SK159596A3 - Pegylation reagents and compounds formed therewith - Google Patents
Pegylation reagents and compounds formed therewith Download PDFInfo
- Publication number
- SK159596A3 SK159596A3 SK1595-96A SK159596A SK159596A3 SK 159596 A3 SK159596 A3 SK 159596A3 SK 159596 A SK159596 A SK 159596A SK 159596 A3 SK159596 A3 SK 159596A3
- Authority
- SK
- Slovakia
- Prior art keywords
- weight
- peg
- composition
- group
- styrene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/259,413 US6552170B1 (en) | 1990-04-06 | 1994-06-14 | PEGylation reagents and compounds formed therewith |
PCT/US1995/007555 WO1995034326A1 (en) | 1994-06-14 | 1995-06-14 | Pegylation reagents and compounds formed therewith |
Publications (1)
Publication Number | Publication Date |
---|---|
SK159596A3 true SK159596A3 (en) | 1997-08-06 |
Family
ID=22984842
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK1595-96A SK159596A3 (en) | 1994-06-14 | 1995-06-14 | Pegylation reagents and compounds formed therewith |
Country Status (15)
Country | Link |
---|---|
US (2) | US6552170B1 (fi) |
EP (1) | EP0758906A1 (fi) |
CN (1) | CN1158089A (fi) |
AU (1) | AU2828695A (fi) |
BG (1) | BG101095A (fi) |
BR (1) | BR9507999A (fi) |
CA (1) | CA2191971C (fi) |
CZ (1) | CZ357696A3 (fi) |
EE (1) | EE9600182A (fi) |
FI (1) | FI964985A (fi) |
HU (1) | HUT77529A (fi) |
NO (1) | NO965342L (fi) |
PL (1) | PL317894A1 (fi) |
SK (1) | SK159596A3 (fi) |
WO (1) | WO1995034326A1 (fi) |
Families Citing this family (170)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5869451A (en) | 1995-06-07 | 1999-02-09 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
NZ503548A (en) | 1996-02-09 | 2001-09-28 | Amgen Inc | A fusion protein comprising an IL-1ra receptor antagonist with a constant domain of human immunoglobulin at the carboxy terminus |
US5747639A (en) * | 1996-03-06 | 1998-05-05 | Amgen Boulder Inc. | Use of hydrophobic interaction chromatography to purify polyethylene glycols |
TW555765B (en) | 1996-07-09 | 2003-10-01 | Amgen Inc | Low molecular weight soluble tumor necrosis factor type-I and type-II proteins |
DE69724451T2 (de) | 1996-12-06 | 2004-03-18 | Amgen Inc., Thousand Oaks | Kombinationtherapie mit einem tnf-bindendem protein zür behandlung von durch tnf verursachten erkrangungen |
CA2273852C (en) | 1996-12-06 | 2009-09-29 | Amgen Inc. | Combination therapy using an il-1 inhibitor for treating il-1 mediated diseases |
ATE200030T1 (de) * | 1997-01-29 | 2001-04-15 | Polymasc Pharmaceuticals Plc | Pegylationsverfahren |
US7153943B2 (en) | 1997-07-14 | 2006-12-26 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins, and methods of use thereof |
US20080076706A1 (en) | 1997-07-14 | 2008-03-27 | Bolder Biotechnology, Inc. | Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof |
US7495087B2 (en) | 1997-07-14 | 2009-02-24 | Bolder Biotechnology, Inc. | Cysteine muteins in the C-D loop of human interleukin-11 |
BR9812267B1 (pt) | 1997-07-14 | 2013-11-26 | Hormônio de crescimento recombinante. | |
US5912342A (en) * | 1997-08-12 | 1999-06-15 | Heinonen; Petri | Compounds a containing a solid support |
CN1084209C (zh) * | 1997-11-07 | 2002-05-08 | 复旦大学 | 一种高分子抗肿瘤导向药物及其制备方法 |
US6703381B1 (en) * | 1998-08-14 | 2004-03-09 | Nobex Corporation | Methods for delivery therapeutic compounds across the blood-brain barrier |
US8288126B2 (en) | 1999-01-14 | 2012-10-16 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
US20040220103A1 (en) | 1999-04-19 | 2004-11-04 | Immunex Corporation | Soluble tumor necrosis factor receptor treatment of medical disorders |
DE60032255T2 (de) * | 1999-10-04 | 2007-06-28 | Nektar Therapeutics Al, Corp., Huntsville | Polymer-stabilisierte neuropeptide |
US6808902B1 (en) | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
ATE364689T1 (de) | 1999-11-18 | 2007-07-15 | Dendreon Corp | Nukleinsäuren, welche für endotheliasen kodieren, endotheliasen, sowie deren verwendung |
US7109299B1 (en) | 1999-12-16 | 2006-09-19 | Affymax, Inc. | Peptides and compounds that bind to the IL-5 receptor |
US7700341B2 (en) | 2000-02-03 | 2010-04-20 | Dendreon Corporation | Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon |
WO2001062827A2 (en) | 2000-02-22 | 2001-08-30 | Shearwater Corporation | N-maleimidyl polymer derivatives |
US7514239B2 (en) * | 2000-03-28 | 2009-04-07 | Amgen Inc. | Nucleic acid molecules encoding beta-like glycoprotein hormone polypeptides and heterodimers thereof |
ES2674888T3 (es) | 2001-06-26 | 2018-07-04 | Amgen Inc. | Anticuerpos para OPGL |
