SK279947B6 - Plochý terapeutický systém, spôsob jeho výroby a p - Google Patents
Plochý terapeutický systém, spôsob jeho výroby a p Download PDFInfo
- Publication number
- SK279947B6 SK279947B6 SK2685-87A SK268587A SK279947B6 SK 279947 B6 SK279947 B6 SK 279947B6 SK 268587 A SK268587 A SK 268587A SK 279947 B6 SK279947 B6 SK 279947B6
- Authority
- SK
- Slovakia
- Prior art keywords
- skin
- active substance
- adhesive
- layer
- therapeutic system
- Prior art date
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- RNFNDJAIBTYOQL-UHFFFAOYSA-N chloral hydrate Chemical compound OC(O)C(Cl)(Cl)Cl RNFNDJAIBTYOQL-UHFFFAOYSA-N 0.000 description 1
- 229960002327 chloral hydrate Drugs 0.000 description 1
- 229960003821 choline theophyllinate Drugs 0.000 description 1
- SXYZQZLHAIHKKY-GSTUPEFVSA-N clocortolone pivalate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(Cl)[C@@H]2[C@@H]2C[C@@H](C)[C@H](C(=O)COC(=O)C(C)(C)C)[C@@]2(C)C[C@@H]1O SXYZQZLHAIHKKY-GSTUPEFVSA-N 0.000 description 1
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- SQCSJQKLUXDURR-UHFFFAOYSA-N diethylamino 2-hydroxybenzoate Chemical compound CCN(CC)OC(=O)C1=CC=CC=C1O SQCSJQKLUXDURR-UHFFFAOYSA-N 0.000 description 1
- FDPIMTJIUBPUKL-UHFFFAOYSA-N dimethylacetone Natural products CCC(=O)CC FDPIMTJIUBPUKL-UHFFFAOYSA-N 0.000 description 1
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- RTWNYYOXLSILQN-UHFFFAOYSA-N methanediamine Chemical compound NCN RTWNYYOXLSILQN-UHFFFAOYSA-N 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
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- 229960000726 moxaverine hydrochloride Drugs 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- RZKNXPAYKMNEOU-UHFFFAOYSA-N n'-hydroxy-2-nitrobenzenecarboximidamide Chemical compound ON=C(N)C1=CC=CC=C1[N+]([O-])=O RZKNXPAYKMNEOU-UHFFFAOYSA-N 0.000 description 1
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- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- GDYUVHBMFVMBAF-LIRRHRJNSA-N oxyfedrine Chemical compound COC1=CC=CC(C(=O)CCN[C@@H](C)[C@H](O)C=2C=CC=CC=2)=C1 GDYUVHBMFVMBAF-LIRRHRJNSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
-
- A—HUMAN NECESSITIES
- A45—HAND OR TRAVELLING ARTICLES
- A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
- A45D34/00—Containers or accessories specially adapted for handling liquid toiletry or cosmetic substances, e.g. perfumes
-
- A—HUMAN NECESSITIES
- A45—HAND OR TRAVELLING ARTICLES
- A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
- A45D44/00—Other cosmetic or toiletry articles, e.g. for hairdressers' rooms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Birds (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Medical Informatics (AREA)
- Hematology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Materials For Medical Uses (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3613002 | 1986-04-17 | ||
| DE19863634016 DE3634016A1 (de) | 1986-04-17 | 1986-10-06 | Flaechenfoermiges therapeutisches system, verfahren zu seiner herstellung und seine verwendung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SK268587A3 SK268587A3 (en) | 1999-06-11 |
| SK279947B6 true SK279947B6 (sk) | 1999-06-11 |
Family
