PT973763E - Novos derivados do 2-(iminometil)amino-fenilo, sua preparacao, sua aplicacao na qualidade de medicamentos e composicoes farmaceuticas que os contem - Google Patents

Novos derivados do 2-(iminometil)amino-fenilo, sua preparacao, sua aplicacao na qualidade de medicamentos e composicoes farmaceuticas que os contem

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Publication number
PT973763E
PT973763E PT98909540T PT98909540T PT973763E PT 973763 E PT973763 E PT 973763E PT 98909540 T PT98909540 T PT 98909540T PT 98909540 T PT98909540 T PT 98909540T PT 973763 E PT973763 E PT 973763E
Authority
PT
Portugal
Prior art keywords
iminomethyl
phenyl
amino
compositions
contain
Prior art date
Application number
PT98909540T
Other languages
English (en)
Inventor
Dennis Bigg
Pierre-Etienne Cha Lassauniere
Serge Auvin
Michel Auguet
Original Assignee
Cons De Rech Et D Applica Scie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cons De Rech Et D Applica Scie filed Critical Cons De Rech Et D Applica Scie
Publication of PT973763E publication Critical patent/PT973763E/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being unsaturated and containing rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/56—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C275/36—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with at least one of the oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. N-aryloxyphenylureas
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    • C07C281/06—Compounds containing any of the groups, e.g. semicarbazides
    • C07C281/08—Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones
    • C07C281/14—Compounds containing any of the groups, e.g. semicarbazides the other nitrogen atom being further doubly-bound to a carbon atom, e.g. semicarbazones the carbon atom being further bound to a carbon atom of a six-membered aromatic ring
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
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    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Organic Chemistry (AREA)
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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Biomedical Technology (AREA)
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  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Addiction (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
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  • Hematology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
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  • Urology & Nephrology (AREA)
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  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
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PT98909540T 1997-03-24 1998-02-16 Novos derivados do 2-(iminometil)amino-fenilo, sua preparacao, sua aplicacao na qualidade de medicamentos e composicoes farmaceuticas que os contem PT973763E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9703528A FR2761066B1 (fr) 1997-03-24 1997-03-24 Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant

Publications (1)

Publication Number Publication Date
PT973763E true PT973763E (pt) 2003-10-31

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PT98909540T PT973763E (pt) 1997-03-24 1998-02-16 Novos derivados do 2-(iminometil)amino-fenilo, sua preparacao, sua aplicacao na qualidade de medicamentos e composicoes farmaceuticas que os contem

Country Status (30)

Country Link
US (1) US6340700B1 (pt)
EP (1) EP0973763B1 (pt)
JP (1) JP4469424B2 (pt)
KR (1) KR100431917B1 (pt)
CN (1) CN1143854C (pt)
AR (1) AR012102A1 (pt)
AT (1) ATE241612T1 (pt)
AU (1) AU733173B2 (pt)
BR (1) BR9808427B1 (pt)
CA (1) CA2285037C (pt)
CZ (1) CZ297562B6 (pt)
DE (1) DE69815094T2 (pt)
DK (1) DK0973763T3 (pt)
ES (1) ES2200318T3 (pt)
FR (1) FR2761066B1 (pt)
HK (1) HK1027563A1 (pt)
HU (1) HU228929B1 (pt)
IL (1) IL131915A (pt)
MY (1) MY124146A (pt)
NO (1) NO324065B1 (pt)
NZ (1) NZ338016A (pt)
PL (1) PL194688B1 (pt)
PT (1) PT973763E (pt)
RU (1) RU2183211C2 (pt)
SK (1) SK282773B6 (pt)
TR (1) TR199902382T2 (pt)
TW (1) TW587080B (pt)
UA (1) UA56219C2 (pt)
WO (1) WO1998042696A1 (pt)
ZA (1) ZA982203B (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6335445B1 (en) * 1997-03-24 2002-01-01 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them
US6809088B2 (en) * 1997-03-24 2004-10-26 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them
AR019190A1 (es) * 1998-07-08 2001-12-26 Sod Conseils Rech Applic Derivados de 2-aminopiridinas, productos intermedios para su preparacion, medicamentos y composiciones farmaceuticas que los contienen y su uso para preparar medicamentos
AU754529B2 (en) 1998-09-22 2002-11-21 Yamanouchi Pharmaceutical Co., Ltd. Cyanophenyl derivatives
FR2783519B1 (fr) * 1998-09-23 2003-01-24 Sod Conseils Rech Applic Nouveaux derives d'amidines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
FR2784678B1 (fr) 1998-09-23 2002-11-29 Sod Conseils Rech Applic Nouveaux derives de n-(iminomethyl)amines, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant
FR2798127A1 (fr) * 1999-09-03 2001-03-09 Expansia Sa Nouveau procede de preparation d'amidines derivees de l'acide 6-hydroxy-2,5,7,8-tetramethylchrommane-2-carboxy- lique
RU2380362C2 (ru) * 1999-10-11 2010-01-27 Сосьете Де Консей Де Решерш З Производные пятичленных гетероциклов, способ их получения и их применение в качестве лекарственных средств
FR2801053B1 (fr) * 1999-11-16 2004-06-25 Sod Conseils Rech Applic Nouveaux derives d'amidines, leur preparation et leur application a titre de medicaments
SE9904677D0 (sv) * 1999-12-20 1999-12-20 Astra Ab Novel compounds
SE9904676D0 (sv) * 1999-12-20 1999-12-20 Astra Ab Novel compounds
WO2001068585A1 (fr) * 2000-03-14 2001-09-20 Fujisawa Pharmaceutical Co., Ltd. Nouveaux composes amides
JP2003527391A (ja) 2000-03-16 2003-09-16 ソシエテ・ド・コンセイユ・ド・ルシエルシエ・エ・ダアツプリカーション・シヤンテイフイツク・（エス．セー．エール．アー．エス） 新規なリポ酸の複素環又はベンゼン誘導体、その製造方法及びその医薬としての使用
FR2812198B1 (fr) * 2000-07-28 2008-07-18 Sod Conseils Rech Applic DERIVES D'AMIDINES INHIBITEURS DE PHOSPHATASES cdc25
AU2001282829A1 (en) * 2000-09-05 2002-03-22 Astrazeneca Ab Amidine derivatives which are inhibitors of nitric oxide synthase
US7078407B2 (en) * 2001-11-23 2006-07-18 Korea Research Institute Of Chemical Technology 4-hydroxycinnamamide derivatives as antioxidants and pharmaceutical compositions containing them
DE10162114A1 (de) * 2001-12-12 2003-06-26 Schering Ag Neue Amidin-Derivate und deren Verwendung in Arzneimitteln
DE10240735A1 (de) * 2002-08-29 2004-03-18 Eberhard-Karls-Universität Tübingen Universitätsklinikum Verwendung von Modulatoren der NO-Signalkaskade und pharmazeutische Zusammensetzung
EP1577289A1 (en) * 2004-03-18 2005-09-21 Revotar Biopharmaceuticals AG Non-glycosylated/-glycosidic/-peptidic small molecule selectin inhibitors for the treament of inflammatory disorders
EP1893583B1 (en) 2005-05-31 2012-04-04 Pfizer Inc. Substituted aryloxy-n-bicyclomethyl acetamide compounds as vr1 antagonists
EP1764096A1 (en) * 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel phloroglucinol derivatives having selectin ligand activity
EP1764094A1 (en) * 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel multi-cyclic compounds and their use
EP1764093A1 (en) * 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel aromatic compounds and their use in medical applications
EP1764095A1 (en) * 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel nitrocatechol derivatives having selectin ligand activity
HUE033757T2 (en) * 2012-07-12 2017-12-28 Khondrion Ip B V Chromanil derivatives for the treatment of mitochondrial disease

