NO963329L - Diastereomert rene trifluormetylketonpeptid-derivater som inhibitorer for human leukocytelastase - Google Patents

Diastereomert rene trifluormetylketonpeptid-derivater som inhibitorer for human leukocytelastase

Info

Publication number
NO963329L
NO963329L NO963329A NO963329A NO963329L NO 963329 L NO963329 L NO 963329L NO 963329 A NO963329 A NO 963329A NO 963329 A NO963329 A NO 963329A NO 963329 L NO963329 L NO 963329L
Authority
NO
Norway
Prior art keywords
inhibitors
human leukocyte
peptide derivatives
diastereomerically pure
leukocyte elastase
Prior art date
Application number
NO963329A
Other languages
English (en)
Other versions
NO963329D0 (no
NO313882B1 (no
Inventor
Stephen John Pegg
George Joseph Sependa
Elwyn Peter Davies
Chris Allan Veale
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9421550A external-priority patent/GB9421550D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of NO963329D0 publication Critical patent/NO963329D0/no
Publication of NO963329L publication Critical patent/NO963329L/no
Publication of NO313882B1 publication Critical patent/NO313882B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO19963329A 1994-02-11 1996-08-09 Diastereomert rene trifluormetylketonpeptidderivater som inhibitorer for human leukocyttelastase og fremstilling avderivatene NO313882B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9402680A GB9402680D0 (en) 1994-02-11 1994-02-11 Pyrrolidine derivatives
GB9421550A GB9421550D0 (en) 1994-10-26 1994-10-26 Heterocyclic derivative
PCT/GB1995/000242 WO1995021855A1 (en) 1994-02-11 1995-02-07 Diastereomeric pure trifluoromethyl ketone peptide derivatives as inhibitors of human leukocyte elastase

Publications (3)

Publication Number Publication Date
NO963329D0 NO963329D0 (no) 1996-08-09
NO963329L true NO963329L (no) 1996-10-09
NO313882B1 NO313882B1 (no) 2002-12-16

Family

ID=26304315

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19963329A NO313882B1 (no) 1994-02-11 1996-08-09 Diastereomert rene trifluormetylketonpeptidderivater som inhibitorer for human leukocyttelastase og fremstilling avderivatene

Country Status (20)

Country Link
US (3) US5739157A (no)
EP (1) EP0743953B1 (no)
JP (1) JP3416142B2 (no)
CN (1) CN1140455A (no)
AT (1) ATE174034T1 (no)
AU (1) AU692515B2 (no)
CA (1) CA2180006A1 (no)
DE (1) DE69506380T2 (no)
DK (1) DK0743953T3 (no)
ES (1) ES2125004T3 (no)
FI (1) FI963132A (no)
GB (1) GB9402680D0 (no)
HK (1) HK1011033A1 (no)
IL (1) IL112613A (no)
MX (1) MX9603291A (no)
NO (1) NO313882B1 (no)
NZ (1) NZ279265A (no)
TW (1) TW414801B (no)
WO (1) WO1995021855A1 (no)
YU (1) YU7195A (no)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9402680D0 (en) * 1994-02-11 1994-04-06 Zeneca Ltd Pyrrolidine derivatives
US5618792A (en) * 1994-11-21 1997-04-08 Cortech, Inc. Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase
US5804560A (en) * 1995-01-06 1998-09-08 Sibia Neurosciences, Inc. Peptide and peptide analog protease inhibitors
US5863902A (en) * 1995-01-06 1999-01-26 Sibia Neurosciences, Inc. Methods of treating neurodegenerative disorders using protease inhibitors
GB9502152D0 (en) * 1995-02-03 1995-03-29 Zeneca Ltd Proline derivatives
JPH11513666A (ja) * 1995-10-10 1999-11-24 イーライ・リリー・アンド・カンパニー Ｎ−［２−置換−３−（２−アミノエチル）−１ｈ−インドール−５−イル］−アミド：新規５−ｈｔ▲下１ｆ▼作動剤
EP0891362B1 (en) * 1996-03-28 2004-03-17 Glaxo Group Limited Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase
GB9719187D0 (en) 1997-09-09 1997-11-12 Glaxo Group Ltd Compounds
GB9719172D0 (en) 1997-09-09 1997-11-12 Glaxo Group Ltd Compounds
PE107899A1 (es) * 1997-09-09 1999-11-17 Glaxo Group Ltd Derivados de pirrolopirrolona como inhibidores de elastasa leucocitaria
EP1539710B1 (en) 2002-09-10 2010-10-27 Bayer Schering Pharma Aktiengesellschaft Heterocyclic derivatives
WO2005080372A1 (en) 2004-02-19 2005-09-01 Bayer Healthcare Ag Dihydropyridinone derivatives
DE102005037791A1 (de) * 2005-08-10 2007-02-15 Ernst-Moritz-Arndt Universität Greifswald Verwendung von spezifischen Trifluormethylketonen zur Vorbeugung und Behandlung einer Pankreatitis
MX2009005252A (es) * 2006-11-17 2009-05-28 Abbott Lab Aminopirrolidinas como antagonistas del receptor de quimiocina.
CN103226756A (zh) * 2013-04-28 2013-07-31 文俊 工艺品生产过程的工艺制作及生产过程的记录方法和系统
EP4031138A1 (en) 2019-09-17 2022-07-27 Mereo Biopharma 4 Limited Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease
MX2022012942A (es) 2020-04-16 2023-01-11 Mereo Biopharma 4 Ltd Metodos que involucran el inhibidor de la elastasa de neutrofilo alvelestat para el tratamiento de enfermedades respiratorias mediadas por deficiencia de alfa-1 antitripsina.
IL312002A (en) 2021-10-20 2024-06-01 Mereo Biopharma 4 Ltd Neutrophil elastase inhibitors for use in the treatment of fibrosis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5055450A (en) * 1985-01-22 1991-10-08 Ici Americas Inc. Peptide derivatives
US5194588A (en) * 1985-01-22 1993-03-16 Ici Americas Inc. Aminoalcohol intermediates for peptide derivatives
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
EP0276101A3 (en) * 1987-01-19 1989-11-23 Ici Americas Inc. Substituted peptide derivatives
GB9402680D0 (en) * 1994-02-11 1994-04-06 Zeneca Ltd Pyrrolidine derivatives

Also Published As

Publication number Publication date
US5907043A (en) 1999-05-25
AU692515B2 (en) 1998-06-11
FI963132A0 (fi) 1996-08-09
JP3416142B2 (ja) 2003-06-16
CA2180006A1 (en) 1995-08-17
DE69506380T2 (de) 1999-05-06
IL112613A0 (en) 1995-05-26
GB9402680D0 (en) 1994-04-06
JPH09508902A (ja) 1997-09-09
EP0743953B1 (en) 1998-12-02
HK1011033A1 (en) 1999-07-02
EP0743953A1 (en) 1996-11-27
ATE174034T1 (de) 1998-12-15
YU7195A (sh) 1998-09-18
ES2125004T3 (es) 1999-02-16
TW414801B (en) 2000-12-11
MX9603291A (es) 1997-02-28
IL112613A (en) 2000-02-29
NZ279265A (en) 1998-01-26
NO963329D0 (no) 1996-08-09
AU1583995A (en) 1995-08-29
NO313882B1 (no) 2002-12-16
DE69506380D1 (de) 1999-01-14
FI963132A (fi) 1996-08-09
US5739157A (en) 1998-04-14
WO1995021855A1 (en) 1995-08-17
CN1140455A (zh) 1997-01-15
US6037363A (en) 2000-03-14
DK0743953T3 (da) 1999-08-16

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