ID=25842978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK2685-87A SK279947B6 (sk) | 1986-04-17 | 1987-04-15 | Plochý terapeutický systém, spôsob jeho výroby a p |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5132115A (cs) |
| EP (1) | EP0242827B1 (cs) |
| JP (1) | JP2542026B2 (cs) |
| KR (1) | KR900007178B1 (cs) |
| AU (1) | AU608223B2 (cs) |
| CA (1) | CA1301005C (cs) |
| CZ (1) | CZ284976B6 (cs) |
| DE (2) | DE3634016A1 (cs) |
| DK (1) | DK170434B1 (cs) |
| ES (1) | ES2055692T3 (cs) |
| FI (1) | FI89243C (cs) |
| GR (1) | GR3003570T3 (cs) |
| HU (1) | HU203842B (cs) |
| IE (1) | IE59729B1 (cs) |
| IL (1) | IL82192A (cs) |
| NZ (1) | NZ220016A (cs) |
| PL (1) | PL155408B1 (cs) |
| PT (1) | PT84674B (cs) |
| SK (1) | SK279947B6 (cs) |
| WO (1) | WO1987006144A1 (cs) |
| YU (1) | YU47135B (cs) |
Families Citing this family (113)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3643987A1 (de) * | 1986-12-22 | 1988-06-23 | Lohmann Therapie Syst Lts | Basische, wirkstoffdurchlaessige haftklebende polymermasse, insbesondere zum einsatz mit basischen wirkstoffen, verfahren zu ihrer herstellung und ihre verwendung |
| DK158336C (da) * | 1987-09-22 | 1990-10-01 | Coloplast As | Forbindsmateriale til behandling af saar samt smaalegemer til brug ved fremstilling deraf |
| DE3809978A1 (de) * | 1988-03-24 | 1989-10-05 | Lohmann Gmbh & Co Kg | Reservoir fuer gesteuerte wirkstoffabgabe, dieses enthaltende vorrichtung, sowie verfahren zu deren herstellung und verwendung der vorrichtung |
| DE3823070A1 (de) * | 1988-07-07 | 1990-02-22 | Kettelhack Riker Pharma Gmbh | Selbstklebendes heftpflaster |
| US5026556A (en) * | 1988-11-10 | 1991-06-25 | Norwich Eaton Pharmaceuticals, Inc. | Compositions for the transdermal delivery of pharmaceutical actives |
| DE3908431A1 (de) * | 1989-03-15 | 1990-09-27 | Lohmann Therapie Syst Lts | Transdermales system mit gestufter wirkstoffabgabe und verwendung fuer die lokale oder systemische wirkstoffverabreichung |
| DE3939376C1 (cs) * | 1989-11-29 | 1991-05-08 | Lts Lohmann Therapie-Systeme Gmbh & Co. Kg, 5450 Neuwied, De | |
| DE4020144A1 (de) * | 1990-06-25 | 1992-01-09 | Lohmann Therapie Syst Lts | Pflaster mit hohem gehalt an weichmachenden inhaltsstoffen |
| GB9021674D0 (en) * | 1990-10-05 | 1990-11-21 | Ethical Pharma Ltd | Transdermal device |
| DE4110027C2 (de) | 1991-03-27 | 1996-08-29 | Lohmann Therapie Syst Lts | Verfahren zur Konfektionierung transdermaler therapeutischer Pflaster |
| GB9207437D0 (en) * | 1992-04-03 | 1992-05-20 | Orion Yhtymae Oy | Topical administration of toremifene and its metabolites |
| DK170792B1 (da) * | 1992-08-27 | 1996-01-22 | Coloplast As | Hudpladeprodukt til dosering af et eller flere medikamenter |
| WO1994007463A1 (en) * | 1992-09-25 | 1994-04-14 | Minnesota Mining And Manufacturing Company | Skin treatment with adhesion enhancement properties |
| US5462743A (en) * | 1992-10-30 | 1995-10-31 | Medipro Sciences Limited | Substance transfer system for topical application |
| DE4333595A1 (de) * | 1993-10-01 | 1995-04-06 | Labtec Gmbh | Transdermales therapeutisches System zur Applikation von Arzneimitteln auf die Haut |
| DE4407742C1 (de) * | 1994-03-08 | 1995-06-22 | Hexal Pharma Gmbh | Transdermales System in Form eines Pflasters mit einem Tamoxifen-Derivat |
| FR2719770A1 (fr) * | 1994-05-11 | 1995-11-17 | Lhd Lab Hygiene Dietetique | Système matriciel pour administration transdermique d'ibuprofène et procédé de préparation. |
