SK281903B6 - Monoestery, farmaceutické kompozície s ich obsahom a ich použitie - Google Patents

Monoestery, farmaceutické kompozície s ich obsahom a ich použitie Download PDF

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Publication number
SK281903B6
SK281903B6 SK397-94A SK39794A SK281903B6 SK 281903 B6 SK281903 B6 SK 281903B6 SK 39794 A SK39794 A SK 39794A SK 281903 B6 SK281903 B6 SK 281903B6
Authority
SK
Slovakia
Prior art keywords
monoester
ara
acid
oleyl
nucleoside
Prior art date
Application number
SK397-94A
Other languages
English (en)
Slovak (sk)
Other versions
SK39794A3 (en
Inventor
Are Dalen
Finn Myhren
Bernt Borretzen
Kjell Torgeir Stokke
Original Assignee
Norsk Hydro A. S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norsk Hydro A. S. filed Critical Norsk Hydro A. S.
Publication of SK39794A3 publication Critical patent/SK39794A3/sk
Publication of SK281903B6 publication Critical patent/SK281903B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
SK397-94A 1991-10-07 1992-09-30 Monoestery, farmaceutické kompozície s ich obsahom a ich použitie SK281903B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9121257A GB2260319B (en) 1991-10-07 1991-10-07 Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity
PCT/NO1992/000162 WO1993007163A1 (en) 1991-10-07 1992-09-30 Chemical compounds

Publications (2)

Publication Number Publication Date
SK39794A3 SK39794A3 (en) 1994-10-05
SK281903B6 true SK281903B6 (sk) 2001-09-11

Family

ID=10702531

Family Applications (1)

Application Number Title Priority Date Filing Date
SK397-94A SK281903B6 (sk) 1991-10-07 1992-09-30 Monoestery, farmaceutické kompozície s ich obsahom a ich použitie

Country Status (27)

Country Link
US (1) US6548486B1 (fi)
EP (1) EP0642525B1 (fi)
JP (1) JP2873313B2 (fi)
KR (1) KR100272732B1 (fi)
AT (1) ATE152454T1 (fi)
CA (1) CA2120725C (fi)
CH (1) CH0642525H1 (fi)
CZ (1) CZ288153B6 (fi)
DE (1) DE69219482T2 (fi)
DK (1) DK0642525T3 (fi)
FI (2) FI105035B (fi)
GB (1) GB2260319B (fi)
GR (1) GR3024149T3 (fi)
HK (1) HK1007430A1 (fi)
HU (1) HU219400B (fi)
IL (1) IL103351A (fi)
MX (1) MX9205715A (fi)
NO (1) NO300014B1 (fi)
NZ (1) NZ244535A (fi)
PL (1) PL170846B1 (fi)
RU (1) RU2126417C1 (fi)
SG (1) SG47759A1 (fi)
SK (1) SK281903B6 (fi)
TW (1) TW347333B (fi)
UA (1) UA41296C2 (fi)
WO (1) WO1993007163A1 (fi)
ZA (1) ZA927432B (fi)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9307043D0 (en) * 1993-04-05 1993-05-26 Norsk Hydro As Chemical compounds
US5869493A (en) * 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
US6703394B2 (en) 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
GB2321455A (en) * 1997-01-24 1998-07-29 Norsk Hydro As Lipophilic derivatives of biologically active compounds
GB0201179D0 (en) * 2002-01-18 2002-03-06 Angeletti P Ist Richerche Bio Therapeutic agents
TWI332507B (en) 2002-11-19 2010-11-01 Hoffmann La Roche Antiviral nucleoside derivatives
WO2006101911A1 (en) 2005-03-16 2006-09-28 Case Western Reserve University Selective inhibitors of translesion dna replication
WO2008147454A1 (en) * 2006-11-16 2008-12-04 Case Western Reserve University Selective inhibitors of translesion dna replication
NO324263B1 (no) * 2005-12-08 2007-09-17 Clavis Pharma Asa Kjemiske forbindelser, anvendelse derav ved behandling av kreft, samt farmasoytiske preparater som omfatter slike forbindelser
US8497292B2 (en) 2005-12-28 2013-07-30 Translational Therapeutics, Inc. Translational dysfunction based therapeutics
US20090111774A1 (en) * 2007-06-01 2009-04-30 Luitpold Pharmaceuticals, Inc. Pmea lipid conjugates
EP2175863B1 (en) 2007-07-09 2018-03-21 Eastern Virginia Medical School Substituted nucleoside derivatives with antiviral and antimicrobial properties
AU2008304380A1 (en) * 2007-09-26 2009-04-02 Mount Sinai School Of Medicine Azacytidine analogues and uses thereof
EP2825546B1 (en) 2011-09-01 2017-07-12 Case Western Reserve University Non-natural nucleosides as theranostic agents
US9493500B2 (en) 2012-07-19 2016-11-15 Richard Daifuku Fluorinated pyrimidine analogs and methods of use thereof
US9821173B2 (en) 2013-02-08 2017-11-21 Case Western Reserve University Anti-cancer agents and methods of use
RU2621145C2 (ru) * 2015-11-03 2017-05-31 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Воронежский государственный университет" (ФГБОУ ВПО "ВГУ") Способ получения липосом
JP2021515771A (ja) * 2018-03-07 2021-06-24 グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ （Ｎｏ．２） Ｌｉｍｉｔｅｄ Ｈｉｖ療法に有用な化合物

