BG105256A - Мускаринови агонисти и антагонисти - Google Patents

Мускаринови агонисти и антагонисти

Info

Publication number
BG105256A
BG105256A BG105256A BG10525601A BG105256A BG 105256 A BG105256 A BG 105256A BG 105256 A BG105256 A BG 105256A BG 10525601 A BG10525601 A BG 10525601A BG 105256 A BG105256 A BG 105256A
Authority
BG
Bulgaria
Prior art keywords
antagonists
muscarinic agonists
present
compounds
muscarinic
Prior art date
Application number
BG105256A
Other languages
English (en)
Inventor
Gurmit Grewal
Anna Toy-Palmer
Xiong CAY
George Latham
Original Assignee
Ucb S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb S.A. filed Critical Ucb S.A.
Publication of BG105256A publication Critical patent/BG105256A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Изобретението се отнася до нови съединения и техни фармацевтични състави, намиращи приложение при лечението на болки. Съединенията са азаадамантани, азанорадамантани и азахомоадамантани.
BG105256A 1998-08-18 2001-02-14 Мускаринови агонисти и антагонисти BG105256A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9697798P 1998-08-18 1998-08-18
PCT/US1999/018570 WO2000011001A1 (en) 1998-08-18 1999-08-16 Muscarinic agonists and antagonists

Publications (1)

Publication Number Publication Date
BG105256A true BG105256A (bg) 2001-11-30

Family

ID=22260061

Family Applications (1)

Application Number Title Priority Date Filing Date
BG105256A BG105256A (bg) 1998-08-18 2001-02-14 Мускаринови агонисти и антагонисти

Country Status (30)

Country Link
US (5) US6093724A (bg)
EP (1) EP1112272B1 (bg)
JP (1) JP2002523416A (bg)
KR (1) KR20010072784A (bg)
CN (1) CN1312812A (bg)
AR (1) AR020199A1 (bg)
AT (1) ATE227724T1 (bg)
AU (1) AU750566B2 (bg)
BG (1) BG105256A (bg)
BR (1) BR9913072A (bg)
CA (1) CA2340946A1 (bg)
CO (1) CO5130018A1 (bg)
DE (1) DE69903961T2 (bg)
EE (1) EE200100096A (bg)
ES (1) ES2191455T3 (bg)
HK (1) HK1038918A1 (bg)
HU (1) HUP0103203A3 (bg)
ID (1) ID27544A (bg)
IL (1) IL141050A0 (bg)
IS (1) IS5827A (bg)
NO (1) NO20010804L (bg)
NZ (1) NZ509762A (bg)
PE (1) PE20000988A1 (bg)
PL (1) PL346247A1 (bg)
RU (1) RU2219179C2 (bg)
SK (1) SK1892001A3 (bg)
TR (1) TR200100462T2 (bg)
WO (1) WO2000011001A1 (bg)
YU (1) YU13301A (bg)
ZA (1) ZA200100978B (bg)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ20031013A3 (en) * 2000-10-19 2004-03-17 Pfizer Products Inc. Bridged piperazine derivatives
GB0117950D0 (en) * 2001-02-16 2001-09-19 Aventis Pharma Inc Novel heterocyclic urea derivatives andd their use as dopamine D3 receptor ligands
WO2002094827A1 (en) * 2001-05-23 2002-11-28 Neurosearch A/S Fused tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US20030064979A1 (en) * 2001-06-29 2003-04-03 Hansen Thomas Kruse Method of inhibiting PTP 1B and /or T-cell PTP and/or other PTPases with an Asp residue at position 48
US6828328B1 (en) * 2002-03-01 2004-12-07 Ucb S.A. Analgesic combination of muscarinic agonists
US7897766B2 (en) 2005-09-23 2011-03-01 Abbott Laboratories Amino-aza-adamantane derivatives and methods of use
US8314119B2 (en) 2006-11-06 2012-11-20 Abbvie Inc. Azaadamantane derivatives and methods of use
US8076350B2 (en) * 2006-12-22 2011-12-13 Abbott Laboratories Spirocyclic azaadamantane derivatives and methods of use
EP2497771A1 (en) * 2007-03-23 2012-09-12 Abbott Laboratories 4 -substituted azaadamantane derivatives and methods of use thereof
ES2378116T3 (es) 2007-03-23 2012-04-09 Abbott Laboratories Derivados acetamida y carboxamida de azaadamantano y métodos de uso de los mismos
JP2012530084A (ja) * 2009-06-19 2012-11-29 アボット・ラボラトリーズ ジアザホモアダマンタン誘導体およびこの使用方法
US10265311B2 (en) 2009-07-22 2019-04-23 PureTech Health LLC Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation
WO2011011060A1 (en) 2009-07-22 2011-01-27 Puretech Ventures Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation
AR081626A1 (es) 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
EP2560488B1 (en) 2010-04-23 2015-10-28 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
AR081331A1 (es) 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
MX2013003344A (es) 2010-09-23 2013-06-28 Abbvie Inc Monohidrato de un derivado de azaadamantano.
US8759380B2 (en) 2011-04-22 2014-06-24 Cytokinetics, Inc. Certain heterocycles, compositions thereof, and methods for their use
WO2019126559A1 (en) 2017-12-20 2019-06-27 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor m4
CA3180743A1 (en) 2018-09-28 2020-04-02 Karuna Therapeutics, Inc. Composition comprising xanomeline and trospium for treating disorders ameliorated by muscarinic receptor activation

