SK285433B6 - Spôsob prípravy bifenylových derivátov vhodných na prípravu 4-aryl-1-fenylalkyl-1,2,3,6-tetrahydropyridínov - Google Patents

Spôsob prípravy bifenylových derivátov vhodných na prípravu 4-aryl-1-fenylalkyl-1,2,3,6-tetrahydropyridínov Download PDF

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Publication number
SK285433B6
SK285433B6 SK593-2003A SK5932003A SK285433B6 SK 285433 B6 SK285433 B6 SK 285433B6 SK 5932003 A SK5932003 A SK 5932003A SK 285433 B6 SK285433 B6 SK 285433B6
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SK
Slovakia
Prior art keywords
group
formula
compound
ethyl
tetrahydropyridine
Prior art date
Application number
SK593-2003A
Other languages
English (en)
Slovak (sk)
Inventor
Domenico Badone
Marco Baroni
Rosanna Cardamone
Jacqueline Fournier
Umberto Guzzi
Alessandra Ielmini
Original Assignee
Sanofi - Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi - Aventis filed Critical Sanofi - Aventis
Publication of SK285433B6 publication Critical patent/SK285433B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
SK593-2003A 1995-06-28 1996-06-26 Spôsob prípravy bifenylových derivátov vhodných na prípravu 4-aryl-1-fenylalkyl-1,2,3,6-tetrahydropyridínov SK285433B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9507760A FR2736053B1 (fr) 1995-06-28 1995-06-28 Nouvelles 1-phenylalkyl-1,2,3,6-tetrahydropyridines
PCT/FR1996/000995 WO1997001536A1 (fr) 1995-06-28 1996-06-26 4-aryl-1-phenylalkyl-1,2,3,6-tetrahydropyridines ayant une activite neurotrophique et neuroprotectrice

Publications (1)

Publication Number Publication Date
SK285433B6 true SK285433B6 (sk) 2007-01-04

Family

ID=9480466

Family Applications (2)

Application Number Title Priority Date Filing Date
SK593-2003A SK285433B6 (sk) 1995-06-28 1996-06-26 Spôsob prípravy bifenylových derivátov vhodných na prípravu 4-aryl-1-fenylalkyl-1,2,3,6-tetrahydropyridínov
SK1781-97A SK283707B6 (sk) 1995-06-28 1996-06-26 4-Aryl-1-fenylalkyl-1,2,3,6-tetrahydropyridínová zlúčenina, spôsob jej prípravy, medziprodukty a farmaceutický prostriedok obsahujúci túto zlúčeninu

Family Applications After (1)

Application Number Title Priority Date Filing Date
SK1781-97A SK283707B6 (sk) 1995-06-28 1996-06-26 4-Aryl-1-fenylalkyl-1,2,3,6-tetrahydropyridínová zlúčenina, spôsob jej prípravy, medziprodukty a farmaceutický prostriedok obsahujúci túto zlúčeninu

Country Status (30)

Country Link
US (1) US5981754A (is)
EP (2) EP1216996A3 (is)
JP (2) JP3147906B2 (is)
KR (1) KR100460581B1 (is)
CN (1) CN1153765C (is)
AT (1) ATE223897T1 (is)
AU (1) AU715090B2 (is)
BR (1) BR9608662A (is)
CA (1) CA2225746C (is)
CY (1) CY2312B1 (is)
CZ (1) CZ291075B6 (is)
DE (1) DE69623631T2 (is)
DK (1) DK0837848T3 (is)
EE (1) EE03870B1 (is)
ES (1) ES2183965T3 (is)
FR (1) FR2736053B1 (is)
HK (1) HK1014952A1 (is)
HU (1) HUP9900055A3 (is)
IL (1) IL122159A (is)
IS (1) IS1999B (is)
NO (1) NO310144B1 (is)
NZ (1) NZ312723A (is)
PL (2) PL187087B1 (is)
PT (1) PT837848E (is)
RU (1) RU2163237C2 (is)
SK (2) SK285433B6 (is)
TR (1) TR199701710T1 (is)
UA (1) UA62914C2 (is)
WO (1) WO1997001536A1 (is)
ZA (1) ZA965527B (is)

Families Citing this family (36)