KR100453877B1 (ko) | 2001-07-26 | 2004-10-20 | 메덱스젠 주식회사 | 연쇄체화에 의한 면역 글로블린 융합 단백질의 제조 방법 및 이 방법에 의해 제조된 TNFR/Fc 융합 단백질, 상기 단백질을 코딩하는 DNA, 상기 DNA를 포함하는벡터, 및 상기 벡터에 의한 형질전환체 |
FR2835829B1 (fr) * | 2002-02-13 | 2007-09-14 | Centre Nat Rech Scient | Nouveau procede de preparation de biopuces a adn ou a proteines et leurs applications |
WO2003093433A2 (en) * | 2002-05-02 | 2003-11-13 | Regents Of The University Of Minnesota | Fibrin-based biomatrix |
US20040014662A1 (en) * | 2002-05-08 | 2004-01-22 | Per Lindquist | Modulation of neural stem cells and neural progenitor cells |
US7351542B2 (en) | 2002-05-20 | 2008-04-01 | The Regents Of The University Of California | Methods of modulating tubulin deacetylase activity |
US20040002451A1 (en) | 2002-06-20 | 2004-01-01 | Bruce Kerwin | Compositions of pegylated soluble tumor necrosis factor receptors and methods of preparing |
EP2213685B1 (en) | 2002-09-06 | 2013-11-27 | Amgen Inc. | Therapeutic anti-IL-1R1 monoclonal antibody |
CA2499075A1 (en) * | 2002-09-16 | 2004-03-25 | Elusys Therapeutics, Inc. | Production of bispecific molecules using polyethylene glycol linkers |
AU2003275077B2 (en) | 2002-09-18 | 2010-02-04 | Ortho-Mcneil Pharmaceutical, Inc. | Methods of increasing platelet and hematopoietic stem cell production |
US20040062748A1 (en) * | 2002-09-30 | 2004-04-01 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
US8129330B2 (en) * | 2002-09-30 | 2012-03-06 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
US7432331B2 (en) | 2002-12-31 | 2008-10-07 | Nektar Therapeutics Al, Corporation | Hydrolytically stable maleimide-terminated polymers |
CA2509153C (en) * | 2002-12-31 | 2013-04-16 | Nektar Therapeutics Al, Corporation | Hydrolytically stable maleimide-terminated polymers |
US8937045B2 (en) | 2003-02-28 | 2015-01-20 | Ares Trading S.A. | Liquid formulations of tumor necrosis factor-binding proteins |
US20090123367A1 (en) * | 2003-03-05 | 2009-05-14 | Delfmems | Soluble Glycosaminoglycanases and Methods of Preparing and Using Soluble Glycosaminoglycanases |
US7871607B2 (en) | 2003-03-05 | 2011-01-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases |
EP2405015B1 (en) * | 2003-03-05 | 2016-01-06 | Halozyme, Inc. | Soluble hyaluronidase glycoprotein (sHASEGP), process for preparing the same, uses and pharmaceutical compositions comprising thereof |
US20060104968A1 (en) * | 2003-03-05 | 2006-05-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases |
CA2529945A1 (en) * | 2003-06-27 | 2005-01-06 | Biogen Idec Ma Inc. | Use of hydrophobic-interaction-chromatography or hinge-region modifications for the production of homogeneous antibody-solutions |
US7482376B2 (en) * | 2003-07-03 | 2009-01-27 | 3-Dimensional Pharmaceuticals, Inc. | Conjugated complement cascade inhibitors |
GB0316294D0 (en) | 2003-07-11 | 2003-08-13 | Polytherics Ltd | Conjugated biological molecules and their preparation |
EP1663188B1 (en) * | 2003-09-12 | 2016-08-10 | Newron Sweden AB | Treatment of disorders of the nervous system |
CA2543484C (en) | 2003-10-27 | 2014-02-04 | Amgen Inc. | Modulation of immune response to an immunogen with ctla-4 and tnfbp |
US7790835B2 (en) | 2003-12-03 | 2010-09-07 | Nektar Therapeutics | Method of preparing maleimide functionalized polymers |
US20070105770A1 (en) * | 2004-01-21 | 2007-05-10 | Novo Nordisk A/S | Transglutaminase mediated conjugation of peptides |
US20080131978A1 (en) * | 2004-02-03 | 2008-06-05 | Asahi Kasei Kabushiki Kaisha | Method of Detecting Analyte Using Magnetic Beads |
EP2287310B1 (en) | 2004-07-22 | 2015-05-06 | Five Prime Therapeutics, Inc. | Compositions and methods using MGD-CSF in disease treatment |
US20060039949A1 (en) * | 2004-08-20 | 2006-02-23 | Nycz Jeffrey H | Acetabular cup with controlled release of an osteoinductive formulation |
US20060045902A1 (en) * | 2004-09-01 | 2006-03-02 | Serbousek Jon C | Polymeric wrap for in vivo delivery of osteoinductive formulations |
US20060057184A1 (en) * | 2004-09-16 | 2006-03-16 | Nycz Jeffrey H | Process to treat avascular necrosis (AVN) with osteoinductive materials |
JP2008521870A (ja) * | 2004-12-02 | 2008-06-26 | ドマンティス リミテッド | 抗il−1r1単一ドメイン抗体および治療使用 |
WO2006074399A2 (en) * | 2005-01-05 | 2006-07-13 | Biogen Idec Ma Inc. | Multispecific binding molecules comprising connecting peptides |
DE602006017071D1 (de) | 2005-01-25 | 2010-11-04 | Five Prime Therapeutics Inc | Zusammensetzungen und verfahren zur behandlung von herzkrankheiten |
US7402730B1 (en) | 2005-02-03 | 2008-07-22 | Lexicon Pharmaceuticals, Inc. | Knockout animals manifesting hyperlipidemia |
