ES2092296T3 - Metodo de tratamiento de tejidos infectados. - Google Patents
Metodo de tratamiento de tejidos infectados.Info
- Publication number
- ES2092296T3 ES2092296T3 ES93908585T ES93908585T ES2092296T3 ES 2092296 T3 ES2092296 T3 ES 2092296T3 ES 93908585 T ES93908585 T ES 93908585T ES 93908585 T ES93908585 T ES 93908585T ES 2092296 T3 ES2092296 T3 ES 2092296T3
- Authority
- ES
- Spain
- Prior art keywords
- liposomes
- entrapped
- infected region
- vesicle
- liposomal composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000002502 liposome Substances 0.000 abstract 3
- 150000002632 lipids Chemical class 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 229920000249 biocompatible polymer Polymers 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/5537—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom the heteroring containing the structure -C(=O)-N-C(=O)- (both carbon atoms belong to the heteroring)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
UN METODO PARA EL TRATAMIENTO DE UN PUNTO DE INFECCION SISTEMATICA QUE CONSISTE EN ADMINISTRAR UN COMPUESTO TERAPEUTICO ATRAPADO EN LIPOSOMAS. TAMBIEN SE PRESENTA UNA COMPOSICION LIPOSOMAL Y UN METODO PARA LA PREPARACION DE LA COMPOSICION LIPOSOMAL A UTILIZAR PARA CONCENTRAR UN COMPUESTO TERAPEUTICO EN UNA REGION INFECTADA A TRAVES DEL FLUJO SANGUINEO. LOS LIPOSOMAS, QUE CONTIENEN EL AGENTE DE FORMA ATRAPADA, SE COMPONEN DE LIPIDOS FORMADORES DE VESICULAS, UN LIPIDO FORMADOR DE VESICULAS DERIVADO CON UN POLIMERO HIDROFILICO BIOCOMPATIBLE, Y SUS TAMAÑOS SE SELECCIONAN DE UNA GAMA DE TAMAÑOS DE ENTRE 0,07 Y 0,2 MICRAS. TRAS LA ADMINISTRACION PARENTERAL, LA REGION INFECTADA TOMA DE FORMA SELECTIVA LOS LIPOSOMAS EN UN PERIODO DE TIEMPO DE 24 A 48 HORAS, PARA LIBERAR EL COMPUESTO ATRAPADO EN LA REGION INFECTADA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/858,171 US5843473A (en) | 1989-10-20 | 1992-03-27 | Method of treatment of infected tissues |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2092296T3 true ES2092296T3 (es) | 1996-11-16 |
Family
ID=25327664
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93908585T Expired - Lifetime ES2092296T3 (es) | 1992-03-27 | 1993-03-24 | Metodo de tratamiento de tejidos infectados. |
Country Status (7)
Country | Link |
---|---|
US (1) | US5843473A (es) |
EP (1) | EP0632719B1 (es) |
AT (1) | ATE142483T1 (es) |
DE (1) | DE69304685T2 (es) |
DK (1) | DK0632719T3 (es) |
ES (1) | ES2092296T3 (es) |
WO (1) | WO1993019738A1 (es) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5356633A (en) * | 1989-10-20 | 1994-10-18 | Liposome Technology, Inc. | Method of treatment of inflamed tissues |
US20060084797A1 (en) * | 1990-06-11 | 2006-04-20 | Gilead Sciences, Inc. | High affinity TGFbeta nucleic acid ligands and inhibitors |
US6465188B1 (en) * | 1990-06-11 | 2002-10-15 | Gilead Sciences, Inc. | Nucleic acid ligand complexes |
US6645463B1 (en) | 1994-05-16 | 2003-11-11 | The Board Of Regents Of The University Of Michigan | Blood-pool selective carrier for lipophilic imaging agents |
US5820873A (en) * | 1994-09-30 | 1998-10-13 | The University Of British Columbia | Polyethylene glycol modified ceramide lipids and liposome uses thereof |
US5885613A (en) * | 1994-09-30 | 1999-03-23 | The University Of British Columbia | Bilayer stabilizing components and their use in forming programmable fusogenic liposomes |