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4739074A (en) * 1986-01-22 1988-04-19 Pennwalt Corporation Adamantane spiro-pyrrolidine derivatives
IE63906B1 (en) * 1987-11-13 1995-06-14 Novo Nordisk As Azabicyclic compounds and their preparation and use
US5527813A (en) * 1990-08-21 1996-06-18 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
WO1992011261A1 (en) * 1990-12-21 1992-07-09 Merck Sharp & Dohme Limited 4-azatricyclo[2.2.1.02,6]heptanes and pharmaceutical compositions
US5955470A (en) * 1991-06-11 1999-09-21 Merrell Pharmaceuticals, Inc. Derivatives of amide analogs of certain methano bridged quinolizines
US5641791A (en) * 1991-08-13 1997-06-24 Novo Nordisk A.S Heterocyclic compounds and their preparation and use
BR9611300A (pt) * 1995-11-02 1999-06-15 Neurosearch As Derivados de tropano em fusão suas preparações e uso
US5914338A (en) * 1996-04-02 1999-06-22 Novo Nordisk Heterocyclic compounds and their preparation and use
US6057446A (en) * 1998-04-02 2000-05-02 Crooks; Peter Anthony Certain 1-aza-tricyclo [3.3.1-13,7 ] decane compounds
US5952339A (en) * 1998-04-02 1999-09-14 Bencherif; Merouane Pharmaceutical compositions and methods of using nicotinic antagonists for treating a condition or disorder characterized by alteration in normal neurotransmitter release
US5986100A (en) * 1998-04-02 1999-11-16 Crooks; Peter Anthony Pharmaceutical compositions and methods for use

