SI9500350B - Oralni multipli emulzijski predkoncentrat - Google Patents
Oralni multipli emulzijski predkoncentrat Download PDFInfo
- Publication number
- SI9500350B SI9500350B SI9500350A SI9500350A SI9500350B SI 9500350 B SI9500350 B SI 9500350B SI 9500350 A SI9500350 A SI 9500350A SI 9500350 A SI9500350 A SI 9500350A SI 9500350 B SI9500350 B SI 9500350B
- Authority
- SI
- Slovenia
- Prior art keywords
- weight
- composition
- ester
- solvent
- polyethylene glycol
- Prior art date
Links
- 239000000839 emulsion Substances 0.000 title claims abstract 3
- 239000000203 mixture Substances 0.000 claims abstract 7
- 239000002904 solvent Substances 0.000 claims abstract 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract 6
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims abstract 2
- 229930105110 Cyclosporin A Natural products 0.000 claims abstract 2
- 108010036949 Cyclosporine Proteins 0.000 claims abstract 2
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract 2
- 229960001265 ciclosporin Drugs 0.000 claims abstract 2
- 229930182912 cyclosporin Natural products 0.000 claims abstract 2
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract 2
- 239000004094 surface-active agent Substances 0.000 claims abstract 2
- -1 glyceride ester Chemical class 0.000 claims 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical group CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000005907 alkyl ester group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 230000005405 multipole Effects 0.000 claims 1
- 235000011007 phosphoric acid Nutrition 0.000 claims 1
- 229940113116 polyethylene glycol 1000 Drugs 0.000 claims 1
- 229920000151 polyglycol Polymers 0.000 claims 1
- 239000010695 polyglycol Substances 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 1
- 229960001295 tocopherol Drugs 0.000 claims 1
- 229930003799 tocopherol Natural products 0.000 claims 1
- 235000010384 tocopherol Nutrition 0.000 claims 1
- 239000011732 tocopherol Substances 0.000 claims 1
- WEAPVABOECTMGR-UHFFFAOYSA-N triethyl 2-acetyloxypropane-1,2,3-tricarboxylate Chemical compound CCOC(=O)CC(C(=O)OCC)(OC(C)=O)CC(=O)OCC WEAPVABOECTMGR-UHFFFAOYSA-N 0.000 claims 1
- 239000001069 triethyl citrate Substances 0.000 claims 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims 1
- 235000013769 triethyl citrate Nutrition 0.000 claims 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 1
- ZAKOWWREFLAJOT-ADUHFSDSSA-N [2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] acetate Chemical group CC(=O)OC1=C(C)C(C)=C2OC(CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-ADUHFSDSSA-N 0.000 abstract 1
- 150000001733 carboxylic acid esters Chemical class 0.000 abstract 1
- 239000012141 concentrate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Transplantation (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9403328A HU215966B (hu) | 1994-11-21 | 1994-11-21 | Orálisan alkalmazható, ciklosporint tartalmazó, összetett emulzió-előkoncentrátum |
Publications (2)
Publication Number | Publication Date |
---|---|
SI9500350A SI9500350A (en) | 1996-06-30 |
SI9500350B true SI9500350B (sl) | 2005-02-28 |
Family
ID=10985774
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI9500350A SI9500350B (sl) | 1994-11-21 | 1995-11-13 | Oralni multipli emulzijski predkoncentrat |
Country Status (17)
Country | Link |
---|---|
US (1) | US5583105A (da) |
EP (1) | EP0712631B1 (da) |
KR (1) | KR100377058B1 (da) |
