SK285043B6 - Spôsob prípravy L-fenylefrín hydrochloridu - Google Patents

Spôsob prípravy L-fenylefrín hydrochloridu Download PDF

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Publication number
SK285043B6
SK285043B6 SK1028-2001A SK10282001A SK285043B6 SK 285043 B6 SK285043 B6 SK 285043B6 SK 10282001 A SK10282001 A SK 10282001A SK 285043 B6 SK285043 B6 SK 285043B6
Authority
SK
Slovakia
Prior art keywords
asymmetric hydrogenation
process according
carried out
methyl
benzyl
Prior art date
Application number
SK1028-2001A
Other languages
English (en)
Slovak (sk)
Other versions
SK10282001A3 (sk
Inventor
Franz Dietrich Klingler
Lienhard Wolter
Wolfgang Dietrich
Original Assignee
Boehringer Ingelheim Pharma Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma Gmbh & Co. Kg filed Critical Boehringer Ingelheim Pharma Gmbh & Co. Kg
Publication of SK10282001A3 publication Critical patent/SK10282001A3/sk
Publication of SK285043B6 publication Critical patent/SK285043B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SK1028-2001A 1999-01-21 2000-01-11 Spôsob prípravy L-fenylefrín hydrochloridu SK285043B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19902229A DE19902229C2 (de) 1999-01-21 1999-01-21 Verfahren zur Herstellung von L-Phenylephrinhydrochlorid
PCT/EP2000/000144 WO2000043345A1 (de) 1999-01-21 2000-01-11 Verfahren zur herstellung von l-phenylephrinhydrochlorid

Publications (2)

Publication Number Publication Date
SK10282001A3 SK10282001A3 (sk) 2001-12-03
SK285043B6 true SK285043B6 (sk) 2006-05-04

Family

ID=7894915

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1028-2001A SK285043B6 (sk) 1999-01-21 2000-01-11 Spôsob prípravy L-fenylefrín hydrochloridu

Country Status (41)

Country Link
US (1) US6187956B1 (es)
EP (1) EP1147075B1 (es)
JP (1) JP4263367B2 (es)
KR (1) KR100655104B1 (es)
CN (1) CN100357255C (es)
AR (1) AR031064A1 (es)
AT (1) ATE249417T1 (es)
AU (1) AU760405B2 (es)
BG (1) BG64620B1 (es)
BR (1) BR0007610B1 (es)
CA (1) CA2355938C (es)
CO (1) CO5150188A1 (es)
CZ (1) CZ299660B6 (es)
DE (2) DE19902229C2 (es)
DK (1) DK1147075T3 (es)
EE (1) EE04234B1 (es)
EG (1) EG23819A (es)
ES (1) ES2204512T3 (es)
HK (1) HK1041873B (es)
HR (1) HRP20010513B1 (es)
HU (1) HU228925B1 (es)
ID (1) ID30091A (es)
IL (1) IL144454A (es)
ME (1) ME00749B (es)
MY (1) MY117204A (es)
NO (1) NO327634B1 (es)
NZ (1) NZ513628A (es)
PE (1) PE20001417A1 (es)
PL (1) PL197539B1 (es)
PT (1) PT1147075E (es)
RS (1) RS49892B (es)
RU (1) RU2237655C2 (es)
SA (1) SA00200921B1 (es)
SI (1) SI1147075T1 (es)
SK (1) SK285043B6 (es)
TR (1) TR200102108T2 (es)
TW (1) TW499409B (es)
UA (1) UA64835C2 (es)
UY (1) UY25984A1 (es)
WO (1) WO2000043345A1 (es)
ZA (1) ZA200105294B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19938709C1 (de) * 1999-08-14 2001-01-18 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Adrenalin
CN1261405C (zh) * 2000-11-09 2006-06-28 三井化学株式会社 旋光性胺衍生物及其合成方法
JP3504254B2 (ja) * 2001-10-31 2004-03-08 関東化学株式会社 光学活性アミノアルコールおよびその中間体の製造方法
DE10249576B3 (de) * 2002-10-24 2004-04-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von (R)-Salbutamol
US7049469B2 (en) 2002-10-24 2006-05-23 Boehringer Ingelheim Pharma Gmbh & Co. Kg Process for preparing (R)-salbutamol
US20050197503A1 (en) * 2004-03-05 2005-09-08 Boehringer Ingelheim International Gmbh Process for the preparation of N-alkyl-N-methyl-3-hydroxy-3-(2-thienyl)-propylamines
DE102004033313A1 (de) 2004-07-08 2006-01-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung von Enantiomeren 3-hydroxy-3-phenyl-propylaminen
DE102004034682A1 (de) * 2004-07-17 2006-02-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verkürztes Verfahren zur Herstellung von chiralem Lobelin
JP4834333B2 (ja) * 2005-06-27 2011-12-14 アルプス薬品工業株式会社 光学活性ベンジルアミン誘導体の製造方法
CN100448842C (zh) * 2006-06-02 2009-01-07 台州明翔化工有限公司 α-(N-甲基-N-苄胺基)-3-羟基苯乙酮盐酸盐合成方法
WO2008077560A1 (en) * 2006-12-22 2008-07-03 Lonza Ag Process for the preparation of optically active 2-amino-1-phenylethanols
WO2008095678A1 (en) * 2007-02-05 2008-08-14 Lonza Ag Process for the preparation of optically active 2-amino-1-phenylethanols
ES2377907T3 (es) 2007-06-20 2012-04-03 Basf Se Procedimiento para la obtención de alcoholes con actividad óptica bajo empleo de una dehidrogenasa de Azoarcus sp. EbN1
WO2009086283A1 (en) * 2007-12-21 2009-07-09 Cambrex Charles City, Inc. Synthesis of enantiomerically pure 2-hydroxy-2-aryl-ethylamines
ES2663272T3 (es) * 2008-09-17 2018-04-11 Siegfried Ag Procedimiento para la preparación de L-fenilefrina mediante uso de una alcoholdeshidrogenasa
CN102234237B (zh) * 2010-04-22 2014-03-26 赤峰艾克制药科技股份有限公司 L-苯福林盐酸盐的制备方法
CN102381990A (zh) * 2010-08-31 2012-03-21 凯瑞斯德生化(苏州)有限公司 一种光学活性的n-苄基新福林的制备方法
US8455692B2 (en) 2010-11-01 2013-06-04 Divi's Laboratories, Ltd. Process for resolution of 1-(3-hydroxyphenyl)-2-methylamino ethanol
CN103553942B (zh) * 2013-11-13 2015-11-18 武汉武药科技有限公司 一种盐酸去氧肾上腺素杂质的制备方法
CN113173859B (zh) * 2021-04-28 2022-08-19 温州大学 一种合成手性α-胺基醇化合物的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1000293A (en) * 1972-03-16 1976-11-23 Arthur J. Solodar Asymmetric reduction of ketones to form optically active alcohols
AU7446196A (en) * 1995-10-13 1997-04-30 Penn State Research Foundation, The Asymmetric synthesis catalyzed by transition metal complexes with new chiral ligands

