DE69506380D1 - Diastereomer reine trifluormetylketon derivate von peptiden als inhibitoren der menschlichen leukozytenelastase - Google Patents

Diastereomer reine trifluormetylketon derivate von peptiden als inhibitoren der menschlichen leukozytenelastase

Info

Publication number
DE69506380D1
DE69506380D1 DE69506380T DE69506380T DE69506380D1 DE 69506380 D1 DE69506380 D1 DE 69506380D1 DE 69506380 T DE69506380 T DE 69506380T DE 69506380 T DE69506380 T DE 69506380T DE 69506380 D1 DE69506380 D1 DE 69506380D1
Authority
DE
Germany
Prior art keywords
derivatives
trifluormetylketone
peptides
inhibitors
human leukocyte
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69506380T
Other languages
English (en)
Other versions
DE69506380T2 (de
Inventor
Stephen Pegg
George Sependa
Elwyn Davies
Chris Veale
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca UK Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9421550A external-priority patent/GB9421550D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of DE69506380D1 publication Critical patent/DE69506380D1/de
Application granted granted Critical
Publication of DE69506380T2 publication Critical patent/DE69506380T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE69506380T 1994-02-11 1995-02-07 Diastereomer reine trifluormetylketon derivate von peptiden als inhibitoren der menschlichen leukozytenelastase Expired - Fee Related DE69506380T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9402680A GB9402680D0 (en) 1994-02-11 1994-02-11 Pyrrolidine derivatives
GB9421550A GB9421550D0 (en) 1994-10-26 1994-10-26 Heterocyclic derivative
PCT/GB1995/000242 WO1995021855A1 (en) 1994-02-11 1995-02-07 Diastereomeric pure trifluoromethyl ketone peptide derivatives as inhibitors of human leukocyte elastase

Publications (2)

Publication Number Publication Date
DE69506380D1 true DE69506380D1 (de) 1999-01-14
DE69506380T2 DE69506380T2 (de) 1999-05-06

Family

ID=26304315

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69506380T Expired - Fee Related DE69506380T2 (de) 1994-02-11 1995-02-07 Diastereomer reine trifluormetylketon derivate von peptiden als inhibitoren der menschlichen leukozytenelastase

Country Status (20)