AT (2) | ATE245994T1 (da) |
CA (1) | CA2145242C (da) |
CZ (1) | CZ286686B6 (da) |
DE (2) | DE69531389T2 (da) |
DK (1) | DK0712631T3 (da) |
ES (1) | ES2202330T3 (da) |
GB (1) | GB2295546B (da) |
HK (1) | HK1016814A1 (da) |
HU (1) | HU215966B (da) |
IT (1) | IT1281337B1 (da) |
PL (1) | PL182716B1 (da) |
PT (1) | PT712631E (da) |
SI (1) | SI9500350B (da) |
SK (1) | SK283045B6 (da) |
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6696413B2 (en) * | 1995-06-16 | 2004-02-24 | Hexal Ag | Pharmaceutical preparation with cyclosporin A |
DE19521974A1 (de) * | 1995-06-16 | 1996-12-19 | Hexal Pharmaforschung Gmbh | Pharmazeutische Zubereitung mit Cyclosporin A |
GB2317562B (en) * | 1995-07-20 | 1999-08-18 | Danbiosyst Uk | Lipid vehicle drug delivery composition containing vitamin E |
US5962019A (en) * | 1995-08-25 | 1999-10-05 | Sangstat Medical Corporation | Oral cyclosporin formulations |
US5827822A (en) * | 1996-03-25 | 1998-10-27 | Sangstat Medical Corporation | Cyclosporin a formulations as nanoparticles |
US5766629A (en) | 1995-08-25 | 1998-06-16 | Sangstat Medical Corporation | Oral cyclosporin formulations |
NZ280689A (en) * | 1995-12-15 | 1997-08-22 | Bernard Charles Sherma Sherman | Pharmaceutical composition comprising a cyclosporipharmaceutical composition comprising a cyclosporin; a tocol, tocopherol or tocotrienol; and propylen; a tocol, tocopherol or tocotrienol; and propylene carbonate or polyethylene glycol ne carbonate or polyethylene glycol |
US5858401A (en) | 1996-01-22 | 1999-01-12 | Sidmak Laboratories, Inc. | Pharmaceutical composition for cyclosporines |
KR0183449B1 (ko) * | 1996-06-19 | 1999-05-01 | 한스 루돌프 하우스, 니콜 케르커 | 사이클로스포린-함유 연질캅셀제 |
US5958876A (en) * | 1996-06-19 | 1999-09-28 | Novartis Ag | Cyclosporin-containing pharmaceutical compositions |
ES2227700T3 (es) * | 1996-06-19 | 2005-04-01 | Novartis Ag | Preparados de capsulas blandas que contienen ciclosporina. |
JP2001523221A (ja) * | 1996-09-01 | 2001-11-20 | ファーモス コーポレイション | 親油性物質の促進された生物学的利用能のための固形共沈物 |
US5891469A (en) * | 1997-04-02 | 1999-04-06 | Pharmos Corporation | Solid Coprecipitates for enhanced bioavailability of lipophilic substances |
US5798333A (en) * | 1996-09-17 | 1998-08-25 | Sherman; Bernard C. | Water-soluble concentrates containing cyclosporins |
US6458373B1 (en) | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
GB2326337A (en) | 1997-06-20 | 1998-12-23 | Phares Pharma Holland | Homogeneous lipid compositions for drug delivery |
US5891845A (en) * | 1997-11-21 | 1999-04-06 | Fuisz Technologies Ltd. | Drug delivery systems utilizing liquid crystal structures |
US6028067A (en) * | 1997-12-05 | 2000-02-22 | Chong Kun Dang Corp. | Cyclosporin-containing microemulsion preconcentrate composition |
US6063762A (en) * | 1997-12-05 | 2000-05-16 | Chong Kun Dang Corp. | Cyclosporin-containing microemulsion preconcentrate composition |
WO1999029335A1 (en) * | 1997-12-05 | 1999-06-17 | Chong Kun Dang Corp. | Pharmaceutical composition containing cyclosporin |
KR100587551B1 (ko) * | 1997-12-10 | 2006-06-08 | 싸이클로스포린 테라퓨틱스 리미티드 | 오메가-3 지방산 오일을 함유하는 약학 조성물 |
ID25908A (id) * | 1998-03-06 | 2000-11-09 | Novartis Ag | Prakonsentrat-prakonsentrat emulsi yang mengandung siklosporin atau makrolida |
US20030216303A1 (en) * | 1998-03-06 | 2003-11-20 | Michael Ambuhl | Emulsion preconcentrates containing cyclosporin or a macrolide |
US7030155B2 (en) * | 1998-06-05 | 2006-04-18 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
