NO943909L - Laktam-dipeptider som har HLE-inhiberende aktivitet - Google Patents

Laktam-dipeptider som har HLE-inhiberende aktivitet

Info

Publication number
NO943909L
NO943909L NO943909A NO943909A NO943909L NO 943909 L NO943909 L NO 943909L NO 943909 A NO943909 A NO 943909A NO 943909 A NO943909 A NO 943909A NO 943909 L NO943909 L NO 943909L
Authority
NO
Norway
Prior art keywords
heterocyclic compounds
hle
dipeptides
lactam
inhibitory activity
Prior art date
Application number
NO943909A
Other languages
English (en)
Other versions
NO943909D0 (no
Inventor
Peter Robert Bernstein
Royston Martin Thomas
Peter Warner
Donald John Wolanin
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929208380A external-priority patent/GB9208380D0/en
Priority claimed from GB929208379A external-priority patent/GB9208379D0/en
Priority claimed from GB929214448A external-priority patent/GB9214448D0/en
Priority claimed from GB929217362A external-priority patent/GB9217362D0/en
Priority claimed from GB929217364A external-priority patent/GB9217364D0/en
Priority claimed from GB929217363A external-priority patent/GB9217363D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of NO943909D0 publication Critical patent/NO943909D0/no
Publication of NO943909L publication Critical patent/NO943909L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Foreliggende oppfinnelse vedrører Visse nye hetero- cykliske forbindelser, som er 1-pyridylacetamid-forbindelser med formel (I) CF, som er inhibitorer av human leukocytt-elastase (HLE), også kjent som human neutrofil elastasé (HNE), som gjør dem nyttige når slik inhibering er ønsket, f.eks. som forskningsredskap ved farmakologiske, diagnostiske og beslektede undersøkelser og ved behandling av slike sykdommer hos pattedyr hvor HLE spiller en rolle. Oppfinnelsen inkluderer også mellomprodukter egnet ved syntese av disse heterocykliske forbindelsene, fremgangsmåter for fremstilling av de heterocykliske for- bindelsene, farmasøytiske preparater som inneholder slike heterocykliske forbindelser og fremgangsmåter for deres anvendelse.
NO943909A 1992-04-16 1994-10-14 Laktam-dipeptider som har HLE-inhiberende aktivitet NO943909L (no)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB929208380A GB9208380D0 (en) 1992-04-16 1992-04-16 Heterocyclic compounds
GB929208379A GB9208379D0 (en) 1992-04-16 1992-04-16 Heterocyclic amines
GB929214448A GB9214448D0 (en) 1992-07-08 1992-07-08 Heterocyclic agents
GB929217362A GB9217362D0 (en) 1992-08-14 1992-08-14 Heterocyclic compounds
GB929217364A GB9217364D0 (en) 1992-08-14 1992-08-14 Heterocyclic agents
GB929217363A GB9217363D0 (en) 1992-08-14 1992-08-14 Heterocyclic amines
PCT/GB1993/000794 WO1993021212A1 (en) 1992-04-16 1993-04-15 Lactam dipeptides having hle inhibiting activity

Publications (2)

Publication Number Publication Date
NO943909D0 NO943909D0 (no) 1994-10-14
NO943909L true NO943909L (no) 1994-10-14

Family

ID=27547161

Family Applications (1)

Application Number Title Priority Date Filing Date
NO943909A NO943909L (no) 1992-04-16 1994-10-14 Laktam-dipeptider som har HLE-inhiberende aktivitet

Country Status (13)

