NO965342L - PEGyleringsreagenser og forbindelser dannet ved anvendelse av slike - Google Patents
PEGyleringsreagenser og forbindelser dannet ved anvendelse av slikeInfo
- Publication number
- NO965342L NO965342L NO965342A NO965342A NO965342L NO 965342 L NO965342 L NO 965342L NO 965342 A NO965342 A NO 965342A NO 965342 A NO965342 A NO 965342A NO 965342 L NO965342 L NO 965342L
- Authority
- NO
- Norway
- Prior art keywords
- biologically active
- compounds
- compounds formed
- peptide polymer
- conjugates
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Polyethers (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Biologisk aktive konjugater som er dannet ved omsetning av en tiol- komponent av et biologisk aktivt molekyl med en ikke-peptid-polymer med en aktiv sulfonkomponent. Forbindelser med formel Rj-X-Rj, hvori minst én R^ ogRj er et biologisk aktivt molekyl med en reaktiv tiolkomponent som danner en kovalent binding med X, en Michael- akseptoraktivert ikke-peptid-polymer, er også beskrevet. Fremgangsmåte for fremstilling av konjugatene og forbind- elsene, så vel som farmasøytiske preparater inneholdende disse er også beskrevet. Aktiverte polymerer egnede for binding til mange forskjellige molekyler og overflater er også beskrevet .
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/259,413 US6552170B1 (en) | 1990-04-06 | 1994-06-14 | PEGylation reagents and compounds formed therewith |
PCT/US1995/007555 WO1995034326A1 (en) | 1994-06-14 | 1995-06-14 | Pegylation reagents and compounds formed therewith |
Publications (2)
Publication Number | Publication Date |
---|---|
NO965342D0 NO965342D0 (no) | 1996-12-12 |
NO965342L true NO965342L (no) | 1997-02-14 |
Family
ID=22984842
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO965342A NO965342L (no) | 1994-06-14 | 1996-12-12 | PEGyleringsreagenser og forbindelser dannet ved anvendelse av slike |
Country Status (15)
Country | Link |
---|---|
US (2) | US6552170B1 (no) |
EP (1) | EP0758906A1 (no) |
CN (1) | CN1158089A (no) |
AU (1) | AU2828695A (no) |
BG (1) | BG101095A (no) |
BR (1) | BR9507999A (no) |
CA (1) | CA2191971C (no) |
CZ (1) | CZ357696A3 (no) |
EE (1) | EE9600182A (no) |
FI (1) | FI964985A (no) |
HU (1) | HUT77529A (no) |
NO (1) | NO965342L (no) |
PL (1) | PL317894A1 (no) |
SK (1) | SK159596A3 (no) |
WO (1) | WO1995034326A1 (no) |
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WO1995034326A1 (en) | 1995-12-21 |
EE9600182A (et) | 1998-02-16 |
FI964985A0 (fi) | 1996-12-12 |
BG101095A (en) | 1997-09-30 |
HU9603442D0 (en) | 1997-02-28 |
EP0758906A1 (en) | 1997-02-26 |
FI964985A (fi) | 1996-12-16 |
CN1158089A (zh) | 1997-08-27 |
HUT77529A (hu) | 1998-05-28 |
US20030190304A1 (en) | 2003-10-09 |
PL317894A1 (en) | 1997-04-28 |
SK159596A3 (en) | 1997-08-06 |
CA2191971C (en) | 2002-03-05 |
US6552170B1 (en) | 2003-04-22 |
NO965342D0 (no) | 1996-12-12 |
CA2191971A1 (en) | 1995-12-21 |
CZ357696A3 (en) | 1997-03-12 |
AU2828695A (en) | 1996-01-05 |
BR9507999A (pt) | 1997-08-12 |
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