PT1015568E - Metodo para a producao de rdspa alfa1 - Google Patents

Metodo para a producao de rdspa alfa1

Info

Publication number
PT1015568E
PT1015568E PT97901624T PT97901624T PT1015568E PT 1015568 E PT1015568 E PT 1015568E PT 97901624 T PT97901624 T PT 97901624T PT 97901624 T PT97901624 T PT 97901624T PT 1015568 E PT1015568 E PT 1015568E
Authority
PT
Portugal
Prior art keywords
chromatography
production
alpha1
rdspa
ending
Prior art date
Application number
PT97901624T
Other languages
English (en)
Inventor
Michael Mccaman
Erno Pungor
Carol Souders
Mei P Tan
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of PT1015568E publication Critical patent/PT1015568E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Paper (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Control Of Motors That Do Not Use Commutators (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT97901624T 1996-02-05 1997-01-31 Metodo para a producao de rdspa alfa1 PT1015568E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/597,059 US5731186A (en) 1996-02-05 1996-02-05 Method for the production of rDSPA α1

Publications (1)

Publication Number Publication Date
PT1015568E true PT1015568E (pt) 2003-07-31

Family

ID=24389906

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97901624T PT1015568E (pt) 1996-02-05 1997-01-31 Metodo para a producao de rdspa alfa1

Country Status (23)

Country Link
US (1) US5731186A (pt)
EP (1) EP1015568B1 (pt)
JP (1) JP3805378B2 (pt)
KR (1) KR100508043B1 (pt)
CN (1) CN1242059C (pt)
AT (1) ATE233316T1 (pt)
AU (1) AU706286B2 (pt)
CZ (1) CZ294827B6 (pt)
DE (1) DE69719382T2 (pt)
DK (1) DK1015568T3 (pt)
ES (1) ES2193349T3 (pt)
HK (1) HK1018795A1 (pt)
HU (1) HU223902B1 (pt)
IL (1) IL124952A (pt)
NO (1) NO322527B1 (pt)
PL (1) PL186410B1 (pt)
PT (1) PT1015568E (pt)
RU (1) RU2223315C2 (pt)
SK (1) SK284179B6 (pt)
TW (1) TW385313B (pt)
UA (1) UA62925C2 (pt)
WO (1) WO1997029188A1 (pt)
ZA (1) ZA97948B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100436655B1 (ko) * 2001-07-25 2004-06-22 (주)엘피스바이오텍 광범위한 단백질에 적용할 수 있는 단백질의 농축 및정제 방법
DE10153601A1 (de) * 2001-11-02 2003-05-22 Paion Gmbh DSPA zur Behandlung von Schlaganfall
DE202006015207U1 (de) * 2006-05-19 2007-08-16 Paion Deutschland Gmbh Verwendung vn Plasminogenaktivatoren zur Behandlung einer Venenthromboembolie
AR068914A1 (es) * 2007-10-18 2009-12-16 Paion Deutschland Gmbh Uso de un activador de plasminogeno para la preparacion de un medicamento para el tratamiento de apoplejia
EP2558580A2 (en) * 2010-04-16 2013-02-20 H. Lundbeck A/S Method for the manufacture of recombinant dspa alpha1
US20120258519A1 (en) * 2011-04-10 2012-10-11 Therapeutic Proteins Inc. Protein Harvesting
EP3302784B1 (en) 2015-06-05 2021-10-06 W.R. Grace & Co.-Conn. Adsorbent bioprocessing clarification agents and methods of making and using the same

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3512910A1 (de) * 1985-04-11 1986-10-16 Behringwerke Ag, 3550 Marburg Verfahren zur reinigung von plasminogenaktivatoren
US4721572A (en) * 1985-07-12 1988-01-26 Miles Laboratories, Inc. Purfication of blood clotting factors and other blood proteins on non-carbohydrate sulfated matrices
US4898825A (en) * 1986-05-07 1990-02-06 Mitsui Toatsu Chemicals, Incorporated Methods for purification of single-chain and double-chain tissue plasminogen activator
JPS6463378A (en) * 1986-08-11 1989-03-09 Mitsui Toatsu Chemicals Separation of single stranded tpa and double standard tpa
US4929560A (en) * 1988-02-03 1990-05-29 Damon Biotech, Inc. Recovery of tissue plasminogen activator
IE69054B1 (en) * 1988-07-20 1996-08-07 Schering Ag Vampire bat salivary plasminogen activators
UA34415C2 (uk) * 1989-02-13 2001-03-15 Шерінг Аг Берлін Унд Бергкамен Істотно чистий білок, що є тромболітиком, виділена днк, що його кодує, культура яйцеклітин xenopus laevis, трансформованих вектором, спосіб одержання активатора плазміногена, лікарський тромболітичний засіб
DE3943241A1 (de) * 1989-12-22 1991-06-27 Schering Ag Thrombolytisch wirkendes kombinationspraeparat
US5141862A (en) * 1990-04-17 1992-08-25 Smithkline Beecham Corporation Method of purifying tpa or plasminogen activator using a tripeptide of the formula: -X-Y-argininal wherein X and Y are selected from the group consisting of pro,phe,trp and tyr

