RU94031474A - Устройство доставки лекарственного препарата, способ получения устройства - Google Patents

Устройство доставки лекарственного препарата, способ получения устройства

Info

Publication number
RU94031474A
RU94031474A RU94031474/14A RU94031474A RU94031474A RU 94031474 A RU94031474 A RU 94031474A RU 94031474/14 A RU94031474/14 A RU 94031474/14A RU 94031474 A RU94031474 A RU 94031474A RU 94031474 A RU94031474 A RU 94031474A
Authority
RU
Russia
Prior art keywords
hydration
core
gel
agent
microscopic particles
Prior art date
Application number
RU94031474/14A
Other languages
English (en)
Other versions
RU2127586C1 (ru
Inventor
С.Рорк Джеральд
Us]
Д.Пипкин Джеймс
Original Assignee
Мерк Энд Ко.
Мерк Энд Ко., Инк.
Инк. (US)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Энд Ко., Мерк Энд Ко., Инк., Инк. (US) filed Critical Мерк Энд Ко.
Publication of RU94031474A publication Critical patent/RU94031474A/ru
Application granted granted Critical
Publication of RU2127586C1 publication Critical patent/RU2127586C1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms

Abstract

Устройство для контролируемого выделения полезного агента в виде гелеобразной дисперсии, состоит из ядра, которое содержит полезный агент, полимер, который образует гелеобразные микроскопические частицы при гидратации, и, при необходимости, агент для модуляции гидратации полимера, непроницаемого, нерастворимого покрытия, которое адгезирует к ядру и окружает ядро и содержит отверстия, которые обеспечивают поверхность для гидратации и освобождения дисперсии, содержащей гелеобразные микроскопические частицы.

Claims (1)

  1. Устройство для контролируемого выделения полезного агента в виде гелеобразной дисперсии, состоит из ядра, которое содержит полезный агент, полимер, который образует гелеобразные микроскопические частицы при гидратации, и, при необходимости, агент для модуляции гидратации полимера, непроницаемого, нерастворимого покрытия, которое адгезирует к ядру и окружает ядро и содержит отверстия, которые обеспечивают поверхность для гидратации и освобождения дисперсии, содержащей гелеобразные микроскопические частицы.
RU94031474/14A 1991-12-27 1992-12-18 Устройство доставки лекарственного препарата, способ получения устройства RU2127586C1 (ru)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US81530491A 1991-12-27 1991-12-27
US815.304 1991-12-27
US815,304 1991-12-27
US90218892A 1992-07-29 1992-07-29
US902,188 1992-07-29
US902.188 1992-07-29

Publications (2)

Publication Number Publication Date
RU94031474A true RU94031474A (ru) 1997-04-20
RU2127586C1 RU2127586C1 (ru) 1999-03-20

Family

ID=27123932

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94031474/14A RU2127586C1 (ru) 1991-12-27 1992-12-18 Устройство доставки лекарственного препарата, способ получения устройства

Country Status (26)