| GB2292520B (en) * | 1994-08-25 | 1998-09-02 | Univ Sheffield | Transdermal dressings for animals |
| US5840327A (en) * | 1995-08-21 | 1998-11-24 | Alza Corporation | Transdermal drug delivery device having enhanced adhesion |
| DE19541260A1 (de) * | 1995-11-06 | 1997-05-07 | Lohmann Therapie Syst Lts | Therapeutische Zubereitung zur transdermalen Applikation von Wirkstoffen durch die Haut |
| US5730721A (en) | 1996-01-25 | 1998-03-24 | Vesture Corporation | Medical applicator and method |
| DE19606025C2 (de) * | 1996-02-19 | 2000-03-30 | Wolfram Sterry | Verfahren und Vorrichtung zur in vivo-Bestimmung optischer Strahlung innerhalb und unterhalb der Epidermis |
| DE19650471A1 (de) * | 1996-12-05 | 1998-06-10 | Beiersdorf Ag | Wirkstoffhaltige Pflaster |
| DE19706824C1 (de) * | 1997-02-21 | 1998-03-26 | Lohmann Therapie Syst Lts | Transdermales oder topisches Plastersystem mit Polyacrylatmatrix mit verbesserten physikalischen Eigenschaften |
| US5968547A (en) * | 1997-02-24 | 1999-10-19 | Euro-Celtique, S.A. | Method of providing sustained analgesia with buprenorphine |
| US5958447A (en) * | 1998-03-17 | 1999-09-28 | Plc Holding, L.L.C. | Adhesive matrix type transdermal patch and method of manufacturing same |
| DE19820999A1 (de) * | 1998-05-11 | 1999-11-18 | Lohmann Therapie Syst Lts | Laminat zum Aufbringen auf einen Akzeptor |
| US6043259A (en) * | 1998-07-09 | 2000-03-28 | Medicure Inc. | Treatment of cardiovascular and related pathologies |
| DE19830732B4 (de) * | 1998-07-09 | 2008-11-13 | Lts Lohmann Therapie-Systeme Ag | Zusammensetzung, enthaltend mindestens einen die Blutfettwerte beeinflussenden Wirkstoff und seine Verwendung |
| JP2002539127A (ja) | 1999-03-08 | 2002-11-19 | メディキュア インコーポレーテッド | ビタミンb−6障害のためのピリドキサル類縁体 |
| DE19911262C2 (de) * | 1999-03-13 | 2003-04-10 | Scs Skin Care Systems Gmbh | Vorrichtung zur Abgabe kosmetischer Wirkstoffe |
| DE19912477A1 (de) * | 1999-03-19 | 2000-09-28 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System und Verfahren zu seiner Herstellung |
| US6183770B1 (en) * | 1999-04-15 | 2001-02-06 | Acutek International | Carrier patch for the delivery of agents to the skin |
| US6328988B1 (en) * | 1999-04-23 | 2001-12-11 | Rutgers, The State University Of New Jersey | Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules |
| US6417227B1 (en) | 1999-04-28 | 2002-07-09 | Cg And Associates | Methods of delivery of cetyl myristoleate |
| US6489345B1 (en) | 1999-07-13 | 2002-12-03 | Medicure, Inc. | Treatment of diabetes and related pathologies |
| US6677356B1 (en) * | 1999-08-24 | 2004-01-13 | Medicure International Inc. | Treatment of cardiovascular and related pathologies |
| KR20030005170A (ko) * | 2000-01-28 | 2003-01-17 | 더 프록터 앤드 갬블 캄파니 | 격리된 이익 영역을 포함하는 클렌징 물품 |
| US7442689B2 (en) * | 2000-02-29 | 2008-10-28 | Medicure International Inc. | Cardioprotective phosphonates and malonates |
| CA2401655C (en) | 2000-02-29 | 2010-06-22 | Medicure International Inc. | Cardioprotective phosphonates and malonates |
| CA2404329A1 (en) | 2000-03-28 | 2001-10-04 | Medicure International Inc. | Treatment of cerebrovascular disease |
| US6548519B1 (en) | 2001-07-06 | 2003-04-15 | Medicure International Inc. | Pyridoxine and pyridoxal analogues: novel uses |
