SK105497A3 - Proline derivatives, preparation method thereof and pharmaceutical composition containing the same - Google Patents

Proline derivatives, preparation method thereof and pharmaceutical composition containing the same Download PDF

Info

Publication number
SK105497A3
SK105497A3 SK1054-97A SK105497A SK105497A3 SK 105497 A3 SK105497 A3 SK 105497A3 SK 105497 A SK105497 A SK 105497A SK 105497 A3 SK105497 A3 SK 105497A3
Authority
SK
Slovakia
Prior art keywords
mixture
hexane
methyl
formula
water
Prior art date
Application number
SK1054-97A
Other languages
English (en)
Slovak (sk)
Inventor
Peter R Bernstein
Chris A Veale
Elwyn P Davies
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of SK105497A3 publication Critical patent/SK105497A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
SK1054-97A 1995-02-03 1996-01-30 Proline derivatives, preparation method thereof and pharmaceutical composition containing the same SK105497A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9502152.3A GB9502152D0 (en) 1995-02-03 1995-02-03 Proline derivatives
PCT/GB1996/000193 WO1996023812A1 (en) 1995-02-03 1996-01-30 Proline derivatives useful as inhibitors of human leukocyte elastase

Publications (1)

Publication Number Publication Date
SK105497A3 true SK105497A3 (en) 1997-12-10

Family

ID=10769064

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1054-97A SK105497A3 (en) 1995-02-03 1996-01-30 Proline derivatives, preparation method thereof and pharmaceutical composition containing the same

Country Status (23)

Country Link
US (4) US5686628A (de)
EP (1) EP0808327A1 (de)
JP (1) JPH10513173A (de)
KR (1) KR19980701869A (de)
CN (1) CN1172486A (de)
AR (1) AR003922A1 (de)
AU (1) AU704704B2 (de)
BR (1) BR9607095A (de)
CA (1) CA2209675A1 (de)
CZ (1) CZ246697A3 (de)
FI (1) FI973211A (de)
GB (1) GB9502152D0 (de)
HR (1) HRP960008A2 (de)
HU (1) HUP9801991A3 (de)
IL (1) IL117013A0 (de)
NO (1) NO973539L (de)
NZ (1) NZ300256A (de)
PL (1) PL321680A1 (de)
RU (1) RU2159249C2 (de)
SK (1) SK105497A3 (de)
TR (1) TR199700732T1 (de)
WO (1) WO1996023812A1 (de)
ZA (1) ZA96851B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998010800A2 (en) * 1996-09-16 1998-03-19 Amersham International Plc Labelled elastase inhibitors
US5773430A (en) * 1997-03-13 1998-06-30 Research Foundation Of State University Of New York Serine proteinase inhibitory activity by hydrophobic tetracycline
US6559127B1 (en) 1997-07-31 2003-05-06 Athena Neurosciences, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
US6583139B1 (en) 1997-07-31 2003-06-24 Eugene D. Thorsett Compounds which inhibit leukocyte adhesion mediated by VLA-4
US6492421B1 (en) 1997-07-31 2002-12-10 Athena Neurosciences, Inc. Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4
US6362341B1 (en) 1997-07-31 2002-03-26 Athena Neurosciences, Inc. Benzyl compounds which inhibit leukocyte adhesion mediated by VLA-4
US7030114B1 (en) 1997-07-31 2006-04-18 Elan Pharmaceuticals, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
US6489300B1 (en) * 1997-07-31 2002-12-03 Eugene D. Thorsett Carbamyloxy compounds which inhibit leukocyte adhesion mediated by VLA-4
US6423688B1 (en) * 1997-07-31 2002-07-23 Athena Neurosciences, Inc. Dipeptide and related compounds which inhibit leukocyte adhesion mediated by VLA-4
US7232918B2 (en) * 2001-11-06 2007-06-19 Shell Oil Company Catalyst composition
US6544732B1 (en) * 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
AU2690100A (en) 1999-12-16 2001-06-25 Dainippon Pharmaceutical Co. Ltd. Processes for producing (aminomethyl)trifluorocarbinol derivatives
WO2006016720A1 (ja) * 2004-08-11 2006-02-16 Dainippon Sumitomo Pharma Co., Ltd. 医薬化合物
WO2006025216A1 (ja) * 2004-08-31 2006-03-09 Dainippon Sumitomo Pharma Co., Ltd. 医薬結晶化合物
US7533740B2 (en) * 2005-02-08 2009-05-19 Smith International Inc. Thermally stable polycrystalline diamond cutting elements and bits incorporating the same
CN109803961B (zh) * 2016-09-23 2021-03-23 科研制药株式会社 (r)-5-(3,4-二氟苯基)-5-[(3-甲基-2-氧代吡啶-1(2h)-基)甲基]咪唑烷-2,4-二酮的制造方法及用于该制造的中间体
CN114650819A (zh) 2019-09-17 2022-06-21 美莱奥生物制药第四有限公司 用于治疗移植物排斥、闭塞性细支气管炎综合征和移植物抗宿主病的阿维来司他
IL297211A (en) 2020-04-16 2022-12-01 Mereo Biopharma 4 Ltd Methods involving the neutrophil elastase inhibitor albalstat for the treatment of respiratory disease mediated by alpha-1 antitrypsin deficiency
AU2022373971A1 (en) 2021-10-20 2024-04-04 Mereo Biopharma 4 Limited Neutrophil elastase inhibitors for use in the treatment of fibrosis