PT1154759E (pt) | 1998-12-30 | 2008-11-20 | Dexcel Ltd | Concentrado dispersível para administração de ciclosporina |
US20080070981A1 (en) | 2000-02-23 | 2008-03-20 | Henryk Borowy-Borowski | Water-soluble compositions of bioactive lipophilic compounds |
US6632443B2 (en) | 2000-02-23 | 2003-10-14 | National Research Council Of Canada | Water-soluble compositions of bioactive lipophilic compounds |
US6045826A (en) * | 1999-04-02 | 2000-04-04 | National Research Council Of Canada | Water-soluble compositions of bioactive lipophilic compounds |
GB9912476D0 (en) | 1999-05-28 | 1999-07-28 | Novartis Ag | Organic compounds |
DE19925001A1 (de) * | 1999-05-31 | 2000-12-07 | Pharma Concepts Gmbh & Co Kg | Flüssiges Konzentrat |
US6479540B1 (en) * | 1999-09-27 | 2002-11-12 | Sonus Pharmaceuticals, Inc. | Compositions of tocol-soluble therapeutics |
AU1545301A (en) * | 1999-11-22 | 2001-06-04 | Philippe R. Baudier | Stable acid labile benzimidazole pharmaceutical compositions |
US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
US7919113B2 (en) * | 1999-12-30 | 2011-04-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Dispersible concentrate lipospheres for delivery of active agents |
US20050037073A1 (en) * | 2000-01-13 | 2005-02-17 | Alpharx Inc. | Solid self-emulsifying dosage form for improved delivery of poorly soluble hydrophobic compounds and the process for preparation thereof |
ES2334207T3 (es) * | 2000-11-14 | 2010-03-08 | Vital Health Sciences Pty Ltd. | Composiciones que comprenden complejos de derivados de fosfato de tocoferol. |
AUPR549901A0 (en) | 2001-06-06 | 2001-07-12 | Vital Health Sciences Pty Ltd | Topical formulation containing tocopheryl phosphates |
WO2003011303A1 (en) * | 2001-07-27 | 2003-02-13 | Vital Health Sciences Pty Ltd | Dermal therapy using phosphate derivatives of electron transfer agents |
US6960563B2 (en) * | 2001-08-31 | 2005-11-01 | Morton Grove Pharmaceuticals, Inc. | Spontaneous emulsions containing cyclosporine |
PL210795B1 (pl) | 2001-10-19 | 2012-03-30 | Isotechnika Inc | Sposób wytwarzania mieszaniny ISATX247 wzbogaconej w izomer (E), sposób wytwarzania mieszaniny ISATX247 wzbogaconej w izomer (Z), sposób stereoselektywnej syntezy izomeru (E) ISATX247, sposób stereoselektywnej syntezy izomeru (Z) ISATX247 i sposób wytwarzania mieszaniny izomerów ISATX247 |
EP1435910B9 (en) * | 2001-10-19 | 2010-02-03 | Isotechnika Inc. | Novel cyclosporin analog microemulsion preconcentrates |
MXPA04005361A (es) * | 2001-12-13 | 2004-09-27 | Vital Health Sciences Pyt Ltd | Transporte transdermico de compuestos. |
AU2002950713A0 (en) * | 2002-08-09 | 2002-09-12 | Vital Health Sciences Pty Ltd | Carrier |
EP1589964B1 (en) * | 2003-01-17 | 2011-11-23 | Vital Health Sciences Pty Ltd. | Compounds having anti-proliferative properties |
AU2003901815A0 (en) * | 2003-04-15 | 2003-05-01 | Vital Health Sciences Pty Ltd | Phosphate derivatives |
US20050074469A1 (en) * | 2003-10-03 | 2005-04-07 | Charles Signorino | Stable lipophilic emulsions for acrylic coating and method of making |
EP1558215A4 (en) * | 2003-10-14 | 2007-09-12 | Wockhardt Ltd | STERILE GELIFYING AGENTS |
WO2005074881A2 (en) * | 2004-02-06 | 2005-08-18 | Showa Denko K.K. | Method for stabilizing oil-based thickening gel composition |
AU2005202477B2 (en) * | 2004-03-03 | 2005-12-15 | Vital Health Sciences Pty Ltd | Alkaloid formulations |
