PT942919E - Inibidores de sulfatase - Google Patents

Inibidores de sulfatase

Info

Publication number
PT942919E
PT942919E PT97947778T PT97947778T PT942919E PT 942919 E PT942919 E PT 942919E PT 97947778 T PT97947778 T PT 97947778T PT 97947778 T PT97947778 T PT 97947778T PT 942919 E PT942919 E PT 942919E
Authority
PT
Portugal
Prior art keywords
group
ring
compound
sulfatase inhibitors
oestrone
Prior art date
Application number
PT97947778T
Other languages
English (en)
Inventor
Michael J Reed
Barry V L Potter
Original Assignee
Sterix Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterix Ltd filed Critical Sterix Ltd
Publication of PT942919E publication Critical patent/PT942919E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
PT97947778T 1996-12-05 1997-12-04 Inibidores de sulfatase PT942919E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9625334.9A GB9625334D0 (en) 1996-12-05 1996-12-05 Compound

Publications (1)

Publication Number Publication Date
PT942919E true PT942919E (pt) 2003-10-31

Family

ID=10804019

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97947778T PT942919E (pt) 1996-12-05 1997-12-04 Inibidores de sulfatase

Country Status (10)

Country Link
EP (2) EP1310508B1 (pt)
JP (1) JP2001505221A (pt)
AT (2) ATE240968T1 (pt)
AU (1) AU5402398A (pt)
DE (2) DE69722240T2 (pt)
DK (1) DK0942919T3 (pt)
ES (2) ES2200201T3 (pt)
GB (1) GB9625334D0 (pt)
PT (1) PT942919E (pt)
WO (1) WO1998024802A2 (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6011024A (en) 1991-08-28 2000-01-04 Imperial College Of Science Technology & Medicine Steroid sulphatase inhibitors
GB9118478D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
US6476011B1 (en) 1991-08-28 2002-11-05 Sterix Limited Methods for introducing an estrogenic compound
US6903084B2 (en) 1991-08-29 2005-06-07 Sterix Limited Steroid sulphatase inhibitors
GB2331988B (en) 1997-12-04 2003-04-16 Imperial College Polycyclic sulphamate inhibitors or oestrone sulphatase
GB2331987B (en) * 1997-12-04 2002-11-27 Imperial College Polycyclic sulphamate inhibitors of oestrone sulphatase
US6046186A (en) * 1997-12-24 2000-04-04 Sri International Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use
CA2334119C (en) 1998-06-10 2011-09-13 Sterix Limited Pharmaceutical composition with tumor necrosis factor a and 2-methoxyestrone-3-o-sulphamate for inhibition of estrone sulphatase
JP2000309599A (ja) 1999-04-13 2000-11-07 Kyowa Hakko Kogyo Co Ltd エストラ−１，３，５（１０），１６−テトラエン誘導体
EP1173182A2 (en) 1999-04-30 2002-01-23 Sterix Limited Use of estrone derivatives as antitumour agents
US7078395B1 (en) 1999-06-16 2006-07-18 Sterix Limited Methods for treating or preventing cancer by preventing, inhibiting or arresting cell cycling
AU2005225148B2 (en) * 1999-04-30 2008-04-03 Sterix Limited Use
GB9913536D0 (en) * 1999-06-10 1999-08-11 Sterix Ltd Use
ATE308556T1 (de) * 1999-12-13 2005-11-15 Sterix Ltd Halogenierte sulphamat-, phosphonat-, thiophosphonat-, sulphonat- und sulphonamid- verbindungen als inhibitoren von steroidsulfatase
US7335650B2 (en) 2000-01-14 2008-02-26 Sterix Limited Composition
JPWO2001081364A1 (ja) 2000-04-24 2004-01-08 協和醗酵工業株式会社 エストラ−１，３，５（１０）−トリエン誘導体
GB0020498D0 (en) * 2000-08-18 2000-10-11 Sterix Ltd Compound
AU2001279955A1 (en) 2000-08-18 2002-03-04 Sterix Limited 2-substituted estradiol derivative for inhibiting superoxid dismutase
GB0025788D0 (en) * 2000-10-20 2000-12-06 Sterix Ltd Use
US8026229B2 (en) 2001-08-13 2011-09-27 Sterix Limited Antitumor-active 2-alkoxyestradiol sulfamates
DE10307103A1 (de) 2003-02-19 2004-09-09 Schering Ag Antitumor wirksame 2-substituierte D-Homostra-1,3,5(10)-trien-3-yl sulfamate
DE10307104A1 (de) * 2003-02-19 2004-09-23 Schering Ag Antitumor wirksame 2-substituierte Estra-1,3,5(10)-trien-3-yl sulfamate
DE10307105A1 (de) * 2003-02-19 2004-09-09 Schering Ag Antitumor wirksame 2-substituierte 18a-Homoestra-1,3,5(10)-trien-3-yl sulfamate
WO2009037539A2 (en) 2007-09-17 2009-03-26 Preglem S.A. Treatment of oestrogen dependant conditions in pre-menopausal women

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4668668A (en) * 1984-03-20 1987-05-26 Wayne State University Compositions inhibiting murine MXT ductal carcinoma
GB9118478D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
DE4447715C2 (de) * 1994-08-09 1998-02-05 Jenapharm Gmbh Verwendung von Estra-1,3,5(10)-trien-Derivaten zur hormonalen Behandlung von Prostatakarzinomen

Also Published As

Publication number Publication date
WO1998024802A2 (en) 1998-06-11
GB9625334D0 (en) 1997-01-22
EP0942919B1 (en) 2003-05-21
ATE240968T1 (de) 2003-06-15
DE69722240D1 (de) 2003-06-26
EP1310508A2 (en) 2003-05-14
EP0942919A2 (en) 1999-09-22
WO1998024802A3 (en) 1998-08-27
ES2200201T3 (es) 2004-03-01
ES2314020T3 (es) 2009-03-16
ATE411335T1 (de) 2008-10-15
AU5402398A (en) 1998-06-29
EP1310508A3 (en) 2004-12-08
JP2001505221A (ja) 2001-04-17
EP1310508B1 (en) 2008-10-15
DK0942919T3 (da) 2003-09-15
DE69722240T2 (de) 2004-04-01
DE69739051D1 (de) 2008-11-27

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