SK279964B6 - Dávkovacia forma na riadené uvoľňovanie liečiva a - Google Patents

Info

Publication number

SK279964B6

SK279964B6 SK769-94A SK76994A SK279964B6 SK 279964 B6 SK279964 B6 SK 279964B6 SK 76994 A SK76994 A SK 76994A SK 279964 B6 SK279964 B6 SK 279964B6

Authority

SK

Slovakia

Prior art keywords

polymer

dosage form

core

controlled release

water

Prior art date

1991-12-27

Links

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• Global Dossier
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• 239000011248 coating agent Substances 0.000 claims abstract description 26
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• -1 pentaerythritol allyl ethers Chemical class 0.000 claims description 23
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• 229960002855 simvastatin Drugs 0.000 claims description 17
• RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 claims description 17
• 239000010410 layer Substances 0.000 claims description 16
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• 150000003839 salts Chemical class 0.000 claims description 14
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
• PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 claims description 12
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• QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 claims description 12
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• FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 claims description 8
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• CXMXRPHRNRROMY-UHFFFAOYSA-L sebacate(2-) Chemical compound [O-]C(=O)CCCCCCCCC([O-])=O CXMXRPHRNRROMY-UHFFFAOYSA-L 0.000 claims 2
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