| US6897228B2 (en) * | 2000-07-07 | 2005-05-24 | Medicure International Inc. | Pyridoxine and pyridoxal analogues: new uses |
| AU7226301A (en) | 2000-07-07 | 2002-01-21 | Medicure Int Inc | Pyridoxine and pyridoxal analogues: cardiovascular therapeutics |
| DE10056009A1 (de) * | 2000-11-11 | 2002-05-16 | Beiersdorf Ag | Hautfreundliches Wirkstoffpflaster zur transdermalen Verabreichung hyperämisierender Wirkstoffe |
| US20040121988A1 (en) * | 2001-03-28 | 2004-06-24 | Medicure International Inc. | Treatment of cerebrovascular disease |
| FR2822711B1 (fr) * | 2001-03-28 | 2003-06-13 | Oreal | Dispositif de traitement comportant une enveloppe definissant une cavite dans laquelle peut-etre engagee une partie du corps |
| JP4865958B2 (ja) * | 2001-05-23 | 2012-02-01 | 株式会社トクホン | 鎮痛抗炎症局所作用型の貼付剤 |
| MXPA04000354A (es) * | 2001-07-12 | 2004-07-23 | Univ Rutgers | Macromoleculas similares a estrella anfifilica para suministro de farmaco. |
| US20040186077A1 (en) * | 2003-03-17 | 2004-09-23 | Medicure International Inc. | Novel heteroaryl phosphonates as cardioprotective agents |
| US8790689B2 (en) * | 2003-04-30 | 2014-07-29 | Purdue Pharma L.P. | Tamper resistant transdermal dosage form |
| EP2316440A1 (en) * | 2003-04-30 | 2011-05-04 | Purdue Pharma L.P. | Transdermal dosage form comprising an active agent component and an adverse agent component at the distal site of the active agent layer and one fluid communication between the surface of the active agent and the adverse agent |
| US20040219195A1 (en) * | 2003-04-30 | 2004-11-04 | 3M Innovative Properties Company | Abuse-resistant transdermal dosage form |
| US20070059351A1 (en) * | 2003-10-17 | 2007-03-15 | Murrell George A C | Transdermal patches containing a nitric oxide-donor and a second active agent and associated methods |
| US20060286159A1 (en) * | 2003-10-17 | 2006-12-21 | Calvert Murrell George A | Treatment of persistent active tendinopathy using transdermal glyceryl trinitrate providing durability of effect |
| US20060286158A1 (en) * | 2003-10-17 | 2006-12-21 | Calvert Murrell George A | Treatment of overuse tendinopathy using transdermal nitric oxide-generating agents |
| US20070053966A1 (en) * | 2003-10-17 | 2007-03-08 | Robert Ang | Medicated orthopedic support structures for treatment of damaged musculoskeletal tissue |
| US20050181029A1 (en) * | 2004-02-18 | 2005-08-18 | Samir Mitragotri | Distributed drug dispensing matrix as a transdermal patch |
| AU2005259735A1 (en) * | 2004-07-07 | 2006-01-12 | Medicure International Inc. | Combination therapies employing platelet aggregation drugs |
| US20070060549A1 (en) * | 2004-08-10 | 2007-03-15 | Friesen Albert D | Combination therapies employing ace inhibitors and uses thereof for the treatment of diabetic disorders |
| CN101005833A (zh) * | 2004-08-20 | 2007-07-25 | 3M创新有限公司 | 具有半透明保护膜的透皮药物递送装置 |
| US9801982B2 (en) | 2004-09-28 | 2017-10-31 | Atrium Medical Corporation | Implantable barrier device |
| US9000040B2 (en) | 2004-09-28 | 2015-04-07 | Atrium Medical Corporation | Cross-linked fatty acid-based biomaterials |
| EP1804717A4 (en) | 2004-09-28 | 2015-11-18 | Atrium Medical Corp | DRUG DELIVERY COATING FOR USE WITH ONE STENT |