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4277395A (en) * 1980-06-16 1981-07-07 Richardson-Merrell Inc. Novel enzyme inhibitors
EP0124317B1 (de) * 1983-04-27 1990-04-11 Ici Americas Inc. Prolin-Derivate
US4518528A (en) * 1983-05-19 1985-05-21 Rasnick David W α Amino fluoro ketones
US5194588A (en) * 1985-01-22 1993-03-16 Ici Americas Inc. Aminoalcohol intermediates for peptide derivatives
US5055450A (en) * 1985-01-22 1991-10-08 Ici Americas Inc. Peptide derivatives
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
CA1341029C (en) * 1985-02-04 2000-06-20 Michael Kolb Peptidase inhibitors
CH672792A5 (de) * 1985-02-19 1989-12-29 Sandoz Ag
GB9402680D0 (en) * 1994-02-11 1994-04-06 Zeneca Ltd Pyrrolidine derivatives

Also Published As

Publication number Publication date
US5686628A (en) 1997-11-11
JPH10513173A (ja) 1998-12-15
US5808097A (en) 1998-09-15
US6048889A (en) 2000-04-11
TR199700732T1 (xx) 1998-02-21
CA2209675A1 (en) 1996-08-08
KR19980701869A (ko) 1998-06-25
CZ246697A3 (en) 1997-11-12
MX9705231A (es) 1997-10-31
AU4494396A (en) 1996-08-21
EP0808327A1 (de) 1997-11-26
HUP9801991A2 (hu) 1999-02-01
US6054593A (en) 2000-04-25
HUP9801991A3 (en) 1999-06-28
CN1172486A (zh) 1998-02-04
AU704704B2 (en) 1999-04-29
PL321680A1 (en) 1997-12-22
NZ300256A (en) 2000-01-28
AR003922A1 (es) 1998-09-30
HRP960008A2 (en) 1998-04-30
BR9607095A (pt) 1997-11-11
NO973539L (no) 1997-10-01
WO1996023812A1 (en) 1996-08-08
FI973211A0 (fi) 1997-08-01
IL117013A0 (en) 1996-06-18
FI973211A (fi) 1997-08-01
RU2159249C2 (ru) 2000-11-20
GB9502152D0 (en) 1995-03-29
NO973539D0 (no) 1997-08-01
ZA96851B (en) 1996-08-05

Similar Documents

Publication Publication Date Title
SK105497A3 (en) Proline derivatives, preparation method thereof and pharmaceutical composition containing the same
US7692038B2 (en) Crystalline forms
CA2252163C (en) D-proline derivatives
US6037363A (en) Diastereomeric pure trifluoromethyl ketone peptide derivatives as inhibitors of human leukocyte elastase
SK278095B6 (en) Peptide derivatives, method of its production and their use
KR910002694B1 (ko) 작용화 펩티딜 아미노디올 및 트리올
US9469609B2 (en) Synthesis of pyrrolidine compounds
CA2255625A1 (en) New amino acid derivatives and their use as thrombin inhibitors
JP2002503714A (ja) 抗腫瘍剤
EP1847536A1 (de) Synthese und Verwendungen von Pyrolglutaminsäurederivaten
JPH058191B2 (de)
JP2872748B2 (ja) フルオロアミド誘導体
JPH0386870A (ja) レニン阻害剤としてのアミノ―置換された複素還式化合物
MXPA97005231A (en) Prolin derivatives useful as inhibitors of elastase leukocyte hum
WO1992016497A1 (en) Amino acid derivative having renin inhibitory activity
JPH09263577A (ja) ジフェニルメチル−アゼチジノン化合物及びエラスターゼ阻害剤