Country Link
US (3) US5739157A (de)
EP (1) EP0743953B1 (de)
JP (1) JP3416142B2 (de)
CN (1) CN1140455A (de)
AT (1) ATE174034T1 (de)
AU (1) AU692515B2 (de)
CA (1) CA2180006A1 (de)
DE (1) DE69506380T2 (de)
DK (1) DK0743953T3 (de)
ES (1) ES2125004T3 (de)
FI (1) FI963132A (de)
GB (1) GB9402680D0 (de)
HK (1) HK1011033A1 (de)
IL (1) IL112613A (de)
MX (1) MX9603291A (de)
NO (1) NO313882B1 (de)
NZ (1) NZ279265A (de)
TW (1) TW414801B (de)
WO (1) WO1995021855A1 (de)
YU (1) YU7195A (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9402680D0 (en) * 1994-02-11 1994-04-06 Zeneca Ltd Pyrrolidine derivatives
US5618792A (en) * 1994-11-21 1997-04-08 Cortech, Inc. Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase
US5804560A (en) * 1995-01-06 1998-09-08 Sibia Neurosciences, Inc. Peptide and peptide analog protease inhibitors
US6017887A (en) * 1995-01-06 2000-01-25 Sibia Neurosciences, Inc. Peptide, peptide analog and amino acid analog protease inhibitors
GB9502152D0 (en) * 1995-02-03 1995-03-29 Zeneca Ltd Proline derivatives
US5942536A (en) * 1995-10-10 1999-08-24 Eli Lilly And Company N- 2-substituted-3-(2-aminoethyl)-1H-indol-5-YL!-Amides: new 5-HT1F agonists
ES2217404T3 (es) * 1996-03-28 2004-11-01 Glaxo Group Limited Derivados de pirrolopirrolona como inhibidores de la elastasa de neutrofilos.
GB9719187D0 (en) 1997-09-09 1997-11-12 Glaxo Group Ltd Compounds
PE107899A1 (es) * 1997-09-09 1999-11-17 Glaxo Group Ltd Derivados de pirrolopirrolona como inhibidores de elastasa leucocitaria
GB9719172D0 (en) 1997-09-09 1997-11-12 Glaxo Group Ltd Compounds
EP1539710B1 (de) 2002-09-10 2010-10-27 Bayer Schering Pharma Aktiengesellschaft Heterocyclische derivate
WO2005080372A1 (en) 2004-02-19 2005-09-01 Bayer Healthcare Ag Dihydropyridinone derivatives
DE102005037791A1 (de) * 2005-08-10 2007-02-15 Ernst-Moritz-Arndt Universität Greifswald Verwendung von spezifischen Trifluormethylketonen zur Vorbeugung und Behandlung einer Pankreatitis
EP2099454A4 (de) * 2006-11-17 2010-11-10 Abbott Lab Aminopyrrolidine als chemokinrezeptor-antagonisten
CN103226756A (zh) * 2013-04-28 2013-07-31 文俊 工艺品生产过程的工艺制作及生产过程的记录方法和系统
EP4031138A1 (de) 2019-09-17 2022-07-27 Mereo Biopharma 4 Limited Alvelestat zur verwendung bei der behandelung von transplantatabstossung, bronchiolitis-obliterans-syndrom und transplantat-gegen-wirtszelle
AU2021256835A1 (en) 2020-04-16 2022-10-13 Mereo Biopharma 4 Limited Methods involving neutrophil elastase inhibitor alvelestat for treating respiratory disease mediated by alpha-1 antitrypsin deficiency
WO2023067103A1 (en) 2021-10-20 2023-04-27 Mereo Biopharma 4 Limited Neutrophil elastase inhibitors for use in the treatment of fibrosis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5055450A (en) * 1985-01-22 1991-10-08 Ici Americas Inc. Peptide derivatives
US5194588A (en) * 1985-01-22 1993-03-16 Ici Americas Inc. Aminoalcohol intermediates for peptide derivatives
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
EP0276101A3 (de) * 1987-01-19 1989-11-23 Ici Americas Inc. Substituierte Peptid-Derivate
GB9402680D0 (en) * 1994-02-11 1994-04-06 Zeneca Ltd Pyrrolidine derivatives

Also Published As

Publication number Publication date
AU692515B2 (en) 1998-06-11
FI963132A0 (fi) 1996-08-09
CN1140455A (zh) 1997-01-15
NO963329L (no) 1996-10-09
EP0743953B1 (de) 1998-12-02
EP0743953A1 (de) 1996-11-27
DK0743953T3 (da) 1999-08-16
NZ279265A (en) 1998-01-26
ES2125004T3 (es) 1999-02-16
TW414801B (en) 2000-12-11
NO963329D0 (no) 1996-08-09
FI963132A (fi) 1996-08-09
AU1583995A (en) 1995-08-29
YU7195A (sh) 1998-09-18
NO313882B1 (no) 2002-12-16
JP3416142B2 (ja) 2003-06-16
MX9603291A (es) 1997-02-28
JPH09508902A (ja) 1997-09-09
HK1011033A1 (en) 1999-07-02
US5739157A (en) 1998-04-14
US5907043A (en) 1999-05-25
GB9402680D0 (en) 1994-04-06
IL112613A (en) 2000-02-29
CA2180006A1 (en) 1995-08-17
IL112613A0 (en) 1995-05-26
US6037363A (en) 2000-03-14
DE69506380T2 (de) 1999-05-06
ATE174034T1 (de) 1998-12-15
WO1995021855A1 (en) 1995-08-17

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ASTRAZENECA UK LTD., LONDON, GB

8339 Ceased/non-payment of the annual fee