SK282044B6 - (r)-5-bróm-n-(1-etyl-4-metylhexahydro-1h-1,4-diazepin-6-yl)-2- metoxy-6-metylamino-3-pyridínkarboxamid, spôsob prípravy, medziprodukt a farmaceutický prostriedok, ktorý ho obsahuje - Google Patents

(r)-5-bróm-n-(1-etyl-4-metylhexahydro-1h-1,4-diazepin-6-yl)-2- metoxy-6-metylamino-3-pyridínkarboxamid, spôsob prípravy, medziprodukt a farmaceutický prostriedok, ktorý ho obsahuje Download PDF

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Publication number
SK282044B6
SK282044B6 SK93-98A SK9398A SK282044B6 SK 282044 B6 SK282044 B6 SK 282044B6 SK 9398 A SK9398 A SK 9398A SK 282044 B6 SK282044 B6 SK 282044B6
Authority
SK
Slovakia
Prior art keywords
compound
formula
ethyl
methylhexahydro
methoxy
Prior art date
Application number
SK93-98A
Other languages
English (en)
Slovak (sk)
Other versions
SK9398A3 (en
Inventor
Shiro Kato
Yoshimi Hirokawa
Toshiya Morie
Hiroshi Harada
Naoyuki Yoshida
Original Assignee
Dainippon Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co., Ltd. filed Critical Dainippon Pharmaceutical Co., Ltd.
Publication of SK9398A3 publication Critical patent/SK9398A3/sk
Publication of SK282044B6 publication Critical patent/SK282044B6/sk

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SK93-98A 1995-07-28 1996-07-23 (r)-5-bróm-n-(1-etyl-4-metylhexahydro-1h-1,4-diazepin-6-yl)-2- metoxy-6-metylamino-3-pyridínkarboxamid, spôsob prípravy, medziprodukt a farmaceutický prostriedok, ktorý ho obsahuje SK282044B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP07212495 1995-07-28
PCT/JP1996/002053 WO1997005129A1 (fr) 1995-07-28 1996-07-23 (r)-5-bromo-n-(1-ethyl-4-methylhexahydro-1h-1,4-diazepin-6-yl)-2-methoxy-6-methylamino-3-pyridine-carboxamide, son procede d'obtention et medicament le contenant

Publications (2)

Publication Number Publication Date
SK9398A3 SK9398A3 (en) 1998-08-05
SK282044B6 true SK282044B6 (sk) 2001-10-08

Family

ID=16623612

Family Applications (1)

Application Number Title Priority Date Filing Date
SK93-98A SK282044B6 (sk) 1995-07-28 1996-07-23 (r)-5-bróm-n-(1-etyl-4-metylhexahydro-1h-1,4-diazepin-6-yl)-2- metoxy-6-metylamino-3-pyridínkarboxamid, spôsob prípravy, medziprodukt a farmaceutický prostriedok, ktorý ho obsahuje

Country Status (24)

Country Link
US (1) US5945415A (cs)
EP (1) EP0855397B1 (cs)
KR (1) KR19990028395A (cs)
CN (1) CN1096459C (cs)
AT (1) ATE201021T1 (cs)
AU (1) AU700635B2 (cs)
BR (1) BR9609691A (cs)
CA (1) CA2228056A1 (cs)
CZ (1) CZ290442B6 (cs)
DE (1) DE69612753T2 (cs)
DK (1) DK0855397T3 (cs)
ES (1) ES2156616T3 (cs)
GR (1) GR3036089T3 (cs)
HU (1) HUP9901208A3 (cs)
IL (1) IL122753A (cs)
MX (1) MX9800620A (cs)
NO (1) NO312964B1 (cs)
NZ (1) NZ312799A (cs)
PL (1) PL184073B1 (cs)
PT (1) PT855397E (cs)
RU (1) RU2156248C2 (cs)
SK (1) SK282044B6 (cs)
TR (1) TR199800165T1 (cs)
WO (1) WO1997005129A1 (cs)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19650778C2 (de) * 1996-12-06 2001-01-04 Asta Medica Ag Verwendung von Dopaminrezeptor-Antagonisten in der palliativen Tumortherapie
AU776053B2 (en) * 2000-03-31 2004-08-26 Astellas Pharma Inc. Diazepan derivatives or salts thereof
GB0216027D0 (en) * 2002-07-10 2002-08-21 Arachnova Therapeutics Ltd New therapeutic use
US20040048874A1 (en) * 2001-05-22 2004-03-11 Bardsley Hazel Judith New therapeutic use of 4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl)thieno[2,3-D]pyrimidine
ITBO20020198A1 (it) * 2002-04-12 2003-10-13 Univ Bologna Derivati 2 , 5 bis diammino 1 , 4 benzochenionici utili per il trattamento della malattia di alzheimer , metodo per la loro preparazione ed
US20040147510A1 (en) * 2003-01-13 2004-07-29 Dynogen Pharmaceuticals, Inc. Method of treating nausea, vomiting, retching or any combination thereof
KR20050111318A (ko) * 2003-01-13 2005-11-24 다이노젠 파마세우티컬스, 인코포레이티드 기능성 장 질환을 치료하는 방법
ATE365554T1 (de) * 2003-04-04 2007-07-15 Dynogen Pharmaceuticals Inc Methode zur behandlung von erkrankungen der unteren harnwege
WO2006105117A2 (en) * 2005-03-28 2006-10-05 Dynogen Pharmaceuticals, Inc. Method of treating disorders and conditions using peripherally-restricted antagonists and inhibitors
EP2415766A4 (en) 2009-03-31 2012-11-21 Zeria Pharm Co Ltd METHOD FOR PRODUCING A BENZODIAZEPINE DERIVATIVE
US9045460B2 (en) 2010-08-26 2015-06-02 Kowa Co., Ltd. Production method for isoquinoline derivatives and salts thereof
RU2438669C1 (ru) * 2010-10-29 2012-01-10 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "ЮЖНЫЙ ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ" Средство, проявляющее свойства антагониста серотониновых 5-ht3-рецепторов
US20170253585A1 (en) * 2014-02-03 2017-09-07 Mylan Laboratories Ltd. Processes for the preparation of intermediates of raltegravir

