MX9705231A - Derivados de prolina utiles como inhibidores de elastasa leucocito humano. - Google Patents
Derivados de prolina utiles como inhibidores de elastasa leucocito humano.Info
- Publication number
- MX9705231A MX9705231A MX9705231A MX9705231A MX9705231A MX 9705231 A MX9705231 A MX 9705231A MX 9705231 A MX9705231 A MX 9705231A MX 9705231 A MX9705231 A MX 9705231A MX 9705231 A MX9705231 A MX 9705231A
- Authority
- MX
- Mexico
- Prior art keywords
- inhibitors
- forms
- human leukocyte
- leukocyte elastase
- derivatives useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invencion se relaciona con formas particulares de una N-[2-metil-1-(trifluoroacetil)propil] pirrolidin-2-carboxamida 1-sustituida de la formula (I) las cuales son inhibidores de la elastasa de leucocito humano (HLE), también conocido como elastasa de neutrofilo humano (HNE) haciendolas utiles siempre que tal inhibicion se desee, tal como para herramienta de investigacion de estudios farmacologicos, de diagnostico y estudios relacionados y en el tratamiento de enfermedades en mamíferos, los cuales la HLE esta implicada. La invencion también incluye composiciones farmacéuticas que contienen tales formas, procesos para preparar las formas e intermediariosutiles en la síntesis de las formas.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9502152.3A GB9502152D0 (en) | 1995-02-03 | 1995-02-03 | Proline derivatives |
| GB9502152.3 | 1995-02-03 | ||
| PCT/GB1996/000193 WO1996023812A1 (en) | 1995-02-03 | 1996-01-30 | Proline derivatives useful as inhibitors of human leukocyte elastase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX9705231A true MX9705231A (es) | 1997-10-31 |
| MXPA97005231A MXPA97005231A (es) | 1998-07-03 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| AU704704B2 (en) | 1999-04-29 |
| TR199700732T1 (xx) | 1998-02-21 |
| HUP9801991A2 (hu) | 1999-02-01 |
| EP0808327A1 (en) | 1997-11-26 |
| CZ246697A3 (en) | 1997-11-12 |
| NO973539L (no) | 1997-10-01 |
| RU2159249C2 (ru) | 2000-11-20 |
| PL321680A1 (en) | 1997-12-22 |
| KR19980701869A (ko) | 1998-06-25 |
| ZA96851B (en) | 1996-08-05 |
| AR003922A1 (es) | 1998-09-30 |
| CA2209675A1 (en) | 1996-08-08 |
| JPH10513173A (ja) | 1998-12-15 |
| FI973211A0 (fi) | 1997-08-01 |
| US6054593A (en) | 2000-04-25 |
| AU4494396A (en) | 1996-08-21 |
| NO973539D0 (no) | 1997-08-01 |
| US5808097A (en) | 1998-09-15 |
| NZ300256A (en) | 2000-01-28 |
| SK105497A3 (en) | 1997-12-10 |
| BR9607095A (pt) | 1997-11-11 |
| US6048889A (en) | 2000-04-11 |
| HUP9801991A3 (en) | 1999-06-28 |
| US5686628A (en) | 1997-11-11 |
| IL117013A0 (en) | 1996-06-18 |
| CN1172486A (zh) | 1998-02-04 |
| FI973211A (fi) | 1997-08-01 |
| GB9502152D0 (en) | 1995-03-29 |
| HRP960008A2 (en) | 1998-04-30 |
| WO1996023812A1 (en) | 1996-08-08 |
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