SK284408B6 - Chemické zlúčeniny s protizápalovou aktivitou obsahujúce indolovú skupinu, spôsob ich prípravy, použitie a farmaceutické kompozície, ktoré ich obsahujú - Google Patents
Chemické zlúčeniny s protizápalovou aktivitou obsahujúce indolovú skupinu, spôsob ich prípravy, použitie a farmaceutické kompozície, ktoré ich obsahujú Download PDFInfo
- Publication number
- SK284408B6 SK284408B6 SK167-2000A SK1672000A SK284408B6 SK 284408 B6 SK284408 B6 SK 284408B6 SK 1672000 A SK1672000 A SK 1672000A SK 284408 B6 SK284408 B6 SK 284408B6
- Authority
- SK
- Slovakia
- Prior art keywords
- group
- indole
- carboxylic acid
- dichlorobenzyl
- alkyl
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Toxicology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Mechanical Coupling Of Light Guides (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- External Artificial Organs (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9716657.3A GB9716657D0 (en) | 1997-08-07 | 1997-08-07 | Chemical compounds |
PCT/GB1998/002341 WO1999007351A2 (en) | 1997-08-07 | 1998-08-04 | Indole derivatives and their use as mcp-1 antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
SK1672000A3 SK1672000A3 (en) | 2000-12-11 |
SK284408B6 true SK284408B6 (sk) | 2005-03-04 |
Family
ID=10817097
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK167-2000A SK284408B6 (sk) | 1997-08-07 | 1998-08-04 | Chemické zlúčeniny s protizápalovou aktivitou obsahujúce indolovú skupinu, spôsob ich prípravy, použitie a farmaceutické kompozície, ktoré ich obsahujú |
Country Status (28)
Country | Link |
---|---|
US (2) | US6441004B1 (pt) |
EP (1) | EP1003504B1 (pt) |
JP (1) | JP3863722B2 (pt) |
KR (1) | KR20010022318A (pt) |
CN (1) | CN1265591A (pt) |
AT (1) | ATE244007T1 (pt) |
AU (1) | AU745907C (pt) |
BR (1) | BR9811818A (pt) |
CA (1) | CA2297290A1 (pt) |
CZ (1) | CZ294600B6 (pt) |
DE (1) | DE69816091T2 (pt) |
DK (1) | DK1003504T3 (pt) |
ES (1) | ES2201517T3 (pt) |
GB (1) | GB9716657D0 (pt) |
HK (1) | HK1027979A1 (pt) |
HR (1) | HRP20000061A2 (pt) |
HU (1) | HUP0004301A3 (pt) |
ID (1) | ID23666A (pt) |
IL (1) | IL133989A0 (pt) |
NO (1) | NO20000573D0 (pt) |
NZ (1) | NZ502056A (pt) |
PL (1) | PL338948A1 (pt) |
PT (1) | PT1003504E (pt) |
RU (1) | RU2217142C2 (pt) |
SK (1) | SK284408B6 (pt) |
TR (1) | TR200000289T2 (pt) |
WO (1) | WO1999007351A2 (pt) |
ZA (1) | ZA987090B (pt) |
Families Citing this family (102)
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GB9716657D0 (en) * | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
FR2768146B1 (fr) | 1997-09-05 | 2000-05-05 | Oreal | Nouveaux composes de la famille des indole-carboxyliques et leur utilisation |
GB9902461D0 (en) * | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902459D0 (en) * | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902453D0 (en) * | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902452D0 (en) * | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902455D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
FR2796274B1 (fr) * | 1999-07-16 | 2001-09-21 | Oreal | Utilisation de l'acide 4,6-dimethoxy-indole 2-carboxylique ou de ses derives pour stimuler ou induire la pousse des cheveux et/ou stopper leur chute |
FR2796279B1 (fr) | 1999-07-16 | 2001-09-21 | Oreal | Utilisation de l'acide 4,6-dimethoxy-indole 2-carboxylique ou de ses derives pour le traitement de la seborrhee |
GB0000626D0 (en) * | 2000-01-13 | 2000-03-01 | Zeneca Ltd | Chemical compounds |
GB0000625D0 (en) * | 2000-01-13 | 2000-03-01 | Zeneca Ltd | Chemical compounds |
EP1341761A1 (en) | 2000-10-10 | 2003-09-10 | Smithkline Beecham Corporation | SUBSTITUTED INDOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INDOLES AND THEIR USE AS PPAR-$g(g) BINDING AGENTS |
EP1351924A2 (en) | 2000-12-20 | 2003-10-15 | Bristol-Myers Squibb Pharma Company | Diamines as modulators of chemokine receptor activity |
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BR0207952A (pt) | 2001-03-07 | 2004-07-27 | Pfizer Prod Inc | Moduladores da atividade de receptores de quimiocina |
ES2180436B1 (es) * | 2001-06-04 | 2003-11-01 | Menarini Lab | Nuevos indoles como inhibidores de la ciclooxigenasa- ii |
