CA2245554A1 - Method for the production of rdspa .alpha.1 - Google Patents

Method for the production of rdspa .alpha.1

Info

Publication number
CA2245554A1
CA2245554A1 CA002245554A CA2245554A CA2245554A1 CA 2245554 A1 CA2245554 A1 CA 2245554A1 CA 002245554 A CA002245554 A CA 002245554A CA 2245554 A CA2245554 A CA 2245554A CA 2245554 A1 CA2245554 A1 CA 2245554A1
Authority
CA
Canada
Prior art keywords
rdspa
alpha
production
chromatography
ending
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002245554A
Other languages
French (fr)
Other versions
CA2245554C (en
Inventor
Michael Mccaman
Erno Pungor
Carol Souders
Mei P. Tan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Intellectual Property GmbH
Original Assignee
Schering Aktiengesellschaft
Michael Mccaman
Erno Pungor
Carol Souders
Mei P. Tan
Bayer Schering Pharma Aktiengesellschaft
Bayer Pharma Aktiengesellschaft
Bayer Intellectual Property Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/597,059 external-priority patent/US5731186A/en
Application filed by Schering Aktiengesellschaft, Michael Mccaman, Erno Pungor, Carol Souders, Mei P. Tan, Bayer Schering Pharma Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, Bayer Intellectual Property Gmbh filed Critical Schering Aktiengesellschaft
Publication of CA2245554A1 publication Critical patent/CA2245554A1/en
Application granted granted Critical
Publication of CA2245554C publication Critical patent/CA2245554C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Landscapes

  • Peptides Or Proteins (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

rDSPA .alpha. 1 is produced in commercial quantities and a purity adequate for clinical standards. The production methods utilize a series of chromatographic steps: cation exchange chromatography, followed by hydrophobic interaction chromatography, and ending with affinity chromatography.
CA002245554A 1996-02-05 1997-01-31 Method for the production of rdspa .alpha.1 Expired - Lifetime CA2245554C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/597,059 1996-02-05
US08/597,059 US5731186A (en) 1996-02-05 1996-02-05 Method for the production of rDSPA α1
PCT/EP1997/000441 WO1997029188A1 (en) 1996-02-05 1997-01-31 METHOD FOR THE PRODUCTION OF rDSPA α1

Publications (2)

Publication Number Publication Date
CA2245554A1 true CA2245554A1 (en) 1997-08-14
CA2245554C CA2245554C (en) 2006-07-04

Family

ID=36648523

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002245554A Expired - Lifetime CA2245554C (en) 1996-02-05 1997-01-31 Method for the production of rdspa .alpha.1

Country Status (1)

Country Link
CA (1) CA2245554C (en)

Also Published As

Publication number Publication date
CA2245554C (en) 2006-07-04

Similar Documents

Publication Publication Date Title
AU6305990A (en) Process for refrigerating, corresponding refrigerating cycle and their application to the distillation of air
EP1193271A3 (en) Compositions and methods for protein structural determinations
EP0670370A3 (en) Method of producing L-glutamic acid by fermentation.
CA2214633A1 (en) Antibody purification by low-ph hydrophobic interaction chromatography
IL88326A0 (en) Purification of serum albumin
EP0242544A3 (en) Adsorbent for chromatography, method of producing the same, and column system for chromatography
AU4976790A (en) Adsorption refrigeration system
AU3893285A (en) Process for producing synthetic gas
AU3822189A (en) Process for producing high cleaness extra low carbon steel
HUP9900149A2 (en) Process for producing l-lysine by fermentation
PH31685A (en) Method of producing l-glutamic acid by fermentation.
ZA97948B (en) Method for the production of rDSPA Ó1.
AU5298390A (en) Process for producing microcapsules
AU6183790A (en) Process for reducing the swellability of starches
CA2165329A1 (en) Process for the preparation of n-acetyl neuraminic acid derivatives
CA2170885A1 (en) Process for the purification of basic fibroblast growth factor
AU564766B2 (en) Process for producing microcapsules
EP0725142A4 (en) Process for producing d-amino acid by using composite immobilized enzyme preparation
CA2245554A1 (en) Method for the production of rdspa .alpha.1
AU7162494A (en) Process to produce methanol
AU5196190A (en) Process for producing low aluminum membrane cell feedbrine
AU698813B2 (en) Process for producing transglutaminase by microorganism
HUT50216A (en) Process for producing l-lysine by fermentation
HUT39184A (en) Process for producing christalline /5r,6s/-2-amino-metil-6-/ /1r/-1-hydroxy-ethyl/-2-penem-3-carboxylic acid
AU6214786A (en) Method for producing composite metal articles

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20170131