SK283575B6 - Zlúčeniny amidíniového typu, farmaceutické prostriedky, ktoré ich obsahujú, a ich použitie - Google Patents

Zlúčeniny amidíniového typu, farmaceutické prostriedky, ktoré ich obsahujú, a ich použitie Download PDF

Info

Publication number
SK283575B6
SK283575B6 SK1182-98A SK118298A SK283575B6 SK 283575 B6 SK283575 B6 SK 283575B6 SK 118298 A SK118298 A SK 118298A SK 283575 B6 SK283575 B6 SK 283575B6
Authority
SK
Slovakia
Prior art keywords
pharmaceutical composition
transfection
nucleic acid
bgtc
amidinium
Prior art date
Application number
SK1182-98A
Other languages
English (en)
Slovak (sk)
Other versions
SK118298A3 (en
Inventor
Jean-Marie Lehn
Pierre Lehn
Jean-Pierre Vigneron
Original Assignee
Centre National De La Recherche Scientifique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26232562&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK283575(B6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from FR9602604A external-priority patent/FR2745569B1/fr
Priority claimed from FR9609557A external-priority patent/FR2751972B1/fr
Application filed by Centre National De La Recherche Scientifique filed Critical Centre National De La Recherche Scientifique
Publication of SK118298A3 publication Critical patent/SK118298A3/sk
Publication of SK283575B6 publication Critical patent/SK283575B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SK1182-98A 1996-03-01 1997-02-28 Zlúčeniny amidíniového typu, farmaceutické prostriedky, ktoré ich obsahujú, a ich použitie SK283575B6 (sk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9602604A FR2745569B1 (fr) 1996-03-01 1996-03-01 Composes apparentes a la famille des amidiniums, compositions pharmaceutiques les contenant et leurs applications
FR9609557A FR2751972B1 (fr) 1996-07-30 1996-07-30 Composes apparentes a la famille des amidiniums, compositions pharmaceutiques les contenant et leurs applications
PCT/FR1997/000364 WO1997031935A1 (fr) 1996-03-01 1997-02-28 Composes apparentes a la famille des amidiniums, compositions pharmaceutiques les contenant et leurs applications

Publications (2)

Publication Number Publication Date
SK118298A3 SK118298A3 (en) 1999-02-11
SK283575B6 true SK283575B6 (sk) 2003-09-11

Family

ID=26232562

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1182-98A SK283575B6 (sk) 1996-03-01 1997-02-28 Zlúčeniny amidíniového typu, farmaceutické prostriedky, ktoré ich obsahujú, a ich použitie

Country Status (18)

Country Link
US (2) US6143729A (no)
EP (1) EP0888379B1 (no)
JP (1) JP4271260B2 (no)
KR (1) KR19990087372A (no)
AT (1) ATE198599T1 (no)
AU (1) AU723998B2 (no)
BR (1) BRPI9707889B8 (no)
CZ (1) CZ295225B6 (no)
DE (1) DE69703878T2 (no)
DK (1) DK0888379T3 (no)
ES (1) ES2154453T3 (no)
GR (1) GR3035205T3 (no)
HU (1) HU228072B1 (no)
IL (1) IL125926A (no)
NO (1) NO311806B1 (no)
PT (1) PT888379E (no)
SK (1) SK283575B6 (no)
WO (1) WO1997031935A1 (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6884430B1 (en) * 1997-02-10 2005-04-26 Aventis Pharma S.A. Formulation of stabilized cationic transfection agent(s) /nucleic acid particles
FR2763943B1 (fr) * 1997-05-28 1999-07-09 Rhone Poulenc Rorer Sa Composes, leur preparation et leur utilisation pour le transfert d'acides nucleiques dans les cellules
JP2002513543A (ja) * 1998-04-02 2002-05-14 アバンテイス・フアルマ・エス・アー 新規核酸移入剤とそれらを含む組成物及びそれらの使用
FR2777017B1 (fr) * 1998-04-02 2002-08-23 Rhone Poulenc Rorer Sa Nouveaux agents de transfert d'acides nucleiques, compositions les contenant et leurs applications
DE10109898A1 (de) 2001-02-21 2002-09-05 Novosom Gmbh Lipide mit veränderlicher Ladung
JP4276439B2 (ja) * 2001-05-14 2009-06-10 サントリオン ポリチオ尿素の脂質誘導体
FR2824557B1 (fr) * 2001-05-14 2003-08-29 Aventis Pharma Sa Derives lipidiques de polythiouree
FR2829136B1 (fr) 2001-08-29 2006-11-17 Aventis Pharma Sa Derives lipidiques d'aminoglycosides
PT1479985T (pt) 2002-01-17 2017-08-03 Alfa Laval Corp Ab Evaporador submerso compreendendo um permutador de calor de placas e um compartimento cilíndrico onde está disposto o permutador de calor de placas
WO2006118283A1 (ja) * 2005-04-28 2006-11-09 Nippon Soda Co., Ltd. 新規なグアニジン化合物、製造方法及びそれらを含有する殺菌性組成物
WO2008040792A2 (en) * 2006-10-04 2008-04-10 Centre National De La Recherche Scientifique (Cnrs) Compositions comprising a sirna and lipidic 4,5-disubstituted 2-deoxystreptamine ring aminoglycoside derivatives and uses thereof
TW201019969A (en) * 2008-11-17 2010-06-01 Enzon Pharmaceuticals Inc Branched cationic lipids for nucleic acids delivery system