US20050277584A1 (en) * | 2004-06-09 | 2005-12-15 | Allergan, Inc. | Pharmaceutical compositions comprising cyclosporins |
US20060088591A1 (en) * | 2004-10-22 | 2006-04-27 | Jinghua Yuan | Tablets from a poorly compressible substance |
BRPI0518239A2 (pt) * | 2004-10-29 | 2008-11-11 | Novartis Ag | composiÇÕes farmacÊuticas espontaneamente dispersÍveis |
JP5221343B2 (ja) * | 2005-06-17 | 2013-06-26 | バイタル ヘルス サイエンシズ プロプライアタリー リミティド | 担体 |
US20070087962A1 (en) * | 2005-10-17 | 2007-04-19 | Allergan, Inc. | Pharmaceutical compositions comprising cyclosporins |
US20090005348A1 (en) * | 2005-12-23 | 2009-01-01 | Vital Health Sciences Pty Ltd | Compounds Having Cytokine Modulating Properties |
EP1867323A1 (en) * | 2006-06-13 | 2007-12-19 | Farmatron Ltd. | Pharmaceutical compositions with biological barriers permeation enhancing properties |
CA2715018C (en) | 2008-03-20 | 2012-11-13 | Virun, Inc. | Vitamin e derivatives and their uses |
EP2268160B1 (en) * | 2008-03-20 | 2012-12-05 | Virun, Inc. | Emulsions including a peg-derivative of tocopherol |
ES2344674B1 (es) * | 2008-08-07 | 2011-06-29 | Gp Pharm, S.A. | Composicion farmaceutica inyectable de taxanos. |
EP2531047A4 (en) | 2010-02-05 | 2014-03-19 | Phosphagenics Ltd | CARRIER WITH AN UNINUTRALIZED TOCOPHERYL PHOSPHATE |
CA2792330C (en) | 2010-03-23 | 2017-01-03 | Virun, Inc | Nanoemulsion including a peg-derivative of vitamin e and a sucrose fatty acid ester |
JP5806287B2 (ja) | 2010-03-30 | 2015-11-10 | フォスファジェニクス リミティド | 経皮送達パッチ |
US8741373B2 (en) | 2010-06-21 | 2014-06-03 | Virun, Inc. | Compositions containing non-polar compounds |
US8722131B2 (en) | 2010-09-07 | 2014-05-13 | Dsm Nutritional Products Ag | Comestible emulsions |
US9561243B2 (en) | 2011-03-15 | 2017-02-07 | Phosphagenics Limited | Composition comprising non-neutralised tocol phosphate and a vitamin A compound |
CN104114154A (zh) * | 2011-12-16 | 2014-10-22 | 阿勒根公司 | 包含聚乙烯基己内酰胺-聚乙酸乙烯酯-聚乙二醇接枝共聚物(Soluplus)的眼用组合物 |
SG11201404640YA (en) | 2012-02-10 | 2014-09-26 | Virun Inc | Beverage compositions containing non-polar compounds |
ITRM20120331A1 (it) | 2012-07-12 | 2014-01-13 | Guidotti & C Spa Labor | Composizioni pediatriche orali liquide contenenti nepadutant. |
GB201222455D0 (en) * | 2012-12-13 | 2013-01-30 | Perioc Ltd | Novel pharmaceutical formulations and their use in the treatment of periodontaldisease |
US9351517B2 (en) | 2013-03-15 | 2016-05-31 | Virun, Inc. | Formulations of water-soluble derivatives of vitamin E and compositions containing same |
US9693574B2 (en) | 2013-08-08 | 2017-07-04 | Virun, Inc. | Compositions containing water-soluble derivatives of vitamin E mixtures and modified food starch |
US9861611B2 (en) | 2014-09-18 | 2018-01-09 | Virun, Inc. | Formulations of water-soluble derivatives of vitamin E and soft gel compositions, concentrates and powders containing same |
US10016363B2 (en) | 2014-09-18 | 2018-07-10 | Virun, Inc. | Pre-spray emulsions and powders containing non-polar compounds |
CN114712308A (zh) | 2015-12-09 | 2022-07-08 | 磷肌酸有限公司 | 药物制剂 |
MX2019006845A (es) | 2016-12-21 | 2019-10-15 | Avecho Biotechnology Ltd | Proceso. |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE295765C (da) * | ||||
DE298351C (da) * | 1915-04-09 | |||
SE445174B (sv) * | 1978-03-07 | 1986-06-09 | Sandoz Ag | Farmaceutisk komposition innehallande en cyklosporin och en berarsubstans |
US4861580A (en) * | 1985-10-15 | 1989-08-29 | The Liposome Company, Inc. | Composition using salt form of organic acid derivative of alpha-tocopheral |