AU714043B2 (en) * | 1994-10-03 | 1999-12-16 | Infectio Recherche Inc. | Liposome-formulations for treatment of viral diseases |
US8071737B2 (en) * | 1995-05-04 | 2011-12-06 | Glead Sciences, Inc. | Nucleic acid ligand complexes |
US6673364B1 (en) | 1995-06-07 | 2004-01-06 | The University Of British Columbia | Liposome having an exchangeable component |
US20110230857A1 (en) * | 1997-01-27 | 2011-09-22 | Ewa Herbst | Electronic delivery systems and methods with feedback |
US20060089751A1 (en) * | 1997-01-27 | 2006-04-27 | Ewa Herbst | Electronic delivery systems and methods with feedback |
US5827533A (en) | 1997-02-06 | 1998-10-27 | Duke University | Liposomes containing active agents aggregated with lipid surfactants |
JP2001524957A (ja) * | 1997-04-11 | 2001-12-04 | ザ ボード オブ リージェンツ オブ ザ ユニヴァーシティ オブ ミシガン | 親油性画像診断剤用の血液プール運搬体 |
US6734171B1 (en) | 1997-10-10 | 2004-05-11 | Inex Pharmaceuticals Corp. | Methods for encapsulating nucleic acids in lipid bilayers |
US20010003580A1 (en) * | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
WO1999059547A1 (en) * | 1998-05-21 | 1999-11-25 | Isis Pharmaceuticals, Inc. | Long-circulating liposomal compositions |
WO1999065461A2 (en) * | 1998-06-19 | 1999-12-23 | Genzyme Corporation | Cationic amphiphile micellar complexes |
US6613352B2 (en) | 1999-04-13 | 2003-09-02 | Universite De Montreal | Low-rigidity liposomal formulation |
GB9918670D0 (en) | 1999-08-06 | 1999-10-13 | Celltech Therapeutics Ltd | Biological product |
US20030147944A1 (en) * | 1999-12-10 | 2003-08-07 | Mayer Lawrence D | Lipid carrier compositions with protected surface reactive functions |
WO2001085131A2 (en) * | 2000-05-11 | 2001-11-15 | Celator Technologies Inc. | Lipid carrier compositions for improved drug retention |
AU2002312410A1 (en) * | 2001-06-08 | 2002-12-23 | Target Protein Technologies, Inc. | Tissue-specific endothelial membrane proteins |
JP2005525992A (ja) * | 2001-06-25 | 2005-09-02 | イサム・リサーチ・デベロツプメント・カンパニー・オブ・ザ・ヘブルー・ユニバーシテイ・オブ・エルサレム | 生物学的物質を充填した小胞の調製法およびそれらの様々な使用 |
JP4555569B2 (ja) * | 2001-11-13 | 2010-10-06 | セレーター ファーマシューティカルズ, インコーポレイテッド | 増強された血中安定性を有する脂質キャリア組成物 |
US20030190320A1 (en) * | 2002-02-21 | 2003-10-09 | Pietro Speziale | Monoclonal antibodies that are cross-reactive against bacterial collagen binding proteins |
JP2005525375A (ja) * | 2002-03-05 | 2005-08-25 | トランセイブ, インク. | 生物活性物質をリポソーム又は脂質複合体内に封入する方法 |
AR036316A1 (es) * | 2002-08-29 | 2004-08-25 | Monte Verde S A | Una composicion farmaceutica de liposomas de tamano pequeno y metodo de preparacion |
ES2439727T3 (es) * | 2002-10-29 | 2014-01-24 | Insmed Incorporated | Liberación sostenida de antiinfectantes |
US7879351B2 (en) * | 2002-10-29 | 2011-02-01 | Transave, Inc. | High delivery rates for lipid based drug formulations, and methods of treatment thereof |
US7718189B2 (en) | 2002-10-29 | 2010-05-18 | Transave, Inc. | Sustained release of antiinfectives |
GB0308731D0 (en) * | 2003-04-15 | 2003-05-21 | Anticancer Therapeutic Inv Sa | Method of radiotherapy |
AU2005292083A1 (en) * | 2004-09-29 | 2006-04-13 | Alza Corporation | Microparticles and nanoparticles containing a lipopolymer |
US20070105757A1 (en) * | 2005-10-31 | 2007-05-10 | May Thomas B | Vancomycin formulations having reduced amount of histamine |
CA2838111C (en) | 2005-12-08 | 2016-01-19 | Insmed Incorporated | Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof |
WO2007127803A2 (en) * | 2006-04-25 | 2007-11-08 | The Regents Of The University Of California | Administration of growth factors for the treatment of cns disorders |