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Publication number Priority date Publication date Assignee Title
FR2762514B1 (fr) * 1997-04-29 1999-10-22 Sanofi Sa Utilisation de derives de la tetrahydropyridine pour la preparation de medicaments pour le traitement des maladies entrainant une demyelinisation
FR2763847B1 (fr) 1997-05-28 2003-06-06 Sanofi Sa Utilisation de tetrahydropyridines 4-substituees pour fabriquer des medicaments agissant sur le tgf-beta-1
FR2771006B1 (fr) * 1997-11-14 2000-12-01 Sanofi Sa Association de principes actifs pour le traitement de la demence senile du type alzheimer
CO4980891A1 (es) * 1997-11-14 2000-11-27 Sanofi Sa Asociacion de principios activos para el tratamiento de la demencia senil de tipo azheimer
FR2771007B1 (fr) * 1997-11-14 2000-12-01 Sanofi Sa Association de principes actifs pour le traitement de la demence senile du type alzheimer
CA2334677A1 (en) * 1998-06-19 1999-12-23 Vincent Patrick Rocco Preparation of heteroaryl compounds
FR2803593B1 (fr) * 2000-01-06 2002-02-15 Sanofi Synthelabo Nouvelles tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant
DE60220779T2 (de) 2001-04-20 2008-03-06 Sanofi-Aventis Tetrahydropyridyl-alkyl-heterozykle, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die sie enthalten
FR2823748B1 (fr) * 2001-04-20 2004-02-20 Sanofi Synthelabo Tetrahydropyridyl-alkyl-benzodiazines, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2840896B1 (fr) * 2002-06-18 2005-04-08 Sanofi Synthelabo Phenyl-et pyridyl-piperazines, procede pour leur preparation et compositions pharmaceutiques les contenant
ZA200505258B (en) * 2002-12-16 2006-09-27 Mitsubishi Pharma Corp 3-Substituted-4-pyrimidone derivatives
JP4866610B2 (ja) 2003-08-18 2012-02-01 富士フイルムファインケミカルズ株式会社 ピリジルテトラヒドロピリジン類およびピリジルピペリジン類
TWI350168B (en) 2004-05-07 2011-10-11 Incyte Corp Amido compounds and their use as pharmaceuticals
EP1758580A4 (en) * 2004-06-24 2008-01-16 Incyte Corp N-SUBSTITUTED PIPERIDINE AND ITS USE AS A MEDICAMENT
EP1773773A4 (en) * 2004-06-24 2009-07-29 Incyte Corp AMID COMPOUNDS AND THEIR USE AS MEDICAMENTS
US20050288317A1 (en) * 2004-06-24 2005-12-29 Wenqing Yao Amido compounds and their use as pharmaceuticals
NZ551602A (en) * 2004-06-24 2010-11-26 Incyte Corp Amido compounds and their use as pharmaceuticals
US7687665B2 (en) 2004-06-24 2010-03-30 Incyte Corporation 2-methylprop anamides and their use as pharmaceuticals
BRPI0514230A (pt) * 2004-08-10 2008-06-03 Incyte Corp compostos de amido e seu uso como produtos farmacêuticos
NZ554906A (en) * 2004-11-10 2011-01-28 Incyte Corp Lactam compounds and their use as pharmaceuticals
US8110581B2 (en) * 2004-11-10 2012-02-07 Incyte Corporation Lactam compounds and their use as pharmaceuticals
EP1824842A4 (en) * 2004-11-18 2009-08-26 Incyte Corp INHIBITORS OF 11-HYDROXYL STEROID DEHYDROGENASE TYPE 1 AND METHOD OF USE
FR2883285B1 (fr) * 2005-03-17 2007-05-18 Sanofi Aventis Sa Sel besylate de la 7-(2-(4-(3-trifluoromethyl-phenyl) -1,2,3,6-tetrahudro-pyrid-1-yl)ethyl) isoquinoleine, sa preparation et son utilisation en therapeutique
JP4864342B2 (ja) * 2005-04-27 2012-02-01 北興化学工業株式会社 ビアリール化合物の製造方法
JP2009508963A (ja) * 2005-09-21 2009-03-05 インサイト・コーポレイション アミド化合物および医薬組成物としてのその使用
WO2007067504A2 (en) * 2005-12-05 2007-06-14 Incyte Corporation Lactam compounds and methods of using the same
WO2007084314A2 (en) * 2006-01-12 2007-07-26 Incyte Corporation MODULATORS OF 11-ß HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME
EP1979318A1 (en) * 2006-01-31 2008-10-15 Incyte Corporation Amido compounds and their use as pharmaceuticals
TW200808807A (en) * 2006-03-02 2008-02-16 Incyte Corp Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same
US20070208001A1 (en) * 2006-03-03 2007-09-06 Jincong Zhuo Modulators of 11- beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same
EP2013163A1 (en) * 2006-05-01 2009-01-14 Incyte Corporation Tetrasubstituted ureas as modulators of 11-beta hydroxyl steroid dehydrogenase type 1
WO2007137066A2 (en) * 2006-05-17 2007-11-29 Incyte Corporation HETEROCYCLIC INHIBITORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE I AND METHODS OF USING THE SAME
CL2008001839A1 (es) 2007-06-21 2009-01-16 Incyte Holdings Corp Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades.
US8217064B2 (en) 2007-12-20 2012-07-10 Envivo Pharmaceuticals, Inc. Tetrasubstituted benzenes
KR101773070B1 (ko) * 2010-01-19 2017-09-12 바이엘 인텔렉쳐 프로퍼티 게엠베하 아릴 및 헤테로아릴아세트산 유도체의 제조방법
WO2018195649A1 (en) * 2017-04-26 2018-11-01 Alberta Research Chemicals Inc. Substituted tetrahydropyridine derivatives as ido-1 inhibitors and uses thereof

