NO943910L - Laktam-peptider med HLE-hemmende virkning - Google Patents

Laktam-peptider med HLE-hemmende virkning

Info

Publication number
NO943910L
NO943910L NO943910A NO943910A NO943910L NO 943910 L NO943910 L NO 943910L NO 943910 A NO943910 A NO 943910A NO 943910 A NO943910 A NO 943910A NO 943910 L NO943910 L NO 943910L
Authority
NO
Norway
Prior art keywords
hle
ketones
heterocyclic ketones
inhibitory effect
heterocyclic
Prior art date
Application number
NO943910A
Other languages
English (en)
Other versions
NO943910D0 (no
Inventor
Peter Robert Bernstein
Andrew Shaw
Royston Martin Thomas
Chris Allan Veale
Peter Warner
Donald John Wolanin
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929208385A external-priority patent/GB9208385D0/en
Priority claimed from GB929217365A external-priority patent/GB9217365D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of NO943910D0 publication Critical patent/NO943910D0/no
Publication of NO943910L publication Critical patent/NO943910L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Hydrogenated Pyridines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Foreliggende oppfinnelse angår visse nye heterocykliske ketoner som er 1-pyridylacetamid-ketoner med formel (I), beskrevet i beskrivelsen, som er inhibitorer for human leuko- cytt elastase (HLE) også kjent som human neutrofil elastase (HNE), hvilket gjør dem nyttige når slik hemning er ønsket, så som for forskningsverktøy ved farmakologiske, diagnostiske og beslektede undersøkelser og ved behandling av sykdommer hos pattedyr hvor HLE er implisert. Oppfinnelsen omfatter også mellomprodukter som er nyttige ved syntese av disse hetero- cykliske ketonene, fremgangsmåter for fremstilling av de heterocykliske ketonene, farmasøytiske preparater inneholdende slike cykliske ketoner og metoder for anvendelse av dem.
NO943910A 1992-04-16 1994-10-14 Laktam-peptider med HLE-hemmende virkning NO943910L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB929208385A GB9208385D0 (en) 1992-04-16 1992-04-16 Heterocyclic ketones
GB929217365A GB9217365D0 (en) 1992-08-14 1992-08-14 Heterocyclic ketones
PCT/GB1993/000795 WO1993021209A1 (en) 1992-04-16 1993-04-15 Lactam peptides having hle inhibiting activity

Publications (2)

Publication Number Publication Date
NO943910D0 NO943910D0 (no) 1994-10-14
NO943910L true NO943910L (no) 1994-12-15

Family

ID=26300737

Family Applications (1)

Application Number Title Priority Date Filing Date
NO943910A NO943910L (no) 1992-04-16 1994-10-14 Laktam-peptider med HLE-hemmende virkning

Country Status (13)