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3920630A (en) * 1970-09-24 1975-11-18 Upjohn Co 2,2{40 -Anhydro-ara-cytidine compounds and process of preparation
GB1325798A (en) * 1970-09-24 1973-08-08 Upjohn Co Derivatives of 2,2-anhydro-ara-cytidine
US4211773A (en) * 1978-10-02 1980-07-08 Sloan Kettering Institute For Cancer Research 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides
DE3100478A1 (de) * 1981-01-09 1982-08-12 Dr. Thilo & Co GmbH, 8021 Sauerlach 5'ester von pyrimidinnucleosiden mit antiviraler wirksamkeit, verfahren zur herstellung und daraus hergestellte arzneimittel
US4355032B2 (en) 1981-05-21 1990-10-30 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
NZ201662A (en) 1981-08-26 1986-07-11 Merck & Co Inc 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation
US4816447A (en) 1981-08-26 1989-03-28 Merck & Co., Inc. Anti-viral guanine compounds
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
US4556659A (en) * 1982-08-09 1985-12-03 Syntex (U.S.A.) Inc. Substituted 9-(1-0- or 3-0-monosubstituted or 1,3-Di-0-substituted propoxymethyl)-purines as antiviral agents
US4684631A (en) 1984-10-09 1987-08-04 Toyama Chemical Co., Ltd. Novel 5-fluoro-2-deoxyuridine derivatives and salts thereof, process for producing the same, and antitumor agents containing the same
JPH0655755B2 (ja) * 1985-01-23 1994-07-27 富山化学工業株式会社 新規な５−フルオロ−２′−デオキシウリジン−３′−ホスフエ−ト誘導体およびその塩
US5223263A (en) * 1988-07-07 1993-06-29 Vical, Inc. Liponucleotide-containing liposomes
JPS6483092A (en) * 1987-09-24 1989-03-28 Arakawa Chotaro & Co Novel n6,n6-dimethyladenosine derivative having carcinostatic activity, its production and carcinostatic agent containing said derivative as active component
EP0355131B1 (en) * 1987-10-28 1996-09-04 Pro-Neuron, Inc. Acyl deoxyribonucleoside derivatives and uses thereof
JPH0278696A (ja) * 1988-09-13 1990-03-19 Shoichiro Ozaki ５−フルオロウラシル誘導体
US5216142A (en) * 1989-04-17 1993-06-01 Efamol Holdings Plc Anti-virals
FI105556B (fi) * 1991-09-30 2000-09-15 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten pyrimidiiniukleosidijohdannaisten valmistamiseksi, joilla on kasvaimen vastaista vaikutusta

Also Published As

Publication number Publication date
CH0642525H1 (en) 1999-06-30
NZ244535A (en) 1995-08-28
KR100272732B1 (ko) 2000-11-15
FI941574A0 (fi) 1994-04-06
HUT68008A (en) 1995-05-29
EP0642525A1 (en) 1995-03-15
EP0642525B1 (en) 1997-05-02
JP2873313B2 (ja) 1999-03-24
ATE152454T1 (de) 1997-05-15
DE69219482T2 (de) 1997-10-23
NO300014B1 (no) 1997-03-17
NO941269L (no) 1994-04-07
GB2260319A (en) 1993-04-14
IL103351A (en) 2000-02-17
NO941269D0 (no) 1994-04-07
RU2126417C1 (ru) 1999-02-20
DK0642525T3 (da) 1997-11-03
IL103351A0 (en) 1993-03-15
DE69219482D1 (de) 1997-06-05
US6548486B1 (en) 2003-04-15
SG47759A1 (en) 1998-04-17
WO1993007163A1 (en) 1993-04-15
MX9205715A (es) 1993-05-01
FI990270A0 (fi) 1999-02-10
HK1007430A1 (en) 1999-04-09
UA41296C2 (uk) 2001-09-17
HU219400B (hu) 2001-04-28
GB9121257D0 (en) 1991-11-20
CA2120725C (en) 2000-04-11
AU672369B2 (en) 1996-10-03
CA2120725A1 (en) 1993-04-15
CZ288153B6 (en) 2001-05-16
JPH06511249A (ja) 1994-12-15
AU2867392A (en) 1993-05-03
PL170846B1 (en) 1997-01-31
SK39794A3 (en) 1994-10-05
GB2260319B (en) 1995-12-06
FI941574A (fi) 1994-04-06
CZ80594A3 (en) 1994-12-15
FI990270A (fi) 1999-02-10
GR3024149T3 (en) 1997-10-31
TW347333B (en) 1998-12-11
FI105035B (fi) 2000-05-31
ZA927432B (en) 1993-06-09
HU9400988D0 (en) 1994-07-28

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Date Code Title Description
MK4A Patent expired

Expiry date: 20120930