SI9200344B - Postopek za pripravo amlodipin benzensulfonata - Google Patents
Postopek za pripravo amlodipin benzensulfonata Download PDFInfo
- Publication number
- SI9200344B SI9200344B SI9200344A SI9200344A SI9200344B SI 9200344 B SI9200344 B SI 9200344B SI 9200344 A SI9200344 A SI 9200344A SI 9200344 A SI9200344 A SI 9200344A SI 9200344 B SI9200344 B SI 9200344B
- Authority
- SI
- Slovenia
- Prior art keywords
- methyl
- dihydro
- ethyl
- temperature
- pyridinedicarboxylate
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 7
- ZPBWCRDSRKPIDG-UHFFFAOYSA-N amlodipine benzenesulfonate Chemical compound OS(=O)(=O)C1=CC=CC=C1.CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl ZPBWCRDSRKPIDG-UHFFFAOYSA-N 0.000 title claims abstract 5
- 238000002360 preparation method Methods 0.000 title claims abstract 3
- SRSXLGNVWSONIS-UHFFFAOYSA-N benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-N 0.000 claims abstract 4
- 238000010992 reflux Methods 0.000 claims abstract 4
- 150000001875 compounds Chemical class 0.000 claims abstract 2
- 229940092714 benzenesulfonic acid Drugs 0.000 claims 3
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims 1
- UUCFCQRFDOVICL-UHFFFAOYSA-N 5-o-ethyl 3-o-methyl 4-(2-chlorophenyl)-2-methyl-6-[2-(tritylamino)ethoxymethyl]-1,4-dihydropyridine-3,5-dicarboxylate Chemical compound N1C(C)=C(C(=O)OC)C(C=2C(=CC=CC=2)Cl)C(C(=O)OCC)=C1COCCNC(C=1C=CC=CC=1)(C=1C=CC=CC=1)C1=CC=CC=C1 UUCFCQRFDOVICL-UHFFFAOYSA-N 0.000 claims 1
- -1 N-tritylamino Chemical group 0.000 claims 1
- IRMNIXXVOOMKKP-UHFFFAOYSA-N [methoxy(diphenyl)methyl]benzene Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(OC)C1=CC=CC=C1 IRMNIXXVOOMKKP-UHFFFAOYSA-N 0.000 claims 1
- 230000004060 metabolic process Effects 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- COCAEBRMIPXXOV-UHFFFAOYSA-N 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid;benzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=CC=C1.OC(=O)C1=C(COCCN)NC(C)=C(C(O)=O)C1C1=CC=CC=C1Cl COCAEBRMIPXXOV-UHFFFAOYSA-N 0.000 abstract 1
- 230000002253 anti-ischaemic effect Effects 0.000 abstract 1
- 229940030600 antihypertensive agent Drugs 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyridine Compounds (AREA)
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI9200344A SI9200344B (sl) | 1992-11-26 | 1992-11-26 | Postopek za pripravo amlodipin benzensulfonata |
CZ932165A CZ283041B6 (cs) | 1992-11-26 | 1993-10-13 | Způsob přípravy amlodipinbenzensulfonátu |
SK1125-93A SK279353B6 (sk) | 1992-11-26 | 1993-10-15 | Spôsob prípravy 3-etyl-5-metyl-(+/-)-2-((2-aminoet |
FI934882A FI103042B (fi) | 1992-11-26 | 1993-11-04 | Menetelmä amlodipiinibentseenisulfonaatin valmistamiseksi ja tässä men etelmässä välituotteena toimiva yhdiste |
US08/149,735 US5389654A (en) | 1992-11-26 | 1993-11-10 | 3-ethyl 5-methyl(±)2-[2-(N-tritylamino)ethoxymethyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-6-methyl-3,5-pyridinedicarboxylate |
PL93321792A PL174647B1 (pl) | 1992-11-26 | 1993-11-17 | Sposób wytwarzania (+) 2-[2-(N-trytyloamino) etoksymetylo]-4-(2-chlorofenylo)-1,4-dihydro-6-metylopirydynodwukarboksylanu-3,5 3-etylowo-5-metylowego i (+)2-[2-(N-trytyloamino) etoksymetylo]-4-(2-chlorofenylo)-1,4-dihydro-6-metylopirydynodwukarboksylan-3,5 3-etylowo-5-metylowy |