Also Published As

Publication number Publication date
RU2237655C2 (ru) 2004-10-10
PE20001417A1 (es) 2001-01-03
WO2000043345A1 (de) 2000-07-27
HK1041873B (zh) 2008-03-28
TR200102108T2 (tr) 2001-12-21
ZA200105294B (en) 2002-02-21
UY25984A1 (es) 2000-09-29
JP2002535298A (ja) 2002-10-22
EP1147075A1 (de) 2001-10-24
CO5150188A1 (es) 2002-04-29
IL144454A (en) 2004-06-01
AR031064A1 (es) 2003-09-10
RS49892B (sr) 2008-08-07
UA64835C2 (uk) 2004-03-15
NO20013569L (no) 2001-07-19
HUP0202651A2 (hu) 2003-02-28
NZ513628A (en) 2001-09-28
ID30091A (id) 2001-11-01
CA2355938C (en) 2009-03-24
BR0007610A (pt) 2001-10-30
CA2355938A1 (en) 2000-07-27
SA00200921B1 (ar) 2006-06-10
PT1147075E (pt) 2004-01-30
CZ20012655A3 (cs) 2001-11-14
ME00749B (me) 2008-08-07
CN1336909A (zh) 2002-02-20
KR20010101608A (ko) 2001-11-14
NO327634B1 (no) 2009-09-07
YU51001A (sh) 2004-03-12
BG64620B1 (bg) 2005-09-30
DE19902229A1 (de) 2000-08-03
JP4263367B2 (ja) 2009-05-13
HRP20010513A2 (en) 2002-08-31
EG23819A (en) 2007-09-19
SK10282001A3 (sk) 2001-12-03
EE04234B1 (et) 2004-02-16
HU228925B1 (en) 2013-06-28
AU760405B2 (en) 2003-05-15
NO20013569D0 (no) 2001-07-19
CN100357255C (zh) 2007-12-26
PL197539B1 (pl) 2008-04-30
HUP0202651A3 (en) 2006-03-28
HRP20010513B1 (en) 2010-02-28
SI1147075T1 (en) 2004-02-29
BR0007610B1 (pt) 2011-08-09
ATE249417T1 (de) 2003-09-15
KR100655104B1 (ko) 2006-12-21
MY117204A (en) 2004-05-31
DE19902229C2 (de) 2000-11-02
DK1147075T3 (da) 2003-12-08
AU2663400A (en) 2000-08-07
DE50003632D1 (de) 2003-10-16
ES2204512T3 (es) 2004-05-01
HK1041873A1 (en) 2002-07-26
IL144454A0 (en) 2002-05-23
BG105693A (en) 2002-03-29
PL348858A1 (en) 2002-06-17
EP1147075B1 (de) 2003-09-10
TW499409B (en) 2002-08-21
US6187956B1 (en) 2001-02-13
EE200100383A (et) 2002-12-16
CZ299660B6 (cs) 2008-10-08

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Date Code Title Description
MK4A Patent expired

Expiry date: 20200111