US7833979B2 (en) * | 2005-04-22 | 2010-11-16 | Amgen Inc. | Toxin peptide therapeutic agents |
US9119901B2 (en) | 2005-04-28 | 2015-09-01 | Warsaw Orthopedic, Inc. | Surface treatments for promoting selective tissue attachment to medical impants |
US8414907B2 (en) | 2005-04-28 | 2013-04-09 | Warsaw Orthopedic, Inc. | Coatings on medical implants to guide soft tissue healing |
ES2336832T3 (es) | 2005-07-22 | 2010-04-16 | Five Prime Therapeutics, Inc. | Composiciones y procedimientos para tratar enfermedades con proteinas de fusion de fgfr. |
US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
EP1928906A2 (en) * | 2005-08-30 | 2008-06-11 | Novo Nordisk Health Care AG | Liquid formulations of pegylated growth hormone |
KR101561760B1 (ko) | 2005-11-22 | 2015-10-20 | 콘드롤드 케미컬즈, 인크. | 옥시코돈 및 다른 조성물에서 오염물질인 마이클 수용체 수준을 감소시키는 방법 |
JP2009517069A (ja) * | 2005-12-01 | 2009-04-30 | ドマンティス リミテッド | インターロイキン1受容体1型に結合する競合ドメイン抗体フォーマット |
US20070179615A1 (en) * | 2006-01-31 | 2007-08-02 | Sdgi Holdings, Inc. | Intervertebral prosthetic disc |
US20070179618A1 (en) * | 2006-01-31 | 2007-08-02 | Sdgi Holdings, Inc. | Intervertebral prosthetic disc |
TW200745163A (en) | 2006-02-17 | 2007-12-16 | Syntonix Pharmaceuticals Inc | Peptides that block the binding of IgG to FcRn |
TWI428448B (zh) | 2006-03-24 | 2014-03-01 | Syntonix Pharmaceuticals Inc | 作為第九因子(factor ix)原肽處理酶之pc5 |
EP2040757A2 (en) * | 2006-07-07 | 2009-04-01 | Novo Nordisk Health Care AG | New protein conjugates and methods for their preparation |
US7767206B2 (en) | 2006-10-02 | 2010-08-03 | Amgen Inc. | Neutralizing determinants of IL-17 Receptor A and antibodies that bind thereto |
WO2008051383A2 (en) * | 2006-10-19 | 2008-05-02 | Amgen Inc. | Use of alcohol co-solvents to improve pegylation reaction yields |
AR063384A1 (es) * | 2006-10-25 | 2009-01-28 | Amgen Inc | Agentes terapeuticos a base de peptidos derivados de toxinas |
DK2121751T3 (en) | 2006-12-08 | 2017-04-24 | Lexicon Pharmaceuticals Inc | Monoclonal antibodies to ANGPTL3 |
US8685417B2 (en) | 2006-12-20 | 2014-04-01 | Arkema, Inc. | Polymer encapsulation and/or binding |
US7943728B2 (en) | 2006-12-26 | 2011-05-17 | National Cheng Kung University | Disintegrin variants and their use in treating osteoporosis-induced bone loss and angiogenesis-related diseases |
US8183201B2 (en) | 2006-12-26 | 2012-05-22 | National Cheng Kung University | Methods of treating αvβ3 integrin-associated diseases by administering polypeptides selective for αvβ3 integrin |
US8088887B2 (en) | 2007-02-13 | 2012-01-03 | Academia Sinica | Peptide-conjugates that bind to VEGF-stimulated or tumor vasculature and methods of treatment |
US8415453B2 (en) | 2007-02-13 | 2013-04-09 | Academia Sinica | Lung cancer-targeted peptides and applications thereof |
GB0708376D0 (en) | 2007-05-01 | 2007-06-06 | Alligator Bioscience Ab | Novel polypeptides and uses thereof |
EP2162540A2 (en) | 2007-05-22 | 2010-03-17 | Amgen Inc. | Compositions and methods for producing bioactive fusion proteins |
EA201070231A1 (ru) | 2007-08-09 | 2010-10-29 | Синтоникс Фармасьютикалз, Инк. | Иммуномодулирующие пептиды |
EP2192924B1 (en) * | 2007-08-20 | 2017-10-11 | Protalix Ltd. | Saccharide-containing protein conjugates and uses thereof |
DK2209494T3 (en) * | 2007-10-09 | 2016-10-03 | Polytherics Ltd | New conjugated proteins and peptides |
US8541543B2 (en) | 2007-11-20 | 2013-09-24 | Academia Sinica | Peptides specific for hepatocellular carcinoma cells and applications thereof |
US20110124841A1 (en) * | 2007-12-13 | 2011-05-26 | Monthony James F | Polypeptides Modified by Protein Trans-Splicing Technology |
EP2910932B1 (en) * | 2008-01-18 | 2018-10-31 | Ffa Sciences, Llc | Development and use of cysteine-labeled fluorescent probes of unbound analytes |
TWI489994B (zh) * | 2008-03-17 | 2015-07-01 | Baxter Healthcare Sa | 供免疫球蛋白及玻尿酸酶之皮下投藥之用的組合及方法 |
KR101647932B1 (ko) | 2008-04-14 | 2016-08-11 | 할로자임, 아이엔씨 | 히알루로난 관련 질환 및 상태 치료용 변형된 히알루로니다제 및 그 용도 |
TWI394580B (zh) | 2008-04-28 | 2013-05-01 | Halozyme Inc | 超快起作用胰島素組成物 |
US20090281054A1 (en) * | 2008-05-06 | 2009-11-12 | Venkata Reddy | Compositions and methods comprising capuramycin analogues |
EP2326349B1 (en) | 2008-07-21 | 2015-02-25 | Polytherics Limited | Novel reagents and method for conjugating biological molecules |
EP2161031A1 (en) * | 2008-09-05 | 2010-03-10 | SuppreMol GmbH | Fc gamma receptor for the treatment of B cell mediated multiple sclerosis |
CA2742710A1 (en) * | 2008-11-04 | 2010-05-14 | Janssen Pharmaceutica Nv | Crhr2 peptide agonists and uses thereof |
PT3037529T (pt) | 2008-12-09 | 2019-05-31 | Halozyme Inc | Polipéptidos ph20 estendidos solúveis e suas utilizações |
