MX9603291A - Derivados de cetona de trifluormetilo diastomericamente puras como inhibidoras de elastasa de leucocitos humanos. - Google Patents
Derivados de cetona de trifluormetilo diastomericamente puras como inhibidoras de elastasa de leucocitos humanos.Info
- Publication number
- MX9603291A MX9603291A MX9603291A MX9603291A MX9603291A MX 9603291 A MX9603291 A MX 9603291A MX 9603291 A MX9603291 A MX 9603291A MX 9603291 A MX9603291 A MX 9603291A MX 9603291 A MX9603291 A MX 9603291A
- Authority
- MX
- Mexico
- Prior art keywords
- inhibitors
- solvates
- human leukocyte
- trifluoromhyl
- kone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06052—Val-amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
la presente invencion se refiere a formas cristalinas del compuesto (S)-l(S)-2-(4-metoxibenzamida)-3-metilbutirilo)-N- ((S)-2-metil-l-(trifluoroacetil)propil)pirridina-2 -carboximida (I) y sus solvatos cristalinos, que son inhibidores de la elastasa de leucocitos (HLE) también conocida como elastasa neutrofila humana (HNE), haciendolos utiles siempre de tal inhibicion se desee, así como para herramientas de investigacion el diagnostico farmacologico y estudios relacionados, y para tratamiento relacionados en mamíferos, en los cuales este aplicado la HLE. La invencion también incluye composiciones farmacéuticas que contiene las formas cristalinas y sus solvatos, procesos para preparar las formas y solvatos cristalinos e intermediarios utiles en la síntesis de las formas cristalinas y solvatos. (Ver Formula).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9402680A GB9402680D0 (en) | 1994-02-11 | 1994-02-11 | Pyrrolidine derivatives |
| GB9421550A GB9421550D0 (en) | 1994-10-26 | 1994-10-26 | Heterocyclic derivative |
| PCT/GB1995/000242 WO1995021855A1 (en) | 1994-02-11 | 1995-02-07 | Diastereomeric pure trifluoromethyl ketone peptide derivatives as inhibitors of human leukocyte elastase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9603291A true MX9603291A (es) | 1997-02-28 |
Family
ID=26304315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9603291A MX9603291A (es) | 1994-02-11 | 1995-02-07 | Derivados de cetona de trifluormetilo diastomericamente puras como inhibidoras de elastasa de leucocitos humanos. |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US5739157A (es) |
| EP (1) | EP0743953B1 (es) |
| JP (1) | JP3416142B2 (es) |
| CN (1) | CN1140455A (es) |
| AT (1) | ATE174034T1 (es) |
| AU (1) | AU692515B2 (es) |
| CA (1) | CA2180006A1 (es) |
| DE (1) | DE69506380T2 (es) |
| DK (1) | DK0743953T3 (es) |
| ES (1) | ES2125004T3 (es) |
| FI (1) | FI963132A (es) |
| GB (1) | GB9402680D0 (es) |
| HK (1) | HK1011033A1 (es) |
| IL (1) | IL112613A (es) |
| MX (1) | MX9603291A (es) |
| NO (1) | NO313882B1 (es) |
| NZ (1) | NZ279265A (es) |
| TW (1) | TW414801B (es) |
| WO (1) | WO1995021855A1 (es) |
| YU (1) | YU7195A (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9402680D0 (en) * | 1994-02-11 | 1994-04-06 | Zeneca Ltd | Pyrrolidine derivatives |
| US5618792A (en) * | 1994-11-21 | 1997-04-08 | Cortech, Inc. | Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase |
| US6017887A (en) * | 1995-01-06 | 2000-01-25 | Sibia Neurosciences, Inc. | Peptide, peptide analog and amino acid analog protease inhibitors |
| US5804560A (en) * | 1995-01-06 | 1998-09-08 | Sibia Neurosciences, Inc. | Peptide and peptide analog protease inhibitors |
| GB9502152D0 (en) * | 1995-02-03 | 1995-03-29 | Zeneca Ltd | Proline derivatives |
| AU7261196A (en) * | 1995-10-10 | 1997-04-30 | Eli Lilly And Company | N-{2-substituted-3-(2-aminoethyl)-1h-indol-5-yl}-amides: new 5-ht1f agonists |
| ATE261969T1 (de) * | 1996-03-28 | 2004-04-15 | Glaxo Group Ltd | Pyrrolopyrrolone als inhibitoren von neutrophiler elastase |
| PE107899A1 (es) * | 1997-09-09 | 1999-11-17 | Glaxo Group Ltd | Derivados de pirrolopirrolona como inhibidores de elastasa leucocitaria |
| GB9719172D0 (en) | 1997-09-09 | 1997-11-12 | Glaxo Group Ltd | Compounds |
| GB9719187D0 (en) | 1997-09-09 | 1997-11-12 | Glaxo Group Ltd | Compounds |
| CA2498052C (en) | 2002-09-10 | 2011-05-17 | Bayer Healthcare Ag | Heterocyclic derivatives |