| US9012506B2 (en) | 2004-09-28 | 2015-04-21 | Atrium Medical Corporation | Cross-linked fatty acid-based biomaterials |
| US8312836B2 (en) * | 2004-09-28 | 2012-11-20 | Atrium Medical Corporation | Method and apparatus for application of a fresh coating on a medical device |
| EP1811935B1 (en) * | 2004-09-28 | 2016-03-30 | Atrium Medical Corporation | Heat cured gel and method of making |
| US8367099B2 (en) | 2004-09-28 | 2013-02-05 | Atrium Medical Corporation | Perforated fatty acid films |
| PL2216018T3 (pl) | 2004-10-21 | 2012-09-28 | Durect Corp | Transdermalne systemy dostarczania |
| US8252319B2 (en) | 2004-10-21 | 2012-08-28 | Durect Corporation | Transdermal delivery system for sufentanil |
| US7812037B2 (en) * | 2004-10-28 | 2010-10-12 | Medicure International, Inc. | Dual antiplatelet/anticoagulant pyridoxine analogs |
| US20060094749A1 (en) * | 2004-10-28 | 2006-05-04 | Medicure International Inc. | Substituted pyridoxines as anti-platelet agents |
| US7459468B2 (en) * | 2004-10-28 | 2008-12-02 | Medicure International, Inc. | Aryl sulfonic pyridoxines as antiplatelet agents |
| US7332268B2 (en) * | 2005-04-07 | 2008-02-19 | Bio-Rad Laboratories, Inc. | Layered support sheet for high-yield spot cutting from gels or membranes |
| US9427423B2 (en) | 2009-03-10 | 2016-08-30 | Atrium Medical Corporation | Fatty-acid based particles |
| US9278161B2 (en) | 2005-09-28 | 2016-03-08 | Atrium Medical Corporation | Tissue-separating fatty acid adhesion barrier |
| AU2006304590A1 (en) | 2005-10-15 | 2007-04-26 | Atrium Medical Corporation | Hydrophobic cross-linked gels for bioabsorbable drug carrier coatings |
| CA2632090A1 (en) * | 2005-11-28 | 2007-05-31 | Medicure International Inc. | Selected dosage for the treatment of cardiovascular and related pathologies |
| US20070202155A1 (en) * | 2006-02-03 | 2007-08-30 | Cure Therapeutics, Inc. | Low dose no donor-containing transdermal patch |
| US20070259026A1 (en) * | 2006-04-20 | 2007-11-08 | Robert Ang | Vasodialating dressing for use with intravenous catheters |
| GB0610096D0 (en) * | 2006-05-22 | 2006-06-28 | Walker Adam | Anti viral spreader |
| EP2626091B1 (en) | 2006-11-06 | 2016-09-28 | Atrium Medical Corporation | Coated surgical mesh |
| US9492596B2 (en) | 2006-11-06 | 2016-11-15 | Atrium Medical Corporation | Barrier layer with underlying medical device and one or more reinforcing support structures |
| US20080108351A1 (en) * | 2006-11-06 | 2008-05-08 | Ut Starcom, Inc. | Seamless transmission of media traffic for roaming mobile terminals during handoffs |
| CA2765190C (en) * | 2008-05-27 | 2016-07-19 | The University Of Melbourne | Methods of treating mammals with eustachian tube dysfunctions |
| US20110038910A1 (en) | 2009-08-11 | 2011-02-17 | Atrium Medical Corporation | Anti-infective antimicrobial-containing biomaterials |
| DE102009056746A1 (de) * | 2009-12-04 | 2011-06-09 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System für die Verabreichung von Peptiden |
| EP2593141B1 (en) | 2010-07-16 | 2018-07-04 | Atrium Medical Corporation | Composition and methods for altering the rate of hydrolysis of cured oil-based materials |
| WO2012138727A1 (en) | 2011-04-04 | 2012-10-11 | The Procter & Gamble Company | Home care article |
| BR112014003460B1 (pt) | 2011-08-15 | 2019-05-21 | The Procter & Gamble Company | Artigos conformáveis para cuidados pessoais |
