002249890A1 (en) * 2001-02-12 2002-08-28 Lilly Icos Llc Carboline derivatives
ATE368040T1 (de) 2001-11-14 2007-08-15 Ortho Mcneil Pharmaceutical Co Substituierte tetrazyklische pyprolochinolonderivate als phosphodiesterase- inhibitoren
US6800625B2 (en) * 2002-06-19 2004-10-05 Janssen Pharmaceutica N.V. Substituted 2,4-dihydro-pyrrolo[3,4-b]quinolin-9-one derivatives useful as phosphodiesterase inhibitors
US7045652B2 (en) * 2002-07-03 2006-05-16 Pfizer Inc Processes for preparing substituted aryl boronic acids
JP4857452B2 (ja) 2004-03-15 2012-01-18 ピーティーシー セラピューティクス，インコーポレーテッド 血管新生の抑制に有用なカルボリン誘導体
US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
US7767689B2 (en) * 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
US20070015798A1 (en) * 2005-02-25 2007-01-18 Xun Li Efficient and stereoselective process for large scale synthesis of (3R)-3-(2,3-dihydrobenzofuran-5-yl)-1,2,3,4-tetrahydropyrrolo[3,4-b]quinolin-9-one derivatives
JP2008531570A (ja) * 2005-02-25 2008-08-14 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ３−（ｒ）−３−（２，３−ジヒドロベンゾフラン−５−イル）−１，２，３，４−テトラヒドロピロロ［３，４−ｂ］キノリン−９−オンの有効かつ立体選択的大規模合成方法
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
CA2625153A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2377531A2 (en) 2006-05-09 2011-10-19 Braincells, Inc. Neurogenesis by modulating angiotensin
US7678808B2 (en) 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
WO2008030651A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
EP2379076B1 (en) 2008-12-23 2014-11-12 The Trustees of Columbia University in the City of New York Phosphodiesterase inhibitors and uses thereof
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
RU2451686C1 (ru) * 2010-12-27 2012-05-27 Александр Васильевич Иващенко ЗАМЕЩЕННЫЕ ГИДРИРОВАННЫЕ ТИЕНО-ПИРРОЛО [3,2-c] ПИРИДИНЫ, ЛИГАНДЫ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ИХ ПРИМЕНЕНИЯ
KR101236188B1 (ko) * 2011-03-10 2013-02-22 한국화학연구원 신규한 피롤로피리디논 유도체 및 그의 ｍｃｈ 수용체-1 관련 질환에 대한 치료학적 용도
WO2013043553A1 (en) * 2011-09-22 2013-03-28 Glaxosmithkline Llc Pyrrolopyridinone compounds and methods for treating hiv
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
JO3407B1 (ar) 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd مركبات رباعي هيدرو بيرازولو بيريميدين
JP6616790B2 (ja) 2014-06-27 2019-12-04 ノグラ ファーマ リミテッド アリール受容体モジュレーターならびにその作製および使用方法
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil
CN107216327A (zh) * 2017-06-27 2017-09-29 山东大学 5型磷酸二酯酶抑制剂及其制备方法和用途
CN108752340B (zh) * 2018-07-18 2020-09-01 山东中医药大学附属医院 吡咯并喹啉衍生物及其在治疗心律失常中的用途
CN109134463B (zh) * 2018-09-17 2020-05-08 山东大学 β-咔啉类5型磷酸二酯酶抑制剂及其制备方法和用途

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UA72611C2 (uk) * 2000-05-17 2005-03-15 Орто-Макнейл Фармацевтикал, Інк. Похідні заміщеного піролопіридинону, корисні як інгібітори фосфодіестерази

Also Published As

Publication number Publication date
ZA200210114B (en) 2004-03-12
CA2409743A1 (en) 2001-11-22
JP2003533524A (ja) 2003-11-11
NZ522732A (en) 2004-10-29
CN1280291C (zh) 2006-10-18
MXPA02011425A (es) 2004-09-06
SK17132002A3 (sk) 2003-12-02
IL152872A0 (en) 2003-06-24
ATE278690T1 (de) 2004-10-15
CZ20023945A3 (cs) 2003-10-15
GEP20053510B (en) 2005-05-10
HUP0302226A3 (en) 2012-12-28
HK1054034A1 (en) 2003-11-14
AU6117801A (en) 2001-11-26
HRP20020911B1 (en) 2009-01-31
KR100854050B1 (ko) 2008-08-26
CN1441801A (zh) 2003-09-10
KR20030031483A (ko) 2003-04-21
DE60106252D1 (de) 2004-11-11
PT1296981E (pt) 2004-12-31
PL363150A1 (en) 2004-11-15
JP5366349B2 (ja) 2013-12-11
DE60106252T2 (de) 2006-03-02
IL152872A (en) 2010-11-30
ES2230316T3 (es) 2005-05-01
NO20025525D0 (no) 2002-11-18
CA2409743C (en) 2010-10-19
HK1054034B (zh) 2005-04-29
US20040044021A1 (en) 2004-03-04
UA72611C2 (uk) 2005-03-15
WO2001087882A3 (en) 2002-05-23
BG65925B1 (bg) 2010-05-31
US20050113402A1 (en) 2005-05-26
US6635638B2 (en) 2003-10-21
WO2001087882A2 (en) 2001-11-22
MY126917A (en) 2006-10-31
BG107284A (bg) 2003-07-31
NO20025525L (no) 2003-01-03
EP1296981A2 (en) 2003-04-02
NO324843B1 (no) 2007-12-17
US20020010183A1 (en) 2002-01-24
US6818646B2 (en) 2004-11-16
HUP0302226A2 (hu) 2003-11-28
EP1296981B1 (en) 2004-10-06
RU2267490C2 (ru) 2006-01-10
HRP20020911A2 (en) 2004-12-31
KR20020094063A (ko) 2002-12-16
AR028575A1 (es) 2003-05-14

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Effective date: 20150503