JPS57112321A - Preparation of prolonged release composite - Google Patents
Preparation of prolonged release compositeInfo
- Publication number
- JPS57112321A JPS57112321A JP18757480A JP18757480A JPS57112321A JP S57112321 A JPS57112321 A JP S57112321A JP 18757480 A JP18757480 A JP 18757480A JP 18757480 A JP18757480 A JP 18757480A JP S57112321 A JPS57112321 A JP S57112321A
- Authority
- JP
- Japan
- Prior art keywords
- emulsion
- prolonged release
- composite
- give
- active substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
PURPOSE: To obtain a microspheric prolonged release composite, by dissolving a physiologically active substance in a buffer solution, preparing a composite emulsion containing a vinyl polymerizable monomer, and polymerizing the monomer by the irradiation with ionizing radiation, etc.
CONSTITUTION: A physiologically active substance is dissolved in a buffer solution of an adjusted pH, and a polymerizable hydrophobic low-temperature vitrifiable vinyl monomer is added thereto with vigorous stirring to give a primary emulsion. An aqueous solution containing a water-soluble high polymer is added to the resultant emulsion as a protective colloid with vigorous stirring to give a composite emulsion of the[(W/O)/W]type. The resultant emulsion is then irradiated with light or ionizing radiation at 0°C or below to polymerize the polymerizable monomer and give the aimed microspheric prolonged release composite containing the physiologically active substance.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP18757480A JPS6059204B2 (en) | 1980-12-29 | 1980-12-29 | Method for producing sustained release complex |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP18757480A JPS6059204B2 (en) | 1980-12-29 | 1980-12-29 | Method for producing sustained release complex |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS57112321A true JPS57112321A (en) | 1982-07-13 |
JPS6059204B2 JPS6059204B2 (en) | 1985-12-24 |
Family
ID=16208476
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP18757480A Expired JPS6059204B2 (en) | 1980-12-29 | 1980-12-29 | Method for producing sustained release complex |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6059204B2 (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01197419A (en) * | 1987-12-30 | 1989-08-09 | Pacific Chem Ind Co | Liposome-containing cosmetics and production thereof |
US4981625A (en) * | 1988-03-14 | 1991-01-01 | California Institute Of Technology | Monodisperse, polymeric microspheres produced by irradiation of slowly thawing frozen drops |
US5019400A (en) * | 1989-05-01 | 1991-05-28 | Enzytech, Inc. | Very low temperature casting of controlled release microspheres |
JPH04130607U (en) * | 1991-05-22 | 1992-11-30 | ダイワラクダ工業株式会社 | Joints for wall panels |
WO2001089477A3 (en) * | 2000-05-19 | 2003-01-30 | Battelle Memorial Institute | Controlled release of materials from polymer matrices |
JP2007503441A (en) * | 2003-08-22 | 2007-02-22 | ヴィスタ サイエンティフィック エルエルシー | Polymer system for controlled drug therapy |
-
1980
- 1980-12-29 JP JP18757480A patent/JPS6059204B2/en not_active Expired
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01197419A (en) * | 1987-12-30 | 1989-08-09 | Pacific Chem Ind Co | Liposome-containing cosmetics and production thereof |
JPH0567605B2 (en) * | 1987-12-30 | 1993-09-27 | Taiheiyo Kagaku Kk | |
US4981625A (en) * | 1988-03-14 | 1991-01-01 | California Institute Of Technology | Monodisperse, polymeric microspheres produced by irradiation of slowly thawing frozen drops |
US5019400A (en) * | 1989-05-01 | 1991-05-28 | Enzytech, Inc. | Very low temperature casting of controlled release microspheres |
JPH04130607U (en) * | 1991-05-22 | 1992-11-30 | ダイワラクダ工業株式会社 | Joints for wall panels |
WO2001089477A3 (en) * | 2000-05-19 | 2003-01-30 | Battelle Memorial Institute | Controlled release of materials from polymer matrices |
JP2007503441A (en) * | 2003-08-22 | 2007-02-22 | ヴィスタ サイエンティフィック エルエルシー | Polymer system for controlled drug therapy |
Also Published As
Publication number | Publication date |
---|---|
JPS6059204B2 (en) | 1985-12-24 |
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