| MX2014001896A (es) | 2011-08-15 | 2014-05-27 | Procter & Gamble | Metodos para el cuidado personal. |
| US9867880B2 (en) | 2012-06-13 | 2018-01-16 | Atrium Medical Corporation | Cured oil-hydrogel biomaterial compositions for controlled drug delivery |
| GB201211309D0 (en) * | 2012-06-26 | 2012-08-08 | Fujifilm Mfg Europe Bv | Process for preparing membranes |
| CN104955516B (zh) | 2012-12-28 | 2019-01-22 | 帝国制药美国公司 | 延长丁丙诺啡经皮递送组合物及其使用方法 |
| EP3013433B1 (en) | 2013-06-27 | 2019-04-17 | The Procter and Gamble Company | Preserving personal care compositions |
| US9756923B2 (en) * | 2013-07-25 | 2017-09-12 | Amg Co., Ltd. | Container for cosmetic material |
| EP3209388B1 (en) | 2014-10-21 | 2019-09-25 | The Procter and Gamble Company | Method of improving skin appearance |
| CA2974517A1 (en) | 2015-01-23 | 2016-07-28 | Marcio Marc Abreu | Apparatus and method for skin treatment |
| US10576023B2 (en) | 2015-10-22 | 2020-03-03 | The Procter & Gamble Company | Barrier patch of a foamed film and methods of improving skin appearance |
| EP3364936B1 (en) | 2015-10-22 | 2019-11-20 | The Procter and Gamble Company | Barrier patch of a foamed film and methods of improving skin appearance |
| MX2018008190A (es) | 2015-12-30 | 2018-11-12 | Corium Int Inc | Sistemas y metodos para la administracion transdermica a largo plazo. |
| JP7174632B2 (ja) | 2016-06-23 | 2022-11-17 | コリウム, インコーポレイテッド | 親水性ドメインおよび疎水性ドメインならびに処置剤との接着剤マトリックス |
| US10300025B2 (en) | 2016-07-27 | 2019-05-28 | Corium, Inc. | Donepezil transdermal delivery system |
| US10806681B2 (en) | 2017-01-09 | 2020-10-20 | The Procter & Gamble Company | Barrier patch with soluble film and methods of improving skin appearance |
| US10857076B2 (en) | 2017-01-09 | 2020-12-08 | The Procter & Gamble Company | Barrier patch with soluble film and methods of improving skin appearance |
| US10751265B2 (en) | 2017-01-09 | 2020-08-25 | The Procter & Gamble | Barrier patch with soluble film and methods of improving skin appearance |
| US10959918B2 (en) | 2017-06-22 | 2021-03-30 | The Procter & Gamble Company | Films including a water-soluble layer and a vapor-deposited coating |
| AU2018392686A1 (en) | 2017-12-20 | 2020-07-09 | Corium Pharma Solutions, Inc. | Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point |
| CN111698984B (zh) | 2018-03-19 | 2023-11-14 | 宝洁公司 | 制备具有可溶性膜的阻隔贴片的方法 |
| DE102021102555A1 (de) | 2021-02-04 | 2022-08-04 | Lts Lohmann Therapie-Systeme Ag. | Verfahren zur Herstellung eines Formelements für die Herstellung von Mikroarrays sowie Formelement |
| PL247048B1 (pl) | 2024-04-25 | 2025-05-05 | Univ Of South Bohemia In Ceske Budejovice | Biostymulator roślinny i sposób jego wytwarzania |
| PL247049B1 (pl) | 2024-04-25 | 2025-05-05 | Univ Of South Bohemia In Ceske Budejovice | Biostymulator roślinny i sposób jego wytwarzania |
| PL448416A1 (pl) | 2024-04-25 | 2025-03-03 | Uniwersytet Przyrodniczy W Lublinie | Biostymulator roślinny |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT201781B (de) * | 1955-05-26 | 1959-01-26 | Smith & Nephew | Verfahren und Vorrichtung zum Aufbringen eines druckempfindlichen, mit einem Lösungsmittel verdünnten Gummiklebstoffs auf poröses Pflastermaterial |
