ES2195315T3 - Procedimiento para sintetizar fosfodiesteres. - Google Patents
Procedimiento para sintetizar fosfodiesteres.Info
- Publication number
- ES2195315T3 ES2195315T3 ES98903734T ES98903734T ES2195315T3 ES 2195315 T3 ES2195315 T3 ES 2195315T3 ES 98903734 T ES98903734 T ES 98903734T ES 98903734 T ES98903734 T ES 98903734T ES 2195315 T3 ES2195315 T3 ES 2195315T3
- Authority
- ES
- Spain
- Prior art keywords
- procedure
- cyclic
- formula
- aliphatic
- phosphodesters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 2
- 230000002194 synthesizing effect Effects 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 108010043958 Peptoids Proteins 0.000 abstract 1
- 108091028664 Ribonucleotide Proteins 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000002015 acyclic group Chemical group 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- JXLHNMVSKXFWAO-UHFFFAOYSA-N azane;7-fluoro-2,1,3-benzoxadiazole-4-sulfonic acid Chemical compound N.OS(=O)(=O)C1=CC=C(F)C2=NON=C12 JXLHNMVSKXFWAO-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
- 125000002524 organometallic group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- -1 phosphodiester compounds Chemical class 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 239000002342 ribonucleoside Substances 0.000 abstract 1
- 239000002336 ribonucleotide Substances 0.000 abstract 1
- 125000002652 ribonucleotide group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229940124530 sulfonamide Drugs 0.000 abstract 1
- 150000003456 sulfonamides Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Un procedimiento para preparar compuestos fosfodiéster que tienen la fórmula:**fórmula** en la que R y R1 pueden ser iguales o diferentes y se seleccionan entre grupos de agentes orgánicos quelatantes alifáticos lineales, ramificados o cíclicos, arilo, heterocíclicos, peptídicos, peptoides, desoxirribo- o ribo-nucleotídicos o nucleosídicos, o cíclicos o acíclicos, todos opcionalmente sustituidos con uno o más sustituyentes nitrógeno, oxígeno, azufre, halógeno, alifáticos, amida, éster, sulfonamida, acilo, sulfonato, fosfato, hidroxilo u organometálicos, y procedimiento que tiene lugar en un recipiente de reacción.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/833,745 US5919967A (en) | 1997-04-11 | 1997-04-11 | Process for synthesizing phosphodiesters |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2195315T3 true ES2195315T3 (es) | 2003-12-01 |
Family
ID=25265165
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES98903734T Expired - Lifetime ES2195315T3 (es) | 1997-04-11 | 1998-01-27 | Procedimiento para sintetizar fosfodiesteres. |
Country Status (21)
Country | Link |
---|---|
US (1) | US5919967A (es) |
EP (1) | EP1021452B1 (es) |
JP (2) | JP4014231B2 (es) |
KR (2) | KR20060066122A (es) |
AT (1) | ATE236171T1 (es) |
AU (1) | AU728902B2 (es) |
BR (1) | BR9809084B1 (es) |
CA (1) | CA2285417C (es) |
CZ (1) | CZ294469B6 (es) |
DE (1) | DE69812983T2 (es) |
DK (1) | DK1021452T3 (es) |
ES (1) | ES2195315T3 (es) |
HU (1) | HU224257B1 (es) |
IL (1) | IL131964A (es) |
IS (1) | IS1994B (es) |
NO (1) | NO325619B1 (es) |
NZ (1) | NZ337921A (es) |
PL (1) | PL188258B1 (es) |
PT (1) | PT1021452E (es) |
SK (1) | SK283832B6 (es) |
WO (1) | WO1998046612A1 (es) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUP0101245A3 (en) * | 1997-10-02 | 2003-10-28 | Epix Pharmaceuticals Inc Cambr | Contrast-enhanced diagnostic imaging method for monitoring interventional therapies |