EP1314733A1 (en) * | 2001-11-22 | 2003-05-28 | Aventis Pharma Deutschland GmbH | Indole-2-carboxamides as factor Xa inhibitors |
US7842693B2 (en) | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
US7589199B2 (en) | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
EP1531822B1 (en) | 2002-06-12 | 2009-08-05 | ChemoCentryx Inc | 1-aryl-4-substituted piperazine derivatives for use as ccr1 antagonists for the treatment of inflammation and immune disorders |
TW200508224A (en) | 2003-02-12 | 2005-03-01 | Bristol Myers Squibb Co | Cyclic derivatives as modulators of chemokine receptor activity |
WO2004071449A2 (en) | 2003-02-12 | 2004-08-26 | Bristol-Myers Squibb Company | Lactams as modulators of chemokine receptor activity |
MXPA05009771A (es) | 2003-03-14 | 2005-10-26 | Ono Pharmaceutical Co | Derivados heterociclicos que contienen nitrogeno y medicamentos que los contienen como el ingrediente activo. |
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EP2364982A1 (en) | 2003-04-18 | 2011-09-14 | ONO Pharmaceutical Co., Ltd. | Spiro-piperidine compounds as chemokine receptor antagonists and medicinal use thereof |
US7291615B2 (en) | 2003-05-01 | 2007-11-06 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
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US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
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US7332521B2 (en) * | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
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CA2572469A1 (en) * | 2004-07-01 | 2006-01-19 | The Regents Of The University Of California | Small molecule inhibition of a pdz-domain interaction |
TWI400232B (zh) | 2004-09-13 | 2013-07-01 | Ono Pharmaceutical Co | 含氮雜環衍生物及以該含氮雜環衍生物為有效成分之藥劑 |
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JP2008527030A (ja) * | 2005-01-19 | 2008-07-24 | バイオリポックス エービー | 炎症の治療に有用なインドール類 |
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-
1997
- 1997-08-07 GB GBGB9716657.3A patent/GB9716657D0/en active Pending
-
1998
- 1998-08-04 IL IL13398998A patent/IL133989A0/xx unknown
- 1998-08-04 AU AU86381/98A patent/AU745907C/en not_active Ceased
- 1998-08-04 AT AT98937659T patent/ATE244007T1/de not_active IP Right Cessation
- 1998-08-04 US US09/485,061 patent/US6441004B1/en not_active Expired - Fee Related
- 1998-08-04 SK SK167-2000A patent/SK284408B6/sk unknown
- 1998-08-04 DE DE69816091T patent/DE69816091T2/de not_active Expired - Fee Related
- 1998-08-04 KR KR1020007000897A patent/KR20010022318A/ko not_active Application Discontinuation
- 1998-08-04 PL PL98338948A patent/PL338948A1/xx unknown
- 1998-08-04 BR BR9811818-8A patent/BR9811818A/pt not_active IP Right Cessation
- 1998-08-04 WO PCT/GB1998/002341 patent/WO1999007351A2/en not_active Application Discontinuation
- 1998-08-04 PT PT98937659T patent/PT1003504E/pt unknown
- 1998-08-04 CZ CZ2000431A patent/CZ294600B6/cs not_active IP Right Cessation
- 1998-08-04 DK DK98937659T patent/DK1003504T3/da active
- 1998-08-04 JP JP2000506944A patent/JP3863722B2/ja not_active Expired - Fee Related
- 1998-08-04 TR TR2000/00289T patent/TR200000289T2/xx unknown
- 1998-08-04 EP EP98937659A patent/EP1003504B1/en not_active Expired - Lifetime
- 1998-08-04 RU RU2000105901/15A patent/RU2217142C2/ru not_active IP Right Cessation
- 1998-08-04 ID IDW20000172A patent/ID23666A/id unknown
- 1998-08-04 CN CN98807795A patent/CN1265591A/zh active Pending
- 1998-08-04 NZ NZ502056A patent/NZ502056A/en unknown
- 1998-08-04 CA CA002297290A patent/CA2297290A1/en not_active Abandoned
- 1998-08-04 ES ES98937659T patent/ES2201517T3/es not_active Expired - Lifetime
- 1998-08-04 HU HU0004301A patent/HUP0004301A3/hu unknown
- 1998-08-06 ZA ZA987090A patent/ZA987090B/xx unknown
-
2000
- 2000-02-03 HR HR20000061A patent/HRP20000061A2/hr not_active Application Discontinuation
- 2000-02-04 NO NO20000573A patent/NO20000573D0/no not_active Application Discontinuation
- 2000-11-21 HK HK00107435A patent/HK1027979A1/xx not_active IP Right Cessation
-
2002
- 2002-07-15 US US10/194,969 patent/US6953809B2/en not_active Expired - Fee Related
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