PL93301080A PL173645B1 (pl) | 1992-11-26 | 1993-11-17 | Sposób wytwarzania monobenzenosulfonianu (+) 2-[(2-aminoetoksy)metylo]-4-(2-chlorofenylo)-1,4-dihydro-6-metylopirydynodwukarboksylanu-3,5 3-etylowo-5-metylowego |
DE69304020T DE69304020T2 (de) | 1992-11-26 | 1993-11-19 | Verfahren zur Herstellung von amlodipin-Benzolsulfonat |
EP93118661A EP0599220B1 (en) | 1992-11-26 | 1993-11-19 | A process for the preparation of amlodipine benzenesulphonate |
HRP-9200344A HRP931429B1 (en) | 1992-11-26 | 1993-11-23 | Process for the preparation of amlodipin benzensulphonate |
RU93052391A RU2105759C1 (ru) | 1992-11-26 | 1993-11-25 | Способ получения 3-этил-5-метил (*01+)2[(2-аминоэтокси)-метил]-4-(2-хлорфенил)-1,4-дигидро-6-метил-3,5-пиридиндикарбоксилатмонобензолсульфоната и промежуточное для него |
US08/295,023 US5438145A (en) | 1992-11-26 | 1994-08-25 | Process for the preparation of amlodipine benzenesulphonate |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SI9200344A SI9200344B (sl) | 1992-11-26 | 1992-11-26 | Postopek za pripravo amlodipin benzensulfonata |
Publications (2)
Publication Number | Publication Date |
---|---|
SI9200344A SI9200344A (en) | 1994-06-30 |
SI9200344B true SI9200344B (sl) | 1998-06-30 |
Family
ID=20431051
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI9200344A SI9200344B (sl) | 1992-11-26 | 1992-11-26 | Postopek za pripravo amlodipin benzensulfonata |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0599220B1 (cs) |
CZ (1) | CZ283041B6 (cs) |
DE (1) | DE69304020T2 (cs) |
FI (1) | FI103042B (cs) |
HR (1) | HRP931429B1 (cs) |
PL (2) | PL173645B1 (cs) |
RU (1) | RU2105759C1 (cs) |
SI (1) | SI9200344B (cs) |
SK (1) | SK279353B6 (cs) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU221810B1 (hu) * | 1997-08-12 | 2003-01-28 | EGIS Gyógyszergyár Rt. | Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei |
PL189666B1 (pl) * | 1998-04-09 | 2005-09-30 | Adamed Sp Z Oo | Sposób otrzymywania benzenosulfonianu amlodypiny |
UA33033A (uk) * | 1998-10-16 | 2001-02-15 | Др.Редіс Леборетрис Лтд | Спосіб одержання безилату амлодипіну |
RU2142942C1 (ru) * | 1999-04-28 | 1999-12-20 | Дж. Б.Кемикалс энд Фармасьютикалс Лтд. | Способ получения монобензолсульфоната 3-этил-5-метилового эфира 2-[(2-аминоэтокси)метил]-4-(2-хлорфенил)-1,4-дигидро-6-метил-3,5-пиридинди карбоновой кислоты |
UA72768C2 (en) * | 1999-07-05 | 2005-04-15 | Richter Gedeon Vegyeszet | A method for obtaining amilodipine benzenesulphonate |
RU2146672C1 (ru) * | 1999-10-13 | 2000-03-20 | Др.Редди'С Лабораторис Лтд. | Способ получения 3-этил-5-метил(±)2[2-аминоэтокси)-метил]-4-(2-хлорфенил)-1,4-дигидро- 6-метил-3,5-пиридиндикарбоксилат монобензолсульфоната |
ATE454890T1 (de) | 2001-07-06 | 2010-01-15 | Lek Pharmaceuticals | Verfahren zur herstellung hochreines amlodipinbenzolsulfonat |
US6680334B2 (en) | 2001-08-28 | 2004-01-20 | Pfizer Inc | Crystalline material |
US6828339B2 (en) * | 2001-11-21 | 2004-12-07 | Synthon Bv | Amlodipine salt forms and processes for preparing them |
SI21233A (sl) * | 2002-05-31 | 2003-12-31 | LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d. | Kristalni hidratni obliki amlodipin benzensulfonata visoke čistote, postopki za njuno pripravo in uporaba |