Country Link
EP (1) EP0549331B1 (ru)
JP (1) JPH089534B2 (ru)
KR (1) KR100281609B1 (ru)
CN (1) CN1074368A (ru)
AT (1) ATE157001T1 (ru)
AU (1) AU660057B2 (ru)
BG (1) BG61751B1 (ru)
CA (1) CA2085871C (ru)
CZ (1) CZ284045B6 (ru)
DE (1) DE69221711T2 (ru)
DK (1) DK0549331T3 (ru)
ES (1) ES2106838T3 (ru)
FI (1) FI109451B (ru)
GR (1) GR3024885T3 (ru)
HU (1) HU219594B (ru)
IL (1) IL104189A (ru)
LV (1) LV12082B (ru)
MX (1) MX9207541A (ru)
NO (1) NO310672B1 (ru)
NZ (1) NZ245514A (ru)
PL (1) PL171110B1 (ru)
RO (1) RO112810B1 (ru)
RU (1) RU2127586C1 (ru)
SK (1) SK279964B6 (ru)
WO (1) WO1993012765A1 (ru)
YU (1) YU48762B (ru)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5582838A (en) * 1994-12-22 1996-12-10 Merck & Co., Inc. Controlled release drug suspension delivery device
US5654005A (en) * 1995-06-07 1997-08-05 Andrx Pharmaceuticals, Inc. Controlled release formulation having a preformed passageway
EP0961611B1 (de) * 1997-01-14 2002-03-27 LTS Lohmann Therapie-Systeme AG Expandierbares gastroretentives therapie-system mit kontrollierter wirkstofffreisetzung im gastrointestinaltrakt
TWI243687B (en) * 1998-04-21 2005-11-21 Teijin Ltd Pharmaceutical composition for application to mucosa
US6506397B1 (en) * 1999-02-19 2003-01-14 Curt Thies Pest controlling
AU3957400A (en) 1999-04-16 2000-11-02 Novo Nordisk A/S Dry, mouldable drug formulation
JP3573287B2 (ja) 2000-08-08 2004-10-06 第一製薬株式会社 高吸収性固形製剤
US7964216B2 (en) 2001-01-12 2011-06-21 Sun Pharma Advanced Research Company Limited Spaced drug delivery system
EP1458352A1 (en) * 2001-12-18 2004-09-22 Novo Nordisk A/S Solid dose micro implant
US8454997B2 (en) 2001-12-18 2013-06-04 Novo Nordisk A/S Solid dose micro implant
AU2002353659A1 (en) * 2001-12-18 2003-07-15 Synthon B.V. Simvastatin dosage forms
AR040588A1 (es) * 2002-07-26 2005-04-13 Schering Corp Formulacion farmaceutica que comprende un inhibidor de la absorcion del colesterol y un inhibidor de una hmg- co a reductasa
KR20050071517A (ko) * 2002-09-28 2005-07-07 맥네일-피피씨, 인코포레이티드 코어를 2개 갖는 개질된 방출성 투여 제형
WO2004108067A2 (en) * 2003-04-03 2004-12-16 Sun Pharmaceutical Industries Limited Programmed drug delivery system
US7922702B2 (en) 2004-07-02 2011-04-12 Qlt Inc. Treatment medium delivery device and methods for delivery of such treatment mediums to the eye using such a delivery device
JP2009532132A (ja) 2006-03-31 2009-09-10 キューエルティー プラグ デリバリー，インク． 薬物治療用鼻涙排液系インプラント
RU2010112417A (ru) 2007-09-07 2011-10-10 Клт Плаг Диливери, Инк. (Us) Обнаружение лакримальных имплантатов
US9974685B2 (en) 2011-08-29 2018-05-22 Mati Therapeutics Drug delivery system and methods of treating open angle glaucoma and ocular hypertension
CN103889401B (zh) 2011-08-29 2017-10-13 Qlt公司 持续释放递送活性剂以治疗青光眼和高眼压
JP2020066606A (ja) * 2018-10-25 2020-04-30 株式会社ダイセル １型ヘルパーｔ細胞増加剤、食品、及び医薬

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4814181A (en) * 1987-09-03 1989-03-21 Alza Corporation Dosage form comprising fast agent delivery followed by slow agent delivery
US4915954A (en) * 1987-09-03 1990-04-10 Alza Corporation Dosage form for delivering a drug at two different rates
IL92966A (en) * 1989-01-12 1995-07-31 Pfizer Hydrogel-operated release devices
US5057321A (en) * 1990-06-13 1991-10-15 Alza Corporation Dosage form comprising drug and maltodextrin

Also Published As

Publication number Publication date
KR100281609B1 (ko) 2001-02-15
LV12082A (lv) 1998-07-20
SK76994A3 (en) 1995-05-10
YU48762B (en) 1999-11-22
KR940703653A (ko) 1994-12-12
DE69221711D1 (de) 1997-09-25
IL104189A (en) 1996-10-31
RO112810B1 (ro) 1998-01-30
FI109451B (fi) 2002-08-15
NO942430D0 (no) 1994-06-27
FI943011A0 (fi) 1994-06-22
AU660057B2 (en) 1995-06-08
DK0549331T3 (da) 1997-09-15
NO310672B1 (no) 2001-08-13
DE69221711T2 (de) 1998-03-12
AU3034892A (en) 1993-08-12
CN1074368A (zh) 1993-07-21
MX9207541A (es) 1994-06-30
CZ284045B6 (cs) 1998-07-15
HU9401913D0 (en) 1994-09-28
ATE157001T1 (de) 1997-09-15
HUT70437A (en) 1995-10-30
GR3024885T3 (en) 1998-01-30
NZ245514A (en) 1994-12-22
PL171110B1 (pl) 1997-03-28
JPH089534B2 (ja) 1996-01-31
RU2127586C1 (ru) 1999-03-20
YU111292A (sh) 1995-12-04
CA2085871A1 (en) 1993-06-28
WO1993012765A1 (en) 1993-07-08
BG98805A (bg) 1995-03-31
SK279964B6 (sk) 1999-06-11
JPH05255071A (ja) 1993-10-05
CA2085871C (en) 2002-05-07
EP0549331A1 (en) 1993-06-30
FI943011A (fi) 1994-06-22
BG61751B1 (bg) 1998-05-29
IL104189A0 (en) 1993-05-13
ES2106838T3 (es) 1997-11-16
LV12082B (en) 1998-09-20
HU219594B (hu) 2001-05-28
EP0549331B1 (en) 1997-08-20
CZ157094A3 (en) 1994-12-15
NO942430L (no) 1994-06-27

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Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20031219