WO2010112034A2 (en) | 2009-04-02 | 2010-10-07 | Aarhus Universitet | Compositions and methods for treatment and diagnosis of synucleinopathies |
CA2766634A1 (en) | 2009-06-22 | 2011-01-13 | Burnham Institute For Medical Research | Methods and compositions using peptides and proteins with c-terminal elements |
US20110097302A1 (en) * | 2009-07-16 | 2011-04-28 | Ta Tung Yuan | Il-1ra-polymer conjugates |
AU2010290077C1 (en) | 2009-08-24 | 2015-12-03 | Bioverativ Therapeutics Inc. | Coagulation factor IX compositions and methods of making and using same |
DK2477603T3 (en) * | 2009-09-17 | 2016-06-13 | Baxalta Inc | STABLE CO-DEVELOPMENT OF hyaluronidase and Immunoglobulin, AND METHODS OF USE THEREOF |
TW201117824A (en) | 2009-10-12 | 2011-06-01 | Amgen Inc | Use of IL-17 receptor a antigen binding proteins |
JP2013510167A (ja) | 2009-11-04 | 2013-03-21 | ヤンセン ファーマシューティカ エヌ.ベー. | ストレスコピン様ペプチドによる心不全の治療方法 |
US9194011B2 (en) | 2009-11-17 | 2015-11-24 | Protalix Ltd. | Stabilized alpha-galactosidase and uses thereof |
RU2012131251A (ru) | 2009-12-23 | 2014-01-27 | Нэйшнл Ченг Кунг Юниверсити | Композиции и способы для лечения связанных с ангиогенезом заболеваний глаз |
EP2523730A4 (en) * | 2010-01-14 | 2013-10-23 | Ngm Biopharmaceuticals Inc | METHOD FOR THE TREATMENT OF GLUCOSE TISSUE CHANGES |
LT2523688T (lt) | 2010-01-15 | 2018-03-12 | Kirin-Amgen, Inc. | Antikūno kompozicija ir terapiniai režimai |
GB201105584D0 (en) | 2011-04-01 | 2011-05-18 | Imp Innovations Ltd | Cancer methods |
WO2012006027A1 (en) | 2010-06-28 | 2012-01-12 | Five Prime Therapeutics, Inc. | Fzd8 extracellular domains and fzd8 extracellular domain fusion molecules and treatments using same |
WO2012006623A1 (en) | 2010-07-09 | 2012-01-12 | Biogen Idec Hemophilia Inc. | Systems for factor viii processing and methods thereof |
EA201390722A1 (ru) | 2010-11-15 | 2013-11-29 | Файв Прайм Терапьютикс, Инк. | Лечение рака повышенными дозами растворимых белков слияния fgfr1 |
MX357166B (es) | 2010-11-24 | 2018-06-28 | Lexicon Pharmaceuticals Inc | Anticuerpos que se unen a notum pectinacetilesterasa. |
EP2663578A2 (en) | 2011-01-14 | 2013-11-20 | Five Prime Therapeutics, Inc. | Il-27 antagonists for treating inflammatory diseases |
EP2665814B1 (en) | 2011-01-20 | 2017-05-17 | Protalix Ltd. | Nucleic acid construct for expression of alpha-galactosidase in plants and plant cells |
WO2012118778A1 (en) | 2011-02-28 | 2012-09-07 | Sanford-Burnham Medical Research Institute | Truncated car peptides and methods and compositions using truncated car peptides |
EP2686340A2 (en) | 2011-03-16 | 2014-01-22 | Amgen Inc. | Potent and selective inhibitors of nav1.3 and nav1.7 |
AU2012240395B2 (en) | 2011-04-06 | 2016-02-04 | The Board Of Regents Of The University Of Texas System | Modulating bacterial MAM polypeptides in pathogenic disease |
WO2012166585A2 (en) | 2011-05-31 | 2012-12-06 | Airware, Inc. | Re-calibration of ab ndir gas sensors |
TWI687226B (zh) | 2011-07-08 | 2020-03-11 | 美商百歐維拉提夫治療公司 | 因子viii嵌合及雜交多肽,及其使用方法 |
KR102042982B1 (ko) | 2011-07-22 | 2019-11-11 | 체에스엘 베링 게엠베하 | 억제성 항-xii/xiia 인자 모노클로날 항체 및 이들의 사용 |
US20140234330A1 (en) | 2011-07-22 | 2014-08-21 | Amgen Inc. | Il-17 receptor a is required for il-17c biology |
US20130101664A1 (en) | 2011-08-18 | 2013-04-25 | Donald W. Kufe | Muc1 ligand traps for use in treating cancers |
US10179801B2 (en) | 2011-08-26 | 2019-01-15 | Sanford-Burnham Medical Research Institute | Truncated LYP-1 peptides and methods and compositions using truncated LYP-1 peptides |
US9243037B2 (en) | 2011-11-10 | 2016-01-26 | Trustees Of Boston College | Gramicidin a mutants that function as antibiotics with improved solubility and reduced toxicity |
KR20140100543A (ko) | 2011-11-29 | 2014-08-14 | 뉴로페이지 파마슈티컬즈, 인크. | 박테리오파아지 유전자 3 단백질 조성물 및 아밀로이드 결합제로서의 용도 |
KR101855242B1 (ko) | 2012-01-26 | 2018-05-09 | 크리스토퍼 제이. 소레스 | 펩타이드 호르몬의 칼시토닌 cgrp 패밀리의 펩타이드 길항제 및 그의 용도 |
EP2623110A1 (en) | 2012-01-31 | 2013-08-07 | CSL Behring GmbH | Factor XII inhibitors for the treatment of neurological inflammatory disorders |
CA2864126A1 (en) | 2012-02-15 | 2013-08-22 | Biogen Idec Ma Inc. | Recombinant factor viii proteins |
WO2013122617A1 (en) | 2012-02-15 | 2013-08-22 | Amunix Operating Inc. | Factor viii compositions and methods of making and using same |
WO2014008480A2 (en) | 2012-07-06 | 2014-01-09 | Biogen Idec Ma Inc. | Cell line expressing single chain factor viii polypeptides and uses thereof |