Country Link
US (2) US5486529A (no)
EP (1) EP0636142B1 (no)
JP (1) JP3415151B2 (no)
AT (1) ATE167481T1 (no)
AU (1) AU4077093A (no)
CA (1) CA2118250A1 (no)
DE (1) DE69319238T2 (no)
FI (1) FI944803A (no)
HU (1) HUT67877A (no)
IL (1) IL105425A0 (no)
MX (1) MX9302219A (no)
NO (1) NO943910L (no)
WO (1) WO1993021209A1 (no)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995013075A1 (en) * 1993-11-12 1995-05-18 Cell Therapeutics, Inc. Method for preventing tissue injury from hypoxia
CN1188401C (zh) * 1995-04-27 2005-02-09 三菱制药株式会社 杂环类酰胺化合物及其医药用途
TW498068B (en) * 1996-09-06 2002-08-11 Nippon Kayaku Kk Novel acetamide derivatives and protease inhibitors
CA2265945A1 (en) 1996-09-16 1998-03-19 Amersham International Plc Labelled elastase inhibitors
US6760441B1 (en) 2000-03-31 2004-07-06 Intel Corporation Generating a key hieararchy for use in an isolated execution environment
US7089418B1 (en) 2000-03-31 2006-08-08 Intel Corporation Managing accesses in a processor for isolated execution
US6934817B2 (en) * 2000-03-31 2005-08-23 Intel Corporation Controlling access to multiple memory zones in an isolated execution environment
US7356817B1 (en) 2000-03-31 2008-04-08 Intel Corporation Real-time scheduling of virtual machines
US7194634B2 (en) * 2000-03-31 2007-03-20 Intel Corporation Attestation key memory device and bus
US7013484B1 (en) 2000-03-31 2006-03-14 Intel Corporation Managing a secure environment using a chipset in isolated execution mode
US7013481B1 (en) 2000-03-31 2006-03-14 Intel Corporation Attestation key memory device and bus
US7111176B1 (en) 2000-03-31 2006-09-19 Intel Corporation Generating isolated bus cycles for isolated execution
US6754815B1 (en) 2000-03-31 2004-06-22 Intel Corporation Method and system for scrubbing an isolated area of memory after reset of a processor operating in isolated execution mode if a cleanup flag is set
US6769058B1 (en) 2000-03-31 2004-07-27 Intel Corporation Resetting a processor in an isolated execution environment
US6976162B1 (en) * 2000-06-28 2005-12-13 Intel Corporation Platform and method for establishing provable identities while maintaining privacy
US7389427B1 (en) 2000-09-28 2008-06-17 Intel Corporation Mechanism to secure computer output from software attack using isolated execution
US7793111B1 (en) 2000-09-28 2010-09-07 Intel Corporation Mechanism to handle events in a machine with isolated execution
US7215781B2 (en) * 2000-12-22 2007-05-08 Intel Corporation Creation and distribution of a secret value between two devices
US6907600B2 (en) 2000-12-27 2005-06-14 Intel Corporation Virtual translation lookaside buffer
US7818808B1 (en) 2000-12-27 2010-10-19 Intel Corporation Processor mode for limiting the operation of guest software running on a virtual machine supported by a virtual machine monitor
US7035963B2 (en) * 2000-12-27 2006-04-25 Intel Corporation Method for resolving address space conflicts between a virtual machine monitor and a guest operating system
US7225441B2 (en) * 2000-12-27 2007-05-29 Intel Corporation Mechanism for providing power management through virtualization
US7117376B2 (en) * 2000-12-28 2006-10-03 Intel Corporation Platform and method of creating a secure boot that enforces proper user authentication and enforces hardware configurations
US7272831B2 (en) 2001-03-30 2007-09-18 Intel Corporation Method and apparatus for constructing host processor soft devices independent of the host processor operating system
US7191440B2 (en) 2001-08-15 2007-03-13 Intel Corporation Tracking operating system process and thread execution and virtual machine execution in hardware or in a virtual machine monitor
US7024555B2 (en) 2001-11-01 2006-04-04 Intel Corporation Apparatus and method for unilaterally loading a secure operating system within a multiprocessor environment
US7103771B2 (en) * 2001-12-17 2006-09-05 Intel Corporation Connecting a virtual token to a physical token
US7308576B2 (en) 2001-12-31 2007-12-11 Intel Corporation Authenticated code module
US20030126453A1 (en) * 2001-12-31 2003-07-03 Glew Andrew F. Processor supporting execution of an authenticated code instruction
US7480806B2 (en) * 2002-02-22 2009-01-20 Intel Corporation Multi-token seal and unseal
US7631196B2 (en) * 2002-02-25 2009-12-08 Intel Corporation Method and apparatus for loading a trustable operating system
US7124273B2 (en) * 2002-02-25 2006-10-17 Intel Corporation Method and apparatus for translating guest physical addresses in a virtual machine environment
US7069442B2 (en) 2002-03-29 2006-06-27 Intel Corporation System and method for execution of a secured environment initialization instruction
US7028149B2 (en) 2002-03-29 2006-04-11 Intel Corporation System and method for resetting a platform configuration register
US20030196096A1 (en) * 2002-04-12 2003-10-16 Sutton James A. Microcode patch authentication
US20030196100A1 (en) * 2002-04-15 2003-10-16 Grawrock David W. Protection against memory attacks following reset
US7127548B2 (en) 2002-04-16 2006-10-24 Intel Corporation Control register access virtualization performance improvement in the virtual-machine architecture
US20030229794A1 (en) * 2002-06-07 2003-12-11 Sutton James A. System and method for protection against untrusted system management code by redirecting a system management interrupt and creating a virtual machine container
US7142674B2 (en) * 2002-06-18 2006-11-28 Intel Corporation Method of confirming a secure key exchange
US20040003321A1 (en) * 2002-06-27 2004-01-01 Glew Andrew F. Initialization of protected system
US6996748B2 (en) 2002-06-29 2006-02-07 Intel Corporation Handling faults associated with operation of guest software in the virtual-machine architecture
