SK14802002A3 - Nový spôsob prípravy medziproduktu torsemidu - Google Patents
Nový spôsob prípravy medziproduktu torsemidu Download PDFInfo
- Publication number
- SK14802002A3 SK14802002A3 SK1480-2002A SK14802002A SK14802002A3 SK 14802002 A3 SK14802002 A3 SK 14802002A3 SK 14802002 A SK14802002 A SK 14802002A SK 14802002 A3 SK14802002 A3 SK 14802002A3
- Authority
- SK
- Slovakia
- Prior art keywords
- ammonia
- pyridine
- chloro
- sulfonamide
- added
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19065000P | 2000-03-20 | 2000-03-20 | |
| US21151000P | 2000-06-14 | 2000-06-14 | |
| PCT/US2001/008866 WO2001070226A1 (en) | 2000-03-20 | 2001-03-20 | Novel processes for preparing torsemide intermediate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK14802002A3 true SK14802002A3 (sk) | 2003-05-02 |
Family
ID=26886305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1480-2002A SK14802002A3 (sk) | 2000-03-20 | 2001-03-20 | Nový spôsob prípravy medziproduktu torsemidu |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6635765B2 (cs) |
| EP (1) | EP1284733A4 (cs) |
| JP (1) | JP2003527425A (cs) |
| KR (1) | KR20020081482A (cs) |
| CN (2) | CN1203059C (cs) |
| AU (2) | AU4759201A (cs) |
| CA (1) | CA2403382A1 (cs) |
| CZ (1) | CZ20023395A3 (cs) |
| HR (1) | HRP20020819A2 (cs) |
| HU (1) | HUP0300241A3 (cs) |
| IL (1) | IL151837A0 (cs) |
| NZ (1) | NZ521852A (cs) |
| PL (1) | PL370039A1 (cs) |
| SK (1) | SK14802002A3 (cs) |
| WO (1) | WO2001070226A1 (cs) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20020025217A (ko) * | 1999-08-11 | 2002-04-03 | 추후보정 | 토르세미드 동질이상 |
| IL149771A0 (en) * | 2002-05-21 | 2002-11-10 | Fintech Lab Ltd | Process for preparation of torsemide |
| ITMI20022749A1 (it) * | 2002-12-23 | 2004-06-24 | Cosma S P A | Nuovo procedimento per la sintesi della tosemide, in particolare della forma ii pura e stabile. |
| US7378527B2 (en) * | 2004-03-16 | 2008-05-27 | Daqing Che | Process for the preparation of torsemide and related intermediates |
| DE102009005095A1 (de) * | 2009-01-19 | 2010-07-22 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Verfahren zur Herstellung von Carbonitriden über Polykondensations- bzw. Sol-Gel-Verfahren unter Verwendung Wasserstoff-freier Isocyanate |
| CN102432532B (zh) * | 2011-11-10 | 2014-06-18 | 天津市汉康医药生物技术有限公司 | 高纯度托拉塞米化合物 |
| CN104370805B (zh) * | 2013-08-13 | 2016-09-07 | 天津汉瑞药业有限公司 | 托拉塞米化合物 |
| JP6817952B2 (ja) * | 2015-10-29 | 2021-01-20 | あすか製薬株式会社 | ピリミジン誘導体 |
| CN110054647B (zh) * | 2019-05-23 | 2021-06-15 | 上海勋和医药科技有限公司 | 托拉塞米磷酸酯类前药、其制备方法及组合物 |
| GB202102575D0 (en) | 2021-02-23 | 2021-04-07 | Teva Pharmaceutical Industries Ltd | Fixed-dose pharmaceutical compositions |
| CN115010659A (zh) * | 2022-06-22 | 2022-09-06 | 南京正科医药股份有限公司 | 一种托拉塞米新杂质对照品及其制备方法 |
| CN115417810B (zh) * | 2022-09-22 | 2023-10-10 | 南京正科医药股份有限公司 | 一种托拉塞米晶型ⅰ的精制方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2516025A (en) | 1947-03-27 | 1950-07-18 | Westinghouse Electric Corp | Ground-relay transmission-line protection |
| BE758749A (fr) | 1969-11-12 | 1971-05-10 | Ciba Geigy | Procede de preparation de nouveaux acides pyridine-sulfoniques |
| US3787573A (en) * | 1970-03-18 | 1974-01-22 | R Mizzoni | Pyridine sulfonic acids as diuretics |
| US3674794A (en) * | 1970-03-18 | 1972-07-04 | Ciba Geigy Corp | Certain-3-pyridine-sulfonamide derivatives |
| US3824241A (en) * | 1970-08-26 | 1974-07-16 | Ciba Geigy Corp | Pyridinesulfonic acids |
| GB1368948A (en) | 1970-11-11 | 1974-10-02 | Manuf Prod Pharma | Pyridine derivatives |