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6286294A (en) * 1993-03-23 1994-10-11 Astra Aktiebolag Guanidine derivatives useful in therapy
US5807885A (en) * 1993-08-12 1998-09-15 Astra Aktiebolag Amidine derivatives with nitric oxide synthetase activities
AU682768B2 (en) * 1994-05-07 1997-10-16 Astra Aktiebolag Bicyclic amidine derivatives as inhibitors of nitric oxide synthetase

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HK1027563A1 (en) 2001-01-19
DE69815094T2 (de) 2004-02-05
KR100431917B1 (ko) 2004-05-20
HUP0001438A3 (en) 2001-09-28
ATE241612T1 (de) 2003-06-15
CZ297562B6 (cs) 2007-02-07
SK129899A3 (en) 2000-05-16
NO994620D0 (no) 1999-09-23
JP2001518114A (ja) 2001-10-09
FR2761066B1 (fr) 2000-11-24
AU6404398A (en) 1998-10-20
CA2285037A1 (fr) 1998-10-01
NO324065B1 (no) 2007-08-06
SK282773B6 (sk) 2002-12-03
TR199902382T2 (xx) 2000-06-21
EP0973763A1 (fr) 2000-01-26
DE69815094D1 (de) 2003-07-03
KR20010005648A (ko) 2001-01-15
NO994620L (no) 1999-11-10
IL131915A0 (en) 2001-03-19
RU2183211C2 (ru) 2002-06-10
UA56219C2 (uk) 2003-05-15
CA2285037C (fr) 2007-02-13
CZ337399A3 (cs) 2000-06-14
BR9808427A (pt) 2000-05-23
JP4469424B2 (ja) 2010-05-26
AR012102A1 (es) 2000-09-27
IL131915A (en) 2004-06-01
HUP0001438A1 (hu) 2001-05-28
FR2761066A1 (fr) 1998-09-25
US6340700B1 (en) 2002-01-22
TW587080B (en) 2004-05-11
ZA982203B (en) 1998-09-16
AU733173B2 (en) 2001-05-10
MY124146A (en) 2006-06-30
WO1998042696A1 (fr) 1998-10-01
ES2200318T3 (es) 2004-03-01
DK0973763T3 (da) 2003-09-29
BR9808427B1 (pt) 2010-08-24
CN1253555A (zh) 2000-05-17
NZ338016A (en) 2000-01-28
PL194688B1 (pl) 2007-06-29
HU228929B1 (en) 2013-06-28
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EP0973763B1 (fr) 2003-05-28
CN1143854C (zh) 2004-03-31

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