Family Cites Families (5)

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Publication number Priority date Publication date Assignee Title
ES2098248T3 (es) * 1989-05-17 1997-05-01 Pfizer Derivados de 2-piperidino-1-alcanoles como agentes antiisquemicos.
FR2650505B1 (fr) * 1989-08-07 1994-06-03 Midy Spa Utilisation de trifluoromethylphenyltetrahydropyridines pour la preparation de medicaments destines a combattre les troubles de la motricite intestinale
FR2662355B1 (fr) * 1990-05-22 1994-11-10 Sanofi Sa Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux.
HU211019B (en) * 1991-12-02 1995-09-28 Richter Gedeon Vegyeszet Process for producing new 1,2,3,6-tetrahydropyridine and piperidine derivatives substituted with n-(hydroxylalkyl) group and compositions comprising such compounds
DE4325855A1 (de) * 1993-08-02 1995-02-09 Boehringer Ingelheim Kg Neue Benzoesäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Also Published As

Publication number Publication date
CA2225746C (en) 2004-05-18
CA2225746A1 (en) 1997-01-16
ATE223897T1 (de) 2002-09-15
EP1216996A3 (fr) 2003-10-15
DE69623631T2 (de) 2003-08-07
HUP9900055A3 (en) 1999-11-29
JP3147906B2 (ja) 2001-03-19
EP0837848A1 (fr) 1998-04-29
JP3302351B2 (ja) 2002-07-15
MX9710472A (es) 1998-03-31
EP0837848B1 (fr) 2002-09-11
WO1997001536A1 (fr) 1997-01-16
IS4641A (is) 1997-12-23
HUP9900055A2 (hu) 1999-04-28
NO310144B1 (no) 2001-05-28
FR2736053A1 (fr) 1997-01-03
KR19990028431A (ko) 1999-04-15
IS1999B (is) 2005-04-15
RU2163237C2 (ru) 2001-02-20
PT837848E (pt) 2002-12-31
PL192353B1 (pl) 2006-10-31
AU6461996A (en) 1997-01-30
SK178197A3 (en) 1998-07-08
NO976079D0 (no) 1997-12-23
EP1216996A2 (fr) 2002-06-26
NZ312723A (en) 1999-10-28
HK1014952A1 (en) 1999-10-08
AU715090B2 (en) 2000-01-13
US5981754A (en) 1999-11-09
SK283707B6 (sk) 2003-12-02
KR100460581B1 (ko) 2005-04-14
FR2736053B1 (fr) 1997-09-19
CN1153765C (zh) 2004-06-16
JP2001114763A (ja) 2001-04-24
CZ422297A3 (cs) 1998-04-15
TR199701710T1 (xx) 1998-05-21
ES2183965T3 (es) 2003-04-01
EE03870B1 (et) 2002-10-15
CN1189154A (zh) 1998-07-29
DK0837848T3 (da) 2003-01-06
CY2312B1 (en) 2003-11-14
BR9608662A (pt) 1999-05-04
JPH11506118A (ja) 1999-06-02
NO976079L (no) 1997-12-23
PL187087B1 (pl) 2004-05-31
UA62914C2 (en) 2004-01-15
PL324216A1 (en) 1998-05-11
IL122159A0 (en) 1998-04-05
IL122159A (en) 2001-06-14
ZA965527B (en) 1997-01-24
CZ291075B6 (cs) 2002-12-11
DE69623631D1 (en) 2002-10-17
EE9700348A (et) 1998-06-15

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