| WO2005080372A1 (en) | 2004-02-19 | 2005-09-01 | Bayer Healthcare Ag | Dihydropyridinone derivatives |
| DE102005037791A1 (de) * | 2005-08-10 | 2007-02-15 | Ernst-Moritz-Arndt Universität Greifswald | Verwendung von spezifischen Trifluormethylketonen zur Vorbeugung und Behandlung einer Pankreatitis |
| MX2009005252A (es) * | 2006-11-17 | 2009-05-28 | Abbott Lab | Aminopirrolidinas como antagonistas del receptor de quimiocina. |
| CN103226756A (zh) * | 2013-04-28 | 2013-07-31 | 文俊 | 工艺品生产过程的工艺制作及生产过程的记录方法和系统 |
| CN114650819A (zh) | 2019-09-17 | 2022-06-21 | 美莱奥生物制药第四有限公司 | 用于治疗移植物排斥、闭塞性细支气管炎综合征和移植物抗宿主病的阿维来司他 |
| EP4252850A3 (en) | 2020-04-16 | 2023-11-15 | Mereo Biopharma 4 Limited | Methods involving neutrophil elastase inhibitor alvelestat for treating respiratory disease mediated by alpha-1 antitrypsin deficiency |
| WO2023067103A1 (en) | 2021-10-20 | 2023-04-27 | Mereo Biopharma 4 Limited | Neutrophil elastase inhibitors for use in the treatment of fibrosis |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8600263D0 (en) * | 1985-01-22 | 1986-02-12 | Ici America Inc | Peptide derivatives |
| US5055450A (en) * | 1985-01-22 | 1991-10-08 | Ici Americas Inc. | Peptide derivatives |
| US5194588A (en) * | 1985-01-22 | 1993-03-16 | Ici Americas Inc. | Aminoalcohol intermediates for peptide derivatives |
| EP0276101A3 (en) * | 1987-01-19 | 1989-11-23 | Ici Americas Inc. | Substituted peptide derivatives |
| GB9402680D0 (en) * | 1994-02-11 | 1994-04-06 | Zeneca Ltd | Pyrrolidine derivatives |
-
1994
- 1994-02-11 GB GB9402680A patent/GB9402680D0/en active Pending
-
1995
- 1995-02-07 WO PCT/GB1995/000242 patent/WO1995021855A1/en active IP Right Grant
- 1995-02-07 EP EP95907743A patent/EP0743953B1/en not_active Expired - Lifetime
- 1995-02-07 DK DK95907743T patent/DK0743953T3/da active
- 1995-02-07 US US08/682,526 patent/US5739157A/en not_active Expired - Fee Related
- 1995-02-07 CN CN95191539A patent/CN1140455A/zh active Pending
- 1995-02-07 MX MX9603291A patent/MX9603291A/es not_active IP Right Cessation
- 1995-02-07 AT AT95907743T patent/ATE174034T1/de not_active IP Right Cessation
- 1995-02-07 DE DE69506380T patent/DE69506380T2/de not_active Expired - Fee Related
- 1995-02-07 AU AU15839/95A patent/AU692515B2/en not_active Ceased
- 1995-02-07 NZ NZ279265A patent/NZ279265A/en unknown
- 1995-02-07 CA CA002180006A patent/CA2180006A1/en not_active Abandoned
- 1995-02-07 ES ES95907743T patent/ES2125004T3/es not_active Expired - Lifetime
- 1995-02-07 JP JP52104195A patent/JP3416142B2/ja not_active Expired - Fee Related
- 1995-02-09 YU YU7195A patent/YU7195A/sh unknown
- 1995-02-12 IL IL11261395A patent/IL112613A/xx not_active IP Right Cessation
- 1995-03-17 TW TW084102596A patent/TW414801B/zh active
-
1996
- 1996-08-09 NO NO19963329A patent/NO313882B1/no not_active IP Right Cessation
- 1996-08-09 FI FI963132A patent/FI963132A/fi unknown
-
1998
- 1998-01-27 US US09/013,853 patent/US5907043A/en not_active Expired - Fee Related
- 1998-11-20 HK HK98112163A patent/HK1011033A1/xx not_active IP Right Cessation
-
1999
- 1999-02-22 US US09/253,659 patent/US6037363A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| GB9402680D0 (en) | 1994-04-06 |
| DE69506380D1 (de) | 1999-01-14 |
| JP3416142B2 (ja) | 2003-06-16 |
| FI963132A0 (fi) | 1996-08-09 |
| NZ279265A (en) | 1998-01-26 |
| WO1995021855A1 (en) | 1995-08-17 |
| CN1140455A (zh) | 1997-01-15 |
| ATE174034T1 (de) | 1998-12-15 |
| CA2180006A1 (en) | 1995-08-17 |
| EP0743953A1 (en) | 1996-11-27 |
| EP0743953B1 (en) | 1998-12-02 |
| ES2125004T3 (es) | 1999-02-16 |
| AU1583995A (en) | 1995-08-29 |
| FI963132A (fi) | 1996-08-09 |
| NO963329D0 (no) | 1996-08-09 |
| IL112613A0 (en) | 1995-05-26 |
| DK0743953T3 (da) | 1999-08-16 |
| AU692515B2 (en) | 1998-06-11 |
| NO313882B1 (no) | 2002-12-16 |
| US6037363A (en) | 2000-03-14 |
| US5739157A (en) | 1998-04-14 |
| JPH09508902A (ja) | 1997-09-09 |
| IL112613A (en) | 2000-02-29 |
| TW414801B (en) | 2000-12-11 |
| NO963329L (no) | 1996-10-09 |
| HK1011033A1 (en) | 1999-07-02 |
| YU7195A (sh) | 1998-09-18 |
| US5907043A (en) | 1999-05-25 |
| DE69506380T2 (de) | 1999-05-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration | ||
| MM | Annulment or lapse due to non-payment of fees |