SK286239B6 - Perfluóralkylované komplexy s polárnymi zvyškami,spôsob ich prípravy a ich použitie - Google Patents

Perfluóralkylované komplexy s polárnymi zvyškami,spôsob ich prípravy a ich použitie Download PDF

Info

Publication number
SK286239B6
SK286239B6 SK155-2003A SK1552003A SK286239B6 SK 286239 B6 SK286239 B6 SK 286239B6 SK 1552003 A SK1552003 A SK 1552003A SK 286239 B6 SK286239 B6 SK 286239B6
Authority
SK
Slovakia
Prior art keywords
mmol
residue
formula
och
groups
Prior art date
Application number
SK155-2003A
Other languages
English (en)
Slovak (sk)
Other versions
SK1552003A3 (en
Inventor
Johannes Platzek
Peter Mareski
Ulrich Niedballa
Bernd Rad�Chel
Hanns-Joachim Weinmann
Bernd Misselwitz
Original Assignee
Schering Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of SK1552003A3 publication Critical patent/SK1552003A3/sk
Publication of SK286239B6 publication Critical patent/SK286239B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F19/00—Metal compounds according to more than one of main groups C07F1/00 - C07F17/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SK155-2003A 2000-08-11 2001-07-23 Perfluóralkylované komplexy s polárnymi zvyškami,spôsob ich prípravy a ich použitie SK286239B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10040858A DE10040858C2 (de) 2000-08-11 2000-08-11 Perfluoralkylhaltige Komplexe mit polaren Resten, Verfahren zu deren Herstellung und ihre Verwendung
PCT/EP2001/008500 WO2002013875A2 (fr) 2000-08-11 2001-07-23 Complexes perfluoroalkyles a residus polaires, leur procede de fabrication et leur utilisation

Publications (2)

Publication Number Publication Date
SK1552003A3 SK1552003A3 (en) 2003-09-11
SK286239B6 true SK286239B6 (sk) 2008-06-06

Family

ID=7653176

Family Applications (1)

Application Number Title Priority Date Filing Date
SK155-2003A SK286239B6 (sk) 2000-08-11 2001-07-23 Perfluóralkylované komplexy s polárnymi zvyškami,spôsob ich prípravy a ich použitie

Country Status (30)

Country Link
EP (1) EP1307237B9 (fr)
JP (1) JP2004506026A (fr)
KR (2) KR20030022381A (fr)
CN (1) CN1468113A (fr)
AR (1) AR035342A1 (fr)
AT (1) ATE359093T1 (fr)
AU (2) AU2001279777B2 (fr)
BG (1) BG107541A (fr)
BR (1) BR0113187A (fr)
CA (1) CA2419259A1 (fr)
CZ (1) CZ2003341A3 (fr)
DE (2) DE10040858C2 (fr)
DK (1) DK1307237T3 (fr)
EE (1) EE200300060A (fr)
ES (1) ES2284671T3 (fr)
HR (1) HRP20030171A2 (fr)
HU (1) HUP0300769A3 (fr)
IL (1) IL154329A0 (fr)
MX (1) MXPA03001286A (fr)
NO (1) NO20030649L (fr)
NZ (1) NZ524080A (fr)
PL (1) PL365367A1 (fr)
PT (1) PT1307237E (fr)
RU (1) RU2289579C2 (fr)
SK (1) SK286239B6 (fr)
UA (1) UA74004C2 (fr)
UY (1) UY26873A1 (fr)
WO (1) WO2002013875A2 (fr)
YU (1) YU10503A (fr)
ZA (1) ZA200301947B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10231799B4 (de) * 2002-07-10 2006-10-05 Schering Ag Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Intravasalen Thromben
US7344704B2 (en) 2002-07-10 2008-03-18 Schering Ag Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of intravascular thrombi
DE102005033903B4 (de) * 2005-07-15 2007-08-09 Bayer Schering Pharma Ag Perfluoralkylhaltige Komplexe, Verfahren zu deren Herstellung, sowie deren Verwendung und diese enthaltende pharmazeutische Mittel
CA2615434A1 (fr) * 2005-07-15 2007-01-25 Bayer Schering Pharma Aktiengesellschaft Complexes perfluoro-alkyles, leur procede de production et leur utilisation
DE102005033902B3 (de) * 2005-07-15 2007-04-05 Schering Ag Perfluoralkylhaltige Komplexe, Verfahren zu deren Herstellung, sowie deren Verwendung und diese enthaltende pharmazeutische Mittel
DE102006049821A1 (de) * 2006-10-18 2008-04-24 Bayer Schering Pharma Aktiengesellschaft Metallchelate mit perfluoriertem PEG-Rest, Verfahren zu deren Herstellung, sowie deren Verwendung
DE102007015598A1 (de) * 2007-03-29 2008-10-02 Heinrich-Heine-Universität Düsseldorf Verwendung von fluorhaltigen Verbindungen zu Diagnosezwecken mit Hilfe bildgebender Verfahren
EP3101012A1 (fr) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft Nouveaux composés de chélate de gadolinium pour une utilisation dans l'imagerie par résonance magnétique
KR102464647B1 (ko) 2016-11-28 2022-11-08 바이엘 파마 악티엔게젤샤프트 자기 공명 영상화에 사용하기 위한 높은 이완도 가돌리늄 킬레이트 화합물
RU2681319C1 (ru) * 2017-10-27 2019-03-06 Федеральное государственное бюджетное образовательное учреждение высшего образования "Российский экономический университет имени Г.В. Плеханова" (ФГБОУ ВО "РЭУ им. Г.В. Плеханова") Ультраволокнистый биополимерный материал с бактерицидным эффектом
CN113164628A (zh) 2018-11-23 2021-07-23 拜耳股份有限公司 造影介质制剂及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4317588C2 (de) * 1993-05-24 1998-04-16 Schering Ag Fluorhaltige makrocyclische Metallkomplexe, Verfahren zu ihrer Herstellung, sowie ihre Verwendung
DE19603033A1 (de) * 1996-01-19 1997-07-24 Schering Ag Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
DE19608278A1 (de) * 1996-02-23 1997-08-28 Schering Ag Pharmazeutische Mittel enthaltend perfluoralkylhaltige Metallkomplexe, und ihre Verwendung in der Tumortherapie und interventioniellen Radiologie
DE19729013A1 (de) * 1997-07-03 1999-02-04 Schering Ag Oligomere, perfluoralkylhaltige Verbindungen, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
DE19744004C1 (de) * 1997-09-26 1999-07-22 Schering Ag Lipophile Metall-Komplexe für Nekrose und Infarkt-Imaging