ES2641373T3 (es) | 2012-10-02 | 2017-11-08 | Proclara Biosciences, Inc. | Uso de P3 de proteínas de fusión de bacteriófagos como agentes de unión amiloides |
WO2014063108A1 (en) | 2012-10-18 | 2014-04-24 | Biogen Idec Ma Inc. | Methods of using a fixed dose of a clotting factor |
EP2914293A4 (en) | 2012-10-30 | 2016-04-20 | Biogen Ma Inc | METHOD OF USE OF FVIII POLYPEPTIDE |
US9383357B2 (en) | 2012-12-07 | 2016-07-05 | Northwestern University | Biomarker for replicative senescence |
EP2935311B1 (en) | 2012-12-20 | 2021-03-31 | Amgen Inc. | Apj receptor agonists and uses thereof |
EP2964255B1 (en) | 2013-03-08 | 2020-11-04 | CSL Behring GmbH | Treatment and prevention of remote ischemia-reperfusion injury |
US9789156B2 (en) | 2013-03-11 | 2017-10-17 | Dana-Farber Cancer Institute, Inc. | Combination anti-human epidermal growth factor receptor 2 (anti-HER2) cancer therapy using mucin 1 (MUC1) peptides and hemotherapeutics |
US10344060B2 (en) | 2013-03-12 | 2019-07-09 | Amgen Inc. | Potent and selective inhibitors of Nav1.7 |
CA2899737A1 (en) | 2013-03-15 | 2014-09-18 | Biogen Ma Inc. | Factor viii polypeptide formulations |
CA2899089C (en) | 2013-03-15 | 2021-10-26 | Biogen Ma Inc. | Factor ix polypeptide formulations |
MX2015015115A (es) | 2013-05-01 | 2016-06-07 | Five Prime Therapeutics Inc | Metodos de tratamiento de cancer. |
WO2014190147A2 (en) | 2013-05-23 | 2014-11-27 | Five Prime Therapeutics, Inc. | Methods of treating cancer |
EP3003349B1 (en) | 2013-05-28 | 2018-12-12 | Proclara Biosciences, Inc. | Polypeptides comprising a modified bacteriophage g3p amino acid sequence with reduced immunogenicity |
US20160166660A1 (en) | 2013-06-28 | 2016-06-16 | Csl Behring Gmbh | Combination therapy using a factor xii inhibitor and a c-1 inhibitor |
US10548953B2 (en) | 2013-08-14 | 2020-02-04 | Bioverativ Therapeutics Inc. | Factor VIII-XTEN fusions and uses thereof |
EP3033098B1 (en) | 2013-08-14 | 2022-06-22 | Bioverativ Therapeutics Inc. | Recombinant factor viii proteins |
EP3082848B1 (en) | 2013-12-06 | 2023-10-18 | Bioverativ Therapeutics Inc. | Population pharmacokinetics tools and uses thereof |
AU2015236340B2 (en) | 2014-03-24 | 2020-02-06 | Bioverativ Therapeutics Inc. | Lyophilized factor IX formulations |
KR102530900B1 (ko) | 2014-03-31 | 2023-05-12 | 암젠 케이-에이, 인크. | 손발톱 및 두피 건선의 치료 방법 |
WO2015191781A2 (en) | 2014-06-10 | 2015-12-17 | Amgen Inc. | Apelin polypeptides |
KR102513050B1 (ko) | 2014-06-18 | 2023-03-29 | 체에스엘 베링 게엠베하 | 신경외상성 장애에서의 인자 xii 억제제를 이용한 치료요법 |
MA40835A (fr) | 2014-10-23 | 2017-08-29 | Biogen Ma Inc | Anticorps anti-gpiib/iiia et leurs utilisations |
MA40861A (fr) | 2014-10-31 | 2017-09-05 | Biogen Ma Inc | Anticorps anti-glycoprotéines iib/iiia |
AU2015358504A1 (en) | 2014-12-03 | 2017-06-29 | Proclara Biosciences, Inc. | Polypeptides comprising a modified bacteriophage g3p amino acid sequence lacking a glycosylation signal |
CN108472337B (zh) | 2015-08-03 | 2022-11-25 | 比奥贝拉蒂治疗公司 | 因子ix融合蛋白以及其制备和使用方法 |
US20170157215A1 (en) | 2015-12-04 | 2017-06-08 | Jomoco, Corp. | Compositions and methods to mitigate or prevent an immune response to an immunogenic therapeutic molecule in non-human primates |
US11020160B2 (en) | 2016-03-21 | 2021-06-01 | Warsaw Orthopedic, Inc. | Surgical injection system and method |
MA45473A (fr) | 2016-04-04 | 2019-02-13 | Shire Human Genetic Therapies | Inhibiteur de c1 estérase conjugué et ses utilisations |
CA3019851A1 (en) | 2016-04-06 | 2017-10-12 | Csl Limited | Method of treating atherosclerosis |
US10709814B2 (en) | 2016-04-22 | 2020-07-14 | Warsaw Orthopedic, Inc. | Osteoimplant comprising an insoluble fibrous polymer |
US10799559B2 (en) | 2016-04-25 | 2020-10-13 | Five Prime Therapeutics, Inc. | NOPE for treatment of pathological muscle loss and weakness |
KR102657418B1 (ko) | 2016-09-02 | 2024-04-15 | 크리스토퍼 제이 소레스 | 신경 보호 및 신경 질환에서의 cgrp 수용체 길항제의 용도 |
BR112019011115A2 (pt) | 2016-12-02 | 2019-10-01 | Bioverativ Therapeutics Inc | métodos para tratar artropatia hemofílica usando fatores de coagulação quiméricos |
KR20190091292A (ko) | 2016-12-02 | 2019-08-05 | 바이오버라티브 테라퓨틱스 인크. | 응고 인자에 대한 면역 내성 유도 방법 |
EP3576762A1 (en) | 2017-01-31 | 2019-12-11 | Bioverativ Therapeutics Inc. | Factor ix fusion proteins and methods of making and using same |
US10294264B2 (en) | 2017-04-21 | 2019-05-21 | Warsaw Orthopedic, Inc. | Oxysterol-therapeutic agent derivative for bone healing |
US20210238238A1 (en) | 2018-05-16 | 2021-08-05 | Csl Limited | Soluble complement receptor type i variants and uses thereof |
EP3793588A1 (en) | 2018-05-18 | 2021-03-24 | Bioverativ Therapeutics Inc. | Methods of treating hemophilia a |
