FI946202A - Fluoria sisältäviä dipeptidejä inhibiittoreina ihmisen lenkosyyttielastaasi-inhibiittoreita vastaan - Google Patents

Fluoria sisältäviä dipeptidejä inhibiittoreina ihmisen lenkosyyttielastaasi-inhibiittoreita vastaan Download PDF

Info

Publication number
FI946202A
FI946202A FI946202A FI946202A FI946202A FI 946202 A FI946202 A FI 946202A FI 946202 A FI946202 A FI 946202A FI 946202 A FI946202 A FI 946202A FI 946202 A FI946202 A FI 946202A
Authority
FI
Finland
Prior art keywords
inhibitors
amide derivatives
human leukocyte
fluorine
leukocyte elastase
Prior art date
Application number
FI946202A
Other languages
English (en)
Swedish (sv)
Other versions
FI946202A0 (fi
Inventor
Philip Duke Edwards
Peter Warner
Donald John Wolanin
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of FI946202A0 publication Critical patent/FI946202A0/fi
Publication of FI946202A publication Critical patent/FI946202A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
FI946202A 1992-07-02 1994-12-30 Fluoria sisältäviä dipeptidejä inhibiittoreina ihmisen lenkosyyttielastaasi-inhibiittoreita vastaan FI946202A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929214053A GB9214053D0 (en) 1992-07-02 1992-07-02 Heterocyclic amides
PCT/GB1993/001380 WO1994001455A1 (en) 1992-07-02 1993-07-01 Fluorine comprising dipeptides as inhibitors against human leucocyte elastase inhibitors

Publications (2)

Publication Number Publication Date
FI946202A0 FI946202A0 (fi) 1994-12-30
FI946202A true FI946202A (fi) 1995-01-26

Family

ID=10718076

Family Applications (1)

Application Number Title Priority Date Filing Date
FI946202A FI946202A (fi) 1992-07-02 1994-12-30 Fluoria sisältäviä dipeptidejä inhibiittoreina ihmisen lenkosyyttielastaasi-inhibiittoreita vastaan

Country Status (11)

Country Link
US (1) US5532366A (fi)
EP (1) EP0649432B1 (fi)
JP (1) JPH07508748A (fi)
AT (1) ATE171191T1 (fi)
AU (1) AU669545B2 (fi)
CA (1) CA2139421A1 (fi)
DE (1) DE69321121T2 (fi)
FI (1) FI946202A (fi)
GB (1) GB9214053D0 (fi)
HU (1) HUT68543A (fi)
WO (1) WO1994001455A1 (fi)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1007056A1 (en) * 1997-09-26 2000-06-14 Eli Lilly And Company Method for the treatment of cystic fibrosis
US6576654B1 (en) 1998-09-23 2003-06-10 Eli Lilly And Company Method for the treatment of cystic fibrosis
EP1132381A1 (en) * 2000-03-08 2001-09-12 Cermol S.A. Ester derivatives of dimethylpropionic acid and pharmaceutical compositions containing them
PA8539401A1 (es) * 2001-02-14 2002-10-28 Warner Lambert Co Quinazolinas como inhibidores de mmp-13
BR0314186A (pt) * 2002-09-10 2005-08-09 Bayer Healthcare Ag Derivados de pirimidinona como agentes terapêuticos contra processos inflamatórios, isquêmicos e remodeladores, agudos e crÈnicos
WO2005080372A1 (en) * 2004-02-19 2005-09-01 Bayer Healthcare Ag Dihydropyridinone derivatives
CA2557271C (en) * 2004-02-26 2012-08-21 Bayer Healthcare Ag 1,4-diaryl-dihydropyrimidin-2-ones and their use as human neutrophil elastase inhibitors
EP1730121B1 (en) * 2004-02-26 2013-08-07 Bayer Intellectual Property GmbH 1,4-diaryl-dihydropyrimidin-2-ones and their use as human neutrophil elastase inhibitors
PL2234985T3 (pl) * 2007-12-20 2012-08-31 Bayer Ip Gmbh 4-(4-cyjano-2-tioarylo)-dihydropirymidynony i ich zastosowanie
CA2980071A1 (en) 2015-03-18 2016-09-22 Bayer Pharma Aktiengesellschaft Method for preparation of (4s)-4-[4-cyano-2-(methylsulfonyl)phenyl]-3,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydro pyrimidine-5-carbonitrile
EP4031138A1 (en) 2019-09-17 2022-07-27 Mereo Biopharma 4 Limited Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease
AU2021256835A1 (en) 2020-04-16 2022-10-13 Mereo Biopharma 4 Limited Methods involving neutrophil elastase inhibitor alvelestat for treating respiratory disease mediated by alpha-1 antitrypsin deficiency
WO2023067103A1 (en) 2021-10-20 2023-04-27 Mereo Biopharma 4 Limited Neutrophil elastase inhibitors for use in the treatment of fibrosis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
US4808618A (en) * 1986-04-16 1989-02-28 Nippon Zoki Pharmaceutical Co., Ltd. Substituted 1,3-dialkylpyrido[4,3-d]pyrimidine-2,4-diones
GB8910550D0 (en) * 1989-05-08 1989-06-21 Ici America Inc Substituted amides
GB9207145D0 (en) * 1991-04-18 1992-05-13 Ici Plc Heterocyclic amides
GB9216272D0 (en) * 1991-08-15 1992-09-09 Ici Plc Substituted heterocycles
AU658426B2 (en) * 1991-08-15 1995-04-13 Zeneca Limited Substituted heterocycles

Also Published As

Publication number Publication date
GB9214053D0 (en) 1992-08-12
HU9403700D0 (en) 1995-02-28
DE69321121D1 (de) 1998-10-22
US5532366A (en) 1996-07-02
AU4507893A (en) 1994-01-31
HUT68543A (en) 1995-06-28
JPH07508748A (ja) 1995-09-28
WO1994001455A1 (en) 1994-01-20
AU669545B2 (en) 1996-06-13
EP0649432A1 (en) 1995-04-26
DE69321121T2 (de) 1999-03-04
FI946202A0 (fi) 1994-12-30
ATE171191T1 (de) 1998-10-15
CA2139421A1 (en) 1994-01-20
EP0649432B1 (en) 1998-09-16

Similar Documents

Publication Publication Date Title
NO943910L (no) Laktam-peptider med HLE-hemmende virkning
TW262475B (en) Heterocyclic amides, intermediates and process for their preparation and pharmaceutical compositions containing them
EP0636143A1 (en) PEPTIDES WITH AN ALPHAAMINOBORONAIRE GROUP AND THEIR USE AS AN ELASTASE INHIBITOR.
IL102805A0 (en) Substituted heterocycles
DE69308291D1 (de) Lactam Dipeptide mit HLE inhibierende Aktivität.
FI946202A (fi) Fluoria sisältäviä dipeptidejä inhibiittoreina ihmisen lenkosyyttielastaasi-inhibiittoreita vastaan
FI945696A0 (fi) Laktaamidipeptidejä, joilla on HLE:a inhiboiva aktiivisuus
MX9705231A (es) Derivados de prolina utiles como inhibidores de elastasa leucocito humano.

Legal Events

Date Code Title Description
FD Application lapsed