ES2092296T3 - Metodo de tratamiento de tejidos infectados. - Google Patents

Metodo de tratamiento de tejidos infectados.

Info

Publication number
ES2092296T3
ES2092296T3 ES93908585T ES93908585T ES2092296T3 ES 2092296 T3 ES2092296 T3 ES 2092296T3 ES 93908585 T ES93908585 T ES 93908585T ES 93908585 T ES93908585 T ES 93908585T ES 2092296 T3 ES2092296 T3 ES 2092296T3
Authority
ES
Spain
Prior art keywords
liposomes
entrapped
infected region
vesicle
liposomal composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93908585T
Other languages
English (en)
Inventor
Martin C Woodle
Irma A J M Bakker-Woudenberg
Francis J Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Sequus Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sequus Pharmaceuticals Inc filed Critical Sequus Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2092296T3 publication Critical patent/ES2092296T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/5537—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom the heteroring containing the structure -C(=O)-N-C(=O)- (both carbon atoms belong to the heteroring)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

UN METODO PARA EL TRATAMIENTO DE UN PUNTO DE INFECCION SISTEMATICA QUE CONSISTE EN ADMINISTRAR UN COMPUESTO TERAPEUTICO ATRAPADO EN LIPOSOMAS. TAMBIEN SE PRESENTA UNA COMPOSICION LIPOSOMAL Y UN METODO PARA LA PREPARACION DE LA COMPOSICION LIPOSOMAL A UTILIZAR PARA CONCENTRAR UN COMPUESTO TERAPEUTICO EN UNA REGION INFECTADA A TRAVES DEL FLUJO SANGUINEO. LOS LIPOSOMAS, QUE CONTIENEN EL AGENTE DE FORMA ATRAPADA, SE COMPONEN DE LIPIDOS FORMADORES DE VESICULAS, UN LIPIDO FORMADOR DE VESICULAS DERIVADO CON UN POLIMERO HIDROFILICO BIOCOMPATIBLE, Y SUS TAMAÑOS SE SELECCIONAN DE UNA GAMA DE TAMAÑOS DE ENTRE 0,07 Y 0,2 MICRAS. TRAS LA ADMINISTRACION PARENTERAL, LA REGION INFECTADA TOMA DE FORMA SELECTIVA LOS LIPOSOMAS EN UN PERIODO DE TIEMPO DE 24 A 48 HORAS, PARA LIBERAR EL COMPUESTO ATRAPADO EN LA REGION INFECTADA.
ES93908585T 1992-03-27 1993-03-24 Metodo de tratamiento de tejidos infectados. Expired - Lifetime ES2092296T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/858,171 US5843473A (en) 1989-10-20 1992-03-27 Method of treatment of infected tissues

Publications (1)

Publication Number Publication Date
ES2092296T3 true ES2092296T3 (es) 1996-11-16

Family

ID=25327664

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93908585T Expired - Lifetime ES2092296T3 (es) 1992-03-27 1993-03-24 Metodo de tratamiento de tejidos infectados.

Country Status (7)

Country Link
US (1) US5843473A (es)
EP (1) EP0632719B1 (es)
AT (1) ATE142483T1 (es)
DE (1) DE69304685T2 (es)
DK (1) DK0632719T3 (es)
ES (1) ES2092296T3 (es)
WO (1) WO1993019738A1 (es)

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KR101424980B1 (ko) * 2002-10-29 2014-08-01 인스메드 인코포레이티드 항감염제의 지속적인 방출
US7879351B2 (en) * 2002-10-29 2011-02-01 Transave, Inc. High delivery rates for lipid based drug formulations, and methods of treatment thereof
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AU2005292083A1 (en) * 2004-09-29 2006-04-13 Alza Corporation Microparticles and nanoparticles containing a lipopolymer
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CA2896083A1 (en) * 2005-12-08 2007-06-14 Insmed Incorporated Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof
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US20070259031A1 (en) * 2006-04-26 2007-11-08 The Regents Of The University Of California Compositions and methods for convection enhanced delivery of high molecular weight neurotherapeutics
JP5333970B2 (ja) * 2007-03-20 2013-11-06 国立大学法人大阪大学 心筋梗塞の予防および／または治療薬
US20100196455A1 (en) 2007-05-04 2010-08-05 Transave, Inc. Compositions of Multicationic Drugs for Reducing Interactions with Polyanionic Biomolecules and Methods of Use Thereof
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
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Also Published As

Publication number Publication date
DE69304685D1 (de) 1996-10-17
US5843473A (en) 1998-12-01
EP0632719A1 (en) 1995-01-11
DE69304685T2 (de) 1997-04-03
ATE142483T1 (de) 1996-09-15
EP0632719B1 (en) 1996-09-11
DK0632719T3 (da) 1997-09-15
WO1993019738A1 (en) 1993-10-14

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