DE19964224B4 (de) * | 1999-09-09 | 2005-09-01 | Schering Ag | Pharmazeutische Mittel enthaltend Calcium-Komplex von [[(4R)-4-[bis[(carboxy-.kappa.O)methyl]amino-.kappa.N]-6,9-bis[(carboxy-.kappa.O)methyl]-1-[(4,4-diphenylcyclohexyl)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-yl-säure-.kappa.N6,.kappa.N9,.kappa.011]1-oxidato(6-)]-, tetrahydrogen (MS-325) und dessen Salze sowie Verfahren zur Herstellung der Mittel |
US20030203879A1 (en) * | 1999-09-09 | 2003-10-30 | Schering Ag | Calcium complex of [[(4R)-4-[bis[(carboxy-.kappa.O)methyl]amino-.kappa.n]-6,9-bis[(carboxy.kappa.O)methyl]-1-[(4,4-diphenylcyclohexy)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-ylic-acid-.kappa.N6,.Kappa.N9,.Kappa 011]1-oxidato(6-)]-, hexahydrogen, its salts, pharmaceutical agents that contain these complexes, their use in treatment and as additives in diagnosis, as well as processes for the production of the complexes and agents |
US6559330B1 (en) * | 1999-09-09 | 2003-05-06 | Schering Aktiengesellschaft | Calcium complex of [[(4r)-4-[bis{carboxy-.kappa.o)methyl]amino-.kappa.n]-6,9-bis[(carboxy.kappa.o)methyl]-1-[(4,4-diphenylcyclohexyl)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-ylic-acid-.kappa.n6,.kappa.n9,.kappa.011]1-oxidato(6-)]-, hexahydrogen, its salts, pharmaceutical agents that contain these complexes, their use in treatment and as additives in diagnosis, as well as processes for the production of the complexes and agents |
WO2003029257A1 (de) * | 2001-09-27 | 2003-04-10 | Schering Aktiengesellschaft | (ethylen)-(propylen/butylen)-phosphodiester-triaminpentaessigsäure-derivate |
EP2301587B1 (en) | 2002-03-01 | 2014-06-25 | Dyax Corp. | KDR and VEGF/KDR binding peptides and their use in diagnosis |
US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
US7794693B2 (en) | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
WO2004065621A1 (en) | 2002-03-01 | 2004-08-05 | Dyax Corp. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
ES2557286T3 (es) | 2003-03-03 | 2016-01-25 | Dyax Corp. | Usos de péptidos que se unen específicamente al receptor del HGF (cMet) |
KR100585219B1 (ko) * | 2004-05-07 | 2006-06-01 | 주식회사 태평양 | 포스페이트 유도체 및 이의 제조방법 |
CN100487093C (zh) * | 2006-03-15 | 2009-05-13 | 中国石油化工股份有限公司 | 一种亚磷酰胺酯类极压抗磨剂及其制备和应用 |
WO2010121133A2 (en) | 2009-04-17 | 2010-10-21 | The General Hospital Corporation | Multimodal imaging of fibrin |
KR20110139274A (ko) | 2009-03-19 | 2011-12-28 | 와이어쓰 엘엘씨 | [2-(8,9-다이옥소-2,6-다이아자바이사이클로[5.2.0]논-1(7)-엔-2-일)에틸]포스폰산 및 이의 전구체의 제조 방법 |
TW201514188A (zh) * | 2013-03-13 | 2015-04-16 | Lantheus Medical Imaging Inc | 製備釓磷維塞三鈉單水合物之方法 |
WO2015171543A1 (en) | 2014-05-05 | 2015-11-12 | California Institute Of Technology | Mutant akt-specific capture agents, compositions, and methods of using and making |
WO2015196208A2 (en) | 2014-06-20 | 2015-12-23 | The General Hospital Corporation | Collagen targeted imaging probes |
CN107624115B (zh) | 2015-03-16 | 2021-10-26 | 加州理工学院 | 肉毒神经毒素特异性捕获剂、组合物、使用方法和制造方法 |
WO2017011769A2 (en) | 2015-07-15 | 2017-01-19 | California Institute Of Technology | Il-17f-specific capture agents, compositions, and methods of using and making |
WO2018064597A1 (en) | 2016-09-29 | 2018-04-05 | Indi Molecular, Inc. | Compositions for detection, inhibition and imaging of indoleamine 2,3-dioxygenase 1 (ido1) and methods of making and using same |
