SK283832B6 - Spôsob prípravy fosfodiesterových zlúčenín - Google Patents

Spôsob prípravy fosfodiesterových zlúčenín Download PDF

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Publication number
SK283832B6
SK283832B6 SK1382-99A SK138299A SK283832B6 SK 283832 B6 SK283832 B6 SK 283832B6 SK 138299 A SK138299 A SK 138299A SK 283832 B6 SK283832 B6 SK 283832B6
Authority
SK
Slovakia
Prior art keywords
formula
amino
prepared
solvent
penta
Prior art date
Application number
SK1382-99A
Other languages
English (en)
Slovak (sk)
Other versions
SK138299A3 (en
Inventor
John C. Amedio
Paul J. Bernard
Mark Fountain
Original Assignee
Epix Medical, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epix Medical, Inc. filed Critical Epix Medical, Inc.
Publication of SK138299A3 publication Critical patent/SK138299A3/sk
Publication of SK283832B6 publication Critical patent/SK283832B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SK1382-99A 1997-04-11 1998-01-27 Spôsob prípravy fosfodiesterových zlúčenín SK283832B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/833,745 US5919967A (en) 1997-04-11 1997-04-11 Process for synthesizing phosphodiesters
PCT/US1998/001473 WO1998046612A1 (en) 1997-04-11 1998-01-27 Process for synthesizing phosphodiesters

Publications (2)

Publication Number Publication Date
SK138299A3 SK138299A3 (en) 2000-05-16
SK283832B6 true SK283832B6 (sk) 2004-02-03

Family

ID=25265165

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1382-99A SK283832B6 (sk) 1997-04-11 1998-01-27 Spôsob prípravy fosfodiesterových zlúčenín

Country Status (21)

Country Link
US (1) US5919967A (cs)
EP (1) EP1021452B1 (cs)
JP (2) JP4014231B2 (cs)
KR (2) KR100593650B1 (cs)
AT (1) ATE236171T1 (cs)
AU (1) AU728902B2 (cs)
BR (1) BR9809084B1 (cs)
CA (1) CA2285417C (cs)
CZ (1) CZ294469B6 (cs)
DE (1) DE69812983T2 (cs)
DK (1) DK1021452T3 (cs)
ES (1) ES2195315T3 (cs)
HU (1) HU224257B1 (cs)
IL (1) IL131964A (cs)
IS (1) IS1994B (cs)
NO (1) NO325619B1 (cs)
NZ (1) NZ337921A (cs)
PL (1) PL188258B1 (cs)
PT (1) PT1021452E (cs)
SK (1) SK283832B6 (cs)
WO (1) WO1998046612A1 (cs)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2303426C (en) * 1997-10-02 2008-09-23 Epix Medical, Inc. Contrast-enhanced diagnostic imaging method for monitoring interventional therapies
DE19964224B4 (de) * 1999-09-09 2005-09-01 Schering Ag Pharmazeutische Mittel enthaltend Calcium-Komplex von [[(4R)-4-[bis[(carboxy-.kappa.O)methyl]amino-.kappa.N]-6,9-bis[(carboxy-.kappa.O)methyl]-1-[(4,4-diphenylcyclohexyl)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-yl-säure-.kappa.N6,.kappa.N9,.kappa.011]1-oxidato(6-)]-, tetrahydrogen (MS-325) und dessen Salze sowie Verfahren zur Herstellung der Mittel
US20030203879A1 (en) * 1999-09-09 2003-10-30 Schering Ag Calcium complex of [[(4R)-4-[bis[(carboxy-.kappa.O)methyl]amino-.kappa.n]-6,9-bis[(carboxy.kappa.O)methyl]-1-[(4,4-diphenylcyclohexy)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-ylic-acid-.kappa.N6,.Kappa.N9,.Kappa 011]1-oxidato(6-)]-, hexahydrogen, its salts, pharmaceutical agents that contain these complexes, their use in treatment and as additives in diagnosis, as well as processes for the production of the complexes and agents
US6559330B1 (en) * 1999-09-09 2003-05-06 Schering Aktiengesellschaft Calcium complex of [[(4r)-4-[bis{carboxy-.kappa.o)methyl]amino-.kappa.n]-6,9-bis[(carboxy.kappa.o)methyl]-1-[(4,4-diphenylcyclohexyl)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-ylic-acid-.kappa.n6,.kappa.n9,.kappa.011]1-oxidato(6-)]-, hexahydrogen, its salts, pharmaceutical agents that contain these complexes, their use in treatment and as additives in diagnosis, as well as processes for the production of the complexes and agents
WO2003029257A1 (de) * 2001-09-27 2003-04-10 Schering Aktiengesellschaft (ethylen)-(propylen/butylen)-phosphodiester-triaminpentaessigsäure-derivate
CA2666005C (en) 2002-03-01 2016-01-19 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
EP1587944A4 (en) 2002-03-01 2007-03-21 Dyax Corp KDR AND VEGF / KDR BINDING PEPTIDES AND THEIR USE FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
WO2004078778A2 (en) 2003-03-03 2004-09-16 Dyax Corp. PEPTIDES THAT SPECIFICALLY BIND HGF RECEPTOR (cMet) AND USES THEREOF
KR100585219B1 (ko) * 2004-05-07 2006-06-01 주식회사 태평양 포스페이트 유도체 및 이의 제조방법
CN100487093C (zh) * 2006-03-15 2009-05-13 中国石油化工股份有限公司 一种亚磷酰胺酯类极压抗磨剂及其制备和应用
WO2010121133A2 (en) 2009-04-17 2010-10-21 The General Hospital Corporation Multimodal imaging of fibrin
JP2012521352A (ja) 2009-03-19 2012-09-13 ワイス・エルエルシー ［２−（８，９−ジオキソ−２，６−ジアザビシクロ［５．２．０］ノナ−１（７）−エン−２−イル）エチル］ホスホン酸およびその前駆体を調製するための方法
TW201514188A (zh) * 2013-03-13 2015-04-16 Lantheus Medical Imaging Inc 製備釓磷維塞三鈉單水合物之方法
WO2015171543A1 (en) 2014-05-05 2015-11-12 California Institute Of Technology Mutant akt-specific capture agents, compositions, and methods of using and making
US10471162B2 (en) 2014-06-20 2019-11-12 The General Hospital Corporation Collagen targeted imaging probes
CN107624115B (zh) 2015-03-16 2021-10-26 加州理工学院 肉毒神经毒素特异性捕获剂、组合物、使用方法和制造方法
CN115112898A (zh) 2015-07-15 2022-09-27 加州理工学院 Il-17f-特异性捕获剂、组合物以及使用和制造的方法
EP3519425B1 (en) 2016-09-29 2024-02-28 Indi Molecular, Inc. Compositions for detection, inhibition and imaging of indoleamine 2,3-dioxygenase 1 (ido1) and methods of making and using same
US11358982B2 (en) 2016-11-01 2022-06-14 Ohio State Innovation Foundation Methods for the iodination of biomolecules
US11719705B2 (en) 2017-06-15 2023-08-08 Indi Molecular, Inc. IL-17F and IL-17A-specific capture agents, compositions, and methods of using and making
US11919972B2 (en) 2018-11-02 2024-03-05 Regeneron Pharmaceuticals, Inc. Peptide libraries with non-canonical amino acids
US11638764B2 (en) 2018-11-08 2023-05-02 Indi Molecular, Inc. Theranostic capture agents, compositions, and methods of using and making
US12201679B2 (en) 2019-04-05 2025-01-21 Institute For Systems Biology Epitope-targeted peptide immunostimulants
US12216122B2 (en) 2019-05-20 2025-02-04 Regeneron Pharmaceuticals, Inc. Compositions and methods relating to detection, inhibition, and imaging of indoleamine 2,3-dioxygenase 1 (IDO1)
US11414460B2 (en) 2019-07-19 2022-08-16 Institute For Systems Biology KRAS-specific capture agents, compositions, and methods of making and using
US12209142B2 (en) 2020-05-29 2025-01-28 Institute For Systems Biology SARS-CoV-2 epitope-targeted peptide immunostimulants
WO2022098745A1 (en) 2020-11-03 2022-05-12 Indi Molecular, Inc. Compositions, delivery systems, and methods useful in tumor therapy
WO2022098743A1 (en) 2020-11-03 2022-05-12 Indi Molecular, Inc. Compositions, imaging, and therapeutic methods targeting folate receptor 1 (folr1)
US20240209008A1 (en) * 2021-03-03 2024-06-27 Tokyo Institute Of Technology Method for producing asymmetric phosphoric acid triester, method for producing symmetric phosphoric acid triester, method for producing phosphoric acid ester, and method for producing organophosphorus compound

