SK284179B6 - Spôsob čistenia rekombinantného aktivátora plazminogénu alfa1 zo slín Desmondus rotundus (rDSPalfa1) z biologického média a spôsob izolácie a čistenia rDSPA alfa1 z biologického média - Google Patents

Spôsob čistenia rekombinantného aktivátora plazminogénu alfa1 zo slín Desmondus rotundus (rDSPalfa1) z biologického média a spôsob izolácie a čistenia rDSPA alfa1 z biologického média Download PDF

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Publication number
SK284179B6
SK284179B6 SK1032-98A SK103298A SK284179B6 SK 284179 B6 SK284179 B6 SK 284179B6 SK 103298 A SK103298 A SK 103298A SK 284179 B6 SK284179 B6 SK 284179B6
Authority
SK
Slovakia
Prior art keywords
rdspa
resin
cation exchange
buffer
affinity chromatography
Prior art date
Application number
SK1032-98A
Other languages
English (en)
Slovak (sk)
Other versions
SK103298A3 (en
Inventor
Michael Mccaman
Erno Pungor
Carol Souders
Mei P. Tan
Original Assignee
Schering Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of SK103298A3 publication Critical patent/SK103298A3/sk
Publication of SK284179B6 publication Critical patent/SK284179B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Paper (AREA)
  • Electric Propulsion And Braking For Vehicles (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Control Of Motors That Do Not Use Commutators (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SK1032-98A 1996-02-05 1997-01-31 Spôsob čistenia rekombinantného aktivátora plazminogénu alfa1 zo slín Desmondus rotundus (rDSPalfa1) z biologického média a spôsob izolácie a čistenia rDSPA alfa1 z biologického média SK284179B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/597,059 US5731186A (en) 1996-02-05 1996-02-05 Method for the production of rDSPA α1
PCT/EP1997/000441 WO1997029188A1 (en) 1996-02-05 1997-01-31 METHOD FOR THE PRODUCTION OF rDSPA α1

Publications (2)

Publication Number Publication Date
SK103298A3 SK103298A3 (en) 1999-03-12
SK284179B6 true SK284179B6 (sk) 2004-10-05

Family

ID=24389906

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1032-98A SK284179B6 (sk) 1996-02-05 1997-01-31 Spôsob čistenia rekombinantného aktivátora plazminogénu alfa1 zo slín Desmondus rotundus (rDSPalfa1) z biologického média a spôsob izolácie a čistenia rDSPA alfa1 z biologického média

Country Status (23)

Country Link
US (1) US5731186A (de)
EP (1) EP1015568B1 (de)
JP (1) JP3805378B2 (de)
KR (1) KR100508043B1 (de)
CN (1) CN1242059C (de)
AT (1) ATE233316T1 (de)
AU (1) AU706286B2 (de)
CZ (1) CZ294827B6 (de)
DE (1) DE69719382T2 (de)
DK (1) DK1015568T3 (de)
ES (1) ES2193349T3 (de)
HK (1) HK1018795A1 (de)
HU (1) HU223902B1 (de)
IL (1) IL124952A (de)
NO (1) NO322527B1 (de)
PL (1) PL186410B1 (de)
PT (1) PT1015568E (de)
RU (1) RU2223315C2 (de)
SK (1) SK284179B6 (de)
TW (1) TW385313B (de)
UA (1) UA62925C2 (de)
WO (1) WO1997029188A1 (de)
ZA (1) ZA97948B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100436655B1 (ko) * 2001-07-25 2004-06-22 (주)엘피스바이오텍 광범위한 단백질에 적용할 수 있는 단백질의 농축 및정제 방법
DE10153601A1 (de) * 2001-11-02 2003-05-22 Paion Gmbh DSPA zur Behandlung von Schlaganfall
WO2007134617A1 (en) * 2006-05-19 2007-11-29 Paion Deutschland Gmbh Use of desmodus salivary plasminogen activator (dspa) for treating venous thromboembolism
AR068914A1 (es) * 2007-10-18 2009-12-16 Paion Deutschland Gmbh Uso de un activador de plasminogeno para la preparacion de un medicamento para el tratamiento de apoplejia
WO2011107299A2 (en) * 2010-04-16 2011-09-09 Paion Deutschland Gmbh Method for the manufacture of recombinant dspa alpha1
US20120258519A1 (en) * 2011-04-10 2012-10-11 Therapeutic Proteins Inc. Protein Harvesting
ES2896897T3 (es) 2015-06-05 2022-02-28 Grace W R & Co Agentes de clarificación para el bioprocesamiento de adsorbentes y métodos para producir y usar los mismos

