JPS57112321A - Preparation of prolonged release composite - Google Patents

Preparation of prolonged release composite

Info

Publication number
JPS57112321A
JPS57112321A JP18757480A JP18757480A JPS57112321A JP S57112321 A JPS57112321 A JP S57112321A JP 18757480 A JP18757480 A JP 18757480A JP 18757480 A JP18757480 A JP 18757480A JP S57112321 A JPS57112321 A JP S57112321A
Authority
JP
Japan
Prior art keywords
emulsion
prolonged release
composite
give
active substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP18757480A
Other languages
Japanese (ja)
Other versions
JPS6059204B2 (en
Inventor
Masaru Yoshida
Isao Kaetsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NIPPON GENSHIRYOKU KENKYUSHO
Japan Atomic Energy Agency
Original Assignee
NIPPON GENSHIRYOKU KENKYUSHO
Japan Atomic Energy Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NIPPON GENSHIRYOKU KENKYUSHO, Japan Atomic Energy Research Institute filed Critical NIPPON GENSHIRYOKU KENKYUSHO
Priority to JP18757480A priority Critical patent/JPS6059204B2/en
Publication of JPS57112321A publication Critical patent/JPS57112321A/en
Publication of JPS6059204B2 publication Critical patent/JPS6059204B2/en
Expired legal-status Critical Current

Links

Abstract

PURPOSE: To obtain a microspheric prolonged release composite, by dissolving a physiologically active substance in a buffer solution, preparing a composite emulsion containing a vinyl polymerizable monomer, and polymerizing the monomer by the irradiation with ionizing radiation, etc.
CONSTITUTION: A physiologically active substance is dissolved in a buffer solution of an adjusted pH, and a polymerizable hydrophobic low-temperature vitrifiable vinyl monomer is added thereto with vigorous stirring to give a primary emulsion. An aqueous solution containing a water-soluble high polymer is added to the resultant emulsion as a protective colloid with vigorous stirring to give a composite emulsion of the[(W/O)/W]type. The resultant emulsion is then irradiated with light or ionizing radiation at 0°C or below to polymerize the polymerizable monomer and give the aimed microspheric prolonged release composite containing the physiologically active substance.
COPYRIGHT: (C)1982,JPO&Japio
JP18757480A 1980-12-29 1980-12-29 Method for producing sustained release complex Expired JPS6059204B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP18757480A JPS6059204B2 (en) 1980-12-29 1980-12-29 Method for producing sustained release complex

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP18757480A JPS6059204B2 (en) 1980-12-29 1980-12-29 Method for producing sustained release complex

Publications (2)

Publication Number Publication Date
JPS57112321A true JPS57112321A (en) 1982-07-13
JPS6059204B2 JPS6059204B2 (en) 1985-12-24

Family

ID=16208476

Family Applications (1)

Application Number Title Priority Date Filing Date
JP18757480A Expired JPS6059204B2 (en) 1980-12-29 1980-12-29 Method for producing sustained release complex

Country Status (1)

Country Link
JP (1) JPS6059204B2 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01197419A (en) * 1987-12-30 1989-08-09 Pacific Chem Ind Co Liposome-containing cosmetics and production thereof
US4981625A (en) * 1988-03-14 1991-01-01 California Institute Of Technology Monodisperse, polymeric microspheres produced by irradiation of slowly thawing frozen drops
US5019400A (en) * 1989-05-01 1991-05-28 Enzytech, Inc. Very low temperature casting of controlled release microspheres
JPH04130607U (en) * 1991-05-22 1992-11-30 ダイワラクダ工業株式会社 Joints for wall panels
WO2001089477A3 (en) * 2000-05-19 2003-01-30 Battelle Memorial Institute Controlled release of materials from polymer matrices
JP2007503441A (en) * 2003-08-22 2007-02-22 ヴィスタ サイエンティフィック エルエルシー Polymer system for controlled drug therapy

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01197419A (en) * 1987-12-30 1989-08-09 Pacific Chem Ind Co Liposome-containing cosmetics and production thereof
JPH0567605B2 (en) * 1987-12-30 1993-09-27 Taiheiyo Kagaku Kk
US4981625A (en) * 1988-03-14 1991-01-01 California Institute Of Technology Monodisperse, polymeric microspheres produced by irradiation of slowly thawing frozen drops
US5019400A (en) * 1989-05-01 1991-05-28 Enzytech, Inc. Very low temperature casting of controlled release microspheres
JPH04130607U (en) * 1991-05-22 1992-11-30 ダイワラクダ工業株式会社 Joints for wall panels
WO2001089477A3 (en) * 2000-05-19 2003-01-30 Battelle Memorial Institute Controlled release of materials from polymer matrices
JP2007503441A (en) * 2003-08-22 2007-02-22 ヴィスタ サイエンティフィック エルエルシー Polymer system for controlled drug therapy

Also Published As

Publication number Publication date
JPS6059204B2 (en) 1985-12-24

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