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4880008A (en) * 1985-05-08 1989-11-14 The General Hospital Corporation Vivo enhancement of NMR relaxivity
TW319763B (cs) * 1995-02-01 1997-11-11 Epix Medical Inc
AU717099B2 (en) * 1995-03-08 2000-03-16 Scripps Research Institute, The Carbopeptoids and carbonucleotoids

Also Published As

Publication number Publication date
ES2195315T3 (es) 2003-12-01
SK138299A3 (en) 2000-05-16
PL337423A1 (en) 2000-08-14
IS5193A (is) 1999-09-24
WO1998046612A1 (en) 1998-10-22
KR20060066122A (ko) 2006-06-15
JP4014231B2 (ja) 2007-11-28
HU224257B1 (hu) 2005-07-28
JP2005206605A (ja) 2005-08-04
DE69812983T2 (de) 2004-01-08
PT1021452E (pt) 2003-08-29
EP1021452B1 (en) 2003-04-02
IL131964A (en) 2004-01-04
JP2002511060A (ja) 2002-04-09
NZ337921A (en) 2000-09-29
CZ355999A3 (cs) 2000-01-12
BR9809084B1 (pt) 2010-12-14
KR20010006177A (ko) 2001-01-26
HUP0004239A2 (en) 2001-03-28
HUP0004239A3 (en) 2001-11-28
CA2285417A1 (en) 1998-10-22
CA2285417C (en) 2006-01-24
BR9809084A (pt) 2000-08-01
NO994919L (no) 1999-10-08
IS1994B (is) 2005-03-15
PL188258B1 (pl) 2005-01-31
DE69812983D1 (de) 2003-05-08
ATE236171T1 (de) 2003-04-15
DK1021452T3 (da) 2003-08-18
KR100593650B1 (ko) 2006-07-03
AU6042598A (en) 1998-11-11
NO994919D0 (no) 1999-10-08
CZ294469B6 (cs) 2005-01-12
IL131964A0 (en) 2001-03-19
EP1021452A1 (en) 2000-07-26
AU728902B2 (en) 2001-01-18
US5919967A (en) 1999-07-06
NO325619B1 (no) 2008-06-30

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MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20100127