SK144293A3 - Orally active antiviral compounds - Google Patents

Orally active antiviral compounds Download PDF

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Publication number
SK144293A3
SK144293A3 SK1442-93A SK144293A SK144293A3 SK 144293 A3 SK144293 A3 SK 144293A3 SK 144293 A SK144293 A SK 144293A SK 144293 A3 SK144293 A3 SK 144293A3
Authority
SK
Slovakia
Prior art keywords
compound
compounds
alkyl
formula
compound according
Prior art date
Application number
SK1442-93A
Other languages
English (en)
Slovak (sk)
Inventor
Viyyoor M Girijavallabhan
Ashit K Ganguly
Richard W Versace
Anil K Saksena
Patrick A Pinto
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of SK144293A3 publication Critical patent/SK144293A3/sk

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30Oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/02Ethers
    • C07C43/20Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/02Ethers
    • C07C43/20Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C07C69/92Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with etherified hydroxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D263/14Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/12Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/28Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40Radicals substituted by oxygen atoms
    • C07D307/42Singly bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Dental Preparations (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SK1442-93A 1991-06-19 1992-06-17 Orally active antiviral compounds SK144293A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71745191A 1991-06-19 1991-06-19
PCT/US1992/004961 WO1992022520A1 (en) 1991-06-19 1992-06-17 Orally active antiviral compounds

Publications (1)

Publication Number Publication Date
SK144293A3 true SK144293A3 (en) 1994-06-08

Family

ID=24882086

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1442-93A SK144293A3 (en) 1991-06-19 1992-06-17 Orally active antiviral compounds

Country Status (23)

Country Link
US (4) US5559133A (de)
EP (2) EP0590026B1 (de)
JP (1) JP2625258B2 (de)
KR (1) KR960004887B1 (de)
AT (1) ATE182874T1 (de)
AU (1) AU674657B2 (de)
CA (1) CA2111854C (de)
CZ (1) CZ279793A3 (de)
DE (1) DE69229733T2 (de)
ES (1) ES2134808T3 (de)
FI (1) FI935690A (de)
IE (1) IE921971A1 (de)
IL (1) IL102241A0 (de)
MX (1) MX9203068A (de)
MY (1) MY107993A (de)
NZ (1) NZ243180A (de)
OA (1) OA09828A (de)
PL (1) PL169699B1 (de)
SK (1) SK144293A3 (de)
TW (1) TW260658B (de)
WO (1) WO1992022520A1 (de)
YU (1) YU63392A (de)
ZA (1) ZA924445B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU63392A (sh) * 1991-06-19 1994-11-15 Schering Corporation Bis(oksi) jedinjenja i postupak za njihovo dobijanje
JPH08507062A (ja) * 1993-02-26 1996-07-30 シェリング・コーポレーション ヒトにおけるエンテロウイルス感染症の選択的処置のための2−クロロ−1−[[4−[(2,6−ジクロロフェノキシ)メチル]フェニル]メトキシ]−4−メトキシベンゼンの使用
US5958983A (en) * 1997-04-10 1999-09-28 Pharmacia & Upjohn Company Polyaromatic antiviral compositions
AU6462500A (en) * 1999-07-29 2001-02-19 Patrick T. Prendergast Dithiolthione compounds for the treatment of neurological disorders and for memory enhancement

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2418571A1 (de) * 1973-04-18 1974-11-14 Ciba Geigy Ag Phenyl-aralkyl-aether, diphenyle und benzophenone, verfahren zu ihrer herstellung und ihre verwendung
JPS509785A (de) * 1973-05-31 1975-01-31
JPS5922697B2 (ja) * 1976-01-13 1984-05-28 エーザイ株式会社 ビス−(メタ−アミジノフエノキシ)−化合物
JPS5651423A (en) 1979-09-13 1981-05-09 Wellcome Found Antiviral agent
EP0099933B1 (de) * 1982-01-29 1986-04-02 Toray Industries, Inc. Verfahren zur herstellung von alpha,omega-bis(2-chlorophenoxy)-alkan-4,4'-dikarbonsäure oder deren niedrigalkylester
US4851423A (en) 1986-12-10 1989-07-25 Schering Corporation Pharmaceutically active compounds
JPH0621083B2 (ja) * 1986-12-22 1994-03-23 株式会社三光開発科学研究所 ジ(アリ−ルオキシ)アルカンの製造方法
US4891449A (en) * 1988-06-30 1990-01-02 Great Lakes Chemical Corporation Halogenated unsymmetrical higher alkyl phenoxy alkanes
AU6062590A (en) * 1989-07-07 1991-02-06 Schering Corporation Pharmaceutically active compounds
YU63392A (sh) * 1991-06-19 1994-11-15 Schering Corporation Bis(oksi) jedinjenja i postupak za njihovo dobijanje

Also Published As

Publication number Publication date
YU63392A (sh) 1994-11-15
WO1992022520A1 (en) 1992-12-23
FI935690A0 (fi) 1993-12-17
MY107993A (en) 1996-07-15
EP0519702A1 (de) 1992-12-23
AU674657B2 (en) 1997-01-09
OA09828A (en) 1994-04-15
US5449782A (en) 1995-09-12
CA2111854A1 (en) 1992-12-23
TW260658B (de) 1995-10-21
ZA924445B (en) 1993-02-24
US5559133A (en) 1996-09-24
DE69229733T2 (de) 1999-12-02
KR960004887B1 (ko) 1996-04-16
EP0590026B1 (de) 1999-08-04
CA2111854C (en) 2001-01-09
MX9203068A (es) 1993-07-01
US5618849A (en) 1997-04-08
DE69229733D1 (de) 1999-09-09
IE921971A1 (en) 1992-12-30
PL169699B1 (en) 1996-08-30
ES2134808T3 (es) 1999-10-16
JPH06503839A (ja) 1994-04-28
ATE182874T1 (de) 1999-08-15
AU2221392A (en) 1993-01-12
US5350772A (en) 1994-09-27
FI935690A (fi) 1993-12-17
JP2625258B2 (ja) 1997-07-02
IL102241A0 (en) 1993-01-14
CZ279793A3 (en) 1994-05-18
EP0590026A1 (de) 1994-04-06
NZ243180A (en) 1995-08-28

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