HUP9801991A2 - Humán leukocita-elasztáz inhibítorokként felhasználható prolinszármazékok - Google Patents

Humán leukocita-elasztáz inhibítorokként felhasználható prolinszármazékok

Info

Publication number
HUP9801991A2
HUP9801991A2 HU9801991A HUP9801991A HUP9801991A2 HU P9801991 A2 HUP9801991 A2 HU P9801991A2 HU 9801991 A HU9801991 A HU 9801991A HU P9801991 A HUP9801991 A HU P9801991A HU P9801991 A2 HUP9801991 A2 HU P9801991A2
Authority
HU
Hungary
Prior art keywords
inhibitors
human leukocyte
derivatives useful
leukocyte elastase
proline derivatives
Prior art date
Application number
HU9801991A
Other languages
English (en)
Inventor
Peter Robert Bernstein
Elwyn Peter Davies
Chris Allan Veale
Original Assignee
Zeneca Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Limited filed Critical Zeneca Limited
Publication of HUP9801991A2 publication Critical patent/HUP9801991A2/hu
Publication of HUP9801991A3 publication Critical patent/HUP9801991A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A találmány az (I) képletű 1-[2-(metőxi-karbőnil-aminő)-3-metil-bűtiril]-N-[2-metil-1-(triflűőr-acetil)-prőpil]-pirrőlidin-2-karbőxamid, tővábbá szőlvátjai, ketáljai és hemiketáljai őlyanfőrmáira vőnatkőzik, amelyek legalább 50%-ban az (Ia) képletnekmegfelelő diasztereőizőmert tartamazzák. A találmány tárgyát képezikaz ezeket tartalmazó gyógyászati készítmények is. A találmány tárgyatővábbá eljárás az (I) képletű vegyületek előállítására a fentifőrmában. ŕ
HU9801991A 1995-02-03 1996-01-30 Proline derivatives useful as inhibitors of human leukocyte elastase HUP9801991A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9502152.3A GB9502152D0 (en) 1995-02-03 1995-02-03 Proline derivatives

Publications (2)

Publication Number Publication Date
HUP9801991A2 true HUP9801991A2 (hu) 1999-02-01
HUP9801991A3 HUP9801991A3 (en) 1999-06-28

Family

ID=10769064

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9801991A HUP9801991A3 (en) 1995-02-03 1996-01-30 Proline derivatives useful as inhibitors of human leukocyte elastase

Country Status (23)