US6784297B2 (en) | 2002-09-04 | 2004-08-31 | Kopran Limited | Process for the preparation of anti-ischemic and anti-hypertensive drug amlodipine besylate |
EP1407773A1 (en) * | 2002-10-08 | 2004-04-14 | Council of Scientific and Industrial Research | A process for the preparation of s (-) amlodipine salts |
AU2002368531A1 (en) * | 2002-12-30 | 2004-07-22 | Eos Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ticaret A.S. | Isolation of dihydropyridine derivative and preparation salts thereof |
JP4539862B2 (ja) | 2003-03-28 | 2010-09-08 | 日産化学工業株式会社 | T型カルシウムチャネル阻害剤 |
WO2007131759A1 (en) * | 2006-05-15 | 2007-11-22 | Lek Pharmaceuticals D.D. | A process for the preparation of amlodipine benzenesulfonate |
RU2357781C1 (ru) * | 2008-02-06 | 2009-06-10 | Емельяна Зиповна Гильдеева | Способ разделения оптических изомеров амлодипина |
ES2665419T3 (es) | 2008-07-08 | 2018-04-25 | Incyte Holdings Corporation | 1,2,5-Oxadiazoles como inhibidores de la indoleamina 2,3-dioxigenasa |
RU2537186C2 (ru) * | 2008-12-22 | 2014-12-27 | Пола Кемикал Индастриз Инк. | Ингибитор продуцирования меланина |
CN102516159B (zh) * | 2011-12-15 | 2013-10-09 | 扬子江药业集团江苏海慈生物药业有限公司 | 一种苯磺酸左旋氨氯地平的生产方法 |
CA2889182A1 (en) | 2012-10-26 | 2014-05-01 | The University Of Chicago | Synergistic combination of immunologic inhibitors for the treatment of cancer |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK161312C (da) * | 1982-03-11 | 1991-12-09 | Pfizer | Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden |
GB8608335D0 (en) * | 1986-04-04 | 1986-05-08 | Pfizer Ltd | Pharmaceutically acceptable salts |
EP0352863A3 (en) * | 1988-07-29 | 1990-08-22 | ZAMBON GROUP S.p.A. | 1,4-dihydropyridine dicarboxylic acid derivatives |
-
1992
- 1992-11-26 SI SI9200344A patent/SI9200344B/sl unknown
-
1993
- 1993-10-13 CZ CZ932165A patent/CZ283041B6/cs not_active IP Right Cessation
- 1993-10-15 SK SK1125-93A patent/SK279353B6/sk not_active IP Right Cessation
- 1993-11-04 FI FI934882A patent/FI103042B/fi not_active IP Right Cessation
- 1993-11-17 PL PL93301080A patent/PL173645B1/pl not_active IP Right Cessation
- 1993-11-17 PL PL93321792A patent/PL174647B1/pl not_active IP Right Cessation
- 1993-11-19 DE DE69304020T patent/DE69304020T2/de not_active Expired - Lifetime
- 1993-11-19 EP EP93118661A patent/EP0599220B1/en not_active Expired - Lifetime
- 1993-11-23 HR HRP-9200344A patent/HRP931429B1/xx not_active IP Right Cessation
- 1993-11-25 RU RU93052391A patent/RU2105759C1/ru not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FI934882L (fi) | 1994-05-27 |
CZ216593A3 (en) | 1994-06-15 |
SK112593A3 (en) | 1994-11-09 |
EP0599220B1 (en) | 1996-08-14 |
CZ283041B6 (cs) | 1997-12-17 |
HRP931429A2 (en) | 1995-12-31 |
FI934882A0 (fi) | 1993-11-04 |
HRP931429B1 (en) | 1997-10-31 |
SK279353B6 (sk) | 1998-10-07 |
EP0599220A1 (en) | 1994-06-01 |
PL173645B1 (pl) | 1998-04-30 |
PL174647B1 (pl) | 1998-08-31 |
SI9200344A (en) | 1994-06-30 |
FI103042B1 (fi) | 1999-04-15 |
DE69304020T2 (de) | 1997-03-06 |
PL301080A1 (en) | 1994-05-30 |
RU2105759C1 (ru) | 1998-02-27 |
DE69304020D1 (de) | 1996-09-19 |
FI103042B (fi) | 1999-04-15 |
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