WO2018085375A1 (en) | 2016-11-01 | 2018-05-11 | Ohio State Innovation Foundation | Methods for the iodination of biomolecules |
EP3638687A1 (en) | 2017-06-15 | 2020-04-22 | Indi Molecular, Inc. | Il-17f and il-17a-specific capture agents, compositions, and methods of using and making |
WO2020093055A2 (en) | 2018-11-02 | 2020-05-07 | Indi Molecular, Inc. | Peptide libraries with non-canonical amino acids |
US11638764B2 (en) | 2018-11-08 | 2023-05-02 | Indi Molecular, Inc. | Theranostic capture agents, compositions, and methods of using and making |
US11414460B2 (en) | 2019-07-19 | 2022-08-16 | Institute For Systems Biology | KRAS-specific capture agents, compositions, and methods of making and using |
WO2022098743A1 (en) | 2020-11-03 | 2022-05-12 | Indi Molecular, Inc. | Compositions, imaging, and therapeutic methods targeting folate receptor 1 (folr1) |
WO2022098745A1 (en) | 2020-11-03 | 2022-05-12 | Indi Molecular, Inc. | Compositions, delivery systems, and methods useful in tumor therapy |
EP4303222A1 (en) * | 2021-03-03 | 2024-01-10 | Tokyo Institute of Technology | Method for producing asymmetric phosphoric acid triester, method for producing symmetric phosphoric acid triester, method for producing phosphoric acid ester, and method for producing organophosphorus compound |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
US4880008A (en) * | 1985-05-08 | 1989-11-14 | The General Hospital Corporation | Vivo enhancement of NMR relaxivity |
TW319763B (es) * | 1995-02-01 | 1997-11-11 | Epix Medical Inc | |
WO1996027379A1 (en) * | 1995-03-08 | 1996-09-12 | The Scripps Research Institute | Carbopeptoids and carbonucleotoids |
-
1997
- 1997-04-11 US US08/833,745 patent/US5919967A/en not_active Expired - Lifetime
-
1998
- 1998-01-27 CZ CZ19993559A patent/CZ294469B6/cs not_active IP Right Cessation
- 1998-01-27 WO PCT/US1998/001473 patent/WO1998046612A1/en not_active Application Discontinuation
- 1998-01-27 IL IL13196498A patent/IL131964A/en not_active IP Right Cessation
- 1998-01-27 DK DK98903734T patent/DK1021452T3/da active
- 1998-01-27 CA CA002285417A patent/CA2285417C/en not_active Expired - Lifetime
- 1998-01-27 ES ES98903734T patent/ES2195315T3/es not_active Expired - Lifetime
- 1998-01-27 PT PT98903734T patent/PT1021452E/pt unknown
- 1998-01-27 KR KR1020067007449A patent/KR20060066122A/ko not_active Application Discontinuation
- 1998-01-27 AT AT98903734T patent/ATE236171T1/de active
- 1998-01-27 BR BRPI9809084-4A patent/BR9809084B1/pt not_active IP Right Cessation
- 1998-01-27 DE DE69812983T patent/DE69812983T2/de not_active Expired - Lifetime
- 1998-01-27 PL PL98337423A patent/PL188258B1/pl not_active IP Right Cessation
- 1998-01-27 EP EP98903734A patent/EP1021452B1/en not_active Expired - Lifetime
- 1998-01-27 AU AU60425/98A patent/AU728902B2/en not_active Ceased
- 1998-01-27 HU HU0004239A patent/HU224257B1/hu not_active IP Right Cessation
- 1998-01-27 KR KR1019997009256A patent/KR100593650B1/ko not_active IP Right Cessation
- 1998-01-27 NZ NZ337921A patent/NZ337921A/xx not_active IP Right Cessation
- 1998-01-27 SK SK1382-99A patent/SK283832B6/sk not_active IP Right Cessation
- 1998-01-27 JP JP54386798A patent/JP4014231B2/ja not_active Expired - Fee Related
-
1999
- 1999-09-24 IS IS5193A patent/IS1994B/is unknown
- 1999-10-08 NO NO19994919A patent/NO325619B1/no not_active IP Right Cessation
-
2005
- 2005-02-21 JP JP2005044872A patent/JP2005206605A/ja not_active Withdrawn
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