US7124327B2 (en) 2002-06-29 2006-10-17 Intel Corporation Control over faults occurring during the operation of guest software in the virtual-machine architecture
US7296267B2 (en) * 2002-07-12 2007-11-13 Intel Corporation System and method for binding virtual machines to hardware contexts
US7165181B2 (en) * 2002-11-27 2007-01-16 Intel Corporation System and method for establishing trust without revealing identity
US20040117532A1 (en) * 2002-12-11 2004-06-17 Bennett Steven M. Mechanism for controlling external interrupts in a virtual machine system
US7073042B2 (en) 2002-12-12 2006-07-04 Intel Corporation Reclaiming existing fields in address translation data structures to extend control over memory accesses
US20040128345A1 (en) * 2002-12-27 2004-07-01 Robinson Scott H. Dynamic service registry
US7900017B2 (en) * 2002-12-27 2011-03-01 Intel Corporation Mechanism for remapping post virtual machine memory pages
US20040128465A1 (en) * 2002-12-30 2004-07-01 Lee Micheil J. Configurable memory bus width
US7415708B2 (en) * 2003-06-26 2008-08-19 Intel Corporation Virtual machine management using processor state information
US20050044292A1 (en) * 2003-08-19 2005-02-24 Mckeen Francis X. Method and apparatus to retain system control when a buffer overflow attack occurs
US7424709B2 (en) 2003-09-15 2008-09-09 Intel Corporation Use of multiple virtual machine monitors to handle privileged events
US7287197B2 (en) * 2003-09-15 2007-10-23 Intel Corporation Vectoring an interrupt or exception upon resuming operation of a virtual machine
US7739521B2 (en) * 2003-09-18 2010-06-15 Intel Corporation Method of obscuring cryptographic computations
US7610611B2 (en) * 2003-09-19 2009-10-27 Moran Douglas R Prioritized address decoder
US7366305B2 (en) * 2003-09-30 2008-04-29 Intel Corporation Platform and method for establishing trust without revealing identity
US7237051B2 (en) 2003-09-30 2007-06-26 Intel Corporation Mechanism to control hardware interrupt acknowledgement in a virtual machine system
US20050080934A1 (en) 2003-09-30 2005-04-14 Cota-Robles Erik C. Invalidating translation lookaside buffer entries in a virtual machine (VM) system
US7177967B2 (en) * 2003-09-30 2007-02-13 Intel Corporation Chipset support for managing hardware interrupts in a virtual machine system
US7636844B2 (en) * 2003-11-17 2009-12-22 Intel Corporation Method and system to provide a trusted channel within a computer system for a SIM device
US20050108534A1 (en) * 2003-11-19 2005-05-19 Bajikar Sundeep M. Providing services to an open platform implementing subscriber identity module (SIM) capabilities
US20050108171A1 (en) * 2003-11-19 2005-05-19 Bajikar Sundeep M. Method and apparatus for implementing subscriber identity module (SIM) capabilities in an open platform
US8156343B2 (en) 2003-11-26 2012-04-10 Intel Corporation Accessing private data about the state of a data processing machine from storage that is publicly accessible
US8037314B2 (en) 2003-12-22 2011-10-11 Intel Corporation Replacing blinded authentication authority
US20050152539A1 (en) * 2004-01-12 2005-07-14 Brickell Ernie F. Method of protecting cryptographic operations from side channel attacks
US7802085B2 (en) 2004-02-18 2010-09-21 Intel Corporation Apparatus and method for distributing private keys to an entity with minimal secret, unique information
US20050216920A1 (en) * 2004-03-24 2005-09-29 Vijay Tewari Use of a virtual machine to emulate a hardware device
US7356735B2 (en) * 2004-03-30 2008-04-08 Intel Corporation Providing support for single stepping a virtual machine in a virtual machine environment
US7620949B2 (en) 2004-03-31 2009-11-17 Intel Corporation Method and apparatus for facilitating recognition of an open event window during operation of guest software in a virtual machine environment
US7490070B2 (en) 2004-06-10 2009-02-10 Intel Corporation Apparatus and method for proving the denial of a direct proof signature
US20050288056A1 (en) * 2004-06-29 2005-12-29 Bajikar Sundeep M System including a wireless wide area network (WWAN) module with an external identity module reader and approach for certifying the WWAN module
US7305592B2 (en) * 2004-06-30 2007-12-04 Intel Corporation Support for nested fault in a virtual machine environment
US7840962B2 (en) * 2004-09-30 2010-11-23 Intel Corporation System and method for controlling switching between VMM and VM using enabling value of VMM timer indicator and VMM timer value having a specified time
US8146078B2 (en) 2004-10-29 2012-03-27 Intel Corporation Timer offsetting mechanism in a virtual machine environment
US8924728B2 (en) * 2004-11-30 2014-12-30 Intel Corporation Apparatus and method for establishing a secure session with a device without exposing privacy-sensitive information
US8533777B2 (en) 2004-12-29 2013-09-10 Intel Corporation Mechanism to determine trust of out-of-band management agents
US7395405B2 (en) 2005-01-28 2008-07-01 Intel Corporation Method and apparatus for supporting address translation in a virtual machine environment
US8014530B2 (en) 2006-03-22 2011-09-06 Intel Corporation Method and apparatus for authenticated, recoverable key distribution with no database secrets
BR112022004861A2 (pt) 2019-09-17 2022-06-07 Univ Duke Alvelestat para uso no tratamento de rejeição de transplante, síndrome de bronquiolite obliterante e doença de transplante versus hospedeiro
SI4106757T1 (sl) 2020-04-16 2023-11-30 Mereo Biopharma 4 Limited Postopki, ki vključujejo zaviralec nevtrofilne elastaze alvelestat, za zdravljenje bolezni dihal, ki jo sproži pomanjkanje antitripsina alfa-1
KR20240090272A (ko) 2021-10-20 2024-06-21 메레오 바이오파마 4 리미티드 섬유화 치료에 사용하기 위한 호중구 엘라스테이스 억제제