US20210236599A1 (en) | 2018-08-13 | 2021-08-05 | Iltoo Pharma | Combination of interleukin-2 with an interleukin 1 inhibitor, conjugates and therapeutic uses thereof |
WO2023222565A1 (en) | 2022-05-16 | 2023-11-23 | Institut National de la Santé et de la Recherche Médicale | Methods for assessing the exhaustion of hematopoietic stems cells induced by chronic inflammation |
Family Cites Families (89)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
IN150740B (fi) | 1978-11-24 | 1982-12-04 | Hoffmann La Roche | |
US4760067A (en) * | 1979-08-15 | 1988-07-26 | Merck & Co., Inc. | Allylsulfoxide enzyme inhibitors |
DE3175151D1 (en) | 1980-05-21 | 1986-09-25 | Teijin Ltd | Reactive polymer and process for the preparation thereof |
US4560649A (en) | 1981-10-15 | 1985-12-24 | Cornell Research Foundation | Assaying for hLH or hCG with immobilized hormone receptors |
JPH0751511B2 (ja) | 1982-03-15 | 1995-06-05 | 味の素株式会社 | インターロイキン2を含有してなる癌治療剤 |
ATE37983T1 (de) | 1982-04-22 | 1988-11-15 | Ici Plc | Mittel mit verzoegerter freigabe. |
US4587046A (en) | 1982-05-18 | 1986-05-06 | The Regents Of The University Of California | Drug-carrier conjugates |
EP0098110B1 (en) | 1982-06-24 | 1989-10-18 | NIHON CHEMICAL RESEARCH KABUSHIKI KAISHA also known as JAPAN CHEMICAL RESEARCH CO., LTD | Long-acting composition |
US4966888A (en) | 1985-07-08 | 1990-10-30 | Cornell Research Foundation, Inc. | hCG-hLH receptor and hCG-hLH receptor-hCG complex as antigens, antibodies thereto and contraceptive vaccine |
US4522750A (en) | 1984-02-21 | 1985-06-11 | Eli Lilly And Company | Cytotoxic compositions of transferrin coupled to vinca alkaloids |
DE3572982D1 (en) | 1984-03-06 | 1989-10-19 | Takeda Chemical Industries Ltd | Chemically modified lymphokine and production thereof |
SE470099B (sv) | 1984-05-17 | 1993-11-08 | Jerker Porath | Sulfonaktiverade tioeteradsorbenter för separation av t ex protein |
US4578335A (en) | 1984-05-21 | 1986-03-25 | Immunex Corporation | Interleukin 2 receptor |
CA1283661C (en) | 1984-06-20 | 1991-04-30 | Franz Jansen | Imidazolides, process for their preparation and application as intermediates for the synthesis of cytotoxic conjugates |
US4675285A (en) | 1984-09-19 | 1987-06-23 | Genetics Institute, Inc. | Method for identification and isolation of DNA encoding a desired protein |
SE454885B (sv) | 1984-10-19 | 1988-06-06 | Exploaterings Ab Tbf | Polymerbelagda partiklar med immobiliserade metalljoner pa sin yta jemte forfarande for framstellning derav |
US4959314A (en) | 1984-11-09 | 1990-09-25 | Cetus Corporation | Cysteine-depleted muteins of biologically active proteins |
DE3675588D1 (de) | 1985-06-19 | 1990-12-20 | Ajinomoto Kk | Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist. |
DE3676670D1 (de) | 1985-06-26 | 1991-02-07 | Cetus Corp | Solubilisierung von proteinen fuer pharmazeutische zusammensetzungen mittels polymerkonjugierung. |
US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
US4917888A (en) | 1985-06-26 | 1990-04-17 | Cetus Corporation | Solubilization of immunotoxins for pharmaceutical compositions using polymer conjugation |
US4935233A (en) | 1985-12-02 | 1990-06-19 | G. D. Searle And Company | Covalently linked polypeptide cell modulators |
JPS62185029A (ja) | 1986-02-07 | 1987-08-13 | Ajinomoto Co Inc | 修飾インタ−ロイキン−2 |
CA1283046C (en) | 1986-05-29 | 1991-04-16 | Nandini Katre | Tumor necrosis factor formulation |
US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
IN165717B (fi) | 1986-08-07 | 1989-12-23 | Battelle Memorial Institute | |
US4931544A (en) | 1986-09-04 | 1990-06-05 | Cetus Corporation | Succinylated interleukin-2 for pharmaceutical compositions |
IL80005A (en) | 1986-09-10 | 1992-11-15 | Yeda Res & Dev | Compositions for modulating the effect of tnf and il-1 |
US4965271A (en) | 1986-12-31 | 1990-10-23 | Hoechst Roussel Pharmaceuticals, Inc. | Method of inhibiting the activity of leukocyte derived cytokines |
DE3855747T2 (de) | 1987-08-26 | 1997-06-12 | Biogen Inc | Biologische materialien, deren herstellung und verwendung in der therapie |
US5359032A (en) | 1987-08-26 | 1994-10-25 | Biogen Inc. | Interkeukin-1 inhibitor |
US5512544A (en) | 1987-09-13 | 1996-04-30 | Yeda Research And Development Co. Ltd. | Pharmaceutical compositions comprising an anticytokine |
IL98078A0 (en) | 1991-05-07 | 1992-06-21 | Yeda Res & Dev | Pharmaceutical compositions comprising an anticytokyne |
IL83878A (en) | 1987-09-13 | 1995-07-31 | Yeda Res & Dev | Soluble protein corresponding to tnf inhibitory protein its preparation and pharmaceutical compositions containing it |