US5154930A (en) * | 1987-03-05 | 1992-10-13 | The Liposome Company, Inc. | Pharmacological agent-lipid solution preparation |
GB2222770B (en) * | 1988-09-16 | 1992-07-29 | Sandoz Ltd | Pharmaceutical compositions containing cyclosporins |
US5342625A (en) * | 1988-09-16 | 1994-08-30 | Sandoz Ltd. | Pharmaceutical compositions comprising cyclosporins |
DE3908047A1 (de) * | 1989-03-13 | 1990-09-20 | Desitin Arzneimittel Gmbh | Hochdisperse pharmazeutische zusammensetzung |
US5364632A (en) * | 1989-04-05 | 1994-11-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Medicinal emulsions |
AU614465B2 (en) * | 1989-04-05 | 1991-08-29 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Medicinal emulsions |
US5234695A (en) * | 1990-07-24 | 1993-08-10 | Eastman Kodak Company | Water dispersible vitamin E composition |
HU208491B (en) * | 1990-11-27 | 1993-11-29 | Gyogyszerkutato Intezet | Process for producing oral pharmaceutical composition containing cyclosporin |
GB9113872D0 (en) * | 1991-06-27 | 1991-08-14 | Sandoz Ag | Improvements in or relating to organic compounds |
IL101241A (en) * | 1992-03-16 | 1997-11-20 | Yissum Res Dev Co | Pharmaceutical or cosmetic composition comprising stabilized oil-in-water type emulsion as carrier |
GB9208712D0 (en) * | 1992-04-22 | 1992-06-10 | Sandoz Ltd | Pharmaceutical compositions containing cyclosporin derivates |
US5527537A (en) * | 1992-05-18 | 1996-06-18 | Dietl; Hans | Pharmaceutical preparation containing cyclosporine(s) for intravenous administration and a process for its production |
ES2168271T3 (es) * | 1992-09-25 | 2002-06-16 | Novartis Ag | Composiciones farmaceuticas que contienen ciclosporinas. |
WO1994008605A1 (en) * | 1992-10-16 | 1994-04-28 | Smithkline Beecham Corporation | Therapeutic microemulsions |
EP0671929A4 (en) * | 1992-10-16 | 1996-09-25 | Smithkline Beecham Corp | COMPOSITIONS. |
DE10199039I2 (de) * | 1993-10-22 | 2008-08-07 | Hexal Ag Ind 25 | Pharmazeutische zusammensetzung mit cyclosporin a, einen vitamin e derivat und einen emulgator |
US5447729A (en) * | 1994-04-07 | 1995-09-05 | Pharmavene, Inc. | Multilamellar drug delivery systems |
-
1994
- 1994-11-21 HU HU9403328A patent/HU215966B/hu not_active IP Right Cessation
-
1995
- 1995-03-21 CA CA002145242A patent/CA2145242C/en not_active Expired - Fee Related
- 1995-03-31 US US08/414,496 patent/US5583105A/en not_active Expired - Lifetime
- 1995-04-25 CZ CZ19951054A patent/CZ286686B6/cs not_active IP Right Cessation
- 1995-04-27 SK SK544-95A patent/SK283045B6/sk not_active IP Right Cessation
- 1995-05-03 EP EP95106655A patent/EP0712631B1/en not_active Expired - Lifetime
- 1995-05-03 PT PT95106655T patent/PT712631E/pt unknown
- 1995-05-03 DK DK95106655T patent/DK0712631T3/da active
- 1995-05-03 ES ES95106655T patent/ES2202330T3/es not_active Expired - Lifetime
- 1995-05-03 AT AT95106655T patent/ATE245994T1/de not_active IP Right Cessation
- 1995-05-03 DE DE69531389T patent/DE69531389T2/de not_active Expired - Fee Related
- 1995-05-08 KR KR1019950011130A patent/KR100377058B1/ko not_active IP Right Cessation
- 1995-11-13 SI SI9500350A patent/SI9500350B/sl not_active IP Right Cessation
- 1995-11-14 GB GB9523295A patent/GB2295546B/en not_active Expired - Fee Related
- 1995-11-20 DE DE19543271A patent/DE19543271B4/de not_active Expired - Fee Related
- 1995-11-20 PL PL95311430A patent/PL182716B1/pl not_active IP Right Cessation