Also Published As

Publication number Publication date
AU7977701A (en) 2002-02-25
CN1468113A (zh) 2004-01-14
KR20080027397A (ko) 2008-03-26
WO2002013875A2 (fr) 2002-02-21
NO20030649L (no) 2003-04-11
HUP0300769A2 (hu) 2003-09-29
DK1307237T3 (da) 2007-07-02
UA74004C2 (en) 2005-10-17
AR035342A1 (es) 2004-05-12
EP1307237A2 (fr) 2003-05-07
ZA200301947B (en) 2004-06-25
CA2419259A1 (fr) 2002-02-21
NZ524080A (en) 2005-10-28
SK1552003A3 (en) 2003-09-11
UY26873A1 (es) 2002-03-22
EP1307237B1 (fr) 2007-04-11
PT1307237E (pt) 2007-07-02
IL154329A0 (en) 2003-09-17
HRP20030171A2 (en) 2004-06-30
CZ2003341A3 (cs) 2003-05-14
ATE359093T1 (de) 2007-05-15
PL365367A1 (en) 2004-12-27
DE50112336D1 (de) 2007-05-24
NO20030649D0 (no) 2003-02-10
DE10040858C2 (de) 2003-12-18
WO2002013875A3 (fr) 2002-08-22
EE200300060A (et) 2004-12-15
BG107541A (bg) 2004-01-30
JP2004506026A (ja) 2004-02-26
YU10503A (sh) 2006-08-17
AU2001279777B2 (en) 2006-08-31
BR0113187A (pt) 2003-07-01
DE10040858A1 (de) 2002-03-28
ES2284671T3 (es) 2007-11-16
MXPA03001286A (es) 2004-04-20
KR20030022381A (ko) 2003-03-15
HUP0300769A3 (en) 2009-03-02
RU2289579C2 (ru) 2006-12-20
EP1307237B9 (fr) 2008-01-09

Similar Documents

Publication Publication Date Title
SK177997A3 (en) Cascade polymer complexes
SK167496A3 (en) Cascade-polymer complexes and methods of producing the same and pharmaceutical composition containing these substances
SK99098A3 (en) Perfluoroalkyl-containing metal complexes and their use in nmr diagnostics
PT1931673E (pt) Compostos que compreendem cadeias de aminoálcoois e complexos metálicos para imagiologia médica
US6083479A (en) Contrast media for infarction and necrosis imaging
JP2009509915A (ja) ペルフルオロアルキル含有錯体、ならびにｎｍｒ、ｘ線および放射線診断、さらに放射線治療のための造影剤としてのその使用法
EP0717737B1 (fr) Agents de chelation utilises en tant qu'agents de rehaussement du contraste
SK286239B6 (sk) Perfluóralkylované komplexy s polárnymi zvyškami,spôsob ich prípravy a ich použitie
US7618957B2 (en) Perfluoroalkyl-containing complexes, process for their production as well as their use
CZ2003340A3 (cs) Perfluoralkylované komplexy s cukernými zbytky, způsob jejich přípravy a jejich použití
JP2009501174A (ja) ペルフルオロアルキル含有錯体、製造方法およびその使用
US6019959A (en) Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis
US20020052354A1 (en) Paramagnetic DOTA derivatives, pharmaceutical agents that contain the latter, process for their production, and their use for MR imaging of necrosis and infarction
SK283334B6 (sk) Komplexy kaskádových polymérov, spôsob ich výroby a farmaceutický prostriedok tieto látky obsahujúci
JP5475454B2 (ja) 過弗素化されたｐｅｇ基を有する金属キレート類、それらの製剤方法、及びそれらの使用
US6676928B2 (en) Perfluoroalkyl-containing complexes with polar radicals, process for their production and their use
ES2205863T3 (es) Derivados paramagneticos de deuteroporfirinas sustituidas en las posiciones 3, 8, agentes farmaceuticos que contienen estos derivados, procedimientos para su preparacion y su utilizacion para la representacion en imagenes por mr de las necrosis y los infartos.