IL90339A (en) | 1989-05-18 | 1996-10-16 | Yeda Res & Dev | Anti-cytotoxic protein and its purification |
US4904584A (en) | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
US5153265A (en) | 1988-01-20 | 1992-10-06 | Cetus Corporation | Conjugation of polymer to colony stimulating factor-1 |
US4847325A (en) | 1988-01-20 | 1989-07-11 | Cetus Corporation | Conjugation of polymer to colony stimulating factor-1 |
GB8806339D0 (en) | 1988-03-17 | 1988-04-13 | Hoffmann La Roche | Monoclonal antibodies |
GB8807803D0 (en) | 1988-03-31 | 1988-05-05 | Glaxo Group Ltd | Biochemical product |
IL89790A (en) | 1988-04-01 | 2002-05-23 | Johns Hopking University | Sequences of nucleic acids encoding and cells producing CR1 protein and methods for its production and purification |
US5214131A (en) | 1988-05-06 | 1993-05-25 | Sumitomo Pharmaceuticals Company, Limited | Polyethylene glycol derivatives, modified peptides and production thereof |
US5075222A (en) * | 1988-05-27 | 1991-12-24 | Synergen, Inc. | Interleukin-1 inhibitors |
KR0148009B1 (ko) | 1988-05-27 | 1998-08-01 | 그래고리 비. 아보트 | 인터루킨-1 억제제 |
JPH0240399A (ja) | 1988-07-27 | 1990-02-09 | Takeda Chem Ind Ltd | 線維芽細胞増殖因子ムテインの複合体あるいは組成物 |
US5359037A (en) | 1988-09-12 | 1994-10-25 | Yeda Research And Development Co. Ltd. | Antibodies to TNF binding protein I |
IL94039A (en) | 1989-08-06 | 2006-09-05 | Yeda Res & Dev | Antibodies to tbp - 1 and their use |
US5811261A (en) | 1988-09-12 | 1998-09-22 | Yeda Research And Development Co. Ltd. | Expression of the recombinant tumor necrosis factor binding protein I (TBP-I) |
GB8824592D0 (en) | 1988-10-20 | 1988-11-23 | Royal Free Hosp School Med | Purification process |
GB8824869D0 (en) | 1988-10-24 | 1988-11-30 | Stevenson G T | Synthetic antibody |
US5681566A (en) | 1988-10-24 | 1997-10-28 | 3I Research Exploitation Limited | Antibody conjugates with two or more covalently linked FC regions |
US5162430A (en) | 1988-11-21 | 1992-11-10 | Collagen Corporation | Collagen-polymer conjugates |
AU4660789A (en) | 1988-11-23 | 1990-06-12 | Genentech Inc. | Polypeptide derivatives |
US5093475A (en) | 1988-12-22 | 1992-03-03 | Xoma Corporation | Hindered linking agents derived from 2-iminothiolanes and methods |
US4902502A (en) | 1989-01-23 | 1990-02-20 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
US5089261A (en) | 1989-01-23 | 1992-02-18 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
CA2011450C (en) | 1989-03-07 | 2002-06-04 | Tadatsugu Taniguchi | Recombinant b-chain of the il-2 receptor |
EP0386289A1 (en) | 1989-03-07 | 1990-09-12 | Taniguchi, Tadatsugu, Dr. | Recombinant interleukin-2 receptor |
US5122614A (en) | 1989-04-19 | 1992-06-16 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
ES2238070T3 (es) | 1989-04-21 | 2005-08-16 | Amgen Inc. | Receptor del tnf, proteina ligante del tnf y adn codante para estos. |
US5166322A (en) * | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
DE3922089A1 (de) | 1989-05-09 | 1990-12-13 | Basf Ag | Neue proteine und ihre herstellung |
CA2017025C (en) | 1989-05-18 | 2008-07-22 | David Wallach | Tumor necrosis factor binding protein ii, its purification and antibodies thereto |
IL95031A (en) | 1989-07-18 | 2007-03-08 | Amgen Inc | A method of producing a recombinant human necrotic factor absorber |
AU630497B2 (en) | 1989-09-05 | 1992-10-29 | Immunex Corporation | Tumor necrosis factor-alpha and -beta receptors |
NZ235148A (en) | 1989-09-05 | 1991-12-23 | Immunex Corp | Tumour necrosis factor receptor protein and dna sequences |
US5395760A (en) | 1989-09-05 | 1995-03-07 | Immunex Corporation | DNA encoding tumor necrosis factor-α and -β receptors |
US5605690A (en) | 1989-09-05 | 1997-02-25 | Immunex Corporation | Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor |
DE10399023I2 (de) | 1989-09-12 | 2006-11-23 | Ahp Mfg B V | TFN-bindende Proteine |
DK0502956T3 (da) | 1989-11-29 | 1997-10-20 | Amgen Boulder Inc | Fremstilling af en rekombinant human interleukin-1-inhibitor. |
EP0433900B1 (en) | 1989-12-13 | 1995-09-20 | Yeda Research And Development Company Limited | Expression of the recombinant tumor necrosis factor binding protein I (TBP-I) |
US5136021A (en) | 1990-02-27 | 1992-08-04 | Health Research, Inc. | TNF-inhibitory protein and a method of production |
US5171264A (en) | 1990-02-28 | 1992-12-15 | Massachusetts Institute Of Technology | Immobilized polyethylene oxide star molecules for bioapplications |
AU649245B2 (en) | 1990-04-02 | 1994-05-19 | Amgen, Inc. | Methods for treating interleukin-1 mediated diseases |