- 1995-11-21 IT IT95MI002411A patent/IT1281337B1/it active IP Right Grant
- 1995-11-21 AT AT0189395A patent/AT408945B/de not_active IP Right Cessation
-
1998
- 1998-12-28 HK HK98116138A patent/HK1016814A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HK1016814A1 (en) | 1999-11-05 |
PL182716B1 (pl) | 2002-02-28 |
US5583105A (en) | 1996-12-10 |
DK0712631T3 (da) | 2003-10-27 |
ITMI952411A0 (da) | 1995-11-21 |
ATA189395A (de) | 2001-09-15 |
HU9403328D0 (en) | 1995-02-28 |
PT712631E (pt) | 2003-11-28 |
ATE245994T1 (de) | 2003-08-15 |
KR100377058B1 (ko) | 2003-06-11 |
ES2202330T3 (es) | 2004-04-01 |
SK54495A3 (en) | 1997-02-05 |
SI9500350A (en) | 1996-06-30 |
GB2295546B (en) | 1998-07-22 |
DE69531389T2 (de) | 2004-04-15 |
DE19543271B4 (de) | 2006-05-24 |
IT1281337B1 (it) | 1998-02-18 |
AT408945B (de) | 2002-04-25 |
CZ105495A3 (en) | 1996-07-17 |
HU215966B (hu) | 1999-07-28 |
EP0712631A2 (en) | 1996-05-22 |
DE69531389D1 (de) | 2003-09-04 |
GB2295546A (en) | 1996-06-05 |
CA2145242A1 (en) | 1996-05-22 |
GB9523295D0 (en) | 1996-01-17 |
SK283045B6 (sk) | 2003-02-04 |
KR960016903A (ko) | 1996-06-17 |
DE19543271A1 (de) | 1996-06-05 |
CZ286686B6 (en) | 2000-06-14 |
EP0712631A3 (en) | 1996-12-04 |
EP0712631B1 (en) | 2003-07-30 |
PL311430A1 (en) | 1996-05-27 |
ITMI952411A1 (it) | 1997-05-21 |
CA2145242C (en) | 2001-08-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SI9500350B (sl) | Oralni multipli emulzijski predkoncentrat | |
FR2710535B1 (fr) | Composition à usage pharmaceutique ou cosmétique apte à former une microémulsion. | |
NO20000467L (no) | Farmasøytisk preparat i form av en selvemulgerende formulering for lipofile forbindelser | |
KR960016904A (ko) | 사이클로스포린-함유 연질캅셀제 조성물 | |
NZ512287A (en) | Pharmaceutical compositions comprising a lipophilic drug in a propylene glycol ester of a higher fatty acid carrier, where 60% of the ester is a monoester | |
JP2003519184A5 (da) | ||
CA2284000A1 (en) | Hydrophilic binary systems for the administration of cyclosporine | |
WO2003011207A3 (fr) | Composition pharmaceutique a usage oral comprenant un principe actif susceptible de subir un important effet de premier passage intestinal | |
DK1073415T3 (da) | Gelerbare farmaceutiske sammensætninger | |
EP1147766A3 (en) | Pharmaceutical compositions | |
CA2358448A1 (en) | Dispersible concentrate for the delivery of cyclosporin | |
SK17222001A3 (sk) | Farmaceutické prostriedky obsahujúce cyklosporín | |
WO2000037057A3 (en) | Novel formulations comprising lipid-regulating agents | |
HRP20020154B1 (en) | Pharmaceutical compositions for oral and topical administration | |
KR970706803A (ko) | 경구용 시클로스포린 제형(oral cyclosporin formulations) | |
ATE396694T1 (de) | O/w-emulsionen mit unpolaren wirkstoffen | |
ES2180065T3 (es) | Formulaciones de uso topico que contienen acetato de vitamina e. | |
RU99121398A (ru) | Фармацевтические композиции |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
IF | Valid on the event date | ||
OU02 | Decision according to article 73(2) ipa 1992, publication of decision on partial fulfilment of the invention and change of patent claims |
Effective date: 20041118 |
|
SP73 | Change of data on owner |
Owner name: TEVA GYOGYSZERGYAR RESZVENYTARSASAG; HU Effective date: 20050517 |
|
SP73 | Change of data on owner |
Owner name: TEVA GYOGYSZERGYAR ZARTKORUEN MUKODO RESZVENYT; HU Effective date: 20070124 |
|
KO00 | Lapse of patent |
Effective date: 20110728 |