SK282773B6 - 2-(Iminometyl)aminofenylové deriváty, spôsob ich výroby, farmaceutický prostriedok s ich obsahom, ich použitie a medziprodukty - Google Patents

2-(Iminometyl)aminofenylové deriváty, spôsob ich výroby, farmaceutický prostriedok s ich obsahom, ich použitie a medziprodukty Download PDF

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SK282773B6
SK282773B6 SK1298-99A SK129899A SK282773B6 SK 282773 B6 SK282773 B6 SK 282773B6 SK 129899 A SK129899 A SK 129899A SK 282773 B6 SK282773 B6 SK 282773B6
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Slovakia
Prior art keywords
phenyl
bis
dimethylethyl
methyl
hydroxy
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SK1298-99A
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English (en)
Slovak (sk)
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SK129899A3 (en
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De Lassauniere Pierre-Etienne Chabrier
Serge Auvin
Dennis Bigg
Michel Auguet
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Soci�T� De Conseils De Recherches Et D'applications
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Publication of SK129899A3 publication Critical patent/SK129899A3/sk
Publication of SK282773B6 publication Critical patent/SK282773B6/sk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being unsaturated and containing rings other than six-membered aromatic rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/56—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C275/36—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with at least one of the oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. N-aryloxyphenylureas
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    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/06—Compounds containing any of the groups, e.g. semicarbazides
    • C07C281/08—Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones
    • C07C281/14—Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones the carbon atom being further bound to a carbon atom of a six-membered aromatic ring
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
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    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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  • Chemical & Material Sciences (AREA)
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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Addiction (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
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  • Diabetes (AREA)
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  • Hospice & Palliative Care (AREA)
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SK1298-99A 1997-03-24 1998-02-16 2-(Iminometyl)aminofenylové deriváty, spôsob ich výroby, farmaceutický prostriedok s ich obsahom, ich použitie a medziprodukty SK282773B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9703528A FR2761066B1 (fr) 1997-03-24 1997-03-24 Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
PCT/FR1998/000288 WO1998042696A1 (fr) 1997-03-24 1998-02-16 Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant

Publications (2)

Publication Number Publication Date
SK129899A3 SK129899A3 (en) 2000-05-16
SK282773B6 true SK282773B6 (sk) 2002-12-03

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SK1298-99A SK282773B6 (sk) 1997-03-24 1998-02-16 2-(Iminometyl)aminofenylové deriváty, spôsob ich výroby, farmaceutický prostriedok s ich obsahom, ich použitie a medziprodukty

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US (1) US6340700B1 (cs)
EP (1) EP0973763B1 (cs)
JP (1) JP4469424B2 (cs)
KR (1) KR100431917B1 (cs)
CN (1) CN1143854C (cs)
AR (1) AR012102A1 (cs)
AT (1) ATE241612T1 (cs)
AU (1) AU733173B2 (cs)
BR (1) BR9808427B1 (cs)
CA (1) CA2285037C (cs)
CZ (1) CZ297562B6 (cs)
DE (1) DE69815094T2 (cs)
DK (1) DK0973763T3 (cs)
ES (1) ES2200318T3 (cs)
FR (1) FR2761066B1 (cs)
HU (1) HU228929B1 (cs)
IL (1) IL131915A (cs)
MY (1) MY124146A (cs)
NO (1) NO324065B1 (cs)
NZ (1) NZ338016A (cs)
PL (1) PL194688B1 (cs)
PT (1) PT973763E (cs)
RU (1) RU2183211C2 (cs)
SK (1) SK282773B6 (cs)
TR (1) TR199902382T2 (cs)
TW (1) TW587080B (cs)
UA (1) UA56219C2 (cs)
WO (1) WO1998042696A1 (cs)
ZA (1) ZA982203B (cs)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6335445B1 (en) * 1997-03-24 2002-01-01 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them
US6809088B2 (en) * 1997-03-24 2004-10-26 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them
AR019190A1 (es) * 1998-07-08 2001-12-26 Sod Conseils Rech Applic Derivados de 2-aminopiridinas, productos intermedios para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y su uso para preparar medicamentos
ATE384048T1 (de) 1998-09-22 2008-02-15 Astellas Pharma Inc Cyanophenyl-derivate
FR2784678B1 (fr) * 1998-09-23 2002-11-29 Sod Conseils Rech Applic Nouveaux derives de n-(iminomethyl)amines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
FR2783519B1 (fr) 1998-09-23 2003-01-24 Sod Conseils Rech Applic Nouveaux derives d'amidines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
FR2798127A1 (fr) 1999-09-03 2001-03-09 Expansia Sa Nouveau procede de preparation d'amidines derivees de l'acide 6-hydroxy-2,5,7,8-tetramethylchrommane-2-carboxy- lique
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ATE241612T1 (de) 2003-06-15
AU6404398A (en) 1998-10-20
FR2761066A1 (fr) 1998-09-25
SK129899A3 (en) 2000-05-16
CA2285037A1 (fr) 1998-10-01
EP0973763A1 (fr) 2000-01-26
RU2183211C2 (ru) 2002-06-10
EP0973763B1 (fr) 2003-05-28
WO1998042696A1 (fr) 1998-10-01
HUP0001438A1 (hu) 2001-05-28
NO324065B1 (no) 2007-08-06
PL335838A1 (en) 2000-05-22
NO994620D0 (no) 1999-09-23
CZ297562B6 (cs) 2007-02-07
HUP0001438A3 (en) 2001-09-28
CZ337399A3 (cs) 2000-06-14
BR9808427B1 (pt) 2010-08-24
TW587080B (en) 2004-05-11
MY124146A (en) 2006-06-30
CN1143854C (zh) 2004-03-31
FR2761066B1 (fr) 2000-11-24
DE69815094T2 (de) 2004-02-05
DK0973763T3 (da) 2003-09-29
CN1253555A (zh) 2000-05-17
US6340700B1 (en) 2002-01-22
ES2200318T3 (es) 2004-03-01
JP2001518114A (ja) 2001-10-09
AU733173B2 (en) 2001-05-10
HU228929B1 (en) 2013-06-28
CA2285037C (fr) 2007-02-13
IL131915A (en) 2004-06-01
PT973763E (pt) 2003-10-31
IL131915A0 (en) 2001-03-19
TR199902382T2 (xx) 2000-06-21
PL194688B1 (pl) 2007-06-29
ZA982203B (en) 1998-09-16
BR9808427A (pt) 2000-05-23
DE69815094D1 (de) 2003-07-03
UA56219C2 (uk) 2003-05-15
HK1027563A1 (en) 2001-01-19
KR20010005648A (ko) 2001-01-15
KR100431917B1 (ko) 2004-05-20
AR012102A1 (es) 2000-09-27
NO994620L (no) 1999-11-10
NZ338016A (en) 2000-01-28

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