Also Published As

Publication number Publication date
HUP0103203A3 (en) 2002-10-28
TR200100462T2 (tr) 2001-09-21
PE20000988A1 (es) 2000-09-30
CO5130018A1 (es) 2002-02-27
ES2191455T3 (es) 2003-09-01
ID27544A (id) 2001-04-12
DE69903961T2 (de) 2003-07-03
US6093724A (en) 2000-07-25
US6555550B1 (en) 2003-04-29
IS5827A (is) 2001-01-26
IL141050A0 (en) 2002-02-10
NZ509762A (en) 2002-12-20
RU2219179C2 (ru) 2003-12-20
EP1112272A1 (en) 2001-07-04
ZA200100978B (en) 2002-02-05
JP2002523416A (ja) 2002-07-30
YU13301A (sh) 2005-06-10
HK1038918A1 (zh) 2002-04-04
US20020045617A1 (en) 2002-04-18
CA2340946A1 (en) 2000-03-02
KR20010072784A (ko) 2001-07-31
SK1892001A3 (en) 2001-11-06
DE69903961D1 (de) 2002-12-19
EE200100096A (et) 2002-06-17
NO20010804L (no) 2001-04-11
BR9913072A (pt) 2001-05-15
ATE227724T1 (de) 2002-11-15
US6423842B1 (en) 2002-07-23
NO20010804D0 (no) 2001-02-16
EP1112272B1 (en) 2002-11-13
HUP0103203A2 (hu) 2002-01-28
AU5775899A (en) 2000-03-14
AR020199A1 (es) 2002-05-02
US6323194B1 (en) 2001-11-27
WO2000011001A1 (en) 2000-03-02
CN1312812A (zh) 2001-09-12
US6251916B1 (en) 2001-06-26
AU750566B2 (en) 2002-07-25
PL346247A1 (en) 2002-01-28

Similar Documents

Publication Publication Date Title
BG105256A (bg) Мускаринови агонисти и антагонисти
DE69905170D1 (en) Thiazolopyrimidinderivate
NZ330667A (en) Use of substituted 2,4-imadazolidinedione compounds as analgesics
IL129592A0 (en) 5-HT1f agonists
BG64475B1 (bg) Ципразидонови соли
IL157093A0 (en) 1,2,3,4-tetrahydroisoquinolines derivatives as urotensin ii receptor antagonists
HUP9800417A3 (en) 5-substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)-indoles and 5-substituted-3-(piperidin-4-yl)-1h-indoles, their use as new 5-ht agonists, pharmaceutical compositions containing these compounds
HUP0104696A3 (en) Pharmaceutical composition containing 5ht1 receptor agonists and metoclopramide for the treatment of migraine
MX9704030A (es) 1,1-dioxidos de 2-heterocicliloxi y tiometil-1,2,5-tiadiazolidin-3-ona y composiciones y metodo de uso de los mismos.
BG104916A (bg) Калцилитични съединения
SE9802937D0 (sv) Novel compounds
IL117209A (en) 1-aryl-2-acylamino-ethane compounds and pharmaceutical compositions containing them
IL115589A0 (en) Use of cck-b antagonists in pharmaceutical compositions
PL350568A1 (en) N-(2-phenyl-4-aminobutyl)-1-naphtamides as antagonists of neurokinin 1 receptors
MXPA04001773A (es) Derivados de 6,7-dihidroxitetrahidroisquinolinas 3-sustituidas parta uso como agentes antibacterianos.
TR200000291T2 (tr) Taşikinin reseptör antagonistleri olarak 2-asilaminopropanaminler.
IL128500A (en) SUBSTITUTED 1,2,3,4-TETRAHYDRO-2-DIBENZOFURANAMINES AND 2-AMINOCYCLOHEPTA[b] BENZOFURANS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
NO20002408D0 (no) 5-HT1F antagonister
DK1100824T3 (da) Forbindelser med væksthormonfrigivende egenskaber
BG101849A (bg) Бициклични тахикининови антагонисти, тяхното приготовляване и използуване в фармацевтични състави
YU58600A (sh) Oblik vi 5,6-dihloro-2-(izopropilamino)-1-(beta-l-ribofuranozil)-1h-benzimidazola
IL139144A0 (en) Mycobacterial inhibitors
EA199700032A1 (ru) Дезинфицирующий состав "велтолен"
MD980129A (en) Antiherpetic remedy
YU26001A (sh) Derivati ureidopiperidina kao selektivni antagonisti ljudskih nk3 receptora