GB2246569A (en) | 1990-06-15 | 1992-02-05 | Charing Cross Sunley Research | Tumour necrosis factor - alpha binding protein |
GB9022648D0 (en) | 1990-10-18 | 1990-11-28 | Charing Cross Sunley Research | Polypeptide and its use |
US5252714A (en) | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
EP0575545B1 (en) | 1991-03-15 | 2003-05-21 | Amgen Inc. | Pegylation of polypeptides |
DE69213240T2 (de) * | 1991-07-04 | 1997-04-24 | Immunodex K S | Wasserlösliche reagenzien und konjugate auf polymerbasis, die vom divinylsulfon abgeleitete reste enthalten |
IL99120A0 (en) | 1991-08-07 | 1992-07-15 | Yeda Res & Dev | Multimers of the soluble forms of tnf receptors,their preparation and pharmaceutical compositions containing them |
US5569779A (en) * | 1991-12-23 | 1996-10-29 | Albemarle Corporation | Polyfunctional michael addition products |
US5382657A (en) | 1992-08-26 | 1995-01-17 | Hoffmann-La Roche Inc. | Peg-interferon conjugates |
EP0622394A1 (en) | 1993-04-30 | 1994-11-02 | S.A. Laboratoires S.M.B. | Reversible modification of sulfur-containing molecules with polyalkylene glycol derivatives and their use |
EP0710121B1 (en) | 1993-07-30 | 2000-10-11 | Kennedy Institute Of Rheumatology | Method for treating multiple sclerosis |
GB9317618D0 (en) * | 1993-08-24 | 1993-10-06 | Royal Free Hosp School Med | Polymer modifications |
US5446090A (en) * | 1993-11-12 | 1995-08-29 | Shearwater Polymers, Inc. | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
US5747639A (en) | 1996-03-06 | 1998-05-05 | Amgen Boulder Inc. | Use of hydrophobic interaction chromatography to purify polyethylene glycols |
-
1994
- 1994-06-14 US US08/259,413 patent/US6552170B1/en not_active Expired - Fee Related
-
1995
- 1995-06-14 BR BR9507999A patent/BR9507999A/pt unknown
- 1995-06-14 PL PL95317894A patent/PL317894A1/xx unknown
- 1995-06-14 CZ CZ963576A patent/CZ357696A3/cs unknown
- 1995-06-14 AU AU28286/95A patent/AU2828695A/en not_active Abandoned
- 1995-06-14 CA CA002191971A patent/CA2191971C/en not_active Expired - Fee Related
- 1995-06-14 HU HU9603442A patent/HUT77529A/hu unknown
- 1995-06-14 EE EE9600182A patent/EE9600182A/xx unknown
- 1995-06-14 CN CN95194463A patent/CN1158089A/zh active Pending
- 1995-06-14 EP EP95923865A patent/EP0758906A1/en not_active Withdrawn
- 1995-06-14 SK SK1595-96A patent/SK159596A3/sk unknown
- 1995-06-14 WO PCT/US1995/007555 patent/WO1995034326A1/en not_active Application Discontinuation
-
1996
- 1996-12-12 NO NO965342A patent/NO965342L/no unknown
- 1996-12-12 FI FI964985A patent/FI964985A/fi not_active Application Discontinuation
- 1996-12-30 BG BG101095A patent/BG101095A/xx unknown
-
2003
- 2003-03-27 US US10/401,634 patent/US20030190304A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
PL317894A1 (en) | 1997-04-28 |
AU2828695A (en) | 1996-01-05 |
CN1158089A (zh) | 1997-08-27 |
BR9507999A (pt) | 1997-08-12 |
HUT77529A (hu) | 1998-05-28 |
EP0758906A1 (en) | 1997-02-26 |
HU9603442D0 (en) | 1997-02-28 |
BG101095A (en) | 1997-09-30 |
CA2191971A1 (en) | 1995-12-21 |
US20030190304A1 (en) | 2003-10-09 |
EE9600182A (et) | 1998-02-16 |
FI964985A0 (fi) | 1996-12-12 |
CA2191971C (en) | 2002-03-05 |
CZ357696A3 (en) | 1997-03-12 |
NO965342L (no) | 1997-02-14 |
FI964985A (fi) | 1996-12-16 |
US6552170B1 (en) | 2003-04-22 |
NO965342D0 (no) | 1996-12-12 |
WO1995034326A1 (en) | 1995-12-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SK159596A3 (en) | Pegylation reagents and compounds formed therewith | |
JP5334347B2 (ja) | 化学的に修飾した新規なエリスロポエチン刺激タンパク質組成物および方法 | |
US7662933B2 (en) | N-terminally chemically modified protein compositions and methods | |
EP2935311B1 (en) | Apj receptor agonists and uses thereof | |
CA2345027C (en) | Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility | |
JP4574007B2 (ja) | ポリオール−ifn−ベータ複体 | |
KR101304157B1 (ko) | 분해가능한 결합을 갖는 컨주게이트 및 이러한 컨주게이트제조에 유용한 고분자 시약 | |
NL1032282C2 (nl) | N-terminaal monogepegyleerde conjugaten van humaan groeihormoon en werkwijze voor de bereiding daarvan. | |
US20040147431A1 (en) | Erythropoietin composition | |
JP2006321808A (ja) | 化学的に修飾されたヒト成長ホルモンコンジュゲート | |
AU2001255256A1 (en) | Chemically modified novel erythropoietin stimulating protein compositions and methods | |
EP1234583A1 (en) | PEG-conjugates of HGF-NK4 | |
PT2234645E (pt) | Formulações de peg-interferão-beta | |
US6956027B2 (en) | N-terminally chemically modified protein compositions and methods | |
JP2007530569A (ja) | 化学修飾タンパク質組成物及び方法 | |
MXPA00010223A (en) | Polyol-ifn-beta conjugates | |
PT89861B (pt) | Processo para a conjugacao de polimeros com factor estimulador de colonias-1 |