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5283185A (en) * 1991-08-28 1994-02-01 University Of Tennessee Research Corporation Method for delivering nucleic acids into cells
WO1995014381A1 (en) * 1993-11-24 1995-06-01 Megabios Corporation Amphiphilic derivatives of guanidine
US5777153A (en) * 1994-07-08 1998-07-07 Gilead Sciences, Inc. Cationic lipids
US6071890A (en) * 1994-12-09 2000-06-06 Genzyme Corporation Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy
US5811406A (en) * 1995-06-07 1998-09-22 Regents Of The University Of California Dry powder formulations of polynucleotide complexes

Also Published As

Publication number Publication date
JP4271260B2 (ja) 2009-06-03
NO311806B1 (no) 2002-01-28
EP0888379B1 (fr) 2001-01-10
HU228072B1 (en) 2012-09-28
PT888379E (pt) 2001-05-31
DE69703878T2 (de) 2001-04-26
AU723998B2 (en) 2000-09-07
EP0888379A1 (fr) 1999-01-07
KR19990087372A (ko) 1999-12-27
HUP9902465A1 (hu) 1999-12-28
NO983691L (no) 1998-08-12
ATE198599T1 (de) 2001-01-15
WO1997031935A1 (fr) 1997-09-04
JP2000506136A (ja) 2000-05-23
HUP9902465A3 (en) 2009-10-28
DK0888379T3 (da) 2001-01-29
IL125926A0 (en) 1999-04-11
US6143729A (en) 2000-11-07
KR100452062B1 (no) 2005-04-08
NO983691D0 (no) 1998-08-12
BR9707889A (pt) 2000-01-04
SK118298A3 (en) 1999-02-11
BR9707889B1 (pt) 2010-03-23
US6316422B1 (en) 2001-11-13
ES2154453T3 (es) 2001-04-01
CZ277298A3 (cs) 1998-12-16
AU1930497A (en) 1997-09-16
IL125926A (en) 2004-09-27
GR3035205T3 (en) 2001-04-30
CZ295225B6 (cs) 2005-06-15
DE69703878D1 (de) 2001-02-15
BRPI9707889B8 (pt) 2016-11-08

Similar Documents

Publication Publication Date Title
US5650096A (en) Cationic amphiphiles for intracellular delivery of therapeutic molecules
US5935936A (en) Compositions comprising cationic amphiphiles and co-lipids for intracellular delivery of therapeutic molecules
JP4176831B2 (ja) トランスフェクション剤としてのリポポリアミン及びその医薬的使用
US5948767A (en) Cationic amphiphile/DNA complexes
US5767099A (en) Cationic amphiphiles containing amino acid or dervatized amino acid groups for intracellular delivery of therapeutic molecules
US5783565A (en) Cationic amphiphiles containing spermine or spermidine cationic group for intracellular delivery of therapeutic molecules
US6107286A (en) Lipopolyamines as transfection agents and pharamaceutical uses thereof
JP4467084B2 (ja) 核酸を細胞に導入するための化合物、その製法及びその使用
US20080306153A1 (en) Lipids and lipid assemblies comprising transfection enhancer elements
AU731503B2 (en) Cationic amphiphile compositions for intracellular delivery of therapeutic molecules
WO1998043994A1 (en) Cationic amphiphiles for intracellular delivery of therapeutic molecules
SK283575B6 (sk) Zlúčeniny amidíniového typu, farmaceutické prostriedky, ktoré ich obsahujú, a ich použitie
US6331524B1 (en) Organ-specific targeting of cationic amphiphile / DNA complexes for gene therapy
CA2248186C (fr) Composes apparentes a la famille des amidiniums, compositions pharmaceutiques les contenant et leurs applications
MXPA98006892A (en) Compounds related to the amidinium family, pharmaceutical compositions containing them and their applications
JP2003516970A (ja) 両親媒性ポリアミン、その使用およびその合成方法
US20020013282A1 (en) Cationic amphipile compositions for interacelluar delivery of therapeutic molecules
MXPA97003928A (en) New transfection agents and their pharmaceutical applications

Legal Events

Date Code Title Description
MK4A Patent expired

Expiry date: 20170228