US20070259031A1 (en) * | 2006-04-26 | 2007-11-08 | The Regents Of The University Of California | Compositions and methods for convection enhanced delivery of high molecular weight neurotherapeutics |
JP5333970B2 (ja) * | 2007-03-20 | 2013-11-06 | 国立大学法人大阪大学 | 心筋梗塞の予防および/または治療薬 |
US20100196455A1 (en) | 2007-05-04 | 2010-08-05 | Transave, Inc. | Compositions of Multicationic Drugs for Reducing Interactions with Polyanionic Biomolecules and Methods of Use Thereof |
US9119783B2 (en) | 2007-05-07 | 2015-09-01 | Insmed Incorporated | Method of treating pulmonary disorders with liposomal amikacin formulations |
US9333214B2 (en) | 2007-05-07 | 2016-05-10 | Insmed Incorporated | Method for treating pulmonary disorders with liposomal amikacin formulations |
US9114081B2 (en) | 2007-05-07 | 2015-08-25 | Insmed Incorporated | Methods of treating pulmonary disorders with liposomal amikacin formulations |
AU2008256644B2 (en) | 2007-05-24 | 2014-07-03 | The United States Government As Represented By The Department Of Veterans Affairs | Intranuclear protein transduction through a nucleoside salvage pathway |
WO2011160110A1 (en) * | 2010-06-19 | 2011-12-22 | Western University Of Health Sciences | Novel formulation of pegylated-liposome encapsulated glycopeptide antibiotics |
CN108743537B (zh) | 2012-05-21 | 2021-06-11 | 英斯麦德公司 | 治疗肺部感染的系统 |
US20140023696A1 (en) * | 2012-07-20 | 2014-01-23 | Frederick Timothy Guilford | Treatment for idiopathic pulmonary fibrosis |
CN104884047A (zh) | 2012-11-29 | 2015-09-02 | 英斯梅德股份有限公司 | 稳定的万古霉素制剂 |
US20140234397A1 (en) * | 2013-02-15 | 2014-08-21 | Lou Ann Brown | Treatment of klebsiella pneumoniae with liposomally formulated glutathione |
WO2014160337A1 (en) * | 2013-03-13 | 2014-10-02 | Mallinckrodt Llc | Liposomal cisplatin compositions for cancer therapy |
MX2016014921A (es) | 2014-05-15 | 2017-07-28 | Insmed In Incorporated | Metodos para tratar infecciones pulmonares micobacterianas no tuberculosas. |
US20170281541A1 (en) * | 2014-09-05 | 2017-10-05 | The Johns Hopkins University | Liposome-based mucus-penetrating particles for mucosal delivery |
NZ733010A (en) | 2014-12-31 | 2023-01-27 | Lantheus Medical Imaging Inc | Lipid-encapsulated gas microsphere compositions and related methods |
IL262647B2 (en) | 2016-05-04 | 2023-03-01 | Lantheus Medical Imaging Inc | Methods and devices for preparing sharpness factors for ultrasound |
US9789210B1 (en) | 2016-07-06 | 2017-10-17 | Lantheus Medical Imaging, Inc. | Methods for making ultrasound contrast agents |
EP3500312B1 (en) * | 2016-08-18 | 2024-04-10 | Troy Bremer | Delivery of urea to cells of the macula and retina using liposome constructs |
EP3731846A4 (en) * | 2017-12-29 | 2022-03-02 | Wayne State University | DRUG DELIVERY SYSTEMS FOR THE TREATMENT OF INFECTIONS |
US11571386B2 (en) | 2018-03-30 | 2023-02-07 | Insmed Incorporated | Methods for continuous manufacture of liposomal drug products |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4426330A (en) * | 1981-07-20 | 1984-01-17 | Lipid Specialties, Inc. | Synthetic phospholipid compounds |
US4534899A (en) * | 1981-07-20 | 1985-08-13 | Lipid Specialties, Inc. | Synthetic phospholipid compounds |
US4501728A (en) * | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
US4981692A (en) * | 1983-03-24 | 1991-01-01 | The Liposome Company, Inc. | Therapeutic treatment by intramammary infusion |
