DK0642525T3 - Nucleosider, der 0-acyleres med en mono-umættet omega-9-c18- eller c20-fedtsyre - Google Patents

Nucleosider, der 0-acyleres med en mono-umættet omega-9-c18- eller c20-fedtsyre

Info

Publication number
DK0642525T3
DK0642525T3 DK92922008.5T DK92922008T DK0642525T3 DK 0642525 T3 DK0642525 T3 DK 0642525T3 DK 92922008 T DK92922008 T DK 92922008T DK 0642525 T3 DK0642525 T3 DK 0642525T3
Authority
DK
Denmark
Prior art keywords
nucleosides
fatty acid
acylated
acid
monounsaturated omega
Prior art date
Application number
DK92922008.5T
Other languages
English (en)
Inventor
Are Dalen
Finn Myhren
Rretzen Bernt B
Kjell Torgeir Stokke
Original Assignee
Norsk Hydro As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norsk Hydro As filed Critical Norsk Hydro As
Application granted granted Critical
Publication of DK0642525T3 publication Critical patent/DK0642525T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
DK92922008.5T 1991-10-07 1992-09-30 Nucleosider, der 0-acyleres med en mono-umættet omega-9-c18- eller c20-fedtsyre DK0642525T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9121257A GB2260319B (en) 1991-10-07 1991-10-07 Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity

Publications (1)

Publication Number Publication Date
DK0642525T3 true DK0642525T3 (da) 1997-11-03

Family

ID=10702531

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92922008.5T DK0642525T3 (da) 1991-10-07 1992-09-30 Nucleosider, der 0-acyleres med en mono-umættet omega-9-c18- eller c20-fedtsyre

Country Status (27)

Country Link
US (1) US6548486B1 (da)
EP (1) EP0642525B1 (da)
JP (1) JP2873313B2 (da)
KR (1) KR100272732B1 (da)
AT (1) ATE152454T1 (da)
CA (1) CA2120725C (da)
CH (1) CH0642525H1 (da)
CZ (1) CZ288153B6 (da)
DE (1) DE69219482T2 (da)
DK (1) DK0642525T3 (da)
FI (2) FI105035B (da)
GB (1) GB2260319B (da)
GR (1) GR3024149T3 (da)
HK (1) HK1007430A1 (da)
HU (1) HU219400B (da)
IL (1) IL103351A (da)
MX (1) MX9205715A (da)
NO (1) NO300014B1 (da)
NZ (1) NZ244535A (da)
PL (1) PL170846B1 (da)
RU (1) RU2126417C1 (da)
SG (1) SG47759A1 (da)
SK (1) SK281903B6 (da)
TW (1) TW347333B (da)
UA (1) UA41296C2 (da)
WO (1) WO1993007163A1 (da)
ZA (1) ZA927432B (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9307043D0 (en) * 1993-04-05 1993-05-26 Norsk Hydro As Chemical compounds
US6703394B2 (en) 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
US5869493A (en) * 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
GB2321455A (en) * 1997-01-24 1998-07-29 Norsk Hydro As Lipophilic derivatives of biologically active compounds
GB0201179D0 (en) * 2002-01-18 2002-03-06 Angeletti P Ist Richerche Bio Therapeutic agents
TWI332507B (en) 2002-11-19 2010-11-01 Hoffmann La Roche Antiviral nucleoside derivatives
US8114847B2 (en) 2005-03-16 2012-02-14 Case Western Reserve University Selective inhibitors of translesion DNA replication
WO2008147454A1 (en) * 2006-11-16 2008-12-04 Case Western Reserve University Selective inhibitors of translesion dna replication
NO324263B1 (no) * 2005-12-08 2007-09-17 Clavis Pharma Asa Kjemiske forbindelser, anvendelse derav ved behandling av kreft, samt farmasoytiske preparater som omfatter slike forbindelser
US8497292B2 (en) 2005-12-28 2013-07-30 Translational Therapeutics, Inc. Translational dysfunction based therapeutics
US20090111774A1 (en) * 2007-06-01 2009-04-30 Luitpold Pharmaceuticals, Inc. Pmea lipid conjugates
US9296776B2 (en) 2007-07-09 2016-03-29 Eastern Virginia Medical School Substituted nucleoside derivatives with antiviral and antimicrobial properties
UA99308C2 (ru) * 2007-09-26 2012-08-10 Маунт Синай Скул Оф Медсин Аналог азацитидина и его применение
WO2013033705A2 (en) 2011-09-01 2013-03-07 Case Western Reserve University Non-natural nucleosides as theranostic agents
US9493500B2 (en) 2012-07-19 2016-11-15 Richard Daifuku Fluorinated pyrimidine analogs and methods of use thereof
US9821173B2 (en) 2013-02-08 2017-11-21 Case Western Reserve University Anti-cancer agents and methods of use
RU2621145C2 (ru) * 2015-11-03 2017-05-31 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Воронежский государственный университет" (ФГБОУ ВПО "ВГУ") Способ получения липосом
EP3762396A1 (en) * 2018-03-07 2021-01-13 GlaxoSmithKline Intellectual Property (No.2) Limited Compounds useful in hiv therapy