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3512910A1 (de) * 1985-04-11 1986-10-16 Behringwerke Ag, 3550 Marburg Verfahren zur reinigung von plasminogenaktivatoren
US4721572A (en) * 1985-07-12 1988-01-26 Miles Laboratories, Inc. Purfication of blood clotting factors and other blood proteins on non-carbohydrate sulfated matrices
US4898825A (en) * 1986-05-07 1990-02-06 Mitsui Toatsu Chemicals, Incorporated Methods for purification of single-chain and double-chain tissue plasminogen activator
JPS6463378A (en) * 1986-08-11 1989-03-09 Mitsui Toatsu Chemicals Separation of single stranded tpa and double standard tpa
US4929560A (en) * 1988-02-03 1990-05-29 Damon Biotech, Inc. Recovery of tissue plasminogen activator
IE69054B1 (en) * 1988-07-20 1996-08-07 Schering Ag Vampire bat salivary plasminogen activators
CA2046632C (en) * 1989-02-13 1999-05-11 Berthold Baldus Thrombolytic from vampire bat saliva
DE3943241A1 (de) * 1989-12-22 1991-06-27 Schering Ag Thrombolytisch wirkendes kombinationspraeparat
US5141862A (en) * 1990-04-17 1992-08-25 Smithkline Beecham Corporation Method of purifying tpa or plasminogen activator using a tripeptide of the formula: -X-Y-argininal wherein X and Y are selected from the group consisting of pro,phe,trp and tyr

Also Published As

Publication number Publication date
ZA97948B (en) 1997-08-19
NO322527B1 (no) 2006-10-16
DK1015568T3 (da) 2003-06-10
CZ294827B6 (cs) 2005-03-16
EP1015568B1 (de) 2003-02-26
ES2193349T3 (es) 2003-11-01
IL124952A (en) 2002-08-14
ATE233316T1 (de) 2003-03-15
US5731186A (en) 1998-03-24
CZ245598A3 (cs) 1999-01-13
DE69719382T2 (de) 2003-11-27
SK103298A3 (en) 1999-03-12
HU223902B1 (hu) 2005-03-29
NO983579L (no) 1998-10-05
EP1015568A1 (de) 2000-07-05
HUP9901029A3 (en) 2001-10-29
CN1242059C (zh) 2006-02-15
HUP9901029A2 (hu) 1999-07-28
PL186410B1 (pl) 2004-01-30
RU2223315C2 (ru) 2004-02-10
PT1015568E (pt) 2003-07-31
WO1997029188A1 (en) 1997-08-14
TW385313B (en) 2000-03-21
KR100508043B1 (ko) 2005-12-21
KR19990082306A (ko) 1999-11-25
DE69719382D1 (de) 2003-04-03
UA62925C2 (en) 2004-01-15
AU706286B2 (en) 1999-06-10
PL328146A1 (en) 1999-01-18
NO983579D0 (no) 1998-08-04
CN1210559A (zh) 1999-03-10
JP3805378B2 (ja) 2006-08-02
JP2000504565A (ja) 2000-04-18
IL124952A0 (en) 1999-01-26
AU1546297A (en) 1997-08-28
HK1018795A1 (en) 2000-01-07

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PC4A Assignment and transfer of rights

Owner name: BAYER INTELLECTUAL PROPERTY GMBH, MONHEIM AM R, DE

Free format text: FORMER OWNER: BAYER PHARMA AKTIENGESELLSCHAFT, BERLIN, DE

Effective date: 20130226

TC4A Change of owner's name

Owner name: BAYER PHARMA AKTIENGESELLSCHAFT, BERLIN, DE

Effective date: 20130502

MK4A Expiry of patent

Expiry date: 20170131