US4885172A (en) * | 1985-06-26 | 1989-12-05 | The Liposome Company, Inc. | Composition for targeting, storing and loading of liposomes |
GB8601100D0 (en) * | 1986-01-17 | 1986-02-19 | Cosmas Damian Ltd | Drug delivery system |
JPS6376862A (ja) * | 1986-09-17 | 1988-04-07 | Nippon Denso Co Ltd | 表面硬化層を有するアルミニウム部材 |
EP0295248B2 (en) * | 1986-12-23 | 1999-04-28 | The Liposome Company, Inc. | Liposome preparation and antibiotic |
US4920016A (en) * | 1986-12-24 | 1990-04-24 | Linear Technology, Inc. | Liposomes with enhanced circulation time |
US4837028A (en) * | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
JP2666345B2 (ja) * | 1987-04-16 | 1997-10-22 | 武田薬品工業株式会社 | リポソーム製剤およびその製造法 |
JPH04234841A (ja) * | 1988-07-08 | 1992-08-24 | Mitsubishi Rayon Co Ltd | 光学活性化合物及び液晶組成物 |
GB8824593D0 (en) * | 1988-10-20 | 1988-11-23 | Royal Free Hosp School Med | Liposomes |
US5153000A (en) * | 1988-11-22 | 1992-10-06 | Kao Corporation | Phosphate, liposome comprising the phosphate as membrane constituent, and cosmetic and liposome preparation comprising the liposome |
US4906476A (en) * | 1988-12-14 | 1990-03-06 | Liposome Technology, Inc. | Novel liposome composition for sustained release of steroidal drugs in lungs |
US5079234A (en) * | 1989-03-23 | 1992-01-07 | Bristol-Myers Squibb Co. | Inhibitors of aminoglycoside nephrotoxicity |
US5013556A (en) * | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
-
1992
- 1992-03-27 US US07/858,171 patent/US5843473A/en not_active Expired - Lifetime
-
1993
- 1993-03-24 ES ES93908585T patent/ES2092296T3/es not_active Expired - Lifetime
- 1993-03-24 WO PCT/US1993/002808 patent/WO1993019738A1/en active IP Right Grant
- 1993-03-24 AT AT93908585T patent/ATE142483T1/de not_active IP Right Cessation
- 1993-03-24 DK DK93908585.8T patent/DK0632719T3/da active
- 1993-03-24 EP EP93908585A patent/EP0632719B1/en not_active Expired - Lifetime
- 1993-03-24 DE DE69304685T patent/DE69304685T2/de not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0632719A1 (en) | 1995-01-11 |
DK0632719T3 (da) | 1997-09-15 |
DE69304685D1 (de) | 1996-10-17 |
EP0632719B1 (en) | 1996-09-11 |
US5843473A (en) | 1998-12-01 |
ATE142483T1 (de) | 1996-09-15 |
WO1993019738A1 (en) | 1993-10-14 |
DE69304685T2 (de) | 1997-04-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2092296T3 (es) | Metodo de tratamiento de tejidos infectados. | |
ATE152614T1 (de) | Mittel zur behandlung entzündeter gewebe | |
NO1999003I1 (no) | Pegylert liposomalt doxorubicin | |
CA2075624C (en) | Ultrasound-enhanced delivery of materials through the skin | |
US20030072814A1 (en) | Topical pharmaceutical composition for the treatment of warts | |
ES2136618T3 (es) | Cicatrizacion de heridas. | |
CA2233961A1 (en) | Stimulation of hair follicles | |
KR900700089A (ko) | 전신성 피부 투과적 투여를 위한 약학적 조성물 | |
CA2251966A1 (en) | Transdermally administered dextromethorphan as antitussive agent | |
EP1063981B1 (en) | Use of selegiline or desmethylselegiline for treating wounds, burns and dermatological damage | |
CA2064039A1 (en) | Treatment to reduce edema for brain and musculature injuries | |
CA2340898A1 (en) | Compositions and methods for treating intracellular infections | |
RU94036344A (ru) | Способ лечения спида | |
RU93048862A (ru) | Способ профилактики и лечения эндометритов у коров "вазокамэтром" |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 632719 Country of ref document: ES |