| US3904636A (en) | 1971-11-09 | 1975-09-09 | Christiaens Sa A | 3-sulfonamido-4-phenyl aminopyridines and derivatives |
| ES436109A1 (es) * | 1974-04-04 | 1977-01-01 | Christiaens Sa A | Procedimiento para la preparacion de nuevos derivados de pi-ridina. |
| US4055650A (en) | 1974-04-17 | 1977-10-25 | A. Christiaens Societe Anonyme | Certain 4-phenoxy(or phenylthio)-3-n-acylated-sulfonamido-pyridines |
| GB1477664A (en) * | 1974-04-17 | 1977-06-22 | Christiaens Sa A | Pyridine derivatives |
| US4042693A (en) | 1975-04-14 | 1977-08-16 | A. Christiaens Societe Anonyme | Derivatives of 1,2,4-thiadiazine |
| GB1593609A (en) | 1978-01-31 | 1981-07-22 | Christiaens Sa A | Pyridine sulfonamides |
| DE3529529A1 (de) | 1985-08-17 | 1987-02-19 | Boehringer Mannheim Gmbh | Verfahren zur herstellung einer stabilen modifikation von torasemid |
| DE3623620A1 (de) | 1986-07-12 | 1988-01-21 | Boehringer Mannheim Gmbh | Spritzfertige, waessrige, alkalische injektionsloesungen von torasemid und verfahren zu ihrer herstellung |
| FR2703051B1 (fr) | 1993-03-26 | 1995-04-28 | Adir | Nouvelles pyridothiadiazines, leurs procédés de préparation, et les compositions pharmaceutiques qui les contiennent. |
| US5914336A (en) | 1998-06-02 | 1999-06-22 | Boehringer Mannheim Gmbh | Method of controlling the serum solubility of orally administered torasemide and composition relating thereto |
-
2001
- 2001-03-20 PL PL01370039A patent/PL370039A1/xx not_active Application Discontinuation
- 2001-03-20 US US09/812,762 patent/US6635765B2/en not_active Expired - Fee Related
- 2001-03-20 AU AU4759201A patent/AU4759201A/xx active Pending
- 2001-03-20 CA CA002403382A patent/CA2403382A1/en not_active Abandoned
- 2001-03-20 CN CNB018068340A patent/CN1203059C/zh not_active Expired - Fee Related
- 2001-03-20 EP EP01920556A patent/EP1284733A4/en not_active Withdrawn
- 2001-03-20 CN CNA2004100787386A patent/CN1623987A/zh active Pending
- 2001-03-20 IL IL15183701A patent/IL151837A0/xx unknown
- 2001-03-20 NZ NZ521852A patent/NZ521852A/en unknown
- 2001-03-20 WO PCT/US2001/008866 patent/WO2001070226A1/en active IP Right Grant
- 2001-03-20 CZ CZ20023395A patent/CZ20023395A3/cs unknown
- 2001-03-20 JP JP2001568424A patent/JP2003527425A/ja not_active Withdrawn
- 2001-03-20 SK SK1480-2002A patent/SK14802002A3/sk unknown
- 2001-03-20 HU HU0300241A patent/HUP0300241A3/hu unknown
- 2001-03-20 AU AU2001247592A patent/AU2001247592B2/en not_active Ceased
- 2001-03-20 KR KR1020027012490A patent/KR20020081482A/ko not_active Application Discontinuation
-
2002
- 2002-10-14 HR HRP20020819 patent/HRP20020819A2/hr not_active Application Discontinuation
-
2003
- 2003-05-02 US US10/428,463 patent/US6670478B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001247592B2 (en) | 2005-08-18 |
| EP1284733A1 (en) | 2003-02-26 |
| US20020019537A1 (en) | 2002-02-14 |
| HUP0300241A2 (hu) | 2003-06-28 |
| US20030212277A1 (en) | 2003-11-13 |
| IL151837A0 (en) | 2003-04-10 |
| CZ20023395A3 (cs) | 2003-04-16 |
| WO2001070226A1 (en) | 2001-09-27 |
| JP2003527425A (ja) | 2003-09-16 |
| CA2403382A1 (en) | 2001-09-27 |
| HRP20020819A2 (en) | 2004-12-31 |
| CN1423558A (zh) | 2003-06-11 |
| KR20020081482A (ko) | 2002-10-26 |
| NZ521852A (en) | 2004-10-29 |
| PL370039A1 (en) | 2005-05-16 |
| AU4759201A (en) | 2001-10-03 |
| US6635765B2 (en) | 2003-10-21 |
| HUP0300241A3 (en) | 2005-11-28 |
| CN1623987A (zh) | 2005-06-08 |
| EP1284733A4 (en) | 2003-07-16 |
| US6670478B2 (en) | 2003-12-30 |
| CN1203059C (zh) | 2005-05-25 |
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