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1325798A (en) * 1970-09-24 1973-08-08 Upjohn Co Derivatives of 2,2-anhydro-ara-cytidine
US3920630A (en) * 1970-09-24 1975-11-18 Upjohn Co 2,2{40 -Anhydro-ara-cytidine compounds and process of preparation
US4211773A (en) * 1978-10-02 1980-07-08 Sloan Kettering Institute For Cancer Research 5-Substituted 1-(2'-Deoxy-2'-substituted-β-D-arabinofuranosyl)pyrimidine nucleosides
DE3100478A1 (de) * 1981-01-09 1982-08-12 Dr. Thilo & Co GmbH, 8021 Sauerlach 5'ester von pyrimidinnucleosiden mit antiviraler wirksamkeit, verfahren zur herstellung und daraus hergestellte arzneimittel
US4355032B2 (en) 1981-05-21 1990-10-30 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
NZ201662A (en) 1981-08-26 1986-07-11 Merck & Co Inc 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation
US4816447A (en) 1981-08-26 1989-03-28 Merck & Co., Inc. Anti-viral guanine compounds
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
US4556659A (en) * 1982-08-09 1985-12-03 Syntex (U.S.A.) Inc. Substituted 9-(1-0- or 3-0-monosubstituted or 1,3-Di-0-substituted propoxymethyl)-purines as antiviral agents
US4684631A (en) 1984-10-09 1987-08-04 Toyama Chemical Co., Ltd. Novel 5-fluoro-2-deoxyuridine derivatives and salts thereof, process for producing the same, and antitumor agents containing the same
JPH0655755B2 (ja) * 1985-01-23 1994-07-27 富山化学工業株式会社 新規な５−フルオロ−２′−デオキシウリジン−３′−ホスフエ−ト誘導体およびその塩
US5223263A (en) * 1988-07-07 1993-06-29 Vical, Inc. Liponucleotide-containing liposomes
JPS6483092A (en) * 1987-09-24 1989-03-28 Arakawa Chotaro & Co Novel n6,n6-dimethyladenosine derivative having carcinostatic activity, its production and carcinostatic agent containing said derivative as active component
ZA888083B (en) * 1987-10-28 1990-06-27 Pro Neuron Inc Acyl deoxyribonucleoside derivatives and uses thereof
JPH0278696A (ja) * 1988-09-13 1990-03-19 Shoichiro Ozaki ５−フルオロウラシル誘導体
US5216142A (en) 1989-04-17 1993-06-01 Efamol Holdings Plc Anti-virals
CA2079413C (en) * 1991-09-30 2003-09-09 Masakatsu Kaneko Pyrimidine nucleoside derivatives having anti-tumor activity, their preparation and use

Also Published As

Publication number Publication date
US6548486B1 (en) 2003-04-15
ATE152454T1 (de) 1997-05-15
EP0642525B1 (en) 1997-05-02
FI990270A0 (fi) 1999-02-10
HK1007430A1 (en) 1999-04-09
HU219400B (hu) 2001-04-28
GB9121257D0 (en) 1991-11-20
GR3024149T3 (en) 1997-10-31
NO941269L (no) 1994-04-07
JP2873313B2 (ja) 1999-03-24
GB2260319A (en) 1993-04-14
NZ244535A (en) 1995-08-28
UA41296C2 (uk) 2001-09-17
AU672369B2 (en) 1996-10-03
HU9400988D0 (en) 1994-07-28
CH0642525H1 (en) 1999-06-30
TW347333B (en) 1998-12-11
JPH06511249A (ja) 1994-12-15
NO941269D0 (no) 1994-04-07
GB2260319B (en) 1995-12-06
FI941574A (fi) 1994-04-06
MX9205715A (es) 1993-05-01
ZA927432B (en) 1993-06-09
RU2126417C1 (ru) 1999-02-20
FI990270A (fi) 1999-02-10
WO1993007163A1 (en) 1993-04-15
SK281903B6 (sk) 2001-09-11
IL103351A (en) 2000-02-17
HUT68008A (en) 1995-05-29
PL170846B1 (en) 1997-01-31
FI941574A0 (fi) 1994-04-06
DE69219482D1 (de) 1997-06-05
NO300014B1 (no) 1997-03-17
FI105035B (fi) 2000-05-31
AU2867392A (en) 1993-05-03
SG47759A1 (en) 1998-04-17
SK39794A3 (en) 1994-10-05
CZ288153B6 (en) 2001-05-16
DE69219482T2 (de) 1997-10-23
KR100272732B1 (ko) 2000-11-15
CZ80594A3 (en) 1994-12-15
CA2120725C (en) 2000-04-11
CA2120725A1 (en) 1993-04-15
IL103351A0 (en) 1993-03-15
EP0642525A1 (en) 1995-03-15

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