| US3993072A (en) * | 1974-08-28 | 1976-11-23 | Alza Corporation | Microporous drug delivery device |
| JPS5348215A (en) * | 1976-10-13 | 1978-05-01 | Hitachi Ltd | Lubricating device for enclosed electric compressor |
| FR2435950A1 (fr) * | 1978-06-05 | 1980-04-11 | Riker Laboratories Inc | Pansement medical comprenant une composition a base de nitroglycerine, sa fabrication et son application |
| JPS55160716A (en) * | 1979-06-01 | 1980-12-13 | Toyo Ink Mfg Co Ltd | Preparation of application |
| JPS609221Y2 (ja) * | 1980-05-12 | 1985-04-02 | 日東電工株式会社 | 貼付剤 |
| JPS5721316A (en) * | 1980-07-14 | 1982-02-04 | Nitto Electric Ind Co Ltd | Plaster |
| JPS57106616A (en) * | 1980-12-22 | 1982-07-02 | Yoshiko Takeno | Formentation band |
| JPS5838212A (ja) * | 1981-09-01 | 1983-03-05 | Daikyo Yakuhin Kogyo Kk | 貼付剤およびその製造方法 |
| GB8334484D0 (en) * | 1983-12-24 | 1984-02-01 | Smith & Nephew Ass | Surgical dressing |
| FR2562800A1 (fr) * | 1984-04-11 | 1985-10-18 | Fournier Laboratoires | Dispositif pour l'administration percutanee de medicaments |
| DE3564073D1 (en) * | 1984-06-23 | 1988-09-08 | Beiersdorf Ag | Self-adhesive plaster |
| DE3423328A1 (de) * | 1984-06-23 | 1986-01-02 | Beiersdorf Ag, 2000 Hamburg | Selbstklebendes pflaster |
| DE3423293C2 (de) * | 1984-06-23 | 1995-08-24 | Lohmann Therapie Syst Lts | Selbstklebendes Pflaster |
| US4687481A (en) * | 1984-10-01 | 1987-08-18 | Biotek, Inc. | Transdermal drug delivery system |
| DE3629304A1 (de) * | 1986-08-28 | 1988-03-24 | Lohmann Gmbh & Co Kg | Transdermales therapeutisches system, seine verwendung und verfahren zu seiner herstellung |
| DE8623009U1 (de) * | 1986-08-28 | 1987-03-12 | Lohmann Gmbh & Co Kg, 5450 Neuwied | Transdermales Pflaster |
-
1986
- 1986-10-06 DE DE19863634016 patent/DE3634016A1/de active Granted
-
1987
- 1987-03-31 FI FI871399A patent/FI89243C/fi not_active IP Right Cessation
- 1987-04-07 CA CA000534036A patent/CA1301005C/en not_active Expired - Lifetime
- 1987-04-12 IL IL82192A patent/IL82192A/xx not_active IP Right Cessation
- 1987-04-14 PT PT84674A patent/PT84674B/pt unknown
- 1987-04-14 IE IE96387A patent/IE59729B1/en not_active IP Right Cessation
- 1987-04-15 CZ CS872685A patent/CZ284976B6/cs not_active IP Right Cessation
- 1987-04-15 YU YU67987A patent/YU47135B/sh unknown
- 1987-04-15 SK SK2685-87A patent/SK279947B6/sk unknown
- 1987-04-15 PL PL1987265181A patent/PL155408B1/pl unknown
- 1987-04-16 DE DE8787105745T patent/DE3775449D1/de not_active Expired - Lifetime
- 1987-04-16 US US07/715,727 patent/US5132115A/en not_active Expired - Lifetime
- 1987-04-16 AU AU72832/87A patent/AU608223B2/en not_active Expired
- 1987-04-16 JP JP62502570A patent/JP2542026B2/ja not_active Expired - Fee Related
- 1987-04-16 WO PCT/DE1987/000174 patent/WO1987006144A1/de not_active Ceased
- 1987-04-16 ES ES87105745T patent/ES2055692T3/es not_active Expired - Lifetime
- 1987-04-16 EP EP87105745A patent/EP0242827B1/de not_active Expired - Lifetime
- 1987-04-16 NZ NZ220016A patent/NZ220016A/xx unknown
- 1987-04-16 KR KR1019870701189A patent/KR900007178B1/ko not_active Expired
- 1987-04-16 HU HU872359A patent/HU203842B/hu unknown
- 1987-12-16 DK DK662887A patent/DK170434B1/da not_active IP Right Cessation
-
1992
- 1992-01-14 GR GR920400027T patent/GR3003570T3/el unknown
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