EA200100477A1 - Фармацевтическая композиция тнр и эналаприла - Google Patents

Фармацевтическая композиция тнр и эналаприла

Info

Publication number
EA200100477A1
EA200100477A1 EA200100477A EA200100477A EA200100477A1 EA 200100477 A1 EA200100477 A1 EA 200100477A1 EA 200100477 A EA200100477 A EA 200100477A EA 200100477 A EA200100477 A EA 200100477A EA 200100477 A1 EA200100477 A1 EA 200100477A1
Authority
EA
Eurasian Patent Office
Prior art keywords
enalapril
thp
pharmaceutical composition
ace
inhibitor
Prior art date
Application number
EA200100477A
Other languages
English (en)
Other versions
EA003470B1 (ru
Inventor
Иварс Калвиньш
Марис Веверис
Юрис Бундулис
Илзе Скарда
Original Assignee
Иварс Калвиньш
Марис Веверис
Юрис Бундулис
Илзе Скарда
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Иварс Калвиньш, Марис Веверис, Юрис Бундулис, Илзе Скарда filed Critical Иварс Калвиньш
Publication of EA200100477A1 publication Critical patent/EA200100477A1/ru
Publication of EA003470B1 publication Critical patent/EA003470B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Фармацевтическая композиция, содержащая дигидрат 3-(2,2,2-триметилгидразиний) пропионата (ТГП) и ингибитор ангиотензинпревращающего фермента (АПФ), в качестве комбинированного препарата для лечения сердечно-сосудистых заболеваний. Предлагается в качестве ингибитора АПФ использовать (S)-1-{N-[1-(этоксикарбонил)-3-фенилпропил]-1-аланил}-L-пролин или Эналаприл. Предпочтительное отношение в комбинации ТГП к Эналаприлу составляет от 8:1 до 12:1.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200100477A 1998-10-29 1999-10-27 Фармацевтическая композиция тгп и ингибитора апф EA003470B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LVP-98-252A LV12491B (lv) 1998-10-29 1998-10-29 Farmaceitiska kompozīcija
PCT/LV1999/000005 WO2000025773A1 (en) 1998-10-29 1999-10-27 Pharmaceutical combination of mildronate and enalapril

Publications (2)

Publication Number Publication Date
EA200100477A1 true EA200100477A1 (ru) 2001-10-22
EA003470B1 EA003470B1 (ru) 2003-06-26

Family

ID=19736545

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100477A EA003470B1 (ru) 1998-10-29 1999-10-27 Фармацевтическая композиция тгп и ингибитора апф

Country Status (5)

Country Link
EP (1) EP1124547A1 (ru)
EA (1) EA003470B1 (ru)
LV (1) LV12491B (ru)
UA (1) UA71934C2 (ru)
WO (1) WO2000025773A1 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LV13450B (en) * 2004-08-24 2006-11-20 Grindeks As Novel medicinal use of meldonium and pharmaceutical compositions thereof
EP2420224A1 (en) * 2010-08-11 2012-02-22 Grindeks, a joint stock company Method for producing a stable 3-(2,2,2-trimethylhydrazinium)propionate dihydrate solid pharmaceutical composition
RU2467748C1 (ru) * 2011-08-08 2012-11-27 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Белгородский государственный национальный исследовательский университет" Производное 3-(2,2,2-триметилгидразиний)пропионата - глицинат 3-(2,2,2-триметилгидразиний)пропионат калия, обладающее эндотелиопротекторной активностью
CN105853349A (zh) * 2016-04-29 2016-08-17 济南康和医药科技有限公司 一种米屈肼注射液及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1254314B (it) * 1992-03-27 1995-09-14 Sigma Tau Ind Farmaceuti Composizioni farmaceutiche conyenenti l-carnitina e acil- carnitine inassociazione con ace-inibitori per il trattamento di patologie cardiovascolari.
LV11728B (en) * 1995-08-21 1997-08-20 Kalvins Ivars Pharmaceutical composition

Also Published As

Publication number Publication date
EP1124547A1 (en) 2001-08-22
UA71934C2 (en) 2005-01-17
LV12491B (lv) 2000-12-20
LV12491A (en) 2000-06-20
WO2000025773A1 (en) 2000-05-11
EA003470B1 (ru) 2003-06-26

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KG MD TJ TM

PC4A Registration of transfer of a eurasian patent by assignment
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY KZ RU