Country Link
US (4) US5686628A (hu)
EP (1) EP0808327A1 (hu)
JP (1) JPH10513173A (hu)
KR (1) KR19980701869A (hu)
CN (1) CN1172486A (hu)
AR (1) AR003922A1 (hu)
AU (1) AU704704B2 (hu)
BR (1) BR9607095A (hu)
CA (1) CA2209675A1 (hu)
CZ (1) CZ246697A3 (hu)
FI (1) FI973211A (hu)
GB (1) GB9502152D0 (hu)
HR (1) HRP960008A2 (hu)
HU (1) HUP9801991A3 (hu)
IL (1) IL117013A0 (hu)
NO (1) NO973539L (hu)
NZ (1) NZ300256A (hu)
PL (1) PL321680A1 (hu)
RU (1) RU2159249C2 (hu)
SK (1) SK105497A3 (hu)
TR (1) TR199700732T1 (hu)
WO (1) WO1996023812A1 (hu)
ZA (1) ZA96851B (hu)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998010800A2 (en) * 1996-09-16 1998-03-19 Amersham International Plc Labelled elastase inhibitors
US5773430A (en) * 1997-03-13 1998-06-30 Research Foundation Of State University Of New York Serine proteinase inhibitory activity by hydrophobic tetracycline
US7030114B1 (en) 1997-07-31 2006-04-18 Elan Pharmaceuticals, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
US6559127B1 (en) 1997-07-31 2003-05-06 Athena Neurosciences, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
US6423688B1 (en) 1997-07-31 2002-07-23 Athena Neurosciences, Inc. Dipeptide and related compounds which inhibit leukocyte adhesion mediated by VLA-4
US6583139B1 (en) 1997-07-31 2003-06-24 Eugene D. Thorsett Compounds which inhibit leukocyte adhesion mediated by VLA-4
US6362341B1 (en) 1997-07-31 2002-03-26 Athena Neurosciences, Inc. Benzyl compounds which inhibit leukocyte adhesion mediated by VLA-4
US6492421B1 (en) 1997-07-31 2002-12-10 Athena Neurosciences, Inc. Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4
US6489300B1 (en) * 1997-07-31 2002-12-03 Eugene D. Thorsett Carbamyloxy compounds which inhibit leukocyte adhesion mediated by VLA-4
US7232918B2 (en) * 2001-11-06 2007-06-19 Shell Oil Company Catalyst composition
US6544732B1 (en) * 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
ES2272258T3 (es) 1999-12-16 2007-05-01 Dainippon Sumitomo Pharma Co., Ltd. Procesos de produccion de derivados del (aminometil) trifluorometilcarbinol.
WO2006016720A1 (ja) * 2004-08-11 2006-02-16 Dainippon Sumitomo Pharma Co., Ltd. 医薬化合物
WO2006025216A1 (ja) * 2004-08-31 2006-03-09 Dainippon Sumitomo Pharma Co., Ltd. 医薬結晶化合物
GB2454122B (en) * 2005-02-08 2009-07-08 Smith International Thermally stable polycrystalline diamond cutting elements and bits incorporating the same
WO2018056373A1 (ja) * 2016-09-23 2018-03-29 科研製薬株式会社 （ｒ）‐５‐（３，４‐ジフルオロフェニル）‐５‐［（３‐メチル‐２‐オキソピリジン‐１（２ｈ）‐イル）メチル］イミダゾリジン‐２，４‐ジオンの製造方法およびその製造のための中間体
KR20220079527A (ko) 2019-09-17 2022-06-13 메레오 바이오파마 4 리미티드 이식편 거부반응, 폐쇄성 세기관지염 증후군 및 이식편 대 숙주병의 치료에 사용하기 위한 알베레스타트
IL297211A (en) 2020-04-16 2022-12-01 Mereo Biopharma 4 Ltd Methods involving the neutrophil elastase inhibitor albalstat for the treatment of respiratory disease mediated by alpha-1 antitrypsin deficiency
AU2022373971A1 (en) 2021-10-20 2024-04-04 Mereo Biopharma 4 Limited Neutrophil elastase inhibitors for use in the treatment of fibrosis

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4277395A (en) * 1980-06-16 1981-07-07 Richardson-Merrell Inc. Novel enzyme inhibitors
DE3481913D1 (de) * 1983-04-27 1990-05-17 Ici America Inc Prolin-derivate.
US4518528A (en) * 1983-05-19 1985-05-21 Rasnick David W α Amino fluoro ketones
US5055450A (en) * 1985-01-22 1991-10-08 Ici Americas Inc. Peptide derivatives
US5194588A (en) * 1985-01-22 1993-03-16 Ici Americas Inc. Aminoalcohol intermediates for peptide derivatives
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
AU600226B2 (en) * 1985-02-04 1990-08-09 Merrell Pharmaceuticals Inc. Novel peptidase inhibitors
CH672792A5 (hu) * 1985-02-19 1989-12-29 Sandoz Ag
GB9402680D0 (en) * 1994-02-11 1994-04-06 Zeneca Ltd Pyrrolidine derivatives

Also Published As

Publication number Publication date
AU704704B2 (en) 1999-04-29
TR199700732T1 (xx) 1998-02-21
EP0808327A1 (en) 1997-11-26
CZ246697A3 (en) 1997-11-12
NO973539L (no) 1997-10-01
RU2159249C2 (ru) 2000-11-20
PL321680A1 (en) 1997-12-22
KR19980701869A (ko) 1998-06-25
ZA96851B (en) 1996-08-05
AR003922A1 (es) 1998-09-30
CA2209675A1 (en) 1996-08-08
JPH10513173A (ja) 1998-12-15
FI973211A0 (fi) 1997-08-01
US6054593A (en) 2000-04-25
AU4494396A (en) 1996-08-21
NO973539D0 (no) 1997-08-01
US5808097A (en) 1998-09-15
NZ300256A (en) 2000-01-28
SK105497A3 (en) 1997-12-10
BR9607095A (pt) 1997-11-11
US6048889A (en) 2000-04-11
HUP9801991A3 (en) 1999-06-28
US5686628A (en) 1997-11-11
IL117013A0 (en) 1996-06-18
CN1172486A (zh) 1998-02-04
MX9705231A (es) 1997-10-31
FI973211A (fi) 1997-08-01
GB9502152D0 (en) 1995-03-29
HRP960008A2 (en) 1998-04-30
WO1996023812A1 (en) 1996-08-08

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