Also Published As

Publication number Publication date
TW385313B (en) 2000-03-21
ZA97948B (en) 1997-08-19
DK1015568T3 (da) 2003-06-10
UA62925C2 (en) 2004-01-15
JP2000504565A (ja) 2000-04-18
KR19990082306A (ko) 1999-11-25
HK1018795A1 (en) 2000-01-07
ATE233316T1 (de) 2003-03-15
IL124952A (en) 2002-08-14
PL328146A1 (en) 1999-01-18
JP3805378B2 (ja) 2006-08-02
CN1242059C (zh) 2006-02-15
CN1210559A (zh) 1999-03-10
HUP9901029A2 (hu) 1999-07-28
NO983579D0 (no) 1998-08-04
AU706286B2 (en) 1999-06-10
CZ294827B6 (cs) 2005-03-16
RU2223315C2 (ru) 2004-02-10
CZ245598A3 (cs) 1999-01-13
DE69719382T2 (de) 2003-11-27
AU1546297A (en) 1997-08-28
US5731186A (en) 1998-03-24
WO1997029188A1 (en) 1997-08-14
SK284179B6 (sk) 2004-10-05
EP1015568B1 (en) 2003-02-26
NO983579L (no) 1998-10-05
HU223902B1 (hu) 2005-03-29
SK103298A3 (en) 1999-03-12
PL186410B1 (pl) 2004-01-30
HUP9901029A3 (en) 2001-10-29
KR100508043B1 (ko) 2005-12-21
NO322527B1 (no) 2006-10-16
ES2193349T3 (es) 2003-11-01
IL124952A0 (en) 1999-01-26
EP1015568A1 (en) 2000-07-05
DE69719382D1 (de) 2003-04-03

Similar Documents

Publication Publication Date Title
EP1193271A3 (en) Compositions and methods for protein structural determinations
DK639288D0 (da) Fremgangsmaade til rensning af serumalbumin
EP0242544A3 (en) Adsorbent for chromatography, method of producing the same, and column system for chromatography
BR9709368A (pt) Método para o fracionamento de uma solução por meio de um processo de leito móvel simulado cromatográfico
AU3598284A (en) Factor viii:c purification
PT1015568E (pt) Metodo para a producao de rdspa alfa1
DE69629299D1 (de) Prozess für die produktion von l-lysin durch fermentation
CA2213577A1 (en) A process for the preparation of factor ix from biological sources
CA2245554A1 (en) Method for the production of rdspa .alpha.1
AU4293485A (en) Heat pump energized by low-grade heat source
FR2540511B1 (fr) Composition liquide de nettoyage, ainsi que procede de nettoyage a partir de cette composition
ES2167911T3 (es) Metodo para preparar 3,3-dimetilbutiraldehido.
IT1219668B (it) Metodo per la determinazione quantitativa dei gangliosidi della serie gangliotetraose mediante tossina colerica congiugata con un enzima
FR2583765B2 (fr) Composition liquide de nettoyage, ainsi que procede de nettoyage a partir de cette composition
PL264665A1 (en) Method for producing spherical silicaceous carriers,especially for chromatography
GB9006338D0 (en) Method for diagnosing serum deficiencies
RO102524B1 (en) 3,5 di-tert-butyl-hydroxy-benzyl alcohol producing method
PL282841A1 (en) Method of obtaining d,1-4,8-diaza-3,6,6,9-tetramethylundecano-2,10-dione as well as its complex labelled with tc 99m
PL247637A1 (en) Method of modifying surfaces of adsorbents,supports and capilary columns used in chromatography
PL257017A1 (en) Method of producing thin-layer chromatography stationary bed
ES282808U (es) Marco iluminador
IT1239478B (it) Sale dell'idrocortisone emisuccinato con la clorexidina per l'impiego topico e composizioni farmaceutiche che lo contengono