SK1892001A3 - Muscarinic agonists and antagonists, pharmaceutical composition them comprising and use thereof - Google Patents
Muscarinic agonists and antagonists, pharmaceutical composition them comprising and use thereof Download PDFInfo
- Publication number
- SK1892001A3 SK1892001A3 SK189-2001A SK1892001A SK1892001A3 SK 1892001 A3 SK1892001 A3 SK 1892001A3 SK 1892001 A SK1892001 A SK 1892001A SK 1892001 A3 SK1892001 A3 SK 1892001A3
- Authority
- SK
- Slovakia
- Prior art keywords
- alkyl
- azatricyclo
- independently
- compound
- halogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9697798P | 1998-08-18 | 1998-08-18 | |
PCT/US1999/018570 WO2000011001A1 (en) | 1998-08-18 | 1999-08-16 | Muscarinic agonists and antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
SK1892001A3 true SK1892001A3 (en) | 2001-11-06 |
Family
ID=22260061
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK189-2001A SK1892001A3 (en) | 1998-08-18 | 1999-08-16 | Muscarinic agonists and antagonists, pharmaceutical composition them comprising and use thereof |
Country Status (30)
Country | Link |
---|---|
US (5) | US6093724A (bg) |
EP (1) | EP1112272B1 (bg) |
JP (1) | JP2002523416A (bg) |
KR (1) | KR20010072784A (bg) |
CN (1) | CN1312812A (bg) |
AR (1) | AR020199A1 (bg) |
AT (1) | ATE227724T1 (bg) |
AU (1) | AU750566B2 (bg) |
BG (1) | BG105256A (bg) |
BR (1) | BR9913072A (bg) |
CA (1) | CA2340946A1 (bg) |
CO (1) | CO5130018A1 (bg) |
DE (1) | DE69903961T2 (bg) |
EE (1) | EE200100096A (bg) |
ES (1) | ES2191455T3 (bg) |
HK (1) | HK1038918A1 (bg) |
HU (1) | HUP0103203A3 (bg) |
ID (1) | ID27544A (bg) |
IL (1) | IL141050A0 (bg) |
IS (1) | IS5827A (bg) |
NO (1) | NO20010804L (bg) |
NZ (1) | NZ509762A (bg) |
PE (1) | PE20000988A1 (bg) |
PL (1) | PL346247A1 (bg) |
RU (1) | RU2219179C2 (bg) |
SK (1) | SK1892001A3 (bg) |
TR (1) | TR200100462T2 (bg) |
WO (1) | WO2000011001A1 (bg) |
YU (1) | YU13301A (bg) |
ZA (1) | ZA200100978B (bg) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL362077A1 (en) * | 2000-10-19 | 2004-10-18 | Pfizer Products Inc. | Bridged piperazine derivatives |
GB0117950D0 (en) * | 2001-02-16 | 2001-09-19 | Aventis Pharma Inc | Novel heterocyclic urea derivatives andd their use as dopamine D3 receptor ligands |
WO2002094827A1 (en) * | 2001-05-23 | 2002-11-28 | Neurosearch A/S | Fused tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
US20030064979A1 (en) * | 2001-06-29 | 2003-04-03 | Hansen Thomas Kruse | Method of inhibiting PTP 1B and /or T-cell PTP and/or other PTPases with an Asp residue at position 48 |
US6828328B1 (en) * | 2002-03-01 | 2004-12-07 | Ucb S.A. | Analgesic combination of muscarinic agonists |
US7897766B2 (en) * | 2005-09-23 | 2011-03-01 | Abbott Laboratories | Amino-aza-adamantane derivatives and methods of use |
US8314119B2 (en) | 2006-11-06 | 2012-11-20 | Abbvie Inc. | Azaadamantane derivatives and methods of use |
US8076350B2 (en) * | 2006-12-22 | 2011-12-13 | Abbott Laboratories | Spirocyclic azaadamantane derivatives and methods of use |
CN101641357B (zh) * | 2007-03-23 | 2013-09-18 | Abbvie公司 | 4-取代的氮杂金刚烷衍生物及其使用方法 |
US8163914B2 (en) | 2007-03-23 | 2012-04-24 | Abbott Laboratories | Acetamide and carboxamide derivatives of azaadamantane and methods of use thereof |
RU2015110025A (ru) * | 2009-06-19 | 2015-08-20 | Эббви Инк. | Производные диазагомоадамантана и способы их применения |
US10265311B2 (en) | 2009-07-22 | 2019-04-23 | PureTech Health LLC | Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation |
WO2011011060A1 (en) | 2009-07-22 | 2011-01-27 | Puretech Ventures | Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation |
AR081331A1 (es) | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos |
US9133123B2 (en) | 2010-04-23 | 2015-09-15 | Cytokinetics, Inc. | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use |
AR081626A1 (es) | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos |
SG188307A1 (en) | 2010-09-23 | 2013-04-30 | Abbvie Inc | Monohydrate of an azaadamantane derivative |
US8759380B2 (en) | 2011-04-22 | 2014-06-24 | Cytokinetics, Inc. | Certain heterocycles, compositions thereof, and methods for their use |
US11325896B2 (en) | 2017-12-20 | 2022-05-10 | Vanderbilt University | Antagonists of the muscarinic acetylcholine receptor M4 |