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3235189A1 (de) * 1982-09-23 1984-03-29 Hoechst Ag, 6230 Frankfurt Polymer-granulat, verfahren zu seiner herstellung und seine verwendung
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
AU600226B2 (en) * 1985-02-04 1990-08-09 Merrell Pharmaceuticals Inc. Novel peptidase inhibitors
EP0204571B1 (en) * 1985-06-07 1992-01-22 Ici Americas Inc. Selected difluoro derivatives
EP0249349B1 (en) * 1986-06-05 1992-10-14 Ici Americas Inc. Difluoroketo compounds
GB8910547D0 (en) * 1989-05-08 1989-06-21 Ici America Inc Substituted ketones
GB9207145D0 (en) * 1991-04-18 1992-05-13 Ici Plc Heterocyclic amides
GB9216272D0 (en) * 1991-08-15 1992-09-09 Ici Plc Substituted heterocycles

Also Published As

Publication number Publication date
NO943910D0 (no) 1994-10-14
HUT67877A (en) 1995-05-29
FI944803A0 (fi) 1994-10-12
IL105425A0 (en) 1993-08-18
MX9302219A (es) 1994-08-31
DE69319238T2 (de) 1998-10-22
EP0636142A1 (en) 1995-02-01
WO1993021209A1 (en) 1993-10-28
CA2118250A1 (en) 1993-10-28
ATE167481T1 (de) 1998-07-15
US5486529A (en) 1996-01-23
EP0636142B1 (en) 1998-06-17
FI944803A (fi) 1994-10-12
JPH07505874A (ja) 1995-06-29
AU4077093A (en) 1993-11-18
JP3415151B2 (ja) 2003-06-09
HU9402970D0 (en) 1995-02-28
US5721222A (en) 1998-02-24
DE69319238D1 (de) 1998-07-23

Similar Documents

Publication Publication Date Title
NO943910L (no) Laktam-peptider med HLE-hemmende virkning
TW262475B (en) Heterocyclic amides, intermediates and process for their preparation and pharmaceutical compositions containing them
NO923197L (no) Substituerte heterocykliske forbindelser
EP0636143A1 (en) PEPTIDES WITH AN ALPHAAMINOBORONAIRE GROUP AND THEIR USE AS AN ELASTASE INHIBITOR.
FI944802A0 (fi) HLE-proteiinien aktiivisuutta inhiboivat laktaamidipeptidit
FI945696A0 (fi) Laktaamidipeptidejä, joilla on HLE:a inhiboiva aktiivisuus
FI946202A (fi) Fluoria sisältäviä dipeptidejä inhibiittoreina ihmisen lenkosyyttielastaasi-inhibiittoreita vastaan
MX9705231A (es) Derivados de prolina utiles como inhibidores de elastasa leucocito humano.