IE782018L - Alkylthiopenoxypropanolamines - Google Patents
AlkylthiopenoxypropanolaminesInfo
- Publication number
- IE782018L IE782018L IE782018A IE201878A IE782018L IE 782018 L IE782018 L IE 782018L IE 782018 A IE782018 A IE 782018A IE 201878 A IE201878 A IE 201878A IE 782018 L IE782018 L IE 782018L
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- gb2006197a
- alkylthiophenoxypropanolamines
- cycloalkyl
- administered
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000017531 blood circulation Effects 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 210000002464 muscle smooth vascular Anatomy 0.000 abstract 1
- 230000000414 obstructive effect Effects 0.000 abstract 1
- 210000005259 peripheral blood Anatomy 0.000 abstract 1
- 239000011886 peripheral blood Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Alkylthiophenoxypropanolamines of the general formula:- <IMAGE> (A,B,R = H,C1-4 alkyl; R1=C1-8 alkyl R2 = C6-12 alkyl, (C5-8 cycloalkyl) - (C2-6 alkyl) ) and the pharmaceutically acceptable acid addition salts thereof increase peripheral blood flow, relax vascular smooth muscle, and inhibit platelet aggregation. They may be administered in the form of pharmaceutical preparations for the treatment of obstructive cerebrovascular deficiencies.
[GB2006197A]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84116877A | 1977-10-11 | 1977-10-11 | |
| US94222278A | 1978-09-14 | 1978-09-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE782018L true IE782018L (en) | 1979-04-11 |
| IE47449B1 IE47449B1 (en) | 1984-03-21 |
Family
ID=27126241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2018/78A IE47449B1 (en) | 1977-10-11 | 1978-10-10 | Alkylthiophenoxypropanolamines |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS6049188B2 (en) |
| AR (2) | AR224239A1 (en) |
| AU (1) | AU520181B2 (en) |
| CA (1) | CA1116636A (en) |
| CH (1) | CH642349A5 (en) |
| DE (1) | DE2844353C2 (en) |
| DK (1) | DK146005C (en) |
| ES (1) | ES474156A1 (en) |
| FI (1) | FI70883C (en) |
| FR (1) | FR2405932A1 (en) |
| GB (1) | GB2006197B (en) |
| GR (1) | GR73919B (en) |
| IE (1) | IE47449B1 (en) |
| IL (1) | IL55695A (en) |
| IT (1) | IT1109310B (en) |
| LU (1) | LU80345A1 (en) |
| NL (1) | NL7810156A (en) |
| NO (1) | NO146161C (en) |
| PH (1) | PH15824A (en) |
| SE (1) | SE443782B (en) |
| YU (1) | YU41602B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4396629A (en) | 1980-12-29 | 1983-08-02 | Sterling Drug Inc. | Compositions, processes and method |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6504268A (en) * | 1965-04-03 | 1966-10-04 | ||
| DE2551141A1 (en) * | 1975-11-14 | 1977-05-18 | Dolorgiet Arzneimittelfabrik | (1)-Cyclododecylamino'(2)-hydroxy-propane derivs. - selective beta-receptor blockers |
| DE2552266A1 (en) * | 1975-11-21 | 1977-05-26 | Dolorgiet Arzneimittelfabrik | (1)-Aryloxy or arylthio-(3)-cyclohexylamino-(2)-propanol derivs. - prepd. e.g. by reacting epoxy propane cpds. with (3,3,5)-trimethyl-cyclohexylamine |
-
1978
- 1978-09-26 GR GR57313A patent/GR73919B/el unknown
- 1978-09-26 CA CA000312115A patent/CA1116636A/en not_active Expired
- 1978-10-02 GB GB7838985A patent/GB2006197B/en not_active Expired
- 1978-10-04 AR AR273952A patent/AR224239A1/en active
- 1978-10-04 AU AU40393/78A patent/AU520181B2/en not_active Expired
- 1978-10-06 YU YU2352/78A patent/YU41602B/en unknown
- 1978-10-09 IL IL55695A patent/IL55695A/en unknown
- 1978-10-09 FI FI783068A patent/FI70883C/en not_active IP Right Cessation
- 1978-10-09 NL NL7810156A patent/NL7810156A/en not_active Application Discontinuation
- 1978-10-10 NO NO783416A patent/NO146161C/en unknown
- 1978-10-10 PH PH21691A patent/PH15824A/en unknown
- 1978-10-10 SE SE7810574A patent/SE443782B/en not_active IP Right Cessation
- 1978-10-10 LU LU80345A patent/LU80345A1/en unknown
- 1978-10-10 DK DK450978A patent/DK146005C/en not_active IP Right Cessation
- 1978-10-10 IT IT51437/78A patent/IT1109310B/en active
- 1978-10-10 IE IE2018/78A patent/IE47449B1/en unknown
- 1978-10-10 FR FR7828916A patent/FR2405932A1/en active Granted
- 1978-10-11 DE DE2844353A patent/DE2844353C2/en not_active Expired
- 1978-10-11 ES ES474156A patent/ES474156A1/en not_active Expired
- 1978-10-11 CH CH1056478A patent/CH642349A5/en not_active IP Right Cessation
- 1978-10-11 JP JP53124219A patent/JPS6049188B2/en not_active Expired
-
1979
- 1979-10-31 AR AR278713A patent/AR223016A1/en active
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