Country Link
EP (1) EP0630382B1 (no)
JP (1) JPH07505873A (no)
AT (1) ATE149175T1 (no)
AU (1) AU4076993A (no)
CA (1) CA2132543A1 (no)
DE (1) DE69308291T2 (no)
FI (1) FI944802A0 (no)
GB (1) GB9307555D0 (no)
HU (1) HUT70430A (no)
IL (1) IL105424A0 (no)
MX (1) MX9302215A (no)
NO (1) NO943909L (no)
WO (1) WO1993021212A1 (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6159938A (en) * 1994-11-21 2000-12-12 Cortech, Inc. Serine protease inhibitors comprising α-keto heterocycles
US5618792A (en) * 1994-11-21 1997-04-08 Cortech, Inc. Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase
US6001814A (en) * 1994-11-21 1999-12-14 Cortech Inc. Serine protease inhibitors
US6150334A (en) * 1994-11-21 2000-11-21 Cortech, Inc. Serine protease inhibitors-tripeptoid analogs
US6001813A (en) * 1994-11-21 1999-12-14 Cortech Inc. Val-pro containing α-keto oxadiazoles as serine protease inhibitors
US6100238A (en) * 1994-11-21 2000-08-08 Cortech Inc. Indole and tetrahydroisoquinoline containing Alpha-keto oxadiazoles as serine protease inhibitors
US5998379A (en) * 1994-11-21 1999-12-07 Cortech Inc. Serine protease inhibitors-proline analogs
US20020119985A1 (en) 1994-11-21 2002-08-29 Albert Gyorkos Serine protease inhibitors
US6001811A (en) * 1994-11-21 1999-12-14 Cortech Inc. Serine protease inhibitors--N-substituted derivatives
US6015791A (en) * 1994-11-21 2000-01-18 Cortech Inc. Serine protease inhibitors-cycloheptane derivatives
CA2219364A1 (en) * 1995-04-27 1996-10-31 Hideki Okunishi Heterocyclic amide compounds and pharmaceutical use thereof
WO1998024806A2 (en) * 1996-12-06 1998-06-11 Cortech, Inc. Substituted oxadiazole, thiadiazole and triazole serine protease inhibitors
US6656910B2 (en) 1997-12-04 2003-12-02 Cortech, Inc. Serine protease inhibitors
EP1089752A4 (en) 1998-06-03 2002-01-02 Cortech Inc ALPHA-KETO OXADIAZOLE AS A SERINE PROTEASE INHIBITOR
US7375150B2 (en) 2001-07-30 2008-05-20 Sanko Chemical Industry Co., Ltd. Anti-static composition and method for production thereof
IL163453A0 (en) 2004-08-10 2009-02-11 Yeda Res & Dev Enzyme inhibitor in leukemia
EP2424841A1 (en) * 2009-04-27 2012-03-07 Elan Pharmaceuticals Inc. Pyridinone antagonists of alpha-4 integrins
EP4031138A1 (en) 2019-09-17 2022-07-27 Mereo Biopharma 4 Limited Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease
MX2022012942A (es) 2020-04-16 2023-01-11 Mereo Biopharma 4 Ltd Metodos que involucran el inhibidor de la elastasa de neutrofilo alvelestat para el tratamiento de enfermedades respiratorias mediadas por deficiencia de alfa-1 antitripsina.
IL312002A (en) 2021-10-20 2024-06-01 Mereo Biopharma 4 Ltd Neutrophil elastase inhibitors for use in the treatment of fibrosis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0369391A3 (en) * 1988-11-15 1991-09-25 Boehringer Ingelheim Pharmaceuticals Inc. N-substituted amides
GB9207145D0 (en) * 1991-04-18 1992-05-13 Ici Plc Heterocyclic amides

Also Published As

Publication number Publication date
MX9302215A (es) 1993-10-01
CA2132543A1 (en) 1993-10-28
HU9402968D0 (en) 1995-02-28
FI944802A (fi) 1994-10-12
EP0630382B1 (en) 1997-02-26
GB9307555D0 (en) 1993-06-02
IL105424A0 (en) 1993-08-18
WO1993021212A1 (en) 1993-10-28
FI944802A0 (fi) 1994-10-12
EP0630382A1 (en) 1994-12-28
NO943909D0 (no) 1994-10-14
JPH07505873A (ja) 1995-06-29
AU4076993A (en) 1993-11-18
ATE149175T1 (de) 1997-03-15
DE69308291D1 (de) 1997-04-03
DE69308291T2 (de) 1997-06-26
HUT70430A (en) 1995-10-30

Similar Documents

Publication Publication Date Title
FI944803A (fi) HLE-estävää aktiivisuutta omaavia laktaamipeptidejä
NO923197L (no) Substituerte heterocykliske forbindelser
TW262475B (en) Heterocyclic amides, intermediates and process for their preparation and pharmaceutical compositions containing them
EP0636143A1 (en) PEPTIDES WITH AN ALPHAAMINOBORONAIRE GROUP AND THEIR USE AS AN ELASTASE INHIBITOR.
NO943909L (no) Laktam-dipeptider som har HLE-inhiberende aktivitet
ATE157099T1 (de) Laktam-dipeptide mit inhibierender wirkung auf die menschliche leukozytenelastase
FI946202A (fi) Fluoria sisältäviä dipeptidejä inhibiittoreina ihmisen lenkosyyttielastaasi-inhibiittoreita vastaan
DK0397427T3 (da) Fluoramidderivater med human leukocytelastase-inhiberende aktivitet