US10933020B2 (en) | 2018-09-28 | 2021-03-02 | Karuna Therapeutics, Inc. | Compositions and methods for treating disorders ameliorated by muscarinic receptor activation |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4739074A (en) * | 1986-01-22 | 1988-04-19 | Pennwalt Corporation | Adamantane spiro-pyrrolidine derivatives |
IE63906B1 (en) * | 1987-11-13 | 1995-06-14 | Novo Nordisk As | Azabicyclic compounds and their preparation and use |
US5527813A (en) * | 1990-08-21 | 1996-06-18 | Novo Nordisk A/S | Heterocyclic compounds and their preparation and use |
WO1992011261A1 (en) * | 1990-12-21 | 1992-07-09 | Merck Sharp & Dohme Limited | 4-azatricyclo[2.2.1.02,6]heptanes and pharmaceutical compositions |
US5955470A (en) * | 1991-06-11 | 1999-09-21 | Merrell Pharmaceuticals, Inc. | Derivatives of amide analogs of certain methano bridged quinolizines |
US5641791A (en) * | 1991-08-13 | 1997-06-24 | Novo Nordisk A.S | Heterocyclic compounds and their preparation and use |
US5998405A (en) * | 1995-11-02 | 1999-12-07 | Neurosearch A/S | Fused tropane-derivatives as neurotransmitter reuptake inhibitors |
US5914338A (en) * | 1996-04-02 | 1999-06-22 | Novo Nordisk | Heterocyclic compounds and their preparation and use |
US5986100A (en) * | 1998-04-02 | 1999-11-16 | Crooks; Peter Anthony | Pharmaceutical compositions and methods for use |
US5952339A (en) * | 1998-04-02 | 1999-09-14 | Bencherif; Merouane | Pharmaceutical compositions and methods of using nicotinic antagonists for treating a condition or disorder characterized by alteration in normal neurotransmitter release |
US6057446A (en) * | 1998-04-02 | 2000-05-02 | Crooks; Peter Anthony | Certain 1-aza-tricyclo [3.3.1-13,7 ] decane compounds |
-
1999
- 1999-08-16 WO PCT/US1999/018570 patent/WO2000011001A1/en not_active Application Discontinuation
- 1999-08-16 CN CN99809775A patent/CN1312812A/zh active Pending
- 1999-08-16 EP EP99945064A patent/EP1112272B1/en not_active Expired - Lifetime
- 1999-08-16 NZ NZ509762A patent/NZ509762A/xx unknown
- 1999-08-16 RU RU2001107139/04A patent/RU2219179C2/ru not_active IP Right Cessation
- 1999-08-16 PL PL99346247A patent/PL346247A1/xx not_active Application Discontinuation
- 1999-08-16 ID IDW20010377A patent/ID27544A/id unknown
- 1999-08-16 KR KR1020017002128A patent/KR20010072784A/ko not_active Application Discontinuation
- 1999-08-16 BR BR9913072-6A patent/BR9913072A/pt not_active IP Right Cessation
- 1999-08-16 JP JP2000566274A patent/JP2002523416A/ja active Pending
- 1999-08-16 CA CA002340946A patent/CA2340946A1/en not_active Abandoned
- 1999-08-16 TR TR2001/00462T patent/TR200100462T2/xx unknown
- 1999-08-16 AT AT99945064T patent/ATE227724T1/de not_active IP Right Cessation
- 1999-08-16 DE DE69903961T patent/DE69903961T2/de not_active Expired - Fee Related
- 1999-08-16 ES ES99945064T patent/ES2191455T3/es not_active Expired - Lifetime
- 1999-08-16 SK SK189-2001A patent/SK1892001A3/sk unknown
- 1999-08-16 HU HU0103203A patent/HUP0103203A3/hu unknown
- 1999-08-16 EE EEP200100096A patent/EE200100096A/xx unknown
- 1999-08-16 US US09/375,149 patent/US6093724A/en not_active Expired - Fee Related
- 1999-08-16 IL IL14105099A patent/IL141050A0/xx unknown
- 1999-08-16 YU YU13301A patent/YU13301A/sh unknown
- 1999-08-16 AU AU57758/99A patent/AU750566B2/en not_active Ceased
- 1999-08-17 AR ARP990104100A patent/AR020199A1/es unknown
- 1999-08-18 CO CO99052330A patent/CO5130018A1/es unknown
- 1999-08-18 PE PE1999000838A patent/PE20000988A1/es not_active Application Discontinuation
-
2000
- 2000-05-09 US US09/567,785 patent/US6251916B1/en not_active Expired - Fee Related
- 2000-10-17 US US09/690,494 patent/US6323194B1/en not_active Expired - Fee Related
-
2001
- 2001-01-26 IS IS5827A patent/IS5827A/is unknown
- 2001-02-05 ZA ZA200100978A patent/ZA200100978B/xx unknown
- 2001-02-14 BG BG105256A patent/BG105256A/bg unknown
- 2001-02-16 NO NO20010804A patent/NO20010804L/no not_active Application Discontinuation
- 2001-10-05 US US09/972,415 patent/US6423842B1/en not_active Expired - Fee Related
-
2002
- 2002-01-18 HK HK02100409.3A patent/HK1038918A1/zh unknown
- 2002-03-27 US US10/108,046 patent/US6555550B1/en not_active Expired - Fee Related
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