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ230068A (en) * 1988-07-29 1991-07-26 Dainippon Pharmaceutical Co Indazole-3-carboxylic acid esters and amides of diaza compounds having 6,7, or 8 ring members: preparatory processes and pharmaceutical compositions
US5166341A (en) * 1988-07-29 1992-11-24 Dainippon Pharmaceutical Co., Ltd. 6-amino-1,4-hexahydro-1H-diazepine derivatives
JPH04210970A (ja) * 1990-01-26 1992-08-03 Dainippon Pharmaceut Co Ltd ベンズアミド誘導体及びその中間体
JPH03223265A (ja) * 1990-01-26 1991-10-02 Dainippon Pharmaceut Co Ltd 環状ジアミン誘導体
SU1825501A3 (ru) * 1990-10-29 1995-12-10 И.В. Комиссаров Dl-3-[(4-[4- (2-пиридил)-1- пиперазинил]бутил)] -1,8,8-триметил -3-азабицикло[3,2,1] октан-2,4-диона дигидрохлорид, проявляющий противотревожную, нейролептическую и противорвотную активность
PT100990A (pt) * 1991-10-24 1994-01-31 Smithkline Beecham Plc Derivados de piridina e sua utilizacao como substancia terapeutica

Also Published As

Publication number Publication date
NO980333L (no) 1998-03-23
KR19990028395A (ko) 1999-04-15
ATE201021T1 (de) 2001-05-15
PL324749A1 (en) 1998-06-08
CA2228056A1 (en) 1997-02-13
US5945415A (en) 1999-08-31
AU700635B2 (en) 1999-01-07
CZ23098A3 (cs) 1998-06-17
HUP9901208A3 (en) 2002-10-28
AU6471796A (en) 1997-02-26
GR3036089T3 (en) 2001-09-28
NO980333D0 (no) 1998-01-26
HK1018049A1 (en) 1999-12-10
EP0855397B1 (en) 2001-05-09
ES2156616T3 (es) 2001-07-01
EP0855397A1 (en) 1998-07-29
WO1997005129A1 (fr) 1997-02-13
DK0855397T3 (da) 2001-06-25
NZ312799A (en) 1999-04-29
NO312964B1 (no) 2002-07-22
PL184073B1 (pl) 2002-08-30
IL122753A0 (en) 1998-08-16
DE69612753D1 (de) 2001-06-13
PT855397E (pt) 2001-08-30
CN1192213A (zh) 1998-09-02
CN1096459C (zh) 2002-12-18
RU2156248C2 (ru) 2000-09-20
CZ290442B6 (cs) 2002-07-17
MX9800620A (es) 1998-04-30
SK9398A3 (en) 1998-08-05
BR9609691A (pt) 1999-03-23
HUP9901208A2 (hu) 2000-04-28
TR199800165T1 (xx) 1998-06-22
IL122753A (en) 2000-10-31
EP0855397A4 (en) 